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Jon D. Piganelli
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Meeting Abstracts

226-LB: Repurposing a Cancer Drug, AZD6738 (ATRi), for the Prevention of Type 1 Diabetes

NORIE SUGITANI, HANNAH R. MASON, SAPTARSHI ROY, JON D. PIGANELLI
Journal: Diabetes
Diabetes 2023;72(Supplement_1):226-LB
https://doi.org/10.2337/db23-226-LB
Published: 20 June 2023
View article titled, 226-LB: Repurposing a Cancer Drug, AZD6738 (ATRi), for the Prevention of Type 1 Diabetes
Journal Articles

Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes

Mijke Buitinga, Aïsha Callebaut, Fernanda Marques Câmara Sodré, Inne Crèvecoeur, Gabriele Blahnik-Fagan, Mei-Ling Yang, Marco Bugliani, David Arribas-Layton, Meghan Marré, Dana P. Cook, Etienne Waelkens, Roberto Mallone, Jon D. Piganelli, Piero Marchetti, Mark J. Mamula, Rita Derua, Eddie A. James, Chantal Mathieu, Lut Overbergh
Journal: Diabetes
Diabetes 2018;67(11):2337–2348
https://doi.org/10.2337/db18-0295
Published: 11 October 2018
View article titled, Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes
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Includes: Supplementary data
Journal Articles

Modifying Enzymes Are Elicited by ER Stress, Generating Epitopes That Are Selectively Recognized by CD4+ T Cells in Patients With Type 1 Diabetes

Meghan L. Marre, John W. McGinty, I-Ting Chow, Megan E. DeNicola, Noah W. Beck, Sally C. Kent, Alvin C. Powers, Rita Bottino, David M. Harlan, Carla J. Greenbaum, William W. Kwok, Jon D. Piganelli, Eddie A. James
Journal: Diabetes
Diabetes 2018;67(7):1356–1368
https://doi.org/10.2337/db17-1166
Published: 13 April 2018
View article titled, Modifying Enzymes Are Elicited by ER Stress, Generating Epitopes That Are Selectively Recognized by CD4<sup>+</sup> T Cells in Patients With Type 1 Diabetes
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Includes: Supplementary data
Journal Articles

Loss of NOX-Derived Superoxide Exacerbates Diabetogenic CD4 T-Cell Effector Responses in Type 1 Diabetes

Lindsey E. Padgett, Brian Anderson, Chao Liu, Douglas Ganini, Ronald P. Mason, Jon D. Piganelli, Clayton E. Mathews, Hubert M. Tse
Journal: Diabetes
Diabetes 2015;64(12):4171–4183
https://doi.org/10.2337/db15-0546
Published: 12 August 2015
View article titled, Loss of NOX-Derived Superoxide Exacerbates Diabetogenic CD4 T-Cell Effector Responses in Type 1 Diabetes
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Includes: Supplementary data
Journal Articles

Cytokine and Chemokine Production by Human Pancreatic Islets Upon Enterovirus Infection

Barbara M. Schulte, Kjerstin H.W. Lanke, Jon D. Piganelli, Esther D. Kers-Rebel, Rita Bottino, Massimo Trucco, Richard J.F. Huijbens, Timothy R.D.J. Radstake, Marten A. Engelse, Eelco J.P. de Koning, Jochem M. Galama, Gosse J. Adema, Frank J.M. van Kuppeveld
Journal: Diabetes
Diabetes 2012;61(8):2030–2036
https://doi.org/10.2337/db11-1547
Published: 17 July 2012
View article titled, Cytokine and Chemokine Production by Human Pancreatic Islets Upon Enterovirus Infection
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Journal Articles

Modulation of Redox Balance Leaves Murine Diabetogenic TH1 T Cells “LAG-3-ing” Behind

Meghan M. Delmastro, Alexis J. Styche, Massimo M. Trucco, Creg J. Workman, Dario A.A. Vignali, Jon D. Piganelli
Journal: Diabetes
Diabetes 2012;61(7):1760–1768
https://doi.org/10.2337/db11-1591
Published: 15 June 2012
View article titled, Modulation of Redox Balance Leaves Murine Diabetogenic TH1 T Cells “LAG-3-ing” Behind
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Journal Articles

Superoxide Production by Macrophages and T Cells Is Critical for the Induction of Autoreactivity and Type 1 Diabetes

Terri C. Thayer, Matthew Delano, Chao Liu, Jing Chen, Lindsey E. Padgett, Hubert M. Tse, Mani Annamali, Jon D. Piganelli, Lyle L. Moldawer, Clayton E. Mathews
Journal: Diabetes
Diabetes 2011;60(8):2144–2151
https://doi.org/10.2337/db10-1222
Published: 18 July 2011
View article titled, Superoxide Production by Macrophages and T Cells Is Critical for the Induction of Autoreactivity and Type 1 Diabetes
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Includes: Supplementary data
Journal Articles

Redox Modulation Protects Islets From Transplant-Related Injury

Martha M. Sklavos, Suzanne Bertera, Hubert M. Tse, Rita Bottino, Jing He, Joshua N. Beilke, Marilyne G. Coulombe, Ronald G. Gill, James D. Crapo, Massimo Trucco, Jon D. Piganelli
Journal: Diabetes
Diabetes 2010;59(7):1731–1738
https://doi.org/10.2337/db09-0588
Published: 22 April 2010
View article titled, Redox Modulation Protects Islets From Transplant-Related Injury
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Includes: Supplementary data
Journal Articles

Phagocytosis of Enterovirus-Infected Pancreatic β-Cells Triggers Innate Immune Responses in Human Dendritic Cells

Barbara M. Schulte, Matthijs Kramer, Marleen Ansems, Kjerstin H.W. Lanke, Neeltje van Doremalen, Jon D. Piganelli, Rita Bottino, Massimo Trucco, Jochem M.D. Galama, Gosse J. Adema, Frank J.M. van Kuppeveld
Journal: Diabetes
Diabetes 2010;59(5):1182–1191
https://doi.org/10.2337/db09-1071
Published: 13 January 2010
View article titled, Phagocytosis of Enterovirus-Infected Pancreatic β-Cells Triggers Innate Immune Responses in Human Dendritic Cells
Open the PDF for Phagocytosis of Enterovirus-Infected Pancreatic β-Cells Triggers Innate Immune Responses in Human Dendritic Cells in another window
Includes: Supplementary data
Journal Articles

Modulatory Role of DR4- to DQ8-restricted CD4 T-Cell Responses and Type 1 Diabetes Susceptibility

Xinhui Ge, Jon D. Piganelli, Hubert M. Tse, Suzanne Bertera, Clayton E. Mathews, Massimo Trucco, Li Wen, William A. Rudert
Journal: Diabetes
Diabetes 2006;55(12):3455–3462
https://doi.org/10.2337/db06-0680
Published: 01 December 2006
View article titled, Modulatory Role of DR4- to DQ8-restricted CD4 T-Cell Responses and Type 1 Diabetes Susceptibility
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Journal Articles

Response of Human Islets to Isolation Stress and the Effect of Antioxidant Treatment

Rita Bottino, A.N. Balamurugan, Hubert Tse, C. Thirunavukkarasu, Xinhui Ge, Jennifer Profozich, Martha Milton, Audra Ziegenfuss, Massimo Trucco, Jon D. Piganelli
Journal: Diabetes
Diabetes 2004;53(10):2559–2568
https://doi.org/10.2337/diabetes.53.10.2559
Published: 01 October 2004
View article titled, Response of Human Islets to Isolation Stress and the Effect of Antioxidant Treatment
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Journal Articles

Caspase-1 Is Not Required for Type 1 Diabetes in the NOD Mouse

William H. Schott, Bradford D. Haskell, Hubert M. Tse, Martha J. Milton, Jon D. Piganelli, Caroline Morgane Choisy-Rossi, Peter C. Reifsnyder, Alexander V. Chervonsky, Edward H. Leiter
Journal: Diabetes
Diabetes 2004;53(1):99–104
https://doi.org/10.2337/diabetes.53.1.99
Published: 01 January 2004
View article titled, Caspase-1 Is Not Required for Type 1 Diabetes in the NOD Mouse
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Journal Articles

Preservation of Human Islet Cell Functional Mass by Anti-Oxidative Action of a Novel SOD Mimic Compound

Rita Bottino, A.N. Balamurugan, Suzanne Bertera, Massimo Pietropaolo, Massimo Trucco, Jon D. Piganelli
Journal: Diabetes
Diabetes 2002;51(8):2561–2567
https://doi.org/10.2337/diabetes.51.8.2561
Published: 01 August 2002
View article titled, Preservation of Human Islet Cell Functional Mass by Anti-Oxidative Action of a Novel SOD Mimic Compound
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Journal Articles

A Metalloporphyrin-Based Superoxide Dismutase Mimic Inhibits Adoptive Transfer of Autoimmune Diabetes by a Diabetogenic T-Cell Clone

Jon D. Piganelli, Sonia C. Flores, Coral Cruz, Jeffrey Koepp, Ines Batinic-Haberle, James Crapo, Brian Day, Remy Kachadourian, Rebekah Young, Brenda Bradley, Kathryn Haskins
Journal: Diabetes
Diabetes 2002;51(2):347–355
https://doi.org/10.2337/diabetes.51.2.347
Published: 01 February 2002
View article titled, A Metalloporphyrin-Based Superoxide Dismutase Mimic Inhibits Adoptive Transfer of Autoimmune Diabetes by a Diabetogenic T-Cell Clone
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Journal Articles

Splenic Macrophages From the NOD Mouse Are Defective in the Ability to Present Antigen

Jon D Piganelli, Tracy Martin, Kathryn Haskins
Journal: Diabetes
Diabetes 1998;47(8):1212–1218
https://doi.org/10.2337/diab.47.8.1212
Published: 01 August 1998
View article titled, Splenic Macrophages From the NOD Mouse Are Defective in the Ability to Present Antigen
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