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Meeting Abstracts

1338-P: Low Birthweight Is Associated with Elevated Risk of Chronic Kidney Disease in Type 2 Diabetes—A Follow-up Study of Persons Diagnosed with Type 2 Diabetes in the DD2 Cohort

ALEKSANDER LÜHR HANSEN, CHRISTIAN FYNBO CHRISTIANSEN, CHARLOTTE BRØNS, LEONIE M. ENGELHARD, TORBEN HANSEN, JENS S. NIELSEN, PETER VESTERGAARD, KURT HOJLUND, NIELS JESSEN, MICHAEL HECHT OLSEN, HENRIK T. SØRENSEN, PETER ROSSING, REIMAR W. THOMSEN, ALLAN A. VAAG
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1338-P
https://doi.org/10.2337/db24-1338-P
Published: 14 June 2024
View article titled, 1338-P: Low Birthweight Is Associated with Elevated Risk of Chronic Kidney Disease in Type 2 Diabetes—A Follow-up Study of Persons Diagnosed with Type 2 Diabetes in the DD2 Cohort
Meeting Abstracts

1357-P: High Plasma Leptin Levels Are Associated with Low Birth Weight and Disease Severity in People with Recently Diagnosed Type 2 Diabetes

PRINCE A. OBENG, ALEKSANDER LÜHR HANSEN, LEONIE M. ENGELHARD, CHARLOTTE BRØNS, VERENA HIRSCHBERG JENSEN, TORBEN HANSEN, NIELS JESSEN, PETER VESTERGAARD, JENS S. NIELSEN, KURT HOJLUND, MICHAEL HECHT OLSEN, REIMAR W. THOMSEN, ALLAN A. VAAG
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1357-P
https://doi.org/10.2337/db24-1357-P
Published: 14 June 2024
View article titled, 1357-P: High Plasma Leptin Levels Are Associated with Low Birth Weight and Disease Severity in People with Recently Diagnosed Type 2 Diabetes
Meeting Abstracts

27-OR: Effect of Acute Exercise and Exercise Training on the Ability of Insulin to Clear Branched-Chain Amino Acids from Plasma in Obesity and Type 2 Diabetes

PAULINE M. MØLLER, RASMUS KJØBSTED, MARIA HOUBORG PETERSEN, JØRGEN F.P. WOJTASZEWSKI, KURT HOJLUND
Journal: Diabetes
Diabetes 2024;73(Supplement_1):27-OR
https://doi.org/10.2337/db24-27-OR
Published: 14 June 2024
View article titled, 27-OR: Effect of Acute Exercise and Exercise Training on the Ability of Insulin to Clear Branched-Chain Amino Acids from Plasma in Obesity and Type 2 Diabetes
Journal Articles

Risk of Diabetic Retinopathy According to Subtype of Type 2 Diabetes

Frederik N. Pedersen, Lonny Stokholm, Nis Andersen, Jens Andresen, Toke Bek, Javad Hajari, Steffen Heegaard, Kurt Højlund, Ryo Kawasaki, Caroline S. Laugesen, Sören Möller, Katja Schielke, Jens Steen Nielsen, Jacob V. Stidsen, Reimar W. Thomsen, Benjamin Thinggaard, Jakob Grauslund
Journal: Diabetes
Diabetes 2024;73(6):977–982
https://doi.org/10.2337/db24-0016
Published: 18 March 2024
View article titled, Risk of Diabetic Retinopathy According to Subtype of Type 2 Diabetes
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Journal Articles

Illumination of the Endogenous Insulin-Regulated TBC1D4 Interactome in Human Skeletal Muscle

Jeppe K. Larsen, Magnus R. Larsen, Jesper B. Birk, Dorte E. Steenberg, Janne R. Hingst, Kurt Højlund, Alexandra Chadt, Hadi Al-Hasani, Atul S. Deshmukh, Jørgen F.P. Wojtaszewski, Rasmus Kjøbsted
Journal: Diabetes
Diabetes 2022;71(5):906–920
https://doi.org/10.2337/db21-0855
Published: 22 February 2022
View article titled, Illumination of the Endogenous Insulin-Regulated TBC1D4 Interactome in Human Skeletal Muscle
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Meeting Abstracts

33-OR: Intact Muscle Insulin Signaling in Patients with a Gain-of-Function LRP5 Mutation Despite Decreased Insulin Sensitivity

RUGIVAN SABARATNAM, JENS-JACOB LINDEGAARD LAUTERLEIN, MORTEN FROST NIELSEN, KURT HOJLUND
Journal: Diabetes
Diabetes 2019;68(Supplement_1):33-OR
https://doi.org/10.2337/db19-33-OR
Published: 01 June 2019
View article titled, 33-OR: Intact Muscle Insulin Signaling in Patients with a Gain-of-Function LRP5 Mutation Despite Decreased Insulin Sensitivity
Journal Articles

Statement of Retraction. The SNARE Protein SNAP23 and the SNARE-Interacting Protein Munc18c in Human Skeletal Muscle Are Implicated in Insulin Resistance/Type 2 Diabetes. Diabetes 2010;59: 1870–1878 . DOI: 10.2337/db09-1503. PMID: 20460426

Pontus Boström, Linda Andersson, Birgitte Vind, Liliana Håversen, Mikael Rutberg, Ylva Wickström, Erik Larsson, Per-Anders Jansson, Maria K. Svensson, Richard Brånemark, Charlotte Ling, Henning Beck-Nielsen, Jan Borén, Kurt Højlund, Sven-Olof Olofsson
Journal: Diabetes
Diabetes 2017;66(5):1426
https://doi.org/10.2337/db17-rt05a
Published: 23 February 2017
View article titled, Statement of Retraction. The SNARE Protein SNAP23 and the SNARE-Interacting Protein Munc18c in Human Skeletal Muscle Are Implicated in Insulin Resistance/Type 2 Diabetes. Diabetes 2010;59: 1870–1878 . DOI: 10.2337/db09-1503. PMID: 20460426
Open the PDF for Statement of Retraction. The SNARE Protein SNAP23 and the SNARE-Interacting Protein Munc18c in Human Skeletal Muscle Are Implicated in Insulin Resistance/Type 2 Diabetes. Diabetes 2010;59: 1870–1878 . DOI: 10.2337/db09-1503. PMID: 20460426 in another window
Journal Articles

Intact Regulation of the AMPK Signaling Network in Response to Exercise and Insulin in Skeletal Muscle of Male Patients With Type 2 Diabetes: Illumination of AMPK Activation in Recovery From Exercise

Rasmus Kjøbsted, Andreas J.T. Pedersen, Janne R. Hingst, Rugivan Sabaratnam, Jesper B. Birk, Jonas M. Kristensen, Kurt Højlund, Jørgen F.P. Wojtaszewski
Journal: Diabetes
Diabetes 2016;65(5):1219–1230
https://doi.org/10.2337/db15-1034
Published: 28 January 2016
View article titled, Intact Regulation of the AMPK Signaling Network in Response to Exercise and Insulin in Skeletal Muscle of Male Patients With Type 2 Diabetes: Illumination of AMPK Activation in Recovery From Exercise
Open the PDF for Intact Regulation of the AMPK Signaling Network in Response to Exercise and Insulin in Skeletal Muscle of Male Patients With Type 2 Diabetes: Illumination of AMPK Activation in Recovery From Exercise in another window
Journal Articles

Human Muscle Fiber Type–Specific Insulin Signaling: Impact of Obesity and Type 2 Diabetes

Peter H. Albers, Andreas J.T. Pedersen, Jesper B. Birk, Dorte E. Kristensen, Birgitte F. Vind, Otto Baba, Jane Nøhr, Kurt Højlund, Jørgen F.P. Wojtaszewski
Journal: Diabetes
Diabetes 2015;64(2):485–497
https://doi.org/10.2337/db14-0590
Published: 03 September 2014
View article titled, Human Muscle Fiber Type–Specific Insulin Signaling: Impact of Obesity and Type 2 Diabetes
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Includes: Supplementary data
Journal Articles

Increased Interaction With Insulin Receptor Substrate 1, a Novel Abnormality in Insulin Resistance and Type 2 Diabetes

Michael Caruso, Danjun Ma, Zaher Msallaty, Monique Lewis, Berhane Seyoum, Wissam Al-janabi, Michael Diamond, Abdul B. Abou-Samra, Kurt Højlund, Rebecca Tagett, Sorin Draghici, Xiangmin Zhang, Jeffrey F. Horowitz, Zhengping Yi
Journal: Diabetes
Diabetes 2014;63(6):1933–1947
https://doi.org/10.2337/db13-1872
Published: 15 May 2014
View article titled, Increased Interaction With Insulin Receptor Substrate 1, a Novel Abnormality in Insulin Resistance and Type 2 Diabetes
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Includes: Supplementary data
Journal Articles

Rac1 Signaling Is Required for Insulin-Stimulated Glucose Uptake and Is Dysregulated in Insulin-Resistant Murine and Human Skeletal Muscle

Lykke Sylow, Thomas E. Jensen, Maximilian Kleinert, Kurt Højlund, Bente Kiens, Jørgen Wojtaszewski, Clara Prats, Peter Schjerling, Erik A. Richter
Journal: Diabetes
Diabetes 2013;62(6):1865–1875
https://doi.org/10.2337/db12-1148
Published: 17 May 2013
View article titled, Rac1 Signaling Is Required for Insulin-Stimulated Glucose Uptake and Is Dysregulated in Insulin-Resistant Murine and Human Skeletal Muscle
Open the PDF for Rac1 Signaling Is Required for Insulin-Stimulated Glucose Uptake and Is Dysregulated in Insulin-Resistant Murine and Human Skeletal Muscle in another window
Includes: Supplementary data
Journal Articles

Increased Reactive Oxygen Species Production and Lower Abundance of Complex I Subunits and Carnitine Palmitoyltransferase 1B Protein Despite Normal Mitochondrial Respiration in Insulin-Resistant Human Skeletal Muscle

Natalie Lefort, Brian Glancy, Benjamin Bowen, Wayne T. Willis, Zachary Bailowitz, Elena A. De Filippis, Colleen Brophy, Christian Meyer, Kurt Højlund, Zhengping Yi, Lawrence J. Mandarino
Journal: Diabetes
Diabetes 2010;59(10):2444–2452
https://doi.org/10.2337/db10-0174
Published: 03 August 2010
View article titled, Increased Reactive Oxygen Species Production and Lower Abundance of Complex I Subunits and Carnitine Palmitoyltransferase 1B Protein Despite Normal Mitochondrial Respiration in Insulin-Resistant Human Skeletal Muscle
Open the PDF for Increased Reactive Oxygen Species Production and Lower Abundance of Complex I Subunits and Carnitine Palmitoyltransferase 1B Protein Despite Normal Mitochondrial Respiration in Insulin-Resistant Human Skeletal Muscle in another window
Includes: Supplementary data
Journal Articles

The SNARE Protein SNAP23 and the SNARE-Interacting Protein Munc18c in Human Skeletal Muscle Are Implicated in Insulin Resistance/Type 2 Diabetes

Pontus Boström, Linda Andersson, Birgitte Vind, Liliana Håversen, Mikael Rutberg, Ylva Wickström, Erik Larsson, Per-Anders Jansson, Maria K. Svensson, Richard Brånemark, Charlotte Ling, Henning Beck-Nielsen, Jan Borén, Kurt Højlund, Sven-Olof Olofsson
Journal: Diabetes
Diabetes 2010;59(8):1870–1878
https://doi.org/10.2337/db09-1503
Published: 11 May 2010
View article titled, The SNARE Protein SNAP23 and the SNARE-Interacting Protein Munc18c in Human Skeletal Muscle Are Implicated in Insulin Resistance/Type 2 Diabetes
Open the PDF for The SNARE Protein SNAP23 and the SNARE-Interacting Protein Munc18c in Human Skeletal Muscle Are Implicated in Insulin Resistance/Type 2 Diabetes in another window
Includes: Multimedia, Supplementary data
Journal Articles

Proteomics Analysis of Human Skeletal Muscle Reveals Novel Abnormalities in Obesity and Type 2 Diabetes

Hyonson Hwang, Benjamin P. Bowen, Natalie Lefort, Charles R. Flynn, Elena A. De Filippis, Christine Roberts, Christopher C. Smoke, Christian Meyer, Kurt Højlund, Zhengping Yi, Lawrence J. Mandarino
Journal: Diabetes
Diabetes 2010;59(1):33–42
https://doi.org/10.2337/db09-0214
Published: 15 October 2009
View article titled, Proteomics Analysis of Human Skeletal Muscle Reveals Novel Abnormalities in Obesity and Type 2 Diabetes
Open the PDF for Proteomics Analysis of Human Skeletal Muscle Reveals Novel Abnormalities in Obesity and Type 2 Diabetes in another window
Includes: Supplementary data
Journal Articles

Impaired Insulin-Stimulated Phosphorylation of Akt and AS160 in Skeletal Muscle of Women With Polycystic Ovary Syndrome Is Reversed by Pioglitazone Treatment

Kurt Højlund, Dorte Glintborg, Nicoline R. Andersen, Jesper B. Birk, Jonas T. Treebak, Christian Frøsig, Henning Beck-Nielsen, Jørgen F.P. Wojtaszewski
Journal: Diabetes
Diabetes 2008;57(2):357–366
https://doi.org/10.2337/db07-0706
Published: 01 February 2008
View article titled, Impaired Insulin-Stimulated Phosphorylation of Akt and AS160 in Skeletal Muscle of Women With Polycystic Ovary Syndrome Is Reversed by Pioglitazone Treatment
Open the PDF for Impaired Insulin-Stimulated Phosphorylation of Akt and AS160 in Skeletal Muscle of Women With Polycystic Ovary Syndrome Is Reversed by Pioglitazone Treatment in another window
Journal Articles

Reduced Expression of Nuclear-Encoded Genes Involved in Mitochondrial Oxidative Metabolism in Skeletal Muscle of Insulin-Resistant Women With Polycystic Ovary Syndrome

Vibe Skov, Dorte Glintborg, Steen Knudsen, Thomas Jensen, Torben A. Kruse, Qihua Tan, Klaus Brusgaard, Henning Beck-Nielsen, Kurt Højlund
Journal: Diabetes
Diabetes 2007;56(9):2349–2355
https://doi.org/10.2337/db07-0275
Published: 01 September 2007
View article titled, Reduced Expression of Nuclear-Encoded Genes Involved in Mitochondrial Oxidative Metabolism in Skeletal Muscle of Insulin-Resistant Women With Polycystic Ovary Syndrome
Open the PDF for Reduced Expression of Nuclear-Encoded Genes Involved in Mitochondrial Oxidative Metabolism in Skeletal Muscle of Insulin-Resistant Women With Polycystic Ovary Syndrome in another window
Includes: Supplementary data
Journal Articles

Mitochondrial Respiration Is Decreased in Skeletal Muscle of Patients With Type 2 Diabetes

Martin Mogensen, Kent Sahlin, Maria Fernström, Dorte Glintborg, Birgitte F. Vind, Henning Beck-Nielsen, Kurt Højlund
Journal: Diabetes
Diabetes 2007;56(6):1592–1599
https://doi.org/10.2337/db06-0981
Published: 01 June 2007
View article titled, Mitochondrial Respiration Is Decreased in Skeletal Muscle of Patients With Type 2 Diabetes
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Journal Articles

Skeletal Muscle Lipid Accumulation in Type 2 Diabetes May Involve the Liver X Receptor Pathway

Eili T. Kase, Andreas J. Wensaas, Vigdis Aas, Kurt Højlund, Klaus Levin, G. Hege Thoresen, Henning Beck-Nielsen, Arild C. Rustan, Michael Gaster
Journal: Diabetes
Diabetes 2005;54(4):1108–1115
https://doi.org/10.2337/diabetes.54.4.1108
Published: 01 April 2005
View article titled, Skeletal Muscle Lipid Accumulation in Type 2 Diabetes May Involve the Liver X Receptor Pathway
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Journal Articles

A Novel Syndrome of Autosomal-Dominant Hyperinsulinemic Hypoglycemia Linked to a Mutation in the Human Insulin Receptor Gene

Kurt Højlund, Torben Hansen, Maria Lajer, Jan Erik Henriksen, Klaus Levin, Jörgen Lindholm, Oluf Pedersen, Henning Beck-Nielsen
Journal: Diabetes
Diabetes 2004;53(6):1592–1598
https://doi.org/10.2337/diabetes.53.6.1592
Published: 01 June 2004
View article titled, A Novel Syndrome of Autosomal-Dominant Hyperinsulinemic Hypoglycemia Linked to a Mutation in the Human Insulin Receptor Gene
Open the PDF for A Novel Syndrome of Autosomal-Dominant Hyperinsulinemic Hypoglycemia Linked to a Mutation in the Human Insulin Receptor Gene in another window
Journal Articles

Increased Phosphorylation of Skeletal Muscle Glycogen Synthase at NH2-Terminal Sites During Physiological Hyperinsulinemia in Type 2 Diabetes

Kurt Højlund, Peter Stæhr, Bo Falck Hansen, Kevin A. Green, D. Grahame Hardie, Erik A. Richter, Henning Beck-Nielsen, Jørgen F.P. Wojtaszewski
Journal: Diabetes
Diabetes 2003;52(6):1393–1402
https://doi.org/10.2337/diabetes.52.6.1393
Published: 01 June 2003
View article titled, Increased Phosphorylation of Skeletal Muscle Glycogen Synthase at NH<sub>2</sub>-Terminal Sites During Physiological Hyperinsulinemia in Type 2 Diabetes
Open the PDF for Increased Phosphorylation of Skeletal Muscle Glycogen Synthase at NH<sub>2</sub>-Terminal Sites During Physiological Hyperinsulinemia in Type 2 Diabetes in another window