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Journal Articles

PNLIPRP1 hypermethylation in exocrine pancreas links type 2 diabetes and cholesterol metabolism

Diabetes db240215

Published: 13 August 2024

View article titled, PNLIPRP1 hypermethylation in exocrine pancreas links type 2 diabetes and cholesterol metabolism

Meeting Abstracts

1750-P: Rescuing Human Beta-Cell Dysfunction Induced by Proinflammatory Cytokines and Glucotoxicity

MARTA TESI, MARA SULEIMAN, ROBERTO SEMERARO, CARMELA DE LUCA, EMANUELE BOSI, SILVIA DEL GUERRA, ALBERTO MAGI, MIRIAM CNOP, DECIO L. EIZIRIK, LORELLA MARSELLI, PIERO MARCHETTI

Diabetes 2024;73(Supplement_1):1750-P

https://doi.org/10.2337/db24-1750-P

Published: 14 June 2024

View article titled, 1750-P: Rescuing Human Beta-Cell Dysfunction Induced by Proinflammatory Cytokines and Glucotoxicity

Meeting Abstracts

1315-P: Pre– and Post–Liver Transplant Diabetes (DM) and Prediabetes (PD), and the Impact on Transplant Outcomes—Results of a Large Single-Center Study

Diabetes 2024;73(Supplement_1):1315-P

https://doi.org/10.2337/db24-1315-P

Published: 14 June 2024

View article titled, 1315-P: Pre– and Post–Liver Transplant Diabetes (DM) and Prediabetes (PD), and the Impact on Transplant Outcomes—Results of a Large Single-Center Study

Meeting Abstracts

1465-P: The C1858T Polymorphism in PTPN22 Modulates the Human Pancreatic Islet Transcriptome

MARA SULEIMAN, CARMELA DE LUCA, ROBERTO SEMERARO, EMANUELE BOSI, ALBERTO MAGI, MARTA TESI, SILVIA DEL GUERRA, OLIVIA PAGLIAROSI, ANNAMARIA CUDINI, LEONARDO ROSSI, DECIO L. EIZIRIK, MIRIAM CNOP, PIERO MARCHETTI, LORELLA MARSELLI, ALESSANDRA FIERABRACCI

Diabetes 2024;73(Supplement_1):1465-P

https://doi.org/10.2337/db24-1465-P

Published: 14 June 2024

View article titled, 1465-P: The C1858T Polymorphism in PTPN22 Modulates the Human Pancreatic Islet Transcriptome

Meeting Abstracts

2087-P: Functional Genomics of Human Islet Gluco/Lipotoxicity and Type 2 Diabetes

XIAOYAN YI, LORELLA MARSELLI, ANTHONY PIRON, MARA SULEIMAN, FLORIAN SZYMCZAK, DECIO L. EIZIRIK, PIERO MARCHETTI, MIRIAM CNOP

Diabetes 2020;69(Supplement_1):2087-P

https://doi.org/10.2337/db20-2087-P

Published: 01 June 2020

View article titled, 2087-P: Functional Genomics of Human Islet Gluco/Lipotoxicity and Type 2 Diabetes

Meeting Abstracts

2136-P: Effects of Cytokine Exposure on the Proteome of Human Islets as Evaluated by Shotgun and 2DE Analysis

FRANCESCA GRANO, FEDERICA CIREGIA, MAURIZIO RONCI, MARIA ROSA MAZZONI, LUTGART OVERBERGH, CARMELA DE LUCA, MARA SULEIMAN, LORELLA MARSELLI, PAOLO DE SIMONE, UGO BOGGI, CHANTAL MATHIEU, DECIO L. EIZIRIK, SR., ANTONIO LUCACCHINI, LAURA GIUSTI, PIERO MARCHETTI, MARCO BUGLIANI

Diabetes 2019;68(Supplement_1):2136-P

https://doi.org/10.2337/db19-2136-P

Published: 01 June 2019

View article titled, 2136-P: Effects of Cytokine Exposure on the Proteome of Human Islets as Evaluated by Shotgun and 2DE Analysis

Meeting Abstracts

273-OR: Intrapancreatic Adipose Tissue of Nondiabetic and Type 2 Diabetic Subjects and Relationships with Islet Morphometry

MARA SULEIMAN, CARMELA DE LUCA, PAOLO DE SIMONE, UGO BOGGI, FRANCESCA GRANO, MARCO BUGLIANI, PIERO MARCHETTI, LORELLA MARSELLI

Diabetes 2019;68(Supplement_1):273-OR

https://doi.org/10.2337/db19-273-OR

Published: 01 June 2019

View article titled, 273-OR: Intrapancreatic Adipose Tissue of Nondiabetic and Type 2 Diabetic Subjects and Relationships with Islet Morphometry

Meeting Abstracts

Malate Dehydrogenase 2 (MDH2) as a New Diabetogene Causing Hyperglycemia in Families with Multigenerational Diabetes

Diabetes 2018;67(Supplement_1):262-OR

https://doi.org/10.2337/db18-262-OR

Published: 01 July 2018

View article titled, Malate Dehydrogenase 2 (MDH2) as a New Diabetogene Causing Hyperglycemia in Families with Multigenerational Diabetes

Meeting Abstracts

The Increment of Noradrenergic Fibers Correlates with the Density of Dedifferentiated ß Cells in Humans

FRANCESCA CINTI, ILENIA SEVERI, MARA SULEIMAN, LORELLA MARSELLI, PIERO MARCHETTI, SAVERIO CINTI, DOMENICO ACCILI

Diabetes 2018;67(Supplement_1):2142-P

https://doi.org/10.2337/db18-2142-P

Published: 01 July 2018

View article titled, The Increment of Noradrenergic Fibers Correlates with the Density of Dedifferentiated ß Cells in Humans

Journal Articles

MCL-1 Is a Key Antiapoptotic Protein in Human and Rodent Pancreatic β-Cells

Kira Meyerovich, Natalia M. Violato, Makiko Fukaya, Violette Dirix, Nathalie Pachera, Lorella Marselli, Piero Marchetti, Andreas Strasser, Decio L. Eizirik, Alessandra K. Cardozo

Diabetes 2017;66(9):2446–2458

https://doi.org/10.2337/db16-1252

Published: 30 June 2017

View article titled, MCL-1 Is a Key Antiapoptotic Protein in Human and Rodent Pancreatic β-Cells

Includes: Supplementary data

Journal Articles

dUTPase (DUT) Is Mutated in a Novel Monogenic Syndrome With Diabetes and Bone Marrow Failure

Reinaldo Sousa Dos Santos, Mathilde Daures, Anne Philippi, Sophie Romero, Lorella Marselli, Piero Marchetti, Valérie Senée, Delphine Bacq, Céline Besse, Baz Baz, Laura Marroquí, Sarah Ivanoff, Julien Masliah-Planchon, Marc Nicolino, Jean Soulier, Gérard Socié, Decio L. Eizirik, Jean-François Gautier, Cécile Julier

Diabetes 2017;66(4):1086–1096

https://doi.org/10.2337/db16-0839

Published: 10 January 2017

View article titled, dUTPase (DUT) Is Mutated in a Novel Monogenic Syndrome With Diabetes and Bone Marrow Failure

Includes: Supplementary data

Journal Articles

TYK2, a Candidate Gene for Type 1 Diabetes, Modulates Apoptosis and the Innate Immune Response in Human Pancreatic β-Cells

Laura Marroqui, Reinaldo Sousa Dos Santos, Tina Fløyel, Fabio A. Grieco, Izortze Santin, Anne Op de beeck, Lorella Marselli, Piero Marchetti, Flemming Pociot, Decio L. Eizirik

Diabetes 2015;64(11):3808–3817

https://doi.org/10.2337/db15-0362

Published: 03 August 2015

View article titled, TYK2, a Candidate Gene for Type 1 Diabetes, Modulates Apoptosis and the Innate Immune Response in Human Pancreatic β-Cells

Includes: Supplementary data

Journal Articles

ADCY5 Couples Glucose to Insulin Secretion in Human Islets

David J. Hodson, Ryan K. Mitchell, Lorella Marselli, Timothy J. Pullen, Silvia Gimeno Brias, Francesca Semplici, Katy L. Everett, Dermot M.F. Cooper, Marco Bugliani, Piero Marchetti, Vanessa Lavallard, Domenico Bosco, Lorenzo Piemonti, Paul R. Johnson, Stephen J. Hughes, Daliang Li, Wen-Hong Li, A.M. James Shapiro, Guy A. Rutter

Diabetes 2014;63(9):3009–3021

https://doi.org/10.2337/db13-1607

Published: 16 August 2014

View article titled, ADCY5 Couples Glucose to Insulin Secretion in Human Islets

Includes: Supplementary data

Journal Articles

BACH2, a Candidate Risk Gene for Type 1 Diabetes, Regulates Apoptosis in Pancreatic β-Cells via JNK1 Modulation and Crosstalk With the Candidate Gene PTPN2

Laura Marroquí, Izortze Santin, Reinaldo Sousa Dos Santos, Lorella Marselli, Piero Marchetti, Decio L. Eizirik

Diabetes 2014;63(7):2516–2527

https://doi.org/10.2337/db13-1443

Published: 14 June 2014

View article titled, BACH2, a Candidate Risk Gene for Type 1 Diabetes, Regulates Apoptosis in Pancreatic β-Cells via JNK1 Modulation and Crosstalk With the Candidate Gene PTPN2

Includes: Supplementary data

Journal Articles

RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate

Miriam Cnop, Baroj Abdulkarim, Guy Bottu, Daniel A. Cunha, Mariana Igoillo-Esteve, Matilde Masini, Jean-Valery Turatsinze, Thasso Griebel, Olatz Villate, Izortze Santin, Marco Bugliani, Laurence Ladriere, Lorella Marselli, Mark I. McCarthy, Piero Marchetti, Michael Sammeth, Décio L. Eizirik

Diabetes 2014;63(6):1978–1993

https://doi.org/10.2337/db13-1383

Published: 15 May 2014

View article titled, RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate

Includes: Supplementary data

Journal Articles

Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress–Mitochondrial Dialog Triggering Lipotoxic Rodent and Human β-Cell Apoptosis

Daniel A. Cunha, Mariana Igoillo-Esteve, Esteban N. Gurzov, Carla M. Germano, Najib Naamane, Ihsane Marhfour, Makiko Fukaya, Jean-Marie Vanderwinden, Conny Gysemans, Chantal Mathieu, Lorella Marselli, Piero Marchetti, Heather P. Harding, David Ron, Décio L. Eizirik, Miriam Cnop

Diabetes 2012;61(11):2763–2775

https://doi.org/10.2337/db12-0123

Published: 16 October 2012

View article titled, Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress–Mitochondrial Dialog Triggering Lipotoxic Rodent and Human β-Cell Apoptosis

Includes: Supplementary data

Journal Articles

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic β-Cell Apoptosis via Regulation of the BH3-Only Protein Bim

Izortze Santin, Fabrice Moore, Maikel L. Colli, Esteban N. Gurzov, Lorella Marselli, Piero Marchetti, Decio L. Eizirik

Diabetes 2011;60(12):3279–3288

https://doi.org/10.2337/db11-0758

Published: 13 November 2011

View article titled, PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic β-Cell Apoptosis via Regulation of the BH3-Only Protein Bim

Includes: Supplementary data

Journal Articles

Functional and Molecular Defects of Pancreatic Islets in Human Type 2 Diabetes

Silvia Del Guerra, Roberto Lupi, Lorella Marselli, Matilde Masini, Marco Bugliani, Simone Sbrana, Scilla Torri, Maria Pollera, Ugo Boggi, Franco Mosca, Stefano Del Prato, Piero Marchetti

Diabetes 2005;54(3):727–735

https://doi.org/10.2337/diabetes.54.3.727

Published: 01 March 2005

View article titled, Functional and Molecular Defects of Pancreatic Islets in Human Type 2 Diabetes

Journal Articles

Prolonged In Vitro Exposure to Autoantibodies Against CD38 Impairs the Function and Survival of Human Pancreatic Islets

Piero Marchetti, Alessandro Antonelli, Roberto Lupi, Lorella Marselli, Poupak Fallahi, Claudia Nesti, Germano Baj, Ele Ferrannini

Diabetes 2002;51(suppl_3):S474–S477

https://doi.org/10.2337/diabetes.51.2007.S474

Published: 01 December 2002

View article titled, Prolonged In Vitro Exposure to Autoantibodies Against CD38 Impairs the Function and Survival of Human Pancreatic Islets

Journal Articles

Insulin Secretory Function Is Impaired in Isolated Human Islets Carrying the Gly⁹⁷²→Arg IRS-1 Polymorphism

Piero Marchetti, Roberto Lupi, Massimo Federici, Lorella Marselli, Matilde Masini, Ugo Boggi, Silvia Del Guerra, Giovanni Patanè, Salvatore Piro, Marcello Anello, Ettore Bergamini, Francesco Purrello, Renato Lauro, Franco Mosca, Giorgio Sesti, Stefano Del Prato

Diabetes 2002;51(5):1419–1424

https://doi.org/10.2337/diabetes.51.5.1419

Published: 01 May 2002

View article titled, Insulin Secretory Function Is Impaired in Isolated Human Islets Carrying the Gly972→Arg IRS-1 Polymorphism

NARROW

PNLIPRP1 hypermethylation in exocrine pancreas links type 2 diabetes and cholesterol metabolism

1750-P: Rescuing Human Beta-Cell Dysfunction Induced by Proinflammatory Cytokines and Glucotoxicity

1315-P: Pre– and Post–Liver Transplant Diabetes (DM) and Prediabetes (PD), and the Impact on Transplant Outcomes—Results of a Large Single-Center Study

1465-P: The C1858T Polymorphism in PTPN22 Modulates the Human Pancreatic Islet Transcriptome

2087-P: Functional Genomics of Human Islet Gluco/Lipotoxicity and Type 2 Diabetes

2136-P: Effects of Cytokine Exposure on the Proteome of Human Islets as Evaluated by Shotgun and 2DE Analysis

273-OR: Intrapancreatic Adipose Tissue of Nondiabetic and Type 2 Diabetic Subjects and Relationships with Islet Morphometry

Malate Dehydrogenase 2 (MDH2) as a New Diabetogene Causing Hyperglycemia in Families with Multigenerational Diabetes

The Increment of Noradrenergic Fibers Correlates with the Density of Dedifferentiated ß Cells in Humans

MCL-1 Is a Key Antiapoptotic Protein in Human and Rodent Pancreatic β-Cells

dUTPase (DUT) Is Mutated in a Novel Monogenic Syndrome With Diabetes and Bone Marrow Failure

TYK2, a Candidate Gene for Type 1 Diabetes, Modulates Apoptosis and the Innate Immune Response in Human Pancreatic β-Cells

ADCY5 Couples Glucose to Insulin Secretion in Human Islets

BACH2, a Candidate Risk Gene for Type 1 Diabetes, Regulates Apoptosis in Pancreatic β-Cells via JNK1 Modulation and Crosstalk With the Candidate Gene PTPN2

RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate

Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress–Mitochondrial Dialog Triggering Lipotoxic Rodent and Human β-Cell Apoptosis

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic β-Cell Apoptosis via Regulation of the BH3-Only Protein Bim

Functional and Molecular Defects of Pancreatic Islets in Human Type 2 Diabetes

Prolonged In Vitro Exposure to Autoantibodies Against CD38 Impairs the Function and Survival of Human Pancreatic Islets

Insulin Secretory Function Is Impaired in Isolated Human Islets Carrying the Gly⁹⁷²→Arg IRS-1 Polymorphism

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