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Meeting Abstracts

203-OR: Measurement of Intact Insulin by Mass Spectrometry Identifies Nonalcoholic Fatty Liver Disease (NAFLD)

FERNANDO BRIL, MICHAEL J. MCPHAUL, SRILAXMI KALAVALAPALLI, ROMINA LOMONACO, DIANA BARB, EDDISON GODINEZ, KENNETH CUSI

Diabetes 2021;70(Supplement_1):203-OR

DOI: https://doi.org/10.2337/db21-203-OR

Published: 01 June 2021

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Meeting Abstracts

283-OR: Inadequate Hepatic Mitochondrial Adaptation in Patients with NASH Is Related to the Severity of Steatohepatitis and Fibrosis Stage

SRILAXMI KALAVALAPALLI, DIANA BARB, EDDISON GODINEZ, ROMINA LOMONACO, JEFFREY FRIEDMAN, STEPHANIE WOHLGEMUTH, NADA FANOUS, RACHEL E. DILLARD, TYLER M. COWAN, DANIELLE POULTON, LYDIA MANSOUR, SULAV SHRESTHA, FERNANDO BRIL, SREEVIDYA K. SUBBARAYAN, SUSHMA KADIYALA, KENNETH CUSI

Diabetes 2021;70(Supplement_1):283-OR

DOI: https://doi.org/10.2337/db21-283-OR

Published: 01 June 2021

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Meeting Abstracts

233-LB: Spinal Cord Injury Inhibited-FGF21 Signaling Is Associated with Dysregulation of Metabolic Gene Expression in Mouse Liver and Adipose Tissue

XIN-HUA LIU, LAUREN HARLOW, ZACHARY GRAHAM, JOSHUA F. YARROW, KENNETH CUSI, WILLIAM A. BAUMAN, CHRISTOPHER P. CARDOZO

Diabetes 2020;69(Supplement_1):233-LB

DOI: https://doi.org/10.2337/db20-233-LB

Published: 01 June 2020

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Meeting Abstracts

1472-P: Clinical Profile of Nonalcoholic Fatty Liver Disease in Adults with Type 2 Diabetes Mellitus

KENNETH CUSI, MICHAEL RODEN, ALFRED S. BARRITT, IV, ROBERTO J. FIRPI, VIRGINIA CLARK, SAMUEL KLEIN, ANNA LOK, PHILIP NEWSOME, KAREN CORBIN, MIRIAM B. VOS, RAJENDER REDDY, CHERYL SCHOEN, ANDREA R. MOSPAN, JAWAHAR L. TAUNK, KATHLEEN WYNE, BRENT NEUSCHWANDER-TETRI, ARUN SANYAL

Diabetes 2020;69(Supplement_1):1472-P

DOI: https://doi.org/10.2337/db20-1472-P

Published: 01 June 2020

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Meeting Abstracts

1463-P: Relationship between Hepatic and Adipose Tissue Insulin Resistance with Liver Fibrosis in Patients with Type 2 Diabetes Mellitus (T2DM) and Nonalcoholic Fatty Liver Disease (NAFLD)

SRILAXMI KALAVALAPALLI, ROMINA LOMONACO, EDDISON GODINEZ, NADA FANOUS, LAZARO J. TEJERA, ALLISON MCCAULEY, LYDIA MANSOUR, SULAV SHRESTHA, JONATHAN S. MARTE, JONATHAN FAKHRY, HANNAH WANG, ALEJANDRA VARGAS, DIANA BARB, FERNANDO BRIL, KENNETH CUSI

Diabetes 2020;69(Supplement_1):1463-P

DOI: https://doi.org/10.2337/db20-1463-P

Published: 01 June 2020

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Meeting Abstracts

1461-P: Liver Fibrosis Is Common in Patients with Type 2 Diabetes Mellitus (T2DM) and Nonalcoholic Fatty Liver Disease (NAFLD)

ROMINA LOMONACO, NADA FANOUS, SRILAXMI KALAVALAPALLI, LAZARO J. TEJERA, ALLISON MCCAULEY, EDDISON GODINEZ, LYDIA MANSOUR, SULAV SHRESTHA, JONATHAN S. MARTE, JONATHAN FAKHRY, HANNAH WANG, DIANA BARB, FERNANDO BRIL, KENNETH CUSI

Diabetes 2020;69(Supplement_1):1461-P

DOI: https://doi.org/10.2337/db20-1461-P

Published: 01 June 2020

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Meeting Abstracts

223-OR: Pioglitazone Discontinuation in Patients with Nonalcoholic Steatohepatitis (NASH) Is Associated with Disease Recurrence

FERNANDO BRIL, ROMINA LOMONACO, SRILAXMI KALAVALAPALLI, JINPING LAI, KENNETH CUSI

Diabetes 2019;68(Supplement_1):223-OR

DOI: https://doi.org/10.2337/db19-223-OR

Published: 01 June 2019

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Meeting Abstracts

135-OR: A Novel Thiazolidinedione (TZD) with Minimal PPAR-γ Activity Maximized for Mitochondrial Pyruvate Carrier (MPC) Modulation: Six-Month Analysis of Glycemia in a 12-Month Nonalcoholic Steatohepatitis (NASH) Study

KENNETH CUSI, ORVILLE G. KOLTERMAN, STEPHEN A. HARRISON, HOWARD C. DITTRICH

Diabetes 2019;68(Supplement_1):135-OR

DOI: https://doi.org/10.2337/db19-135-OR

Published: 01 June 2019

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Meeting Abstracts

Role of Vitamin E for the Treatment of Nonalcoholic Steatohepatitis (NASH) in Patients with T2DM—A Randomized, Controlled Trial

FERNANDO BRIL, DIANE M. BIERNACKI, ROMINA LOMONACO, SRILAXMI KALAVALAPALLI, SREEVIDYA K. SUBBARAYAN, JINPING LAI, FERMIN O. TIO, AMITABH SUMAN, BEVERLY K. ORSAK, JOAN HECHT, KENNETH CUSI

Diabetes 2018;67(Supplement_1):1223-P

DOI: https://doi.org/10.2337/db18-1223-P

Published: 01 July 2018

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Meeting Abstracts

Utility of Fibroscan in Screening Overweight and Obese Children at Risk for Nonalcoholic Fatty Liver Disease

KRISTIN A. DAYTON, FERNANDO BRIL, KENNETH CUSI

Diabetes 2018;67(Supplement_1):1364-P

DOI: https://doi.org/10.2337/db18-1364-P

Published: 01 July 2018

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Meeting Abstracts

Exenatide Treatment Improves Mitochondrial Metabolism and Hepatic Insulin Sensitivity in Mice with Nonalcoholic Steatohepatitis (NASH)

SRILAXMI KALAVALAPALLI, FERNANDO BRIL, ARIANA VERGARA, NISHANTH SUNNY, KENNETH CUSI

Diabetes 2018;67(Supplement_1):1846-P

DOI: https://doi.org/10.2337/db18-1846-P

Published: 01 July 2018

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Meeting Abstracts

Clinical Profile of Adults with Nonalcoholic Steatohepatitis (NASH) With and Without Type 2 Diabetes Mellitus (T2DM)

KENNETH CUSI, ALFRED S. BARRITT, IV, VIRGINIA CLARK, ROBERTO J. FIRPI, SAMUEL KLEIN, ANNA LOK, ROHIT LOOMBA, LAURA MALAHIAS, BRENT NEUSCHWANDER-TETRI, CHERYL SCHOEN, K. RAJENDER REDDY, JAWAHAR L. TAUNK, KATHLEEN WYNE, ARUN J. SANYAL

Diabetes 2018;67(Supplement_1):1640-P

DOI: https://doi.org/10.2337/db18-1640-P

Published: 01 July 2018

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Meeting Abstracts

Use of Plasma Metabolomics and Lipidomics for the Diagnosis of Nonalcoholic Fatty Liver Disease in Type 2 Diabetes

FERNANDO BRIL, SRILAXMI KALAVALAPALLI, KEVIN L. DUFFIN, MARK L. HARTMAN, YU CHEN, QIAN YANG, JOSEPH V. HAAS, PAUL L. MILLIGAN, JR., KENNETH D. ROTH, KENNETH CUSI

Diabetes 2018;67(Supplement_1):1847-P

DOI: https://doi.org/10.2337/db18-1847-P

Published: 01 July 2018

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Journal Articles

Comment on: Høeg et al. Lipid-Induced Insulin Resistance Affects Women Less Than Men and Is Not Accompanied by Inflammation or Impaired Proximal Insulin Signaling. Diabetes 2011;60:64–73

Kenneth Cusi

Diabetes 2011;60(9):e23

DOI: https://doi.org/10.2337/db11-0687

Published: 20 August 2011

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Journal Articles

Dose-Response Effect of Elevated Plasma Free Fatty Acid on Insulin Signaling

Renata Belfort, Lawrence Mandarino, Sangeeta Kashyap, Kelly Wirfel, Thongchai Pratipanawatr, Rachele Berria, Ralph A. DeFronzo, Kenneth Cusi

Diabetes 2005;54(6):1640–1648

DOI: https://doi.org/10.2337/diabetes.54.6.1640

Published: 01 June 2005

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Journal Articles

A Sustained Increase in Plasma Free Fatty Acids Impairs Insulin Secretion in Nondiabetic Subjects Genetically Predisposed to Develop Type 2 Diabetes

Sangeeta Kashyap, Renata Belfort, Amalia Gastaldelli, Thongchai Pratipanawatr, Rachele Berria, Wilailak Pratipanawatr, Mandeep Bajaj, Lawrence Mandarino, Ralph DeFronzo, Kenneth Cusi

Diabetes 2003;52(10):2461–2474

DOI: https://doi.org/10.2337/diabetes.52.10.2461

Published: 01 October 2003

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Journal Articles

Free Fatty Acids Reduce Splanchnic and Peripheral Glucose Uptake in Patients With Type 2 Diabetes

Mandeep Bajaj, Thongchai Pratipanawatr, Rachele Berria, Wilailak Pratipanawatr, Sangeeta Kashyap, Kenneth Cusi, Lawrence Mandarino, Ralph A. DeFronzo

Diabetes 2002;51(10):3043–3048

DOI: https://doi.org/10.2337/diabetes.51.10.3043

Published: 01 October 2002

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Journal Articles

Normalization of Plasma Glucose Concentration by Insulin Therapy Improves Insulin-Stimulated Glycogen Synthesis in Type 2 Diabetes

Thongchai Pratipanawatr, Kenneth Cusi, Peter Ngo, Wilailak Pratipanawatr, Lawrence J. Mandarino, Ralph A. DeFronzo

Diabetes 2002;51(2):462–468

DOI: https://doi.org/10.2337/diabetes.51.2.462

Published: 01 February 2002

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Journal Articles

Skeletal Muscle Insulin Resistance in Normoglycemic Subjects With a Strong Family History of Type 2 Diabetes Is Associated With Decreased Insulin-Stimulated Insulin Receptor Substrate-1 Tyrosine Phosphorylation

Wilailak Pratipanawatr, Thongchai Pratipanawatr, Kenneth Cusi, Rachele Berria, John M. Adams, Christopher P. Jenkinson, Katsumi Maezono, Ralph A. DeFronzo, Lawrence J. Mandarino

Diabetes 2001;50(11):2572–2578

DOI: https://doi.org/10.2337/diabetes.50.11.2572

Published: 01 November 2001

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NARROW

203-OR: Measurement of Intact Insulin by Mass Spectrometry Identifies Nonalcoholic Fatty Liver Disease (NAFLD)

283-OR: Inadequate Hepatic Mitochondrial Adaptation in Patients with NASH Is Related to the Severity of Steatohepatitis and Fibrosis Stage

233-LB: Spinal Cord Injury Inhibited-FGF21 Signaling Is Associated with Dysregulation of Metabolic Gene Expression in Mouse Liver and Adipose Tissue

1472-P: Clinical Profile of Nonalcoholic Fatty Liver Disease in Adults with Type 2 Diabetes Mellitus

1463-P: Relationship between Hepatic and Adipose Tissue Insulin Resistance with Liver Fibrosis in Patients with Type 2 Diabetes Mellitus (T2DM) and Nonalcoholic Fatty Liver Disease (NAFLD)

1461-P: Liver Fibrosis Is Common in Patients with Type 2 Diabetes Mellitus (T2DM) and Nonalcoholic Fatty Liver Disease (NAFLD)

223-OR: Pioglitazone Discontinuation in Patients with Nonalcoholic Steatohepatitis (NASH) Is Associated with Disease Recurrence

135-OR: A Novel Thiazolidinedione (TZD) with Minimal PPAR-γ Activity Maximized for Mitochondrial Pyruvate Carrier (MPC) Modulation: Six-Month Analysis of Glycemia in a 12-Month Nonalcoholic Steatohepatitis (NASH) Study

Role of Vitamin E for the Treatment of Nonalcoholic Steatohepatitis (NASH) in Patients with T2DM—A Randomized, Controlled Trial

Utility of Fibroscan in Screening Overweight and Obese Children at Risk for Nonalcoholic Fatty Liver Disease

Exenatide Treatment Improves Mitochondrial Metabolism and Hepatic Insulin Sensitivity in Mice with Nonalcoholic Steatohepatitis (NASH)

Clinical Profile of Adults with Nonalcoholic Steatohepatitis (NASH) With and Without Type 2 Diabetes Mellitus (T2DM)

Use of Plasma Metabolomics and Lipidomics for the Diagnosis of Nonalcoholic Fatty Liver Disease in Type 2 Diabetes

Comment on: Høeg et al. Lipid-Induced Insulin Resistance Affects Women Less Than Men and Is Not Accompanied by Inflammation or Impaired Proximal Insulin Signaling. Diabetes 2011;60:64–73

Dose-Response Effect of Elevated Plasma Free Fatty Acid on Insulin Signaling

A Sustained Increase in Plasma Free Fatty Acids Impairs Insulin Secretion in Nondiabetic Subjects Genetically Predisposed to Develop Type 2 Diabetes

Free Fatty Acids Reduce Splanchnic and Peripheral Glucose Uptake in Patients With Type 2 Diabetes

Normalization of Plasma Glucose Concentration by Insulin Therapy Improves Insulin-Stimulated Glycogen Synthesis in Type 2 Diabetes

Skeletal Muscle Insulin Resistance in Normoglycemic Subjects With a Strong Family History of Type 2 Diabetes Is Associated With Decreased Insulin-Stimulated Insulin Receptor Substrate-1 Tyrosine Phosphorylation

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