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Journal Articles

The Endoplasmic Reticulum Chaperone Improves Insulin Resistance in Type 2 Diabetes

Kentaro Ozawa, Mayuki Miyazaki, Munehide Matsuhisa, Katsura Takano, Yoshihisa Nakatani, Masahiro Hatazaki, Takashi Tamatani, Kazuya Yamagata, Jun-ichiro Miyagawa, Yasuko Kitao, Osamu Hori, Yoshimitsu Yamasaki, Satoshi Ogawa

Diabetes 2005;54(3):657–663

https://doi.org/10.2337/diabetes.54.3.657

Published: 01 March 2005

View article titled, The Endoplasmic Reticulum Chaperone Improves Insulin Resistance in Type 2 Diabetes

Includes: Supplementary data

Journal Articles

Overexpression of PACAP in Transgenic Mouse Pancreatic β-Cells Enhances Insulin Secretion and Ameliorates Streptozotocin-induced Diabetes

Kyohei Yamamoto, Hitoshi Hashimoto, Shuhei Tomimoto, Norihito Shintani, Jun-ichi Miyazaki, Fumi Tashiro, Hiroyuki Aihara, Takao Nammo, Ming Li, Kazuya Yamagata, Jun-ichiro Miyagawa, Yuji Matsuzawa, Yuki Kawabata, Yuji Fukuyama, Kazumi Koga, Wakaba Mori, Kazuhiro Tanaka, Toshio Matsuda, Akemichi Baba

Diabetes 2003;52(5):1155–1162

https://doi.org/10.2337/diabetes.52.5.1155

Published: 01 May 2003

View article titled, Overexpression of PACAP in Transgenic Mouse Pancreatic β-Cells Enhances Insulin Secretion and Ameliorates Streptozotocin-induced Diabetes

Journal Articles

Hepatocyte Nuclear Factor-1α Modulates Pancreatic β-Cell Growth by Regulating the Expression of Insulin-Like Growth Factor-1 in INS-1 Cells

Qin Yang, Kazuya Yamagata, Kenji Fukui, Yang Cao, Takao Nammo, Hiromi Iwahashi, Haiyan Wang, Itaru Matsumura, Toshiaki Hanafusa, Richard Bucala, Claes B. Wollheim, Jun-ichiro Miyagawa, Yuji Matsuzawa

Diabetes 2002;51(6):1785–1792

https://doi.org/10.2337/diabetes.51.6.1785

Published: 01 June 2002

View article titled, Hepatocyte Nuclear Factor-1α Modulates Pancreatic β-Cell Growth by Regulating the Expression of Insulin-Like Growth Factor-1 in INS-1 Cells

Journal Articles

Thyroid Hormone Receptor Interacting Protein 3 (Trip3) Is a Novel Coactivator of Hepatocyte Nuclear Factor-4α

Hiromi Iwahashi, Kazuya Yamagata, Issei Yoshiuchi, Jungo Terasaki, Qin Yang, Kenji Fukui, Arisa Ihara, Qian Zhu, Takeshi Asakura, Yang Cao, Akihisa Imagawa, Mitsuyoshi Namba, Toshiaki Hanafusa, Jun-ichiro Miyagawa, Yuji Matsuzawa

Diabetes 2002;51(4):910–914

https://doi.org/10.2337/diabetes.51.4.910

Published: 01 April 2002

View article titled, Thyroid Hormone Receptor Interacting Protein 3 (Trip3) Is a Novel Coactivator of Hepatocyte Nuclear Factor-4α

Journal Articles

Overexpression of Dominant-Negative Mutant Hepatocyte Nuclear Factor-1α in Pancreatic β-Cells Causes Abnormal Islet Architecture With Decreased Expression of E-Cadherin, Reduced β-cell Proliferation, and Diabetes

Kazuya Yamagata, Takao Nammo, Makoto Moriwaki, Arisa Ihara, Katsumi Iizuka, Qin Yang, Tomomi Satoh, Ming Li, Rikako Uenaka, Kohei Okita, Hiromi Iwahashi, Qian Zhu, Yang Cao, Akihisa Imagawa, Yoshihiro Tochino, Toshiaki Hanafusa, Jun-ichiro Miyagawa, Yuji Matsuzawa

Diabetes 2002;51(1):114–123

https://doi.org/10.2337/diabetes.51.1.114

Published: 01 January 2002

View article titled, Overexpression of Dominant-Negative Mutant Hepatocyte Nuclear Factor-1α in Pancreatic β-Cells Causes Abnormal Islet Architecture With Decreased Expression of E-Cadherin, Reduced β-cell Proliferation, and Diabetes

Journal Articles

Pancreatic Biopsy as a Procedure for Detecting In Situ Autoimmune Phenomena in Type 1 Diabetes: Close Correlation Between Serological Markers and Histological Evidence of Cellular Autoimmunity

Akihisa Imagawa, Toshiaki Hanafusa, Shinji Tamura, Makoto Moriwaki, Naoto Itoh, Koji Yamamoto, Hiromi Iwahashi, Kazuya Yamagata, Masako Waguri, Takao Nanmo, Sae Uno, Hiromu Nakajima, Mitsuyoshi Namba, Sumio Kawata, Jun-ichiro Miyagawa, Yuji Matsuzawa

Diabetes 2001;50(6):1269–1273

https://doi.org/10.2337/diabetes.50.6.1269

Published: 01 June 2001

View article titled, Pancreatic Biopsy as a Procedure for Detecting In Situ Autoimmune Phenomena in Type 1 Diabetes: <subtitle>Close Correlation Between Serological Markers and Histological Evidence of Cellular Autoimmunity</subtitle>

Journal Articles

The Pro¹²→Ala Substitution in PPAR-γ Is Associated With Resistance to Development of Diabetes in the General Population: Possible Involvement in Impairment of Insulin Secretion in Individuals With Type 2 Diabetes

Diabetes 2001;50(4):891–894

https://doi.org/10.2337/diabetes.50.4.891

Published: 01 April 2001

View article titled, The Pro12→Ala Substitution in PPAR-γ Is Associated With Resistance to Development of Diabetes in the General Population: <subtitle>Possible Involvement in Impairment of Insulin Secretion in Individuals With Type 2 Diabetes</subtitle>

Journal Articles

Mutation P291fsinsC in the Transcription Factor Hepatocyte Nuclear Factor-1α is Dominant Negative

Kazuya Yamagata, Qin Yang, Koji Yamamoto, Hiromi Iwahashi, Jun-ichiro Miyagawa, Kohei Okita, Issei Yoshiuchi, Jun-ichi Miyazaki, Tamio Noguchi, Hiromu Nakajima, Mitsuyoshi Namba, Toshiaki Hanafusa, Yuji Matsuzawa

Diabetes 1998;47(8):1231–1235

https://doi.org/10.2337/diab.47.8.1231

Published: 01 August 1998

View article titled, Mutation P291fsinsC in the Transcription Factor Hepatocyte Nuclear Factor-1α is Dominant Negative

Journal Articles

Organization and Partial Sequence of the Hepatocyte Nuclear Factor-4α/MODY1 Gene and Identification of a Missense Mutation, R127W, in a Japanese Family With MODY

Hiroto Furuta, Naoko Iwasaki, Naohisa Oda, Yoshinori Hinokio, Yukio Horikawa, Kazuya Yamagata, Nobuki Yano, Jun Sugahiro, Makiko Ogata, Hisako Ohgawara, Yasue Omori, Yasuhiko Iwamoto, Graeme I Bell

Diabetes 1997;46(10):1652–1657

https://doi.org/10.2337/diacare.46.10.1652

Published: 01 October 1997

View article titled, Organization and Partial Sequence of the Hepatocyte Nuclear Factor-4α/MODY1 Gene and Identification of a Missense Mutation, R127W, in a Japanese Family With MODY

Journal Articles

Mutations in the Hepatocyte Nuclear Factor-1α/MODY3 Gene in Japanese Subjects With Early- and Late-Onset NIDDM

Naoko Iwasaki, Naohisa Oda, Makiko Ogata, Manami Hara, Yoshinori Hinokio, Yukie Oda, Kazuya Yamagata, Sachiko Kanematsu, Hisako Ohgawara, Yasue Omori, Graeme I Bell

Diabetes 1997;46(9):1504–1508

https://doi.org/10.2337/diab.46.9.1504

Published: 01 September 1997

View article titled, Mutations in the Hepatocyte Nuclear Factor-1α/MODY3 Gene in Japanese Subjects With Early- and Late-Onset NIDDM

Journal Articles

Mutations in the Hepatocyte Nuclear Factor–1α Gene Are a Common Cause of Maturity-Onset Diabetes of the Young in the U.K.

Timothy M Frayling, Michael P Bulman, Sian Ellard, Maggie Appleton, Mark J Dronsfield, Alasdair D R Mackie, Joyce D Baird, Pamela J Kaisaki, Kazuya Yamagata, Graeme I Bell, Stephen C Bain, Andrew T Hattersley

Diabetes 1997;46(4):720–725

https://doi.org/10.2337/diab.46.4.720

Published: 01 April 1997

View article titled, Mutations in the Hepatocyte Nuclear Factor–1α Gene Are a Common Cause of Maturity-Onset Diabetes of the Young in the U.K.

Journal Articles

Mutations in the Hepatocyte Nuclear Factor-1α Gene in MODY and Early-Onset NIDDM: Evidence for a Mutational Hotspot in Exon 4

Pamela J Kaisaki, Stephan Menzel, Tom Lindner, Naohisa Oda, Ilona Rjasanowski, Jürgen Sahm, Gustav Meincke, Jan Schulze, Harald Schmechel, Cornelia Petzold, Hellmuth M Ledermann, Günther Sachse, V Vicky Boriraj, Ruth Menzel, Wolfgang Kerner, Robert C Turner, Kazuya Yamagata, Graeme I Bell

Diabetes 1997;46(3):528–535

https://doi.org/10.2337/diab.46.3.528

Published: 01 March 1997

View article titled, Mutations in the Hepatocyte Nuclear Factor-1α Gene in MODY and Early-Onset NIDDM: Evidence for a Mutational Hotspot in Exon 4

Journal Articles

Altered Insulin Secretory Responses to Glucose in Diabetic and Nondiabetic Subjects With Mutations in the Diabetes Susceptibility Gene MODY3 on Chromosome 12

Maria M Byrne, Jeppe Sturis, Stephan Menzel, Kazuya Yamagata, Stefan S Fajans, Mark J Dronsfield, Stephen C Bain, Andrew T Hattersley, Gilberto Velho, Phillipe Froguel, Graeme I Bell, Kenneth S Polonsky

Diabetes 1996;45(11):1503–1510

https://doi.org/10.2337/diab.45.11.1503

Published: 01 November 1996

View article titled, Altered Insulin Secretory Responses to Glucose in Diabetic and Nondiabetic Subjects With Mutations in the Diabetes Susceptibility Gene MODY3 on Chromosome 12

Journal Articles

An Approach for Identifying Simple Sequence Repeat DNA Polymorphisms Near Cloned cDNAs and Genes: Linkage Studies of the Islet Amyloid Polypeptide/Amylin and Liver Glycogen Synthase Genes and NIDDM

Diabetes 1996;45(3):291–294

https://doi.org/10.2337/diab.45.3.291

Published: 01 March 1996

View article titled, An Approach for Identifying Simple Sequence Repeat DNA Polymorphisms Near Cloned cDNAs and Genes: Linkage Studies of the Islet Amyloid Polypeptide/Amylin and Liver Glycogen Synthase Genes and NIDDM

Journal Articles

Identification of Microsatellite Markers Near the Human Genes Encoding the β-cell ATP-Sensitive K⁺ Channel and Linkage Studies with NIDDM in Japanese

Naoko Iwasaki, Makiko Kawamura, Kazuya Yamagata, Nancy J Cox, Sachiyo Karibe, Hisako Ohgawara, Nobuya Inagaki, Susumu Seino, G I Bell, Yasue Omori

Diabetes 1996;45(2):267–269

https://doi.org/10.2337/diab.45.2.267

Published: 01 February 1996

View article titled, Identification of Microsatellite Markers Near the Human Genes Encoding the β-cell ATP-Sensitive K+ Channel and Linkage Studies with NIDDM in Japanese

Journal Articles

Localization of MODY3 to a 5-cM Region of Human Chromosome 12

Stephan Menzel, Kazuya Yamagata, Jeffrey B Trabb, Jørn Nerup, M Alan Permutt, Stefan S Fajans, Ruth Menzel, Naoko Iwasaki, Yasue Omori, Nancy J Cox, Graeme I Bell

Diabetes 1995;44(12):1408–1413

https://doi.org/10.2337/diab.44.12.1408

Published: 01 December 1995

View article titled, Localization of MODY3 to a 5-cM Region of Human Chromosome 12

NARROW

The Endoplasmic Reticulum Chaperone Improves Insulin Resistance in Type 2 Diabetes

Overexpression of PACAP in Transgenic Mouse Pancreatic β-Cells Enhances Insulin Secretion and Ameliorates Streptozotocin-induced Diabetes

Hepatocyte Nuclear Factor-1α Modulates Pancreatic β-Cell Growth by Regulating the Expression of Insulin-Like Growth Factor-1 in INS-1 Cells

Thyroid Hormone Receptor Interacting Protein 3 (Trip3) Is a Novel Coactivator of Hepatocyte Nuclear Factor-4α

Overexpression of Dominant-Negative Mutant Hepatocyte Nuclear Factor-1α in Pancreatic β-Cells Causes Abnormal Islet Architecture With Decreased Expression of E-Cadherin, Reduced β-cell Proliferation, and Diabetes

Pancreatic Biopsy as a Procedure for Detecting In Situ Autoimmune Phenomena in Type 1 Diabetes: Close Correlation Between Serological Markers and Histological Evidence of Cellular Autoimmunity

The Pro¹²→Ala Substitution in PPAR-γ Is Associated With Resistance to Development of Diabetes in the General Population: Possible Involvement in Impairment of Insulin Secretion in Individuals With Type 2 Diabetes

Mutation P291fsinsC in the Transcription Factor Hepatocyte Nuclear Factor-1α is Dominant Negative

Organization and Partial Sequence of the Hepatocyte Nuclear Factor-4α/MODY1 Gene and Identification of a Missense Mutation, R127W, in a Japanese Family With MODY

Mutations in the Hepatocyte Nuclear Factor-1α/MODY3 Gene in Japanese Subjects With Early- and Late-Onset NIDDM

Mutations in the Hepatocyte Nuclear Factor–1α Gene Are a Common Cause of Maturity-Onset Diabetes of the Young in the U.K.

Mutations in the Hepatocyte Nuclear Factor-1α Gene in MODY and Early-Onset NIDDM: Evidence for a Mutational Hotspot in Exon 4

Altered Insulin Secretory Responses to Glucose in Diabetic and Nondiabetic Subjects With Mutations in the Diabetes Susceptibility Gene MODY3 on Chromosome 12

An Approach for Identifying Simple Sequence Repeat DNA Polymorphisms Near Cloned cDNAs and Genes: Linkage Studies of the Islet Amyloid Polypeptide/Amylin and Liver Glycogen Synthase Genes and NIDDM

Identification of Microsatellite Markers Near the Human Genes Encoding the β-cell ATP-Sensitive K⁺ Channel and Linkage Studies with NIDDM in Japanese

Localization of MODY3 to a 5-cM Region of Human Chromosome 12

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