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Ko Willems van Dijk
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Journal Articles

Genetic Studies of Metabolomics Change After a Liquid Meal Illuminate Novel Pathways for Glucose and Lipid Metabolism

Ruifang Li-Gao, David A. Hughes, Jan B. van Klinken, Renée de Mutsert, Frits R. Rosendaal, Dennis O. Mook-Kanamori, Nicholas J. Timpson, Ko Willems van Dijk
Journal: Diabetes
Diabetes 2021;70(12):2932–2946
https://doi.org/10.2337/db21-0397
Published: 05 October 2021
View articletitled, Genetic Studies of Metabolomics Change After a Liquid Meal Illuminate Novel Pathways for Glucose and Lipid Metabolism
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Journal Articles

Stratification of Type 2 Diabetes by Age of Diagnosis in the UK Biobank Reveals Subgroup-Specific Genetic Associations and Causal Risk Profiles

Raymond Noordam, Kristi Läll, Roelof A.J. Smit, Triin Laisk, Andres Metspalu, Tõnu Esko, Lili Milani, Ruth J.F. Loos, Reedik Mägi, Ko Willems van Dijk, Diana van Heemst, Estonian Biobank Research Team, Andres Metspalu, Tõnu Esko, Lili Milani
Journal: Diabetes
Diabetes 2021;70(8):1816–1825
https://doi.org/10.2337/db20-0602
Published: 10 May 2021
View articletitled, Stratification of Type 2 Diabetes by Age of Diagnosis in the UK Biobank Reveals Subgroup-Specific Genetic Associations and Causal Risk Profiles
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Journal Articles

Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity

Hanieh Yaghootkar, Yiying Zhang, Cassandra N. Spracklen, Tugce Karaderi, Lam Opal Huang, Jonathan Bradfield, Claudia Schurmann, Rebecca S. Fine, Michael H. Preuss, Zoltan Kutalik, Laura B.L. Wittemans, Yingchang Lu, Sophia Metz, Sara M. Willems, Ruifang Li-Gao, Niels Grarup, Shuai Wang, Sophie Molnos, América A. Sandoval-Zárate, Mike A. Nalls, Leslie A. Lange, Jeffrey Haesser, Xiuqing Guo, Leo-Pekka Lyytikäinen, Mary F. Feitosa, Colleen M. Sitlani, Cristina Venturini, Anubha Mahajan, Tim Kacprowski, Carol A. Wang, Daniel I. Chasman, Najaf Amin, Linda Broer, Neil Robertson, Kristin L. Young, Matthew Allison, Paul L. Auer, Matthias Blüher, Judith B. Borja, Jette Bork-Jensen, Germán D. Carrasquilla, Paraskevi Christofidou, Ayse Demirkan, Claudia A. Doege, Melissa E. Garcia, Mariaelisa Graff, Kaiying Guo, Hakon Hakonarson, Jaeyoung Hong, Yii-Der Ida Chen, Rebecca Jackson, Hermina Jakupović, Pekka Jousilahti, Anne E. Justice, Mika Kähönen, Jorge R. Kizer, Jennifer Kriebel, Charles A. LeDuc, Jin Li, Lars Lind, Jian’an Luan, David A. Mackey, Massimo Mangino, Satu Männistö, Jayne F. Martin Carli, Carolina Medina-Gomez, Dennis O. Mook-Kanamori, Andrew P. Morris, Renée de Mutsert, Matthias Nauck, Ivana Prokic, Craig E. Pennell, Arund D. Pradhan, Bruce M. Psaty, Olli T. Raitakari, Robert A. Scott, Tea Skaaby, Konstantin Strauch, Kent D. Taylor, Alexander Teumer, Andre G. Uitterlinden, Ying Wu, Jie Yao, Mark Walker, Kari E. North, Peter Kovacs, M. Arfan Ikram, Cornelia M. van Duijn, Paul M. Ridker, Stephen Lye, Georg Homuth, Erik Ingelsson, Tim D. Spector, Barbara McKnight, Michael A. Province, Terho Lehtimäki, Linda S. Adair, Jerome I. Rotter, Alexander P. Reiner, James G. Wilson, Tamara B. Harris, Samuli Ripatti, Harald Grallert, James B. Meigs, Veikko Salomaa, Torben Hansen, Ko Willems van Dijk, Nicholas J. Wareham, Struan F.A. Grant, Claudia Langenberg, Timothy M. Frayling, Cecilia M. Lindgren, Karen L. Mohlke, Rudolph L. Leibel, Ruth J.F. Loos, Tuomas O. Kilpeläinen
Journal: Diabetes
Diabetes 2020;69(12):2806–2818
https://doi.org/10.2337/db20-0070
Published: 11 September 2020
View articletitled, Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity
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Journal Articles

Genome-Wide Association Study on the Early-Phase Insulin Response to a Liquid Mixed Meal: Results From the NEO Study

Ruifang Li-Gao, Françoise Carlotti, Renée de Mutsert, Astrid van Hylckama Vlieg, Eelco J.P. de Koning, J. Wouter Jukema, Frits R. Rosendaal, Ko Willems van Dijk, Dennis O. Mook-Kanamori
Journal: Diabetes
Diabetes 2019;68(12):2327–2336
https://doi.org/10.2337/db19-0378
Published: 19 September 2019
View articletitled, Genome-Wide Association Study on the Early-Phase Insulin Response to a Liquid Mixed Meal: Results From the NEO Study
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Includes: Supplementary data
Journal Articles

A Mendelian Randomization Study of Metabolite Profiles, Fasting Glucose, and Type 2 Diabetes

Jun Liu, Jan Bert van Klinken, Sabina Semiz, Ko Willems van Dijk, Aswin Verhoeven, Thomas Hankemeier, Amy C. Harms, Eric Sijbrands, Nuala A. Sheehan, Cornelia M. van Duijn, Ayşe Demirkan
Journal: Diabetes
Diabetes 2017;66(11):2915–2926
https://doi.org/10.2337/db17-0199
Published: 28 August 2017
View articletitled, A Mendelian Randomization Study of Metabolite Profiles, Fasting Glucose, and Type 2 Diabetes
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Includes: Supplementary data
Journal Articles

Mannose-Binding Lectin Is Required for the Effective Clearance of Apoptotic Cells by Adipose Tissue Macrophages During Obesity

Rinke Stienstra, Wieneke Dijk, Lianne van Beek, Henry Jansen, Mattijs Heemskerk, Riekelt H. Houtkooper, Simone Denis, Vanessa van Harmelen, Ko Willems van Dijk, Cees J. Tack, Sander Kersten
Journal: Diabetes
Diabetes 2014;63(12):4143–4153
https://doi.org/10.2337/db14-0256
Published: 13 November 2014
View articletitled, Mannose-Binding Lectin Is Required for the Effective Clearance of Apoptotic Cells by Adipose Tissue Macrophages During Obesity
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Includes: Supplementary data
Journal Articles

Mendelian Randomization Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes

Hanieh Yaghootkar, Claudia Lamina, Robert A. Scott, Zari Dastani, Marie-France Hivert, Liling L. Warren, Alena Stancáková, Sarah G. Buxbaum, Leo-Pekka Lyytikäinen, Peter Henneman, Ying Wu, Chloe Y.Y. Cheung, James S. Pankow, Anne U. Jackson, Stefan Gustafsson, Jing Hua Zhao, Christie M. Ballantyne, Weijia Xie, Richard N. Bergman, Michael Boehnke, Fatiha el Bouazzaoui, Francis S. Collins, Sandra H. Dunn, Josee Dupuis, Nita G. Forouhi, Christopher Gillson, Andrew T. Hattersley, Jaeyoung Hong, Mika Kähönen, Johanna Kuusisto, Lyudmyla Kedenko, Florian Kronenberg, Alessandro Doria, Themistocles L. Assimes, Ele Ferrannini, Torben Hansen, Ke Hao, Hans Häring, Joshua W. Knowles, Cecilia M. Lindgren, John J. Nolan, Jussi Paananen, Oluf Pedersen, Thomas Quertermous, Ulf Smith, the GENESIS Consortium, the RISC Consortium, Terho Lehtimäki, Ching-Ti Liu, Ruth J.F. Loos, Mark I. McCarthy, Andrew D. Morris, Ramachandran S. Vasan, Tim D. Spector, Tanya M. Teslovich, Jaakko Tuomilehto, Ko Willems van Dijk, Jorma S. Viikari, Na Zhu, Claudia Langenberg, Erik Ingelsson, Robert K. Semple, Alan R. Sinaiko, Colin N.A. Palmer, Mark Walker, Karen S.L. Lam, Bernhard Paulweber, Karen L. Mohlke, Cornelia van Duijn, Olli T. Raitakari, Aurelian Bidulescu, Nick J. Wareham, Markku Laakso, Dawn M. Waterworth, Debbie A. Lawlor, James B. Meigs, J. Brent Richards, Timothy M. Frayling
Journal: Diabetes
Diabetes 2013;62(10):3589–3598
https://doi.org/10.2337/db13-0128
Published: 17 September 2013
View articletitled, Mendelian Randomization Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes
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Includes: Supplementary data
Journal Articles

The Suprachiasmatic Nucleus Controls Circadian Energy Metabolism and Hepatic Insulin Sensitivity

Claudia P. Coomans, Sjoerd A.A. van den Berg, Eliane A. Lucassen, Thijs Houben, Amanda C.M. Pronk, Rianne D. van der Spek, Andries Kalsbeek, Nienke R. Biermasz, Ko Willems van Dijk, Johannes A. Romijn, Johanna H. Meijer
Journal: Diabetes
Diabetes 2013;62(4):1102–1108
https://doi.org/10.2337/db12-0507
Published: 14 March 2013
View articletitled, The Suprachiasmatic Nucleus Controls Circadian Energy Metabolism and Hepatic Insulin Sensitivity
Open the PDF for The Suprachiasmatic Nucleus Controls Circadian Energy Metabolism and Hepatic Insulin Sensitivity in another window
Includes: Supplementary data