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Kate L. Graham
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Journal Articles

Granzyme A Deficiency Breaks Immune Tolerance and Promotes Autoimmune Diabetes Through a Type I Interferon–Dependent Pathway

Free
Zia U.A. Mollah, Hong Sheng Quah, Kate L. Graham, Gaurang Jhala, Balasubramanian Krishnamurthy, Joanna Francisca M. Dharma, Jonathan Chee, Prerak M. Trivedi, Evan G. Pappas, Leanne Mackin, Edward P.F. Chu, Satoru Akazawa, Stacey Fynch, Charlotte Hodson, Andrew J. Deans, Joseph A. Trapani, Mark M.W. Chong, Phillip I. Bird, Thomas C. Brodnicki, Helen E. Thomas, Thomas W.H. Kay
Journal: Diabetes
Diabetes 2017;66(12):3041–3050
https://doi.org/10.2337/db17-0517
Published: 21 July 2017
View articletitled, Granzyme A Deficiency Breaks Immune Tolerance and Promotes Autoimmune Diabetes Through a Type I Interferon–Dependent Pathway
Open the PDF for Granzyme A Deficiency Breaks Immune Tolerance and Promotes Autoimmune Diabetes Through a Type I Interferon–Dependent Pathway in another window
Includes: Supplementary data
Journal Articles

Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice

Free
Prerak M. Trivedi, Kate L. Graham, Nicholas A. Scott, Misty R. Jenkins, Suktilang Majaw, Robyn M. Sutherland, Stacey Fynch, Andrew M. Lew, Christopher J. Burns, Balasubramanian Krishnamurthy, Thomas C. Brodnicki, Stuart I. Mannering, Thomas W. Kay, Helen E. Thomas
Journal: Diabetes
Diabetes 2017;66(6):1650–1660
https://doi.org/10.2337/db16-1250
Published: 14 March 2017
View articletitled, Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice
Open the PDF for Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice in another window
Includes: Multimedia, Supplementary data
Journal Articles

BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells

Free
Balasubramanian Krishnamurthy, Jonathan Chee, Gaurang Jhala, Prerak Trivedi, Tara Catterall, Claudia Selck, Esteban N. Gurzov, Thomas C. Brodnicki, Kate L. Graham, Jibran A. Wali, Yifan Zhan, Daniel Gray, Andreas Strasser, Janette Allison, Helen E. Thomas, Thomas W.H. Kay
Journal: Diabetes
Diabetes 2015;64(9):3229–3238
https://doi.org/10.2337/db14-1851
Published: 06 May 2015
View articletitled, BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells
Open the PDF for BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells in another window
Includes: Supplementary data
Journal Articles

Deficiency in Type I Interferon Signaling Prevents the Early Interferon–Induced Gene Signature in Pancreatic Islets but Not Type 1 Diabetes in NOD Mice

Open Access
Hong Sheng Quah, Socorro Miranda-Hernandez, Aimee Khoo, Ashley Harding, Stacey Fynch, Lorraine Elkerbout, Thomas C. Brodnicki, Alan G. Baxter, Thomas W.H. Kay, Helen E. Thomas, Kate L. Graham
Journal: Diabetes
Diabetes 2014;63(3):1032–1040
https://doi.org/10.2337/db13-1210
Published: 13 February 2014
View articletitled, Deficiency in Type I Interferon Signaling Prevents the Early Interferon–Induced Gene Signature in Pancreatic Islets but Not Type 1 Diabetes in NOD Mice
Open the PDF for Deficiency in Type I Interferon Signaling Prevents the Early Interferon–Induced Gene Signature in Pancreatic Islets but Not Type 1 Diabetes in NOD Mice in another window
Includes: Supplementary data
Journal Articles

Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells

Open Access
Balasubramanian Krishnamurthy, Jonathan Chee, Gaurang Jhala, Stacey Fynch, Kate L. Graham, Pere Santamaria, Grant Morahan, Janette Allison, David Izon, Helen E. Thomas, Thomas W.H. Kay
Journal: Diabetes
Diabetes 2012;61(2):425–435
https://doi.org/10.2337/db11-0948
Published: 17 January 2012
View articletitled, Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells
Open the PDF for Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells in another window
Includes: Supplementary data
Journal Articles

Macrophage Deletion of SOCS1 Increases Sensitivity to LPS and Palmitic Acid and Results in Systemic Inflammation and Hepatic Insulin Resistance

Open Access
Nirupa Sachithanandan, Kate L. Graham, Sandra Galic, Jane E. Honeyman, Stacey L. Fynch, Kimberly A. Hewitt, Gregory R. Steinberg, Thomas W. Kay
Journal: Diabetes
Diabetes 2011;60(8):2023–2031
https://doi.org/10.2337/db11-0259
Published: 18 July 2011
View articletitled, Macrophage Deletion of SOCS1 Increases Sensitivity to LPS and Palmitic Acid and Results in Systemic Inflammation and Hepatic Insulin Resistance
Open the PDF for Macrophage Deletion of SOCS1 Increases Sensitivity to LPS and Palmitic Acid and Results in Systemic Inflammation and Hepatic Insulin Resistance in another window
Includes: Supplementary data