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Journal Articles

Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity

Mei-Ling Yang, Sean E. Connolly, Renelle J. Gee, TuKiet T. Lam, Jean Kanyo, Jian Peng, Perrin Guyer, Farooq Syed, Hubert M. Tse, Steven G. Clarke, Catherine F. Clarke, Eddie A. James, Cate Speake, Carmella Evans-Molina, Peter Arvan, Kevan C. Herold, Li Wen, Mark J. Mamula
Journal: Diabetes
Diabetes 2022;71(9):1979–1993
https://doi.org/10.2337/db21-0989
Published: 22 June 2022
View article titled, Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity
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Journal Articles

Differentiating MHC-Dependent and -Independent Mechanisms of Lymph Node Stromal Cell Regulation of Proinsulin-Specific CD8+ T Cells in Type 1 Diabetes

Terri C. Thayer, Joanne Davies, James A. Pearson, Stephanie J. Hanna, Li Wen, F. Susan Wong
Journal: Diabetes
Diabetes 2021;70(2):529–537
https://doi.org/10.2337/db19-1050
Published: 29 November 2020
View article titled, Differentiating MHC-Dependent and -Independent Mechanisms of Lymph Node Stromal Cell Regulation of Proinsulin-Specific CD8<sup>+</sup> T Cells in Type 1 Diabetes
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Journal Articles

TLR9 Deficiency in B Cells Promotes Immune Tolerance via Interleukin-10 in a Type 1 Diabetes Mouse Model

Sha Sha, James A. Pearson, Jian Peng, Youjia Hu, Juan Huang, Yanpeng Xing, Luyao Zhang, Ying Zhu, Hongyu Zhao, F. Susan Wong, Li Chen, Li Wen
Journal: Diabetes
Diabetes 2021;70(2):504–515
https://doi.org/10.2337/db20-0373
Published: 05 November 2020
View article titled, TLR9 Deficiency in B Cells Promotes Immune Tolerance via Interleukin-10 in a Type 1 Diabetes Mouse Model
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Journal Articles

Altered Gut Microbiota Activate and Expand Insulin B15-23–Reactive CD8+ T Cells

James A. Pearson, Dimitri Kakabadse, Joanne Davies, Jian Peng, Jeremy Warden-Smith, Simone Cuff, Mark Lewis, Larissa Camargo da Rosa, Li Wen, F. Susan Wong
Journal: Diabetes
Diabetes 2019;68(5):1002–1013
https://doi.org/10.2337/db18-0487
Published: 22 February 2019
View article titled, Altered Gut Microbiota Activate and Expand Insulin B15-23–Reactive CD8+ T Cells
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Includes: Supplementary data
Journal Articles

Peripheral Proinsulin Expression Controls Low-Avidity Proinsulin-Reactive CD8 T Cells in Type 1 Diabetes

Terri C. Thayer, James A. Pearson, Evy De Leenheer, Stephanie J. Hanna, Joanne Boldison, Joanne Davies, Adrian Tsui, Sartaj Ahmed, Peter Easton, Lai Khai Siew, Li Wen, F. Susan Wong
Journal: Diabetes
Diabetes 2016;65(11):3429–3439
https://doi.org/10.2337/db15-1649
Published: 05 August 2016
View article titled, Peripheral Proinsulin Expression Controls Low-Avidity Proinsulin-Reactive CD8 T Cells in Type 1 Diabetes
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Includes: Supplementary data
Journal Articles

Proinsulin Expression Shapes the TCR Repertoire but Fails to Control the Development of Low-Avidity Insulin-Reactive CD8+ T Cells

James A. Pearson, Terri C. Thayer, James E. McLaren, Kristin Ladell, Evy De Leenheer, Amy Phillips, Joanne Davies, Dimitri Kakabadse, Kelly Miners, Peter Morgan, Li Wen, David A. Price, F. Susan Wong
Journal: Diabetes
Diabetes 2016;65(6):1679–1689
https://doi.org/10.2337/db15-1498
Published: 07 March 2016
View article titled, Proinsulin Expression Shapes the TCR Repertoire but Fails to Control the Development of Low-Avidity Insulin-Reactive CD8<sup>+</sup> T Cells
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Includes: Supplementary data
Journal Articles

Interleukin-10+ Regulatory B Cells Arise Within Antigen-Experienced CD40+ B Cells to Maintain Tolerance to Islet Autoantigens

Sonja Kleffel, Andrea Vergani, Sara Tezza, Moufida Ben Nasr, Monika A. Niewczas, Susan Wong, Roberto Bassi, Francesca D’Addio, Tobias Schatton, Reza Abdi, Mark Atkinson, Mohamed H. Sayegh, Li Wen, Clive H. Wasserfall, Kevin C. O’Connor, Paolo Fiorina
Journal: Diabetes
Diabetes 2015;64(1):158–171
https://doi.org/10.2337/db13-1639
Published: 03 September 2014
View article titled, Interleukin-10<sup>+</sup> Regulatory B Cells Arise Within Antigen-Experienced CD40<sup>+</sup> B Cells to Maintain Tolerance to Islet Autoantigens
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Includes: Supplementary data
Journal Articles

IRAK-M Deficiency Promotes the Development of Type 1 Diabetes in NOD Mice

Qiyuan Tan, Monika Majewska-Szczepanik, Xiaojun Zhang, Marian Szczepanik, Zhiguang Zhou, F. Susan Wong, Li Wen
Journal: Diabetes
Diabetes 2014;63(8):2761–2775
https://doi.org/10.2337/db13-1504
Published: 17 July 2014
View article titled, IRAK-M Deficiency Promotes the Development of Type 1 Diabetes in NOD Mice
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Includes: Supplementary data
Journal Articles

A Humanized Mouse Model of Autoimmune Insulitis

Ashley A. Viehmann Milam, Stephen E. Maher, Joanna A. Gibson, Jasmin Lebastchi, Li Wen, Nancy H. Ruddle, Kevan C. Herold, Alfred L.M. Bothwell
Journal: Diabetes
Diabetes 2014;63(5):1712–1724
https://doi.org/10.2337/db13-1141
Published: 12 April 2014
View article titled, A Humanized Mouse Model of Autoimmune Insulitis
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Includes: Supplementary data
Journal Articles

Combination Treatment With Anti-CD20 and Oral Anti-CD3 Prevents and Reverses Autoimmune Diabetes

Changyun Hu, Heyuan Ding, Xiaojun Zhang, F. Susan Wong, Li Wen
Journal: Diabetes
Diabetes 2013;62(8):2849–2858
https://doi.org/10.2337/db12-1175
Published: 17 July 2013
View article titled, Combination Treatment With Anti-CD20 and Oral Anti-CD3 Prevents and Reverses Autoimmune Diabetes
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Includes: Supplementary data
Journal Articles

Activation of Insulin-Reactive CD8 T-Cells for Development of Autoimmune Diabetes

F. Susan Wong, Lai Khai Siew, Gwen Scott, Ian J. Thomas, Stephen Chapman, Christophe Viret, Li Wen
Journal: Diabetes
Diabetes 2009;58(5):1156–1164
https://doi.org/10.2337/db08-0800
Published: 10 February 2009
View article titled, Activation of Insulin-Reactive CD8 T-Cells for Development of Autoimmune Diabetes
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Includes: Supplementary data
Journal Articles

Modulatory Role of DR4- to DQ8-restricted CD4 T-Cell Responses and Type 1 Diabetes Susceptibility

Xinhui Ge, Jon D. Piganelli, Hubert M. Tse, Suzanne Bertera, Clayton E. Mathews, Massimo Trucco, Li Wen, William A. Rudert
Journal: Diabetes
Diabetes 2006;55(12):3455–3462
https://doi.org/10.2337/db06-0680
Published: 01 December 2006
View article titled, Modulatory Role of DR4- to DQ8-restricted CD4 T-Cell Responses and Type 1 Diabetes Susceptibility
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Journal Articles

The Influence of the Major Histocompatibility Complex on Development of Autoimmune Diabetes in RIP-B7.1 Mice

F. Susan Wong, Wei Du, Ian J. Thomas, Li Wen
Journal: Diabetes
Diabetes 2005;54(7):2032–2040
https://doi.org/10.2337/diabetes.54.7.2032
Published: 01 July 2005
View article titled, The Influence of the Major Histocompatibility Complex on Development of Autoimmune Diabetes in RIP-B7.1 Mice
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Journal Articles

Investigation of the Role of B-Cells in Type 1 Diabetes in the NOD Mouse

F. Susan Wong, Li Wen, Michelle Tang, Murugappan Ramanathan, Irene Visintin, Joanne Daugherty, Lynn G. Hannum, Charles A. Janeway, Jr, Mark J. Shlomchik
Journal: Diabetes
Diabetes 2004;53(10):2581–2587
https://doi.org/10.2337/diabetes.53.10.2581
Published: 01 October 2004
View article titled, Investigation of the Role of B-Cells in Type 1 Diabetes in the NOD Mouse
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Journal Articles

A Reg Family Protein Is Overexpressed in Islets From a Patient With New-Onset Type 1 Diabetes and Acts as T-Cell Autoantigen in NOD Mice

Werner Gurr, Reza Yavari, Li Wen, Margaret Shaw, Conchi Mora, Laurence Christa, Robert S. Sherwin
Journal: Diabetes
Diabetes 2002;51(2):339–346
https://doi.org/10.2337/diabetes.51.2.339
Published: 01 February 2002
View article titled, A Reg Family Protein Is Overexpressed in Islets From a Patient With New-Onset Type 1 Diabetes and Acts as T-Cell Autoantigen in NOD Mice
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Journal Articles

Report From the 1st International NOD Mouse T-Cell Workshop and the Follow-Up Mini-Workshop

Daniel L. Kaufman, Roland Tisch, Nora Sarvetnick, Lucienne Chatenoud, Leonard C. Harrison, Kathryn Haskins, Anthony Quinn, Eli Sercarz, Bhagi Singh, Matthias von Herrath, Dale Wegmann, Li Wen, Dan Zekzer
Journal: Diabetes
Diabetes 2001;50(11):2459–2463
https://doi.org/10.2337/diabetes.50.11.2459
Published: 01 November 2001
View article titled, Report From the 1st International NOD Mouse T-Cell Workshop and the Follow-Up Mini-Workshop
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Includes: Supplementary data
Journal Articles

Inhibition of Diabetes by an Insulin-Reactive CD4 T-Cell Clone in the Nonobese Diabetic Mouse

Dan Zekzer, F Susan Wong, Li Wen, Martha Altieri, Tatyana Gurlo, Hermann von Grafenstein, Robert S Sherwin
Journal: Diabetes
Diabetes 1997;46(7):1124–1132
https://doi.org/10.2337/diab.46.7.1124
Published: 01 July 1997
View article titled, Inhibition of Diabetes by an Insulin-Reactive CD4 T-Cell Clone in the Nonobese Diabetic Mouse
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