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Meeting Abstracts

1607-P: Multiomic Analyses of GLP-1/GIP/GCGR Triagonism Highlights the Role of Hepatic Lipid Metabolism during Weight Loss in Obese Mice

TEAYOUN KIM, KHADIJA SECK, RICHARD DIMARCHI, KIRK M. HABEGGER

Diabetes 2025;74(Supplement_1):1607-P

https://doi.org/10.2337/db25-1607-P

Published: 20 June 2025

View article titled, 1607-P: Multiomic Analyses of GLP-1/GIP/GCGR Triagonism Highlights the Role of Hepatic Lipid Metabolism during Weight Loss in Obese Mice

Meeting Abstracts

1721-P: Bile Acid Binding Resins Improve Glucagon Receptor Agonist-Mediated Weight Loss in Diet-Induced Obese Mice

TEAYOUN KIM, KHADIJA SECK, RICHARD DIMARCHI, KIRK M. HABEGGER

Diabetes 2025;74(Supplement_1):1721-P

https://doi.org/10.2337/db25-1721-P

Published: 20 June 2025

View article titled, 1721-P: Bile Acid Binding Resins Improve Glucagon Receptor Agonist-Mediated Weight Loss in Diet-Induced Obese Mice

Meeting Abstracts

104-OR: State-Dependent Activity in Hindbrain Glucagon-Like Peptide 1—Producing Neurons Regulates Consummatory and Valence Behavior through Functionally Interconnected Hypothalamic and Limbic Circuits

MIGUEL DURAN, SONJA VIRKUS, KYLIE A. MCMICHEN, YASLLE ANDRADE CAVALCANTE MORAES, ESHITA YADAV, JAGJOT K. SINGH, ZOE FOKAKIS, SAMANTHA Q. STOCKING, SAMUEL O. POOLE, CHAD S. HUNTER, KIRK M. HABEGGER, JAMES A. HARDAWAY

Diabetes 2024;73(Supplement_1):104-OR

https://doi.org/10.2337/db24-104-OR

Published: 14 June 2024

View article titled, 104-OR: State-Dependent Activity in Hindbrain Glucagon-Like Peptide 1—Producing Neurons Regulates Consummatory and Valence Behavior through Functionally Interconnected Hypothalamic and Limbic Circuits

Meeting Abstracts

1559-P: Glucagon Receptor–Mediated Improvements in Glycemia Are Dependent on Agonist Pharmacodynamics

SHELLY NASON, TEAYOUN KIM, JESSICA ANTIPENKO, BIN YANG, RICHARD DIMARCHI, KIRK M. HABEGGER

Diabetes 2023;72(Supplement_1):1559-P

https://doi.org/10.2337/db23-1559-P

Published: 20 June 2023

View article titled, 1559-P: Glucagon Receptor–Mediated Improvements in Glycemia Are Dependent on Agonist Pharmacodynamics

Meeting Abstracts

1612-P: Energetic Contributions of GLP1 and GCGR Activity in GLP1/GIP/GCGR Triagonism

SHELLY NASON, JESSICA ANTIPENKO, KIRK M. HABEGGER

Diabetes 2023;72(Supplement_1):1612-P

https://doi.org/10.2337/db23-1612-P

Published: 20 June 2023

View article titled, 1612-P: Energetic Contributions of GLP1 and GCGR Activity in GLP1/GIP/GCGR Triagonism

Meeting Abstracts

823-P: GLY-200, a Pharmacologic Duodenal Exclusion Therapy, Improved Metabolic Parameters in the DIO Rat

ASHISH NIMGAONKAR, CHRISTINE BRYANT, KIRK M. HABEGGER, KEVIN COLBERT, TAYLOR CARLSON, STEVEN POLOMOSCANIK, JOHN S. PETERSEN, THOMAS H. JOZEFIAK, MARK FINEMAN

Diabetes 2023;72(Supplement_1):823-P

https://doi.org/10.2337/db23-823-P

Published: 20 June 2023

View article titled, 823-P: GLY-200, a Pharmacologic Duodenal Exclusion Therapy, Improved Metabolic Parameters in the DIO Rat

Meeting Abstracts

97-OR: Antidiabetic TIX100 Improves NAFLD/NASH in Mice With and Without Diabetes and Obesity

SEONGHO JO, JUNQIN CHEN, GU JING, KIRK M. HABEGGER, ANATH SHALEV

Diabetes 2023;72(Supplement_1):97-OR

https://doi.org/10.2337/db23-97-OR

Published: 20 June 2023

View article titled, 97-OR: Antidiabetic TIX100 Improves NAFLD/NASH in Mice With and Without Diabetes and Obesity

Meeting Abstracts

1648-P: Triagonism Targeting GCGR/GLP-1/GIP-1 Receptors Improves Insulin Sensitivity in Obese Mice

TEAYOUN KIM, SHELLY NASON, JESSICA ANTIPENKO, KIRK M. HABEGGER

Diabetes 2023;72(Supplement_1):1648-P

https://doi.org/10.2337/db23-1648-P

Published: 20 June 2023

View article titled, 1648-P: Triagonism Targeting GCGR/GLP-1/GIP-1 Receptors Improves Insulin Sensitivity in Obese Mice

Journal Articles

Hepatic mTORC2 Signaling Facilitates Acute Glucagon Receptor Enhancement of Insulin-Stimulated Glucose Homeostasis in Mice

Teayoun Kim, Shelly Nason, Jessica Antipenko, Brian Finan, Anath Shalev, Richard DiMarchi, Kirk M. Habegger

Diabetes 2022;71(10):2123–2135

https://doi.org/10.2337/db21-1018

Published: 25 July 2022

View article titled, Hepatic mTORC2 Signaling Facilitates Acute Glucagon Receptor Enhancement of Insulin-Stimulated Glucose Homeostasis in Mice

Journal Articles

Cross Talk Between Insulin and Glucagon Receptor Signaling in the Hepatocyte

Kirk M. Habegger

Diabetes 2022;71(9):1842–1851

https://doi.org/10.2337/dbi22-0002

Published: 03 June 2022

View article titled, Cross Talk Between Insulin and Glucagon Receptor Signaling in the Hepatocyte

Meeting Abstracts

818-P: Chronic Oral Polymeric Duodenal Exclusion Therapy Has Profound Metabolic Benefits in a T2D Rat Model and Affects Duodenal Morphological Enteroplasticity Similar to RYGB surgery: Implications for T2D Therapy

ASHISH NIMGAONKAR, FLORENCE GUERINA, SHANNON L. KELLEHER, TAYLOR CARLSON, KEVIN COLBERT, STEVEN POLOMOSCANIK, JOHN S. PETERSEN, KIRK M. HABEGGER, PANKAJ J. PASRICHA, MARK FINEMAN, THOMAS H. JOZEFIAK

Diabetes 2022;71(Supplement_1):818-P

https://doi.org/10.2337/db22-818-P

Published: 01 June 2022

View article titled, 818-P: Chronic Oral Polymeric Duodenal Exclusion Therapy Has Profound Metabolic Benefits in a T2D Rat Model and Affects Duodenal Morphological Enteroplasticity Similar to RYGB surgery: Implications for T2D Therapy

Meeting Abstracts

197-OR: Glucagon Receptor Agonism Stimulates Time-Dependent Glycemic Regulation

SHELLY NASON, TEAYOUN KIM, JESSICA P. ANTIPENKO, BRIAN FINAN, RICHARD DIMARCHI, KIRK M. HABEGGER

Diabetes 2022;71(Supplement_1):197-OR

https://doi.org/10.2337/db22-197-OR

Published: 01 June 2022

View article titled, 197-OR: Glucagon Receptor Agonism Stimulates Time-Dependent Glycemic Regulation

Meeting Abstracts

230-OR: Hepatic TORC2 Signaling Facilitates Glucagon-Receptor Enhancement of Insulin-Stimulated Glucose Homeostasis in Mice

TEAYOUN KIM, SHELLY NASON, JESSICA P. ANTIPENKO, BRIAN FINAN, ANATH SHALEV, RICHARD DIMARCHI, KIRK M. HABEGGER

Diabetes 2022;71(Supplement_1):230-OR

https://doi.org/10.2337/db22-230-OR

Published: 01 June 2022

View article titled, 230-OR: Hepatic TORC2 Signaling Facilitates Glucagon-Receptor Enhancement of Insulin-Stimulated Glucose Homeostasis in Mice

Journal Articles

A Small Molecule, UAB126, Reverses Diet-Induced Obesity and its Associated Metabolic Disorders

Guang Ren, Teayoun Kim, Hae-Suk Kim, Martin E. Young, Donald D. Muccio, Venkatram R. Atigadda, Samuel I. Blum, Hubert M. Tse, Kirk M. Habegger, Sushant Bhatnagar, Tatjana Coric, Mary-Ann Bjornsti, Anath Shalev, Stuart J. Frank, Jeong-a Kim

Diabetes 2020;69(9):2003–2016

https://doi.org/10.2337/db19-1001

Published: 01 July 2020

View article titled, A Small Molecule, UAB126, Reverses Diet-Induced Obesity and its Associated Metabolic Disorders

Meeting Abstracts

46-OR: The Transcriptional Coregulator Ldb1 Directly Regulates Brown Adipose Thermogenic Function

JESSICA KEPPLE, YANPING LIU, TEAYOUN KIM, KIRK M. HABEGGER, MARTIN YOUNG, CHAD S. HUNTER

Diabetes 2020;69(Supplement_1):46-OR

https://doi.org/10.2337/db20-46-OR

Published: 01 June 2020

View article titled, 46-OR: The Transcriptional Coregulator Ldb1 Directly Regulates Brown Adipose Thermogenic Function

Meeting Abstracts

1870-P: Glucagon-Receptor Signaling Reverses Hepatic Steatosis Independent of Leptin Receptor Expression

SHELLY NASON, TEAYOUN KIM, JESSICA P. ANTIPENKO, BRIAN FINAN, RICHARD DIMARCHI, KIRK M. HABEGGER

Diabetes 2019;68(Supplement_1):1870-P

https://doi.org/10.2337/db19-1870-P

Published: 01 June 2019

View article titled, 1870-P: Glucagon-Receptor Signaling Reverses Hepatic Steatosis Independent of Leptin Receptor Expression

Meeting Abstracts

1965-P: Glucagon Receptor Agonism Stimulates Body Weight Loss in Antibiotic Treatment in Obese Mice

TEAYOUN KIM, JESSICA P. ANTIPENKO, SHELLY NASON, NATALIE PRESEDO, WILLIAM J. VAN DER POL, BRIAN FINAN, RICHARD DIMARCHI, CASEY D. MORROW, KIRK M. HABEGGER

Diabetes 2019;68(Supplement_1):1965-P

https://doi.org/10.2337/db19-1965-P

Published: 01 June 2019

View article titled, 1965-P: Glucagon Receptor Agonism Stimulates Body Weight Loss in Antibiotic Treatment in Obese Mice

Journal Articles

Hepatic Glucagon Receptor Signaling Enhances Insulin-Stimulated Glucose Disposal in Rodents

Teayoun Kim, Cassie L. Holleman, Shelly Nason, Deanna M. Arble, Nickki Ottaway, Joseph Chabenne, Christine Loyd, Jeong-a Kim, Darleen Sandoval, Daniel J. Drucker, Richard DiMarchi, Diego Perez-Tilve, Kirk M. Habegger

Diabetes 2018;67(11):2157–2166

https://doi.org/10.2337/db18-0068

Published: 27 August 2018

View article titled, Hepatic Glucagon Receptor Signaling Enhances Insulin-Stimulated Glucose Disposal in Rodents

Includes: Supplementary data

Meeting Abstracts

The Ldb1 Transcriptional Coregulator Is Required for Brown Adipose Development and Function

JESSICA KEPPLE, YANPING LIU, TEAYOUN KIM, GLENN C. ROWE, KIRK M. HABEGGER, CHAD S. HUNTER

Diabetes 2018;67(Supplement_1):2020-P

https://doi.org/10.2337/db18-2020-P

Published: 01 July 2018

View article titled, The Ldb1 Transcriptional Coregulator Is Required for Brown Adipose Development and Function

Meeting Abstracts

Maternal Dietary Manipulation Programs Offspring’s Metabolism

MINSUNG KANG, JESSICA P. ANTIPENKO, XIAOBING LIU, KIRK M. HABEGGER, W. TIMOTHY GARVEY

Diabetes 2018;67(Supplement_1):281-LB

https://doi.org/10.2337/db18-281-LB

Published: 01 July 2018

View article titled, Maternal Dietary Manipulation Programs Offspring’s Metabolism

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1607-P: Multiomic Analyses of GLP-1/GIP/GCGR Triagonism Highlights the Role of Hepatic Lipid Metabolism during Weight Loss in Obese Mice

1721-P: Bile Acid Binding Resins Improve Glucagon Receptor Agonist-Mediated Weight Loss in Diet-Induced Obese Mice

104-OR: State-Dependent Activity in Hindbrain Glucagon-Like Peptide 1—Producing Neurons Regulates Consummatory and Valence Behavior through Functionally Interconnected Hypothalamic and Limbic Circuits

1559-P: Glucagon Receptor–Mediated Improvements in Glycemia Are Dependent on Agonist Pharmacodynamics

1612-P: Energetic Contributions of GLP1 and GCGR Activity in GLP1/GIP/GCGR Triagonism

823-P: GLY-200, a Pharmacologic Duodenal Exclusion Therapy, Improved Metabolic Parameters in the DIO Rat

97-OR: Antidiabetic TIX100 Improves NAFLD/NASH in Mice With and Without Diabetes and Obesity

1648-P: Triagonism Targeting GCGR/GLP-1/GIP-1 Receptors Improves Insulin Sensitivity in Obese Mice

Hepatic mTORC2 Signaling Facilitates Acute Glucagon Receptor Enhancement of Insulin-Stimulated Glucose Homeostasis in Mice

Cross Talk Between Insulin and Glucagon Receptor Signaling in the Hepatocyte

818-P: Chronic Oral Polymeric Duodenal Exclusion Therapy Has Profound Metabolic Benefits in a T2D Rat Model and Affects Duodenal Morphological Enteroplasticity Similar to RYGB surgery: Implications for T2D Therapy

197-OR: Glucagon Receptor Agonism Stimulates Time-Dependent Glycemic Regulation

230-OR: Hepatic TORC2 Signaling Facilitates Glucagon-Receptor Enhancement of Insulin-Stimulated Glucose Homeostasis in Mice

A Small Molecule, UAB126, Reverses Diet-Induced Obesity and its Associated Metabolic Disorders

46-OR: The Transcriptional Coregulator Ldb1 Directly Regulates Brown Adipose Thermogenic Function

1870-P: Glucagon-Receptor Signaling Reverses Hepatic Steatosis Independent of Leptin Receptor Expression

1965-P: Glucagon Receptor Agonism Stimulates Body Weight Loss in Antibiotic Treatment in Obese Mice

Hepatic Glucagon Receptor Signaling Enhances Insulin-Stimulated Glucose Disposal in Rodents

The Ldb1 Transcriptional Coregulator Is Required for Brown Adipose Development and Function

Maternal Dietary Manipulation Programs Offspring’s Metabolism

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