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Klaus H. Kaestner
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Journal Articles

The IsletTester mouse: an immunodeficient model with stable hyperglycemia for the study of human islets

Eric L. Waite, Mark Tigue, Ming Yu, Deeksha Lahori, Kai Kelly, Catherine Lee May, Ali Naji, Jeffrey Roman, Nicolai Doliba, Dana Avrahami, Kim-Vy Nguyen-Ngoc, Maike Sander, Benjamin Glaser, Klaus H. Kaestner
Journal: Diabetes
Diabetes db230887
https://doi.org/10.2337/db23-0887
Published: 21 November 2024
View article titled, The IsletTester mouse: an immunodeficient model with stable hyperglycemia for the study of human islets
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Journal Articles

No Evidence for Persistent Enteroviral B Infection of Pancreatic Islets in Patients With Type 1 Diabetes and Prediabetes From RNA Sequencing Data

Elisabetta Manduchi, Hélène C. Descamps, Jonathan Schug, Tong Da, Deeksha Lahori, Hilana El-Mekkoussi, Michael R. Betts, Klaus H. Kaestner
Journal: Diabetes
Diabetes 2024;73(10):1697–1704
https://doi.org/10.2337/db24-0076
Published: 31 July 2024
View article titled, No Evidence for Persistent Enteroviral B Infection of Pancreatic Islets in Patients With Type 1 Diabetes and Prediabetes From RNA Sequencing Data
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Meeting Abstracts

273-OR: Initial eQTL Discovery in Individual Pancreatic Cell Types from the Human Pancreas Analysis Program

MARY A. WEIDEKAMP, RUTH ELGAMAL, KIMBERLY LORENZ, KLAUS H. KAESTNER, KYLE J. GAULTON, STRUAN F. GRANT, BENJAMIN F. VOIGHT
Journal: Diabetes
Diabetes 2024;73(Supplement_1):273-OR
https://doi.org/10.2337/db24-273-OR
Published: 14 June 2024
View article titled, 273-OR: Initial eQTL Discovery in Individual Pancreatic Cell Types from the Human Pancreas Analysis Program
Meeting Abstracts

1736-P: Exploring Intrinsic Features of Human Pancreatic a- and ß-Cell Physiology Using Pseudoislets

ANDREA V. ROZO, JEFFEREY ROMAN, WEI QIN, CHENGYANG LIU, ALI NAJI, KLAUS H. KAESTNER, TOSHINORI HOSHI, DORIS A. STOFFERS, NICOLAI M. DOLIBA
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1736-P
https://doi.org/10.2337/db24-1736-P
Published: 14 June 2024
View article titled, 1736-P: Exploring Intrinsic Features of Human Pancreatic a- and ß-Cell Physiology Using Pseudoislets
Journal Articles

DNA Methylation–Based Assessment of Cell Composition in Human Pancreas and Islets

Zeina Drawshy, Daniel Neiman, Ori Fridlich, Ayelet Peretz, Judith Magenheim, Andrea V. Rozo, Nicolai M. Doliba, Doris A. Stoffers, Klaus H. Kaestner, Desmond A. Schatz, Clive Wasserfall, Martha Campbell-Thompson, James Shapiro, Tommy Kaplan, Ruth Shemer, Benjamin Glaser, Agnes Klochendler, Yuval Dor
Journal: Diabetes
Diabetes 2024;73(4):554–564
https://doi.org/10.2337/db23-0704
Published: 24 January 2024
View article titled, DNA Methylation–Based Assessment of Cell Composition in Human Pancreas and Islets
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Journal Articles

Franz Matschinsky, MD (1931–2022): Paragon of Scientific Rigor and Curiosity Who Discovered Glucokinase as the Pancreatic Glucose Sensor

Mitchell A. Lazar, Mark A. Magnuson, Klaus H. Kaestner
Journal: Diabetes
Diabetes 2022;71(10):2078–2083
https://doi.org/10.2337/dbi22-0017
Published: 12 September 2022
View article titled, Franz Matschinsky, MD (1931–2022): Paragon of Scientific Rigor and Curiosity Who Discovered Glucokinase as the Pancreatic Glucose Sensor
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Meeting Abstracts

211-LB: The Islet Tester Mouse, a Stable and Reproducible In Vivo Model to Study Human Islet Function

ERIC WAITE, CATHERINE L. MAY, HUMAN PANCREAS ANALYSIS PROGRAM (HPAP), KLAUS H. KAESTNER
Journal: Diabetes
Diabetes 2022;71(Supplement_1):211-LB
https://doi.org/10.2337/db22-211-LB
Published: 01 June 2022
View article titled, 211-LB: The Islet Tester Mouse, a Stable and Reproducible In Vivo Model to Study Human Islet Function
Meeting Abstracts

229-LB: G6PC2, a GWAS Locus for Fasting Glucose and HbA1c, Regulates Glucose-Suppression of Glucagon Secretion in a-Cells

VARUN BAHL, CATHERINE L. MAY, HUMAN PANCREAS ANALYSIS PROGRAM, KLAUS H. KAESTNER
Journal: Diabetes
Diabetes 2022;71(Supplement_1):229-LB
https://doi.org/10.2337/db22-229-LB
Published: 01 June 2022
View article titled, 229-LB: G6PC2, a GWAS Locus for Fasting Glucose and HbA1c, Regulates Glucose-Suppression of Glucagon Secretion in a-Cells
Meeting Abstracts

192-LB: Ductal Epithelial Cells Adopt Transcriptional Features of Tolerogenic Dendritic Cells in Type 1 Diabetes

KLAUS H. KAESTNER, HPAP CONSORTIUM, GOLNAZ VAHEDI
Journal: Diabetes
Diabetes 2022;71(Supplement_1):192-LB
https://doi.org/10.2337/db22-192-LB
Published: 01 June 2022
View article titled, 192-LB: Ductal Epithelial Cells Adopt Transcriptional Features of Tolerogenic Dendritic Cells in Type 1 Diabetes
Meeting Abstracts

253-LB: Ethnic Differences in Pancreatic Hormone Secretion in Health and T2D

NICOLAI M. DOLIBA, JEFFREY ROMAN, ANDREA V. ROZO, WEI QIN, CHENGYANG LIU, ALI NAJI, MICHAEL R. RICKELS, MARK A. ATKINSON, ALVIN C. POWERS, MARCELA BRISSOVA, KLAUS H. KAESTNER, DORIS A. STOFFERS
Journal: Diabetes
Diabetes 2022;71(Supplement_1):253-LB
https://doi.org/10.2337/db22-253-LB
Published: 01 June 2022
View article titled, 253-LB: Ethnic Differences in Pancreatic Hormone Secretion in Health and T2D
Meeting Abstracts

247-OR: Variant-to-Gene-Mapping Analyses Reveal a Role for Pancreatic Islet Cells in Conferring Genetic Susceptibility to Sleep-Related Traits

CHIARA LASCONI, MATTHEW C. PAHL, JAMES A. PIPPIN, CHUN SU, MATTHEW JOHNSON, ALESSANDRA CHESI, ANDREW D. WELLS, KLAUS H. KAESTNER, STRUAN F.A. GRANT
Journal: Diabetes
Diabetes 2021;70(Supplement_1):247-OR
https://doi.org/10.2337/db21-247-OR
Published: 01 June 2021
View article titled, 247-OR: Variant-to-Gene-Mapping Analyses Reveal a Role for Pancreatic Islet Cells in Conferring Genetic Susceptibility to Sleep-Related Traits
Meeting Abstracts

322-OR: Impairment of Alpha-Cell Bioenergetics Contributes to Increased Basal Yet Decreased Glucose Stimulated Oxygen Consumption Rates of Isolated Human Pancreatic Islets in T1DM and T2DM

NICOLAI M. DOLIBA, ANDREA V. ROZO, WEI QIN, JEFFREY ROMAN, CHENGYANG LIU, ALI NAJI, KLAUS H. KAESTNER, DORIS A. STOFFERS, FRANZ MATSCHINSKY
Journal: Diabetes
Diabetes 2020;69(Supplement_1):322-OR
https://doi.org/10.2337/db20-322-OR
Published: 01 June 2020
View article titled, 322-OR: Impairment of Alpha-Cell Bioenergetics Contributes to Increased Basal Yet Decreased Glucose Stimulated Oxygen Consumption Rates of Isolated Human Pancreatic Islets in T1DM and T2DM
Meeting Abstracts

2129-P: Glucagon Secretion from Pancreatic Islets Is Regulated by Beta-Arrestin-1

DIPTADIP DATTAROY, LUIZ F. BARELLA, SAI PRASAD PYDI, YINGHONG CUI, KLAUS H. KAESTNER, JÜRGEN WESS
Journal: Diabetes
Diabetes 2020;69(Supplement_1):2129-P
https://doi.org/10.2337/db20-2129-P
Published: 01 June 2020
View article titled, 2129-P: Glucagon Secretion from Pancreatic Islets Is Regulated by Beta-Arrestin-1
Journal Articles

NIH Initiative to Improve Understanding of the Pancreas, Islet, and Autoimmunity in Type 1 Diabetes: The Human Pancreas Analysis Program (HPAP)

Klaus H. Kaestner, Alvin C. Powers, Ali Naji, HPAP Consortium, Mark A. Atkinson
Journal: Diabetes
Diabetes 2019;68(7):1394–1402
https://doi.org/10.2337/db19-0058
Published: 24 May 2019
View article titled, NIH Initiative to Improve Understanding of the Pancreas, Islet, and Autoimmunity in Type 1 Diabetes: The Human Pancreas Analysis Program (HPAP)
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Journal Articles

Examining How the MAFB Transcription Factor Affects Islet β-Cell Function Postnatally

Holly A. Cyphert, Emily M. Walker, Yan Hang, Sangeeta Dhawan, Rachana Haliyur, Lauren Bonatakis, Dana Avrahami, Marcela Brissova, Klaus H. Kaestner, Anil Bhushan, Alvin C. Powers, Roland Stein
Journal: Diabetes
Diabetes 2019;68(2):337–348
https://doi.org/10.2337/db18-0903
Published: 13 November 2018
View article titled, Examining How the MAFB Transcription Factor Affects Islet β-Cell Function Postnatally
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Includes: Supplementary data
Journal Articles

Epigenetics and Epigenomics: Implications for Diabetes and Obesity

Evan D. Rosen, Klaus H. Kaestner, Rama Natarajan, Mary-Elizabeth Patti, Richard Sallari, Maike Sander, Katalin Susztak
Journal: Diabetes
Diabetes 2018;67(10):1923–1931
https://doi.org/10.2337/db18-0537
Published: 12 September 2018
View article titled, Epigenetics and Epigenomics: Implications for Diabetes and Obesity
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Journal Articles

The Dysregulation of the DLK1-MEG3 Locus in Islets From Patients With Type 2 Diabetes Is Mimicked by Targeted Epimutation of Its Promoter With TALE-DNMT Constructs

Vasumathi Kameswaran, Maria L. Golson, Mireia Ramos-Rodríguez, Kristy Ou, Yue J. Wang, Jia Zhang, Lorenzo Pasquali, Klaus H. Kaestner
Journal: Diabetes
Diabetes 2018;67(9):1807–1815
https://doi.org/10.2337/db17-0682
Published: 03 July 2018
View article titled, The Dysregulation of the <em>DLK1</em>-<em>MEG3</em> Locus in Islets From Patients With Type 2 Diabetes Is Mimicked by Targeted Epimutation of Its Promoter With TALE-DNMT Constructs
Open the PDF for The Dysregulation of the <em>DLK1</em>-<em>MEG3</em> Locus in Islets From Patients With Type 2 Diabetes Is Mimicked by Targeted Epimutation of Its Promoter With TALE-DNMT Constructs in another window
Includes: Supplementary data
Journal Articles

Sleeve Gastrectomy Improves Glycemia Independent of Weight Loss by Restoring Hepatic Insulin Sensitivity

Samir Abu-Gazala, Elad Horwitz, Rachel Ben-Haroush Schyr, Aya Bardugo, Hadar Israeli, Ayat Hija, Jonathan Schug, Soona Shin, Yuval Dor, Klaus H. Kaestner, Danny Ben-Zvi
Journal: Diabetes
Diabetes 2018;67(6):1079–1085
https://doi.org/10.2337/db17-1028
Published: 23 February 2018
View article titled, Sleeve Gastrectomy Improves Glycemia Independent of Weight Loss by Restoring Hepatic Insulin Sensitivity
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Includes: Supplementary data
Journal Articles

Functional and Metabolomic Consequences of KATP Channel Inactivation in Human Islets

Changhong Li, Amanda M. Ackermann, Kara E. Boodhansingh, Tricia R. Bhatti, Chengyang Liu, Jonathan Schug, Nicolai Doliba, Bing Han, Karen E. Cosgrove, Indraneel Banerjee, Franz M. Matschinsky, Itzhak Nissim, Klaus H. Kaestner, Ali Naji, N. Scott Adzick, Mark J. Dunne, Charles A. Stanley, Diva D. De León
Journal: Diabetes
Diabetes 2017;66(7):1901–1913
https://doi.org/10.2337/db17-0029
Published: 25 April 2017
View article titled, Functional and Metabolomic Consequences of K<sub>ATP</sub> Channel Inactivation in Human Islets
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Includes: Supplementary data
Journal Articles

Single-Cell Transcriptomics of the Human Endocrine Pancreas

Yue J. Wang, Jonathan Schug, Kyoung-Jae Won, Chengyang Liu, Ali Naji, Dana Avrahami, Maria L. Golson, Klaus H. Kaestner
Journal: Diabetes
Diabetes 2016;65(10):3028–3038
https://doi.org/10.2337/db16-0405
Published: 30 June 2016
View article titled, Single-Cell Transcriptomics of the Human Endocrine Pancreas
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Includes: Supplementary data