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Meeting Abstracts

336-OR: A First-in-Human Single- and Multiple-Ascending Dose Study Evaluating Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Novel Oral Nonpeptide GLP-1 Receptor Agonist in Healthy Subjects

EDWARD J. PRATT, XIAOSU MA, RONG LIU, DEBORAH A. ROBINS, KYLE SLOOP, CHARLES BENSON
Journal: Diabetes
Diabetes 2022;71(Supplement_1):336-OR
DOI: https://doi.org/10.2337/db22-336-OR
Published: 01 June 2022
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Meeting Abstracts

366-OR: 14-3-3-ζ Contributes to Effect of ß-Cell GLP1 Receptor Signaling to Alter a-Cell Proglucagon Processing

MARLENA HOLTER, DARYL PHUONG, ISAAC S.H. LEE, MRIDUSMITA SAIKIA, LISA A. WEIKERT, ELIZABETH T. ANDERSON, QIN FU, SHENG ZHANG, KYLE SLOOP, BETHANY CUMMINGS
Journal: Diabetes
Diabetes 2022;71(Supplement_1):366-OR
DOI: https://doi.org/10.2337/db22-366-OR
Published: 01 June 2022
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Meeting Abstracts

229-LB: Quantification of GLP-1R Internalization and Recycling in Live ß Cells

SARAH M. GRAY, KYLE SLOOP, PETER RAVN, JONATHAN CAMPBELL, DAVID A. D’ALESSIO
Journal: Diabetes
Diabetes 2021;70(Supplement_1):229-LB
DOI: https://doi.org/10.2337/db21-229-LB
Published: 01 June 2021
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Meeting Abstracts

679-P: The Novel GIP, GLP-1, and Glucagon Triple Receptor Agonist LY3437943 Exhibits Robust Efficacy in Preclinical Models of Obesity and Diabetes

TAMER COSKUN, JULIE S. MOYERS, WILLIAM C. ROELL, LIBBEY O’FARRELL, AJIT REGMI, XIAOPING RUAN, AARON D. SHOWALTER, KYLE SLOOP, DAVID B. WAINSCOTT, FRANCIS S. WILLARD, JAMES V. FICORILLI, OVER CABRERA, SHWETA URVA, FARIBA NOROUZIYAN COOPER, LILI GUO, JORGE ALSINA-FERNANDEZ, HONGCHANG QU
Journal: Diabetes
Diabetes 2021;70(Supplement_1):679-P
DOI: https://doi.org/10.2337/db21-679-P
Published: 01 June 2021
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Meeting Abstracts

639-P: GIP Receptor Agonism Enhances Weight Loss from Either a Biased or an Unbiased GLP-1 Receptor Agonist in DIO Mice

MATTHEW P. COGHLAN, LIBBEY O’FARRELL, AARON D. SHOWALTER, DAVID B. WAINSCOTT, CYNTHIA STUTSMAN, GUEMALLI CARDONA, OVER CABRERA, JORGE ALSINA-FERNANDEZ, FRANCIS S. WILLARD, KYLE SLOOP, TAMER COSKUN
Journal: Diabetes
Diabetes 2021;70(Supplement_1):639-P
DOI: https://doi.org/10.2337/db21-639-P
Published: 01 June 2021
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Meeting Abstracts

142-OR: Tirzepatide, a Dual GIP and GLP-1 Receptor Agonist, Mediates Its Anorexigenic Effect in Mice Due to a Reduction in Homeostatic and Reward-Related Feeding

RICHARD COSGROVE, MEGHAN P. ANTONELLIS, BRIAN DROZ, WILLIAM C. ROELL, KYLE SLOOP, JULIE MOYERS, MATTHEW P. COGHLAN, PAUL EMMERSON, TAMER COSKUN, RICARDO J. SAMMS
Journal: Diabetes
Diabetes 2020;69(Supplement_1):142-OR
DOI: https://doi.org/10.2337/db20-142-OR
Published: 01 June 2020
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Meeting Abstracts

325-OR: ß-Arrestin 1 Regulates Glucagon-Like Peptide-1 Receptor Mediated Insulin Secretion in a Ligand-Dependent Manner

JONATHAN D. DOUROS, II, KYLE SLOOP, JONATHAN CAMPBELL, DAVID D’ALESSIO
Journal: Diabetes
Diabetes 2020;69(Supplement_1):325-OR
DOI: https://doi.org/10.2337/db20-325-OR
Published: 01 June 2020
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Meeting Abstracts

324-OR: The Incretin Action of GIP Is Mediated through Both Alpha and Beta Cells

KIMBERLEY M. EL, MEGAN CAPOZZI, SARAH M. GRAY, JENNIFER L. BROWN, FRANCIS S. WILLARD, PAUL EMMERSON, KYLE SLOOP, DAVID D’ALESSIO, JONATHAN CAMPBELL
Journal: Diabetes
Diabetes 2020;69(Supplement_1):324-OR
DOI: https://doi.org/10.2337/db20-324-OR
Published: 01 June 2020
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Meeting Abstracts

255-OR: ADA Presidents’ Select Abstract: Glucagon Receptor Antagonism Stimulates Beta-Cell Proliferation in Mouse and Human Islets

KATIE C. COATE, ERICK SPEARS, CHUNHUA DAI, SCOTT WISNIEWSKI, GREG POFFENBERGER, LEONARD D. SHULTZ, DALE L. GREINER, DANIEL J. DRUCKER, HAI YAN, KYLE SLOOP, ALVIN C. POWERS, DANIELLE DEAN
Journal: Diabetes
Diabetes 2020;69(Supplement_1):255-OR
DOI: https://doi.org/10.2337/db20-255-OR
Published: 01 June 2020
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Meeting Abstracts

2114-P: Quantification of GLP-1R Trafficking in Primary Beta Cells in Response to Different Ligands

SARAH M. GRAY, PETER RAVN, KYLE SLOOP, JONATHAN CAMPBELL, JONATHAN D’ALESSIO
Journal: Diabetes
Diabetes 2020;69(Supplement_1):2114-P
DOI: https://doi.org/10.2337/db20-2114-P
Published: 01 June 2020
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Meeting Abstracts

2113-P: Discrepancy between Single-Cell RNA Sequencing and Protein Expression Assessments of GLP-1Rr Heterogeneity in Beta Cells

SARAH M. GRAY, BRYANNA M. CHAZOTTE, ELIZABETH C. ROSS, BERIT SVENDSEN, PETER RAVN, KYLE SLOOP, JONATHAN CAMPBELL, DAVID D’ALESSIO
Journal: Diabetes
Diabetes 2020;69(Supplement_1):2113-P
DOI: https://doi.org/10.2337/db20-2113-P
Published: 01 June 2020
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Meeting Abstracts

2125-P: Incretin-Stimulated Insulin Secretion Is Mediated by Gas Dependent and Independent Mechanisms

MEGAN CAPOZZI, SARAH M. GRAY, PAUL EMMERSON, FRANCIS S. WILLARD, KYLE SLOOP, DAVID D’ALESSIO, JONATHAN CAMPBELL
Journal: Diabetes
Diabetes 2020;69(Supplement_1):2125-P
DOI: https://doi.org/10.2337/db20-2125-P
Published: 01 June 2020
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