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Keshav Gopal
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Journal Articles

Redefining Diabetic Cardiomyopathy: Perturbations in Substrate Metabolism at the Heart of Its Pathology

Lisa C. Heather, Keshav Gopal, Nikola Srnic, John R. Ussher
Journal: Diabetes
Diabetes 2024;73(5):659–670
https://doi.org/10.2337/dbi23-0019
Published: 22 February 2024
View article titled, Redefining Diabetic Cardiomyopathy: Perturbations in Substrate Metabolism at the Heart of Its Pathology
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Journal Articles

The Antipsychotic Dopamine 2 Receptor Antagonist Diphenylbutylpiperidines Improve Glycemia in Experimental Obesity by Inhibiting Succinyl-CoA:3-Ketoacid CoA Transferase

Seyed Amirhossein Tabatabaei Dakhili, Amanda A. Greenwell, Kunyan Yang, Rabih Abou Farraj, Christina T. Saed, Keshav Gopal, Jordan S.F. Chan, Jadin J. Chahade, Farah Eaton, Crystal Lee, Carlos A. Velázquez-Martínez, Peter A. Crawford, J.N. Mark Glover, Rami Al Batran, John R. Ussher
Journal: Diabetes
Diabetes 2023;72(1):126–134
https://doi.org/10.2337/db22-0221
Published: 18 October 2022
View article titled, The Antipsychotic Dopamine 2 Receptor Antagonist Diphenylbutylpiperidines Improve Glycemia in Experimental Obesity by Inhibiting Succinyl-CoA:3-Ketoacid CoA Transferase
Open the PDF for The Antipsychotic Dopamine 2 Receptor Antagonist Diphenylbutylpiperidines Improve Glycemia in Experimental Obesity by Inhibiting Succinyl-CoA:3-Ketoacid CoA Transferase in another window
Meeting Abstracts

1397-P: A Cocoa Butter–Based Ketogenic Diet Fails to Improve Glucose Homeostasis and Promote Weight Loss in Obese Mice

AMANDA A. GREENWELL, CHRISTINA T. SAED, SEYED AMIRHOSSEIN TABATABAEI DAKHILI, KIM HO, KESHAV GOPAL, JORDAN S.F. CHAN, OKSANA KACZMAR, SCOTT A. DYER, FARAH EATON, GARY LOPASCHUK, RAMI A. BATRAN, JOHN R. USSHER
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1397-P
https://doi.org/10.2337/db22-1397-P
Published: 01 June 2022
View article titled, 1397-P: A Cocoa Butter–Based Ketogenic Diet Fails to Improve Glucose Homeostasis and Promote Weight Loss in Obese Mice
Meeting Abstracts

233-LB: Ranolazine Fails to Improve Glycemia in Obese Liver-Specific Pyruvate Dehydrogenase–Deficient Mice

CHRISTINA T. SAED, SEYED AMIRHOSSEIN TABATABAEI DAKHILI, AMANDA A. GREENWELL, JORDAN S.F. CHAN, KUNYAN YANG, KESHAV GOPAL, FARAH EATON, JOHN R. USSHER
Journal: Diabetes
Diabetes 2022;71(Supplement_1):233-LB
https://doi.org/10.2337/db22-233-LB
Published: 01 June 2022
View article titled, 233-LB: Ranolazine Fails to Improve Glycemia in Obese Liver-Specific Pyruvate Dehydrogenase–Deficient Mice
Meeting Abstracts

207-LB: Aldose Reductase Inhibition by AT-001 Limits Diastolic Dysfunction and Adverse Remodelling in Diabetic Cardiomyopathy

QUTUBA G. KARWI, KESHAV GOPAL, SEYED AMIRHOSSEIN TABATABAEI DAKHILI, CORY S. WAGG, LIYAN ZHANG, QIUYU SUN, CHRISTINA T. SAED, SAI PANIDARAPU, RICCARDO PERFETTI, RAVICHANDRAN RAMASAMY, JOHN R. USSHER, GARY LOPASCHUK
Journal: Diabetes
Diabetes 2022;71(Supplement_1):207-LB
https://doi.org/10.2337/db22-207-LB
Published: 01 June 2022
View article titled, 207-LB: Aldose Reductase Inhibition by AT-001 Limits Diastolic Dysfunction and Adverse Remodelling in Diabetic Cardiomyopathy
Meeting Abstracts

118-LB: The Antipsychotic D2 Receptor Antagonist Diphenylbutylpiperidines Improve Glycemia in Experimental Obesity by Inhibiting Succinyl-CoA—3-Ketoacid CoA transferase

SEYED AMIRHOSSEIN TABATABAEI DAKHILI, RABIH ABOU FARRAJ, AMANDA A. GREENWELL, CHRISTINA T. SAED, KUNYAN YANG, KESHAV GOPAL, JORDAN S.F. CHAN, CRYSTAL LEE, FARAH EATON, CARLOS A. VELAZQUEZ, PETER A. CRAWFORD, MARK GLOVER, RAMI AL BATRAN, JOHN R. USSHER
Journal: Diabetes
Diabetes 2022;71(Supplement_1):118-LB
https://doi.org/10.2337/db22-118-LB
Published: 01 June 2022
View article titled, 118-LB: The Antipsychotic D2 Receptor Antagonist Diphenylbutylpiperidines Improve Glycemia in Experimental Obesity by Inhibiting Succinyl-CoA—3-Ketoacid CoA transferase
Meeting Abstracts

379-P: Aldose Reductase Inhibition by AT-001 Prevents Diabetic Cardiomyopathy via Reducing Myocardial Fatty Acid Oxidation Rates

KESHAV GOPAL, QUTUBA G. KARWI, SEYED AMIRHOSSEIN TABATABAEI DAKHILI, CORY S. WAGG, RICCARDO PERFETTI, RAVICHANDRAN RAMASAMY, JOHN R. USSHER, GARY LOPASCHUK
Journal: Diabetes
Diabetes 2021;70(Supplement_1):379-P
https://doi.org/10.2337/db21-379-P
Published: 01 June 2021
View article titled, 379-P: Aldose Reductase Inhibition by AT-001 Prevents Diabetic Cardiomyopathy via Reducing Myocardial Fatty Acid Oxidation Rates
Meeting Abstracts

34-OR: Maladaptive Increases in Skeletal Muscle Ketone Body Oxidation Contribute to Dysglycemia in Mice Subjected to Experimental Obesity

RAMI AL BATRAN, KESHAV GOPAL, JADIN J. CHAHADE, JOHN R. USSHER
Journal: Diabetes
Diabetes 2019;68(Supplement_1):34-OR
https://doi.org/10.2337/db19-34-OR
Published: 01 June 2019
View article titled, 34-OR: Maladaptive Increases in Skeletal Muscle Ketone Body Oxidation Contribute to Dysglycemia in Mice Subjected to Experimental Obesity
Journal Articles

Genetic and Pharmacological Inhibition of Malonyl CoA Decarboxylase Does Not Exacerbate Age-Related Insulin Resistance in Mice

John R. Ussher, Natasha Fillmore, Wendy Keung, Liyan Zhang, Jun Mori, Vaninder K. Sidhu, Arata Fukushima, Keshav Gopal, David G. Lopaschuk, Cory S. Wagg, Jagdip S. Jaswal, Jason R.B. Dyck, Gary D. Lopaschuk
Journal: Diabetes
Diabetes 2016;65(7):1883–1891
https://doi.org/10.2337/db15-1145
Published: 13 May 2016
View article titled, Genetic and Pharmacological Inhibition of Malonyl CoA Decarboxylase Does Not Exacerbate Age-Related Insulin Resistance in Mice
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Includes: Supplementary data