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Lawrence J. Mandarino
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Journal Articles

Identification of Novel Changes in Human Skeletal Muscle Proteome After Roux-en-Y Gastric Bypass Surgery

Latoya E. Campbell, Paul R. Langlais, Samantha E. Day, Richard L. Coletta, Tonya R. Benjamin, Elena Anna De Filippis, James A. Madura, II, Lawrence J. Mandarino, Lori R. Roust, Dawn K. Coletta
Journal: Diabetes
Diabetes 2016;65(9):2724–2731
https://doi.org/10.2337/db16-0004
Published: 10 May 2016
View articletitled, Identification of Novel Changes in Human Skeletal Muscle Proteome After Roux-en-Y Gastric Bypass Surgery
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Includes: Supplementary data
Journal Articles

Time to Look Back and to Look Forward

K. Sreekumaran Nair, E. Dale Abel, Sharon G. Adler, Peter J. Dyck, Thomas W. Gardner, Kathryn M. Haskins, Gökhan Hotamisligil, Michael D. Jensen, Anna Krook, Lawrence J. Mandarino, Braxton D. Mitchell, Jeffrey E. Pessin, James R. Sowers, Lori Sussel, Nick Wareham, Adrian Vella
Journal: Diabetes
Diabetes 2014;63(4):1169–1170
https://doi.org/10.2337/db14-0067
Published: 13 March 2014
View articletitled, Time to Look Back and to Look Forward
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Journal Articles

Increased Reactive Oxygen Species Production and Lower Abundance of Complex I Subunits and Carnitine Palmitoyltransferase 1B Protein Despite Normal Mitochondrial Respiration in Insulin-Resistant Human Skeletal Muscle

Natalie Lefort, Brian Glancy, Benjamin Bowen, Wayne T. Willis, Zachary Bailowitz, Elena A. De Filippis, Colleen Brophy, Christian Meyer, Kurt Højlund, Zhengping Yi, Lawrence J. Mandarino
Journal: Diabetes
Diabetes 2010;59(10):2444–2452
https://doi.org/10.2337/db10-0174
Published: 03 August 2010
View articletitled, Increased Reactive Oxygen Species Production and Lower Abundance of Complex I Subunits and Carnitine Palmitoyltransferase 1B Protein Despite Normal Mitochondrial Respiration in Insulin-Resistant Human Skeletal Muscle
Open the PDF for Increased Reactive Oxygen Species Production and Lower Abundance of Complex I Subunits and Carnitine Palmitoyltransferase 1B Protein Despite Normal Mitochondrial Respiration in Insulin-Resistant Human Skeletal Muscle in another window
Includes: Supplementary data
Journal Articles

Proteomics Analysis of Human Skeletal Muscle Reveals Novel Abnormalities in Obesity and Type 2 Diabetes

Hyonson Hwang, Benjamin P. Bowen, Natalie Lefort, Charles R. Flynn, Elena A. De Filippis, Christine Roberts, Christopher C. Smoke, Christian Meyer, Kurt Højlund, Zhengping Yi, Lawrence J. Mandarino
Journal: Diabetes
Diabetes 2010;59(1):33–42
https://doi.org/10.2337/db09-0214
Published: 15 October 2009
View articletitled, Proteomics Analysis of Human Skeletal Muscle Reveals Novel Abnormalities in Obesity and Type 2 Diabetes
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Includes: Supplementary data
Journal Articles

Global Assessment of Regulation of Phosphorylation of Insulin Receptor Substrate-1 by Insulin In Vivo in Human Muscle

Zhengping Yi, Paul Langlais, Elena A. De Filippis, Moulun Luo, Charles R. Flynn, Stefanie Schroeder, Susan T. Weintraub, Rebekka Mapes, Lawrence J. Mandarino
Journal: Diabetes
Diabetes 2007;56(6):1508–1516
https://doi.org/10.2337/db06-1355
Published: 01 June 2007
View articletitled, Global Assessment of Regulation of Phosphorylation of Insulin Receptor Substrate-1 by Insulin In Vivo in Human Muscle
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Includes: Supplementary data
Journal Articles

Paradoxical Changes in Muscle Gene Expression in Insulin-Resistant Subjects After Sustained Reduction in Plasma Free Fatty Acid Concentration

Mandeep Bajaj, Rafael Medina-Navarro, Swangjit Suraamornkul, Christian Meyer, Ralph A. DeFronzo, Lawrence J. Mandarino
Journal: Diabetes
Diabetes 2007;56(3):743–752
https://doi.org/10.2337/db06-0840
Published: 01 March 2007
View articletitled, Paradoxical Changes in Muscle Gene Expression in Insulin-Resistant Subjects After Sustained Reduction in Plasma Free Fatty Acid Concentration
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Journal Articles

Reduced Skeletal Muscle Inhibitor of κBβ Content Is Associated With Insulin Resistance in Subjects With Type 2 Diabetes: Reversal by Exercise Training

Apiradee Sriwijitkamol, Christine Christ-Roberts, Rachele Berria, Phyllis Eagan, Thongchai Pratipanawatr, Ralph A. DeFronzo, Lawrence J. Mandarino, Nicolas Musi
Journal: Diabetes
Diabetes 2006;55(3):760–767
https://doi.org/10.2337/diabetes.55.03.06.db05-0677
Published: 01 March 2006
View articletitled, Reduced Skeletal Muscle Inhibitor of κBβ Content Is Associated With Insulin Resistance in Subjects With Type 2 Diabetes: Reversal by Exercise Training
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Journal Articles

Effect of a Sustained Reduction in Plasma Free Fatty Acid Concentration on Intramuscular Long-Chain Fatty Acyl-CoAs and Insulin Action in Type 2 Diabetic Patients

Mandeep Bajaj, Swangjit Suraamornkul, Anthony Romanelli, Gary W. Cline, Lawrence J. Mandarino, Gerald I. Shulman, Ralph A. DeFronzo
Journal: Diabetes
Diabetes 2005;54(11):3148–3153
https://doi.org/10.2337/diabetes.54.11.3148
Published: 01 November 2005
View articletitled, Effect of a Sustained Reduction in Plasma Free Fatty Acid Concentration on Intramuscular Long-Chain Fatty Acyl-CoAs and Insulin Action in Type 2 Diabetic Patients
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Journal Articles

Ceramide Content Is Increased in Skeletal Muscle From Obese Insulin-Resistant Humans

John M. Adams, II, Thongchai Pratipanawatr, Rachele Berria, Elaine Wang, Ralph A. DeFronzo, M. Cameron Sullards, Lawrence J. Mandarino
Journal: Diabetes
Diabetes 2004;53(1):25–31
https://doi.org/10.2337/diabetes.53.1.25
Published: 01 January 2004
View articletitled, Ceramide Content Is Increased in Skeletal Muscle From Obese Insulin-Resistant Humans
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Journal Articles

Rosiglitazone Improves Downstream Insulin Receptor Signaling in Type 2 Diabetic Patients

Yoshinori Miyazaki, Helen He, Lawrence J. Mandarino, Ralph A. DeFronzo
Journal: Diabetes
Diabetes 2003;52(8):1943–1950
https://doi.org/10.2337/diabetes.52.8.1943
Published: 01 August 2003
View articletitled, Rosiglitazone Improves Downstream Insulin Receptor Signaling in Type 2 Diabetic Patients
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Journal Articles

Normalization of Plasma Glucose Concentration by Insulin Therapy Improves Insulin-Stimulated Glycogen Synthesis in Type 2 Diabetes

Thongchai Pratipanawatr, Kenneth Cusi, Peter Ngo, Wilailak Pratipanawatr, Lawrence J. Mandarino, Ralph A. DeFronzo
Journal: Diabetes
Diabetes 2002;51(2):462–468
https://doi.org/10.2337/diabetes.51.2.462
Published: 01 February 2002
View articletitled, Normalization of Plasma Glucose Concentration by Insulin Therapy Improves Insulin-Stimulated Glycogen Synthesis in Type 2 Diabetes
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Journal Articles

Skeletal Muscle Insulin Resistance in Normoglycemic Subjects With a Strong Family History of Type 2 Diabetes Is Associated With Decreased Insulin-Stimulated Insulin Receptor Substrate-1 Tyrosine Phosphorylation

Wilailak Pratipanawatr, Thongchai Pratipanawatr, Kenneth Cusi, Rachele Berria, John M. Adams, Christopher P. Jenkinson, Katsumi Maezono, Ralph A. DeFronzo, Lawrence J. Mandarino
Journal: Diabetes
Diabetes 2001;50(11):2572–2578
https://doi.org/10.2337/diabetes.50.11.2572
Published: 01 November 2001
View articletitled, Skeletal Muscle Insulin Resistance in Normoglycemic Subjects With a Strong Family History of Type 2 Diabetes Is Associated With Decreased Insulin-Stimulated Insulin Receptor Substrate-1 Tyrosine Phosphorylation
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Journal Articles

Seven Days of Euglycemic Hyperinsulinemia Induces Insulin Resistance for Glucose Metabolism but Not Hypertension, Elevated Catecholamine Levels, or Increased Sodium Retention in Conscious Normal Rats

Sietse J Koopmans, Lynne Ohman, Joseph R Haywood, Lawrence J Mandarino, Ralph A DeFronzo
Journal: Diabetes
Diabetes 1997;46(10):1572–1578
https://doi.org/10.2337/diacare.46.10.1572
Published: 01 October 1997
View articletitled, Seven Days of Euglycemic Hyperinsulinemia Induces Insulin Resistance for Glucose Metabolism but Not Hypertension, Elevated Catecholamine Levels, or Increased Sodium Retention in Conscious Normal Rats
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Journal Articles

Intracellular Defects in Glucose Metabolism in Obese Patients With NIDDM

David E Kelley, Marian Mokan, Lawrence J Mandarino
Journal: Diabetes
Diabetes 1992;41(6):698–706
https://doi.org/10.2337/diab.41.6.698
Published: 01 June 1992
View articletitled, Intracellular Defects in Glucose Metabolism in Obese Patients With NIDDM
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Journal Articles

Decreased Activation of Skeletal Muscle Glycogen Synthase by Mixed-Meal Ingestion in NIDDM

Kimberly S Wright, Henning Beck-Nielsen, Orville G Kolterman, Lawrence J Mandarino
Journal: Diabetes
Diabetes 1988;37(4):436–440
https://doi.org/10.2337/diab.37.4.436
Published: 01 April 1988
View articletitled, Decreased Activation of Skeletal Muscle Glycogen Synthase by Mixed-Meal Ingestion in NIDDM
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Journal Articles

Familial Insulin Resistance and Acanthosis Nigricans: Presence of a Postbinding Defect

W Frederick Schwenk, Robert A Rizza, Lawrence J Mandarino, John E Gerich, Alvin B Hayles, Morey W Haymond
Journal: Diabetes
Diabetes 1986;35(1):33–37
https://doi.org/10.2337/diab.35.1.33
Published: 01 January 1986
View articletitled, Familial Insulin Resistance and Acanthosis Nigricans: Presence of a Postbinding Defect
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Journal Articles

Effects of Growth Hormone on Insulin Action in Man: Mechanisms of Insulin Resistance, Impaired Suppression of Glucose Production, and Impaired Stimulation of Glucose Utilization

Robert A Rizza, Lawrence J Mandarino, John E Gerich
Journal: Diabetes
Diabetes 1982;31(8):663–669
https://doi.org/10.2337/diab.31.8.663
Published: 01 August 1982
View articletitled, Effects of Growth Hormone on Insulin Action in Man: Mechanisms of Insulin Resistance, Impaired Suppression of Glucose Production, and Impaired Stimulation of Glucose Utilization
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Journal Articles

Mechanism and Significance of Insulin Resistance in Non-insulin-dependent Diabetes Mellitus

Robert A Rizza, Lawrence J Mandarino, John E Gerich
Journal: Diabetes
Diabetes 1981;30(12):990–995
https://doi.org/10.2337/diab.30.12.990
Published: 01 December 1981
View articletitled, Mechanism and Significance of Insulin Resistance in Non-insulin-dependent Diabetes Mellitus
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Journal Articles

Pathogenesis of Hypoglycemia in Insulinoma Patients: Suppression of Hepatic Glucose Production by Insulin

Robert A Rizza, Morey W Haymond, Carlos A Verdonk, Lawrence J Mandarino, John M Miles, F John Service, John E Gerich
Journal: Diabetes
Diabetes 1981;30(5):377–381
https://doi.org/10.2337/diab.30.5.377
Published: 01 May 1981
View articletitled, Pathogenesis of Hypoglycemia in Insulinoma Patients: Suppression of Hepatic Glucose Production by Insulin
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