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Loranne Agius
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Journal Articles

A Novel Mechanism for Regulating Hepatic Glycogen Synthesis Involving Serotonin and Cyclin-Dependent Kinase-5

Susan J. Tudhope, Chung-Chi Wang, John L. Petrie, Lloyd Potts, Fiona Malcomson, Julius Kieswich, Muhammad M. Yaqoob, Catherine Arden, Laura J. Hampson, Loranne Agius
Journal: Diabetes
Diabetes 2012;61(1):49–60
https://doi.org/10.2337/db11-0870
Published: 12 December 2011
View article titled, A Novel Mechanism for Regulating Hepatic Glycogen Synthesis Involving Serotonin and Cyclin-Dependent Kinase-5
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Journal Articles

Susceptibility of Glucokinase-MODY Mutants to Inactivation by Oxidative Stress in Pancreatic β-Cells

Kirsty S. Cullen, Franz M. Matschinsky, Loranne Agius, Catherine Arden
Journal: Diabetes
Diabetes 2011;60(12):3175–3185
https://doi.org/10.2337/db11-0423
Published: 13 November 2011
View article titled, Susceptibility of Glucokinase-MODY Mutants to Inactivation by Oxidative Stress in Pancreatic β-Cells
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Includes: Supplementary data
Journal Articles

Elevated Glucose Represses Liver Glucokinase and Induces Its Regulatory Protein to Safeguard Hepatic Phosphate Homeostasis

Catherine Arden, John L. Petrie, Susan J. Tudhope, Ziad Al-Oanzi, Amy J. Claydon, Robert J. Beynon, Howard C. Towle, Loranne Agius
Journal: Diabetes
Diabetes 2011;60(12):3110–3120
https://doi.org/10.2337/db11-0061
Published: 13 November 2011
View article titled, Elevated Glucose Represses Liver Glucokinase and Induces Its Regulatory Protein to Safeguard Hepatic Phosphate Homeostasis
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Includes: Supplementary data
Journal Articles

Targeting Hepatic Glucokinase in Type 2 Diabetes: Weighing the Benefits and Risks

Loranne Agius
Journal: Diabetes
Diabetes 2009;58(1):18–20
https://doi.org/10.2337/db08-1470
Published: 01 January 2009
View article titled, Targeting Hepatic Glucokinase in Type 2 Diabetes: <subtitle>Weighing the Benefits and Risks</subtitle>
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Journal Articles

Cell Biology Assessment of Glucokinase Mutations V62M and G72R in Pancreatic β-Cells: Evidence for Cellular Instability of Catalytic Activity

Catherine Arden, Alison Trainer, Nuria de la Iglesia, Kathleen T. Scougall, Anna L. Gloyn, Alex J. Lange, James A.M. Shaw, Franz M. Matschinsky, Loranne Agius
Journal: Diabetes
Diabetes 2007;56(7):1773–1782
https://doi.org/10.2337/db06-1151
Published: 01 July 2007
View article titled, Cell Biology Assessment of Glucokinase Mutations V62M and G72R in Pancreatic β-Cells: <subtitle>Evidence for Cellular Instability of Catalytic Activity</subtitle>
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Journal Articles

Dual Role of Phosphofructokinase-2/Fructose Bisphosphatase-2 in Regulating the Compartmentation and Expression of Glucokinase in Hepatocytes

Victoria A. Payne, Catherine Arden, Chaodong Wu, Alex J. Lange, Loranne Agius
Journal: Diabetes
Diabetes 2005;54(7):1949–1957
https://doi.org/10.2337/diabetes.54.7.1949
Published: 01 July 2005
View article titled, Dual Role of Phosphofructokinase-2/Fructose Bisphosphatase-2 in Regulating the Compartmentation and Expression of Glucokinase in Hepatocytes
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Journal Articles

Increased Potency and Efficacy of Combined Phosphorylase Inactivation and Glucokinase Activation in Control of Hepatocyte Glycogen Metabolism

Laura J. Hampson, Loranne Agius
Journal: Diabetes
Diabetes 2005;54(3):617–623
https://doi.org/10.2337/diabetes.54.3.617
Published: 01 March 2005
View article titled, Increased Potency and Efficacy of Combined Phosphorylase Inactivation and Glucokinase Activation in Control of Hepatocyte Glycogen Metabolism
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Journal Articles

Glucokinase Is an Integral Component of the Insulin Granules in Glucose-Responsive Insulin Secretory Cells and Does Not Translocate During Glucose Stimulation

Catherine Arden, Andrew Harbottle, Simone Baltrusch, Markus Tiedge, Loranne Agius
Journal: Diabetes
Diabetes 2004;53(9):2346–2352
https://doi.org/10.2337/diabetes.53.9.2346
Published: 01 September 2004
View article titled, Glucokinase Is an Integral Component of the Insulin Granules in Glucose-Responsive Insulin Secretory Cells and Does Not Translocate During Glucose Stimulation
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Journal Articles

Stimulation of Hepatocyte Glucose Metabolism by Novel Small Molecule Glucokinase Activators

Katy J. Brocklehurst, Victoria A. Payne, Rick A. Davies, Debra Carroll, Helen L. Vertigan, Heather J. Wightman, Susan Aiston, Ian D. Waddell, Brendan Leighton, Matthew P. Coghlan, Loranne Agius
Journal: Diabetes
Diabetes 2004;53(3):535–541
https://doi.org/10.2337/diabetes.53.3.535
Published: 01 March 2004
View article titled, Stimulation of Hepatocyte Glucose Metabolism by Novel Small Molecule Glucokinase Activators
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Journal Articles

Glucose 6-Phosphate Regulates Hepatic Glycogenolysis Through Inactivation of Phosphorylase

Susan Aiston, Birgitte Andersen, Loranne Agius
Journal: Diabetes
Diabetes 2003;52(6):1333–1339
https://doi.org/10.2337/diabetes.52.6.1333
Published: 01 June 2003
View article titled, Glucose 6-Phosphate Regulates Hepatic Glycogenolysis Through Inactivation of Phosphorylase
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