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Meeting Abstracts

1086-P: A Retrospective Nationwide Surveillance on the First-Line Antidiabetic Medication for the Patients with Type 2 Diabetes in Japan

RYOTARO BOUCHI, TAKEHIRO SUGIYAMA, ATSUSHI GOTO, KENJIRO IMAI, NORIKO IHANA-SUGIYAMA, MITSURU OHSUGI, TOSHIMASA YAMAUCHI, TAKASHI KADOWAKI, KOHJIRO UEKI

Diabetes 2021;70(Supplement_1):1086-P

DOI: https://doi.org/10.2337/db21-1086-P

Published: 01 June 2021

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Journal Articles

MEK/ERK Signaling in β-Cells Bifunctionally Regulates β-Cell Mass and Glucose-Stimulated Insulin Secretion Response to Maintain Glucose Homeostasis

Yoshiko Matsumoto Ikushima, Motoharu Awazawa, Naoki Kobayashi, Sho Osonoi, Seiichi Takemiya, Hiroshi Kobayashi, Hirotsugu Suwanai, Yuichi Morimoto, Kotaro Soeda, Jun Adachi, Masafumi Muratani, Jean Charron, Hiroki Mizukami, Noriko Takahashi, Kohjiro Ueki

Diabetes 2021;70(7):1519–1535

DOI: https://doi.org/10.2337/db20-1295

Published: 27 April 2021

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Meeting Abstracts

1741-P: Immune Regulation of Postprandial Glycemia and Whole-Body Insulin Sensitivity through Myeloid Production of IL-10

GOTARO TODA, KOTARO SOEDA, NAOKO ARAKAWA, YUKARI MASUDA, NAOKI KOBAYASHI, HIROTSUGU SUWANAI, YOSHIHIKO IZUMIDA, TOSHIMASA YAMAUCHI, TAKASHI KADOWAKI, KOHJIRO UEKI

Diabetes 2020;69(Supplement_1):1741-P

DOI: https://doi.org/10.2337/db20-1741-P

Published: 01 June 2020

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Meeting Abstracts

Distinct Phenotypes of Islet Antigen-Specific CD4⁺ T Cells among the Three Subtypes of Type 1 Diabetes

DAISUKE CHUJO, AKITSU KAWABE, NOBUYUKI TAKAHASHI, MAYA MATSUSHITA, CHIHARU TSUTSUMI, FUMITAKA HASEDA, AKIHISA IMAGAWA, TOSHIAKI HANAFUSA, KUNIMASA YAGI, MASAYUKI SHIMODA, KOHJIRO UEKI, HIROSHI KAJIO

Diabetes 2018;67(Supplement_1):100-OR

DOI: https://doi.org/10.2337/db18-100-OR

Published: 01 July 2018

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Meeting Abstracts

Impairment of M2a-Subtype Macrophage Activation by Il-4-Irs2 Pathway in Obesity

TETSUYA KUBOTA, MARIKO INOUE, NAOTO KUBOTA, ISEKI TAKAMOTO, KOHJIRO UEKI, TOSHIMASA YAMAUCHI, TAKASHI KADOWAKI

Diabetes 2018;67(Supplement_1):2012-P

DOI: https://doi.org/10.2337/db18-2012-P

Published: 01 July 2018

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Meeting Abstracts

Macrophages React to Postprandial Signals and Regulate the Response to Feeding through Akt-mTOR–Dependent Production of IL-10

GOTARO TODA, NOZOMU KAMEI, KOTARO SOEDA, YUKARI MASUDA, YOSHIHIKO IZUMIDA, NAOKI KOBAYASHI, TAKAYOSI SASAKO, KAZUYUKI TOBE, MORRIS J. BIRNBAUM, TAKASHI KADOWAKI, KOHJIRO UEKI

Diabetes 2018;67(Supplement_1):359-OR

DOI: https://doi.org/10.2337/db18-359-OR

Published: 01 July 2018

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Meeting Abstracts

Contribution of Pancreatic Alpha-Cell Function to Insulin Sensitivity and Glucose Variability in Type 1 Diabetes Patients

NOBUYUKI TAKAHASHI, DAISUKE CHUJO, HIROSHI KAJIO, KOHJIRO UEKI

Diabetes 2018;67(Supplement_1):1940-P

DOI: https://doi.org/10.2337/db18-1940-P

Published: 01 July 2018

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Journal Articles

Dual Regulation of Gluconeogenesis by Insulin and Glucose in the Proximal Tubules of the Kidney

Motohiro Sasaki, Takayoshi Sasako, Naoto Kubota, Yoshitaka Sakurai, Iseki Takamoto, Tetsuya Kubota, Reiko Inagi, George Seki, Moritaka Goto, Kohjiro Ueki, Masaomi Nangaku, Takahito Jomori, Takashi Kadowaki

Diabetes 2017;66(9):2339–2350

DOI: https://doi.org/10.2337/db16-1602

Published: 17 June 2017

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Includes: Supplementary data

Journal Articles

Insulin Receptor Substrate-2 (Irs2) in Endothelial Cells Plays a Crucial Role in Insulin Secretion

Shinji Hashimoto, Naoto Kubota, Hiroyuki Sato, Motohiro Sasaki, Iseki Takamoto, Tetsuya Kubota, Keizo Nakaya, Mitsuhiko Noda, Kohjiro Ueki, Takashi Kadowaki

Diabetes 2015;64(3):876–886

DOI: https://doi.org/10.2337/db14-0432

Published: 01 October 2014

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Journal Articles

Gene Silencing of Phogrin Unveils Its Essential Role in Glucose-Responsive Pancreatic β-Cell Growth

Seiji Torii, Naoya Saito, Ayumi Kawano, Ni Hou, Kohjiro Ueki, Rohit N. Kulkarni, Toshiyuki Takeuchi

Diabetes 2009;58(3):682–692

DOI: https://doi.org/10.2337/db08-0970

Published: 01 March 2009

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Includes: Supplementary data

Journal Articles

Regulation of Calcium-Permeable TRPV2 Channel by Insulin in Pancreatic β-Cells

Etsuko Hisanaga, Masahiro Nagasawa, Kohjiro Ueki, Rohit N. Kulkarni, Masatomo Mori, Itaru Kojima

Diabetes 2009;58(1):174–184

DOI: https://doi.org/10.2337/db08-0862

Published: 01 January 2009

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Includes: Supplementary data

Journal Articles

Activation of Vascular Protein Kinase C-β Inhibits Akt-Dependent Endothelial Nitric Oxide Synthase Function in Obesity-Associated Insulin Resistance

Keiko Naruse, Christian Rask-Madsen, Noriko Takahara, Sung-woo Ha, Kiyoshi Suzuma, Kerrie J. Way, Judith R.C. Jacobs, Allen C. Clermont, Kohjiro Ueki, Yuzuru Ohshiro, Junqing Zhang, Allison B. Goldfine, George L. King

Diabetes 2006;55(3):691–698

DOI: https://doi.org/10.2337/diabetes.55.03.06.db05-0771

Published: 01 March 2006

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Journal Articles

A Role for iNOS in Fasting Hyperglycemia and Impaired Insulin Signaling in the Liver of Obese Diabetic Mice

Masaki Fujimoto, Nobuyuki Shimizu, Kaiko Kunii, J.A. Jeevendra Martyn, Kohjiro Ueki, Masao Kaneki

Diabetes 2005;54(5):1340–1348

DOI: https://doi.org/10.2337/diabetes.54.5.1340

Published: 01 May 2005

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Includes: Supplementary data

Journal Articles

Impact of Genetic Background on Development of Hyperinsulinemia and Diabetes in Insulin Receptor/Insulin Receptor Substrate-1 Double Heterozygous Mice

Rohit N. Kulkarni, Katrine Almind, H. Joseph Goren, Jonathon N. Winnay, Kohjiro Ueki, Terumasa Okada, C. Ronald Kahn

Diabetes 2003;52(6):1528–1534

DOI: https://doi.org/10.2337/diabetes.52.6.1528

Published: 01 June 2003

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NARROW

1086-P: A Retrospective Nationwide Surveillance on the First-Line Antidiabetic Medication for the Patients with Type 2 Diabetes in Japan

MEK/ERK Signaling in β-Cells Bifunctionally Regulates β-Cell Mass and Glucose-Stimulated Insulin Secretion Response to Maintain Glucose Homeostasis

1741-P: Immune Regulation of Postprandial Glycemia and Whole-Body Insulin Sensitivity through Myeloid Production of IL-10

Distinct Phenotypes of Islet Antigen-Specific CD4⁺ T Cells among the Three Subtypes of Type 1 Diabetes

Impairment of M2a-Subtype Macrophage Activation by Il-4-Irs2 Pathway in Obesity

Macrophages React to Postprandial Signals and Regulate the Response to Feeding through Akt-mTOR–Dependent Production of IL-10

Contribution of Pancreatic Alpha-Cell Function to Insulin Sensitivity and Glucose Variability in Type 1 Diabetes Patients

Dual Regulation of Gluconeogenesis by Insulin and Glucose in the Proximal Tubules of the Kidney

Insulin Receptor Substrate-2 (Irs2) in Endothelial Cells Plays a Crucial Role in Insulin Secretion

Gene Silencing of Phogrin Unveils Its Essential Role in Glucose-Responsive Pancreatic β-Cell Growth

Regulation of Calcium-Permeable TRPV2 Channel by Insulin in Pancreatic β-Cells

Activation of Vascular Protein Kinase C-β Inhibits Akt-Dependent Endothelial Nitric Oxide Synthase Function in Obesity-Associated Insulin Resistance

A Role for iNOS in Fasting Hyperglycemia and Impaired Insulin Signaling in the Liver of Obese Diabetic Mice

Impact of Genetic Background on Development of Hyperinsulinemia and Diabetes in Insulin Receptor/Insulin Receptor Substrate-1 Double Heterozygous Mice

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