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Meeting Abstracts

1343-P: Unmet Needs for Early-Stage T1D—Ask the Experts Experience

Free
KIMBERLY A. BAUTISTA, MARICELA MUNOZ, IMAN TAKI, DANIEL FELIPE-MORALES, JOEY WONG, RACHEL KARBAN, HOLLY K. O'DONNELL, BRIGITTE I. FROHNERT, ANDREA STECK, LIPING YU, MARIAN REWERS, KIMBER M. SIMMONS
Journal: Diabetes
Diabetes 2025;74(Supplement_1):1343-P
https://doi.org/10.2337/db25-1343-P
Published: 20 June 2025
View article titled, 1343-P: Unmet Needs for Early-Stage T1D—Ask the Experts Experience
Meeting Abstracts

29-OR: T-Cell Receptor Sequences Targeting Beta-Cell Proteins Are Present in Blood across the Stages of Type 1 Diabetes Development

Free
KAGAN E. KARAKUS, ERIN E. BASCHAL, KRISTEN MCDANIEL, LIPING YU, MAKI NAKAYAMA, AARON W. MICHELS
Journal: Diabetes
Diabetes 2025;74(Supplement_1):29-OR
https://doi.org/10.2337/db25-29-OR
Published: 20 June 2025
View article titled, 29-OR: T-Cell Receptor Sequences Targeting Beta-Cell Proteins Are Present in Blood across the Stages of Type 1 Diabetes Development
Meeting Abstracts

2075-LB: Identify High-Risk Insulin Autoantibodies for T1D in General Population by a New Bridging ELISA

Free
CAIGUO ZHANG, KATHLEEN WAUGH, AARON W. MICHELS, MARIAN REWERS, LIPING YU, XIAOFAN JIA
Journal: Diabetes
Diabetes 2025;74(Supplement_1):2075-LB
https://doi.org/10.2337/db25-2075-LB
Published: 20 June 2025
View article titled, 2075-LB: Identify High-Risk Insulin Autoantibodies for T1D in General Population by a New Bridging ELISA
Meeting Abstracts

1223-P: Novel Multiplex Elisa Assay to Measure Islet Autoantibodies Fit for Large-Scale Population Screening of Type 1 Diabetes

Free
XIAOFAN JIA, CAIGUO ZHANG, AARON W. MICHELS, MARIAN REWERS, LIPING YU
Journal: Diabetes
Diabetes 2025;74(Supplement_1):1223-P
https://doi.org/10.2337/db25-1223-P
Published: 20 June 2025
View article titled, 1223-P: Novel Multiplex Elisa Assay to Measure Islet Autoantibodies Fit for Large-Scale Population Screening of Type 1 Diabetes
Meeting Abstracts

17-OR: Novel Autoantibodies Specific to β-Cell Surface Extracellular Epitope of ZnT8 Predict Progression to Type 1 Diabetes

Free
XIAOFAN JIA, CAIGUO ZHANG, FRAN DONG, KATHLEEN WAUGH, MARIAN REWERS, DAX FU, LIPING YU
Journal: Diabetes
Diabetes 2025;74(Supplement_1):17-OR
https://doi.org/10.2337/db25-17-OR
Published: 20 June 2025
View article titled, 17-OR: Novel Autoantibodies Specific to β-Cell Surface Extracellular Epitope of ZnT8 Predict Progression to Type 1 Diabetes
Journal Articles

A Comparative Analysis of the Sensitivity, Specificity, Concordance, and the 5-year Predictive Power of Diabetes-related Autoantibody Assays

Available to Purchase
Jeffrey P. Krischer, PhD, Sarah Muller, BS, Lu You, PhD, Peter Achenbach, MD, Elena Bazzigaluppi, BSc, Cristina Brigatti, BSc, Vito Lampasona, MD, Anu Mathew, PhD, Peter Robinson, PhD, David Seftel, MD, George Sigal, PhD, Cheng-ting Tsai, PhD, Mingyue Wang, MD, Liping Yu, MD, Type 1 Diabetes TrialNet Study Group
Journal: Diabetes
Diabetes db240814
https://doi.org/10.2337/db24-0814
Published: 10 March 2025
View article titled, A Comparative Analysis of the Sensitivity, Specificity, Concordance, and the 5-year Predictive Power of Diabetes-related Autoantibody Assays
Open the PDF for A Comparative Analysis of the Sensitivity, Specificity, Concordance, and the 5-year Predictive Power of Diabetes-related Autoantibody Assays in another window
Journal Articles

Strong Association of Autoantibodies Targeting Deamidated Extracellular Epitopes of Insulinoma Antigen-2 With Clinical Onset of Type 1 Diabetes

Free
Xiaofan Jia, Janet M. Wenzlau, Caiguo Zhang, Fran Dong, Kathleen Waugh, R. David Leslie, Marian J. Rewers, Aaron W. Michels, Liping Yu, Diabetes Autoimmunity Study in the Young (DAISY) and Autoimmunity Screening for Kids (ASK) Study Group and the Action LADA Consortium
Journal: Diabetes
Diabetes 2025;74(4):544–553
https://doi.org/10.2337/db24-0571
Published: 16 January 2025
View article titled, Strong Association of Autoantibodies Targeting Deamidated Extracellular Epitopes of Insulinoma Antigen-2 With Clinical Onset of Type 1 Diabetes
Open the PDF for Strong Association of Autoantibodies Targeting Deamidated Extracellular Epitopes of Insulinoma Antigen-2 With Clinical Onset of Type 1 Diabetes in another window
Meeting Abstracts

397-P: The C/EBPß-XOR Axis and Genetic Risk for Diabetic Kidney Disease

Free
UBONG EKPERIKPE, LIPING YU, ILSE S. DAEHN
Journal: Diabetes
Diabetes 2024;73(Supplement_1):397-P
https://doi.org/10.2337/db24-397-P
Published: 14 June 2024
View article titled, 397-P: The C/EBPß-XOR Axis and Genetic Risk for Diabetic Kidney Disease
Meeting Abstracts

331-OR: Clinical and Immunologic Features Differ in Children at Type 1 Diabetes Onset by Ethnicity

Free
KAGAN E. KARAKUS, THEODORE FLEURY, ERIN E. BASCHAL, KRISTEN MCDANIEL, HYELIN CHOI, VANESSA LANGARICA, LIPING YU, KIMBER M. SIMMONS, AARON W. MICHELS
Journal: Diabetes
Diabetes 2024;73(Supplement_1):331-OR
https://doi.org/10.2337/db24-331-OR
Published: 14 June 2024
View article titled, 331-OR: Clinical and Immunologic Features Differ in Children at Type 1 Diabetes Onset by Ethnicity
Meeting Abstracts

1178-P: Autoantibodies Specifically Targeting Oxidative Post-translationally Modified Insulin in Type 1 Diabetes

Free
XIAOFAN JIA, PAOLO POZZILLI, AHUVA NISSIM, ROCKY STROLLO, LIPING YU
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1178-P
https://doi.org/10.2337/db24-1178-P
Published: 14 June 2024
View article titled, 1178-P: Autoantibodies Specifically Targeting Oxidative Post-translationally Modified Insulin in Type 1 Diabetes
Meeting Abstracts

1292-P: Loss of Multiple Islet Autoantibody Status during Progression to Type 1 Diabetes

Free
KIMBER M. SIMMONS, FRAN DONG, KATHLEEN WAUGH, LIPING YU, MARIAN REWERS
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1292-P
https://doi.org/10.2337/db24-1292-P
Published: 14 June 2024
View article titled, 1292-P: Loss of Multiple Islet Autoantibody Status during Progression to Type 1 Diabetes
Journal Articles

Cell-Surface ZnT8 Antibody Prevents and Reverses Autoimmune Diabetes in Mice

Free
Devi Kasinathan, Zheng Guo, Dylan C. Sarver, G. William Wong, Shumei Yun, Aaron W. Michels, Liping Yu, Chandan Sona, Matthew N. Poy, Maria L. Golson, Dax Fu
Journal: Diabetes
Diabetes 2024;73(5):806–818
https://doi.org/10.2337/db23-0568
Published: 22 February 2024
View article titled, Cell-Surface ZnT8 Antibody Prevents and Reverses Autoimmune Diabetes in Mice
Open the PDF for Cell-Surface ZnT8 Antibody Prevents and Reverses Autoimmune Diabetes in Mice in another window
Meeting Abstracts

174-LB: Autoantibodies against PTM-IA2 Extracellular Domain Are Only Associated with Late Progression of Type 1 Diabetes

Free
XIAOFAN JIA, JANET M. WENZLAU, MARIAN REWERS, AARON W. MICHELS, LIPING YU
Journal: Diabetes
Diabetes 2023;72(Supplement_1):174-LB
https://doi.org/10.2337/db23-174-LB
Published: 20 June 2023
View article titled, 174-LB: Autoantibodies against PTM-IA2 Extracellular Domain Are Only Associated with Late Progression of Type 1 Diabetes
Journal Articles

Cell-Surface Autoantibody Targets Zinc Transporter-8 (ZnT8) for In Vivo β-Cell Imaging and Islet-Specific Therapies

Free
Zheng Guo, Devi Kasinathan, Chengfeng Merriman, Maki Nakayama, Hua Li, Huilin Li, Cheng Xu, G. William Wong, Liping Yu, Maria L. Golson, Dax Fu
Journal: Diabetes
Diabetes 2023;72(2):184–195
https://doi.org/10.2337/db22-0477
Published: 30 November 2022
View article titled, Cell-Surface Autoantibody Targets Zinc Transporter-8 (ZnT8) for In Vivo β-Cell Imaging and Islet-Specific Therapies
Open the PDF for Cell-Surface Autoantibody Targets Zinc Transporter-8 (ZnT8) for In Vivo β-Cell Imaging and Islet-Specific Therapies in another window
Meeting Abstracts

34-OR: SARS-CoV-2 Infection Is Not Associated with Presence of Islet Autoantibodies in Children: Autoimmunity Screening for Kids (ASK)

Free
CRISTY GENO RASMUSSEN, XIAOFAN JIA, HANAN SHORROSH, LIPING YU, BRIGITTE I. FROHNERT, KIMBER M. SIMMONS, ANDREA STECK, LAURA PYLE, MARIAN REWERS
Journal: Diabetes
Diabetes 2022;71(Supplement_1):34-OR
https://doi.org/10.2337/db22-34-OR
Published: 01 June 2022
View article titled, 34-OR: SARS-CoV-2 Infection Is Not Associated with Presence of Islet Autoantibodies in Children: Autoimmunity Screening for Kids (ASK)
Meeting Abstracts

1187-P: Distinct Islet Autoantibody Profiles in Hispanic Youth at Type 1 Diabetes Onset

Free
KIMBER M. SIMMONS, TIMOTHY B. VIGERS, LAURA PYLE, ERIN M. YOUNGKIN, ERIN E. BASCHAL, KRISTEN MCDANIEL, LIPING YU, AARON W. MICHELS
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1187-P
https://doi.org/10.2337/db22-1187-P
Published: 01 June 2022
View article titled, 1187-P: Distinct Islet Autoantibody Profiles in Hispanic Youth at Type 1 Diabetes Onset
Meeting Abstracts

186-OR: Novel Autoantibodies to Deamidated IA2 Extracellular Domain in Type 1 Diabetes

Free
XIAOFAN JIA, DONGMEI MIAO, CAIGUO ZHANG, AARON W. MICHELS, LIPING YU, JANET M. WENZLAU
Journal: Diabetes
Diabetes 2022;71(Supplement_1):186-OR
https://doi.org/10.2337/db22-186-OR
Published: 01 June 2022
View article titled, 186-OR: Novel Autoantibodies to Deamidated IA2 Extracellular Domain in Type 1 Diabetes
Meeting Abstracts

185-OR: T-Cell Receptor Repertoires during Type 1 Diabetes Development

Free
ANGELA M. MITCHELL, ERIN E. BASCHAL, KRISTEN MCDANIEL, LAURA PYLE, KATHLEEN WAUGH, ANDREA STECK, LIPING YU, PETER GOTTLIEB, MARIAN REWERS, MAKI NAKAYAMA, AARON W. MICHELS
Journal: Diabetes
Diabetes 2022;71(Supplement_1):185-OR
https://doi.org/10.2337/db22-185-OR
Published: 01 June 2022
View article titled, 185-OR: T-Cell Receptor Repertoires during Type 1 Diabetes Development
Meeting Abstracts

1119-P: Improving Clinical Utility of GAD65 Autoantibodies by Electrochemiluminescence Assay When Identifying Autoimmune Adult-Onset Diabetes

Free
XIAOFAN JIA, YONG GU, TANWI VARTAK, DONGMEI MIAO, FRAN DONG, SAMUEL T. JERRAM, MARIAN REWERS, ASSIAMIRA FERRARA, JEAN M. LAWRENCE, LIPING YU, RICHARD D. LESLIE, THE ACTION LADA CONSORTIUM, THE DIABETES IN YOUNG ADULTS (DIYA) STUDY GROUP
Journal: Diabetes
Diabetes 2021;70(Supplement_1):1119-P
https://doi.org/10.2337/db21-1119-P
Published: 01 June 2021
View article titled, 1119-P: Improving Clinical Utility of GAD65 Autoantibodies by Electrochemiluminescence Assay When Identifying Autoimmune Adult-Onset Diabetes
Meeting Abstracts

1127-P: Expression-Based Genome-Wide Association Study Links Osteopontin and Interleukin-1 Receptor Antagonist with Type 1 Diabetes

Free
XIAOFAN JIA, KYOKO TODA, LING HE, DONGMEI MIAO, SATORU YAMADA, LIPING YU, KEIICHI KODAMA
Journal: Diabetes
Diabetes 2021;70(Supplement_1):1127-P
https://doi.org/10.2337/db21-1127-P
Published: 01 June 2021
View article titled, 1127-P: Expression-Based Genome-Wide Association Study Links Osteopontin and Interleukin-1 Receptor Antagonist with Type 1 Diabetes