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Kate L. Graham
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Journal Articles

Granzyme A Deficiency Breaks Immune Tolerance and Promotes Autoimmune Diabetes Through a Type I Interferon–Dependent Pathway

Zia U.A. Mollah, Hong Sheng Quah, Kate L. Graham, Gaurang Jhala, Balasubramanian Krishnamurthy, Joanna Francisca M. Dharma, Jonathan Chee, Prerak M. Trivedi, Evan G. Pappas, Leanne Mackin, Edward P.F. Chu, Satoru Akazawa, Stacey Fynch, Charlotte Hodson, Andrew J. Deans, Joseph A. Trapani, Mark M.W. Chong, Phillip I. Bird, Thomas C. Brodnicki, Helen E. Thomas, Thomas W.H. Kay
Journal: Diabetes
Diabetes 2017;66(12):3041–3050
DOI: https://doi.org/10.2337/db17-0517
Published: 21 July 2017
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Includes: Supplementary data
Journal Articles

Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice

Prerak M. Trivedi, Kate L. Graham, Nicholas A. Scott, Misty R. Jenkins, Suktilang Majaw, Robyn M. Sutherland, Stacey Fynch, Andrew M. Lew, Christopher J. Burns, Balasubramanian Krishnamurthy, Thomas C. Brodnicki, Stuart I. Mannering, Thomas W. Kay, Helen E. Thomas
Journal: Diabetes
Diabetes 2017;66(6):1650–1660
DOI: https://doi.org/10.2337/db16-1250
Published: 14 March 2017
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Includes: Multimedia, Supplementary data
Journal Articles

BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells

Balasubramanian Krishnamurthy, Jonathan Chee, Gaurang Jhala, Prerak Trivedi, Tara Catterall, Claudia Selck, Esteban N. Gurzov, Thomas C. Brodnicki, Kate L. Graham, Jibran A. Wali, Yifan Zhan, Daniel Gray, Andreas Strasser, Janette Allison, Helen E. Thomas, Thomas W.H. Kay
Journal: Diabetes
Diabetes 2015;64(9):3229–3238
DOI: https://doi.org/10.2337/db14-1851
Published: 06 May 2015
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Includes: Supplementary data
Journal Articles

Deficiency in Type I Interferon Signaling Prevents the Early Interferon–Induced Gene Signature in Pancreatic Islets but Not Type 1 Diabetes in NOD Mice

Hong Sheng Quah, Socorro Miranda-Hernandez, Aimee Khoo, Ashley Harding, Stacey Fynch, Lorraine Elkerbout, Thomas C. Brodnicki, Alan G. Baxter, Thomas W.H. Kay, Helen E. Thomas, Kate L. Graham
Journal: Diabetes
Diabetes 2014;63(3):1032–1040
DOI: https://doi.org/10.2337/db13-1210
Published: 13 February 2014
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Includes: Supplementary data
Journal Articles

Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells

Balasubramanian Krishnamurthy, Jonathan Chee, Gaurang Jhala, Stacey Fynch, Kate L. Graham, Pere Santamaria, Grant Morahan, Janette Allison, David Izon, Helen E. Thomas, Thomas W.H. Kay
Journal: Diabetes
Diabetes 2012;61(2):425–435
DOI: https://doi.org/10.2337/db11-0948
Published: 17 January 2012
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Includes: Supplementary data
Journal Articles

Macrophage Deletion of SOCS1 Increases Sensitivity to LPS and Palmitic Acid and Results in Systemic Inflammation and Hepatic Insulin Resistance

Nirupa Sachithanandan, Kate L. Graham, Sandra Galic, Jane E. Honeyman, Stacey L. Fynch, Kimberly A. Hewitt, Gregory R. Steinberg, Thomas W. Kay
Journal: Diabetes
Diabetes 2011;60(8):2023–2031
DOI: https://doi.org/10.2337/db11-0259
Published: 18 July 2011
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Includes: Supplementary data