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Kyle W. Sloop
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Journal Articles

A Contemporary Rationale for Agonism of the GIP Receptor in the Treatment of Obesity

Free
Ricardo J. Samms, Kyle W. Sloop
Journal: Diabetes
Diabetes dbi240026
https://doi.org/10.2337/dbi24-0026
Published: 16 June 2025
View articletitled, A Contemporary Rationale for Agonism of the GIP Receptor in the Treatment of Obesity
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Journal Articles

GIPR Agonism Enhances TZD-Induced Insulin Sensitivity in Obese IR Mice

Free
Ellen C. Furber, Karissa Hyatt, Kyla Collins, Xinxin Yu, Brian A. Droz, Adrienne Holland, Jessica L. Friedrich, Samantha Wojnicki, Debra L. Konkol, Libbey S. O’Farrell, Hana E. Baker, Tamer Coskun, Philipp E. Scherer, Christine M. Kusminski, Michael E. Christe, Kyle W. Sloop, Ricardo J. Samms
Journal: Diabetes
Diabetes 2024;73(2):292–305
https://doi.org/10.2337/db23-0172
Published: 07 November 2023
View articletitled, GIPR Agonism Enhances TZD-Induced Insulin Sensitivity in Obese IR Mice
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Journal Articles

GIPR Agonism Inhibits PYY-Induced Nausea-Like Behavior

Free
Ricardo J. Samms, Richard Cosgrove, Brandy M. Snider, Ellen C. Furber, Brian A. Droz, Daniel A. Briere, James Dunbar, Mridula Dogra, Jorge Alsina-Fernandez, Tito Borner, Bart C. De Jonghe, Matthew R. Hayes, Tamer Coskun, Kyle W. Sloop, Paul J. Emmerson, Minrong Ai
Journal: Diabetes
Diabetes 2022;71(7):1410–1423
https://doi.org/10.2337/db21-0848
Published: 02 May 2022
View articletitled, GIPR Agonism Inhibits PYY-Induced Nausea-Like Behavior
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Journal Articles

GIPR Function in the Central Nervous System: Implications and Novel Perspectives for GIP-Based Therapies in Treating Metabolic Disorders

Open Access
Ricardo J. Samms, Kyle W. Sloop, Fiona M. Gribble, Frank Reimann, Alice E. Adriaenssens
Journal: Diabetes
Diabetes 2021;70(9):1938–1944
https://doi.org/10.2337/dbi21-0002
Published: 27 June 2021
View articletitled, GIPR Function in the Central Nervous System: Implications and Novel Perspectives for GIP-Based Therapies in Treating Metabolic Disorders
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Journal Articles

The Limited Role of Glucagon for Ketogenesis During Fasting or in Response to SGLT2 Inhibition

Free
Megan E. Capozzi, Reilly W. Coch, Jepchumba Koech, Inna I. Astapova, Jacob B. Wait, Sara E. Encisco, Jonathan D. Douros, Kimberly El, Brian Finan, Kyle W. Sloop, Mark A. Herman, David A. D’Alessio, Jonathan E. Campbell
Journal: Diabetes
Diabetes 2020;69(5):882–892
https://doi.org/10.2337/db19-1216
Published: 31 January 2020
View articletitled, The Limited Role of Glucagon for Ketogenesis During Fasting or in Response to SGLT2 Inhibition
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Includes: Supplementary data
Journal Articles

Erratum. GLP-1 Receptor in Pancreatic α-Cells Regulates Glucagon Secretion in a Glucose-Dependent Bidirectional Manner. Diabetes 2019;68:

Free
Yanqing Zhang, Keshab R. Parajuli, Genevieve E. Fava, Rajesh Gupta, Weiwei Xu, Lauren U. Nguyen, Anadil F. Zakaria, Vivian A. Fonseca, Hongjun Wang, Franck Mauvais-Jarvis, Kyle W. Sloop, Hongju Wu
Journal: Diabetes
Diabetes 2020;69(2):267–268
https://doi.org/10.2337/db20-er02c
Published: 16 December 2019
View articletitled, Erratum. GLP-1 Receptor in Pancreatic α-Cells Regulates Glucagon Secretion in a Glucose-Dependent Bidirectional Manner. Diabetes 2019;68:
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Journal Articles

GLP-1 Receptor in Pancreatic α-Cells Regulates Glucagon Secretion in a Glucose-Dependent Bidirectional Manner

Free
Yanqing Zhang, Keshab R. Parajuli, Genevieve E. Fava, Rajesh Gupta, Weiwei Xu, Lauren U. Nguyen, Anadil F. Zakaria, Vivian A. Fonseca, Hongjun Wang, Franck Mauvais-Jarvis, Kyle W. Sloop, Hongju Wu
Journal: Diabetes
Diabetes 2019;68(1):34–44
https://doi.org/10.2337/db18-0317
Published: 02 November 2018
View articletitled, GLP-1 Receptor in Pancreatic α-Cells Regulates Glucagon Secretion in a Glucose-Dependent Bidirectional Manner
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Includes: Supplementary data
Meeting Abstracts

The Role of GLP-1 Receptor Expressed in Pancreatic a Cells in Regulating Glucagon Secretion

Free
YANQING ZHANG, KESHAB R. PARAJULI, GENEVIEVE E. SMITH, RAJESH GUPTA, WEIWEI XU, LAUREN U. NGUYEN, ANADIL F. ZAKARIA, FRANCK MAUVAIS-JARVIS, VIVIAN FONSECA, KYLE W. SLOOP, HONGJU WU
Journal: Diabetes
Diabetes 2018;67(Supplement_1):355-OR
https://doi.org/10.2337/db18-355-OR
Published: 01 July 2018
View articletitled, The Role of GLP-1 Receptor Expressed in Pancreatic a Cells in Regulating Glucagon Secretion
Journal Articles

Mechanisms to Elevate Endogenous GLP-1 Beyond Injectable GLP-1 Analogs and Metabolic Surgery

Free
Daniel A. Briere, Ana B. Bueno, Ellen J. Gunn, M. Dodson Michael, Kyle W. Sloop
Journal: Diabetes
Diabetes 2018;67(2):309–320
https://doi.org/10.2337/db17-0607
Published: 04 December 2017
View articletitled, Mechanisms to Elevate Endogenous GLP-1 Beyond Injectable GLP-1 Analogs and Metabolic Surgery
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Journal Articles

Absence of Glucagon and Insulin Action Reveals a Role for the GLP-1 Receptor in Endogenous Glucose Production

Free
Lucy S. Jun, Rohn L. Millican, Eric D. Hawkins, Debra L. Konkol, Aaron D. Showalter, Michael E. Christe, M. Dodson Michael, Kyle W. Sloop
Journal: Diabetes
Diabetes 2015;64(3):819–827
https://doi.org/10.2337/db14-1052
Published: 06 October 2014
View articletitled, Absence of Glucagon and Insulin Action Reveals a Role for the GLP-1 Receptor in Endogenous Glucose Production
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Journal Articles

Novel Small Molecule Glucagon-Like Peptide-1 Receptor Agonist Stimulates Insulin Secretion in Rodents and From Human Islets

Open Access
Kyle W. Sloop, Francis S. Willard, Martin B. Brenner, James Ficorilli, Kathleen Valasek, Aaron D. Showalter, Thomas B. Farb, Julia X.C. Cao, Amy L. Cox, M. Dodson Michael, Sonia Maria Gutierrez Sanfeliciano, Mark J. Tebbe, Michael J. Coghlan
Journal: Diabetes
Diabetes 2010;59(12):3099–3107
https://doi.org/10.2337/db10-0689
Published: 07 September 2010
View articletitled, Novel Small Molecule Glucagon-Like Peptide-1 Receptor Agonist Stimulates Insulin Secretion in Rodents and From Human Islets
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Journal Articles

Reduction of Hepatic and Adipose Tissue Glucocorticoid Receptor Expression With Antisense Oligonucleotides Improves Hyperglycemia and Hyperlipidemia in Diabetic Rodents Without Causing Systemic Glucocorticoid Antagonism

Free
Lynnetta M. Watts, Vara Prasad Manchem, Thomas A. Leedom, Amber L. Rivard, Robert A. McKay, Dingjiu Bao, Teri Neroladakis, Brett P. Monia, Diane M. Bodenmiller, Julia Xiao-Chun Cao, Hong Yan Zhang, Amy L. Cox, Steven J. Jacobs, M. Dodson Michael, Kyle W. Sloop, Sanjay Bhanot
Journal: Diabetes
Diabetes 2005;54(6):1846–1853
https://doi.org/10.2337/diabetes.54.6.1846
Published: 01 June 2005
View articletitled, Reduction of Hepatic and Adipose Tissue Glucocorticoid Receptor Expression With Antisense Oligonucleotides Improves Hyperglycemia and Hyperlipidemia in Diabetic Rodents Without Causing Systemic Glucocorticoid Antagonism
Open the PDF for Reduction of Hepatic and Adipose Tissue Glucocorticoid Receptor Expression With Antisense Oligonucleotides Improves Hyperglycemia and Hyperlipidemia in Diabetic Rodents Without Causing Systemic Glucocorticoid Antagonism in another window