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Meeting Abstracts

473-P: HDAC Inhibition Augments TGF-ß-Induced JNK Activation, CTGF Expression, and NF-E2 Degradation Promoting Profibrotic Signaling in Renal Proximal Tubules

JIA LI, MADHAVI JAGDISH RANE, LU CAI, YI TAN
Journal: Diabetes
Diabetes 2020;69(Supplement_1):473-P
https://doi.org/10.2337/db20-473-P
Published: 01 June 2020
View article titled, 473-P: HDAC Inhibition Augments TGF-ß-Induced JNK Activation, CTGF Expression, and NF-E2 Degradation Promoting Profibrotic Signaling in Renal Proximal Tubules
Meeting Abstracts

409-P: Engineered Cardiac Tissues: A Novel In Vitro Model to Investigate the Pathophysiology of Diabetic Cardiomyopathy

XIANG WANG, YANG ZHENG, BRADLEY B. KELLER, LU CAI
Journal: Diabetes
Diabetes 2020;69(Supplement_1):409-P
https://doi.org/10.2337/db20-409-P
Published: 01 June 2020
View article titled, 409-P: Engineered Cardiac Tissues: A Novel In Vitro Model to Investigate the Pathophysiology of Diabetic Cardiomyopathy
Meeting Abstracts

1831-P: Activating AMPK Mediates FGF1 Protection from NAFLD in Diabetic Mice

QIAN LIN, GENXIANG CAI, ZHENGSHUAI LIU, JINGYA LI, JIA LI, KUPPER A. WINTERGERST, PAUL N. EPSTEIN, LU CAI, YU LI, YI TAN
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1831-P
https://doi.org/10.2337/db20-1831-P
Published: 01 June 2020
View article titled, 1831-P: Activating AMPK Mediates FGF1 Protection from NAFLD in Diabetic Mice
Meeting Abstracts

605-P: Endothelial-Specific Overexpression of Metallothionein Prevents Diabetes Mellitus–Induced Impairment in Ischemia Angiogenesis via Preservation of HIF-1a/SDF-1/VEGF Signaling in Endothelial Progenitor Cells

KAI WANG, XIAOZHEN DAI, JING CHEN, FEIXIA SHEN, KUPPER A. WINTERGERST, PAUL N. EPSTEIN, LU CAI, YI TAN
Journal: Diabetes
Diabetes 2020;69(Supplement_1):605-P
https://doi.org/10.2337/db20-605-P
Published: 01 June 2020
View article titled, 605-P: Endothelial-Specific Overexpression of Metallothionein Prevents Diabetes Mellitus–Induced Impairment in Ischemia Angiogenesis via Preservation of HIF-1a/SDF-1/VEGF Signaling in Endothelial Progenitor Cells
Journal Articles

Erratum. Metallothionein Preserves Akt2 Activity and Cardiac Function via Inhibiting TRB3 in Diabetic Hearts. Diabetes 2018;67:

Junlian Gu, Xiaoqing Yan, Xiaozhen Dai, Yuehui Wang, Qian Lin, Jian Xiao, Shanshan Zhou, Jian Zhang, Kai Wang, Jun Zeng, Ying Xin, Michelle T. Barati, Chi Zhang, Yang Bai, Yan Li, Paul N. Epstein, Kupper A. Wintergerst, Xiaokun Li, Yi Tan, Lu Cai
Journal: Diabetes
Diabetes 2020;69(2):267
https://doi.org/10.2337/db20-er02a
Published: 16 December 2019
View article titled, Erratum. Metallothionein Preserves Akt2 Activity and Cardiac Function via Inhibiting TRB3 in Diabetic Hearts. Diabetes 2018;67:
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Meeting Abstracts

625-P: Metallothionein Improves Angiogenic Function of Endothelial Progenitor Cells via HIF-1α/SDF-1/Akt Pathway in Diabetic Limb Ischemia

KAI WANG, XIAOZHEN DAI, JUNHONG HE, CHENGKUI YANG, JING CHEN, KUPPER A. WINTERGERST, PAUL N. EPSTEIN, LU CAI, YI TAN
Journal: Diabetes
Diabetes 2019;68(Supplement_1):625-P
https://doi.org/10.2337/db19-625-P
Published: 01 June 2019
View article titled, 625-P: Metallothionein Improves Angiogenic Function of Endothelial Progenitor Cells via HIF-1α/SDF-1/Akt Pathway in Diabetic Limb Ischemia
Meeting Abstracts

613-P: Preventive Effect of Sulforaphane on Type 2 Diabetes-Induced Diabetic Cardiomyopathy via AMPK-Mediated Activation of Glucose/Lipid Metabolism and Nrf2 Function

YIKE SUN, LU CAI, ZHUO LI
Journal: Diabetes
Diabetes 2019;68(Supplement_1):613-P
https://doi.org/10.2337/db19-613-P
Published: 01 June 2019
View article titled, 613-P: Preventive Effect of Sulforaphane on Type 2 Diabetes-Induced Diabetic Cardiomyopathy via AMPK-Mediated Activation of Glucose/Lipid Metabolism and Nrf2 Function
Meeting Abstracts

470-P: Combined Use of Sulforaphane and Zinc Provides a Better Protection against Diabetic Cardiomyopathy than Either One Alone in Type 1 Diabetic OVE26 Mice

JIQUN WANG, WANNING WANG, LU CAI
Journal: Diabetes
Diabetes 2019;68(Supplement_1):470-P
https://doi.org/10.2337/db19-470-P
Published: 01 June 2019
View article titled, 470-P: Combined Use of Sulforaphane and Zinc Provides a Better Protection against Diabetic Cardiomyopathy than Either One Alone in Type 1 Diabetic OVE26 Mice
Meeting Abstracts

512-P: Sexual Differences in Progression of Diabetic Nephropathy in over 26 Type 1 Diabetic Mice

WANNING WANG, LU CAI
Journal: Diabetes
Diabetes 2019;68(Supplement_1):512-P
https://doi.org/10.2337/db19-512-P
Published: 01 June 2019
View article titled, 512-P: Sexual Differences in Progression of Diabetic Nephropathy in over 26 Type 1 Diabetic Mice
Meeting Abstracts

516-P: Preventive Effect of Sulforaphane on Type 2 Diabetes-Induced Diabetic Nephropathy via AMPK-Mediated Activation of Glucose/Lipid Metabolism and Nrf2 Antioxidative Function

ZHUO LI, LU CAI, YIKE SUN
Journal: Diabetes
Diabetes 2019;68(Supplement_1):516-P
https://doi.org/10.2337/db19-516-P
Published: 01 June 2019
View article titled, 516-P: Preventive Effect of Sulforaphane on Type 2 Diabetes-Induced Diabetic Nephropathy via AMPK-Mediated Activation of Glucose/Lipid Metabolism and Nrf2 Antioxidative Function
Meeting Abstracts

CXCR7 Agonist TC14012 Improves Angiogenic Function of Endothelial Progenitor Cells in Diabetic Limb Ischemia

KAI WANG, XIAOZHEN DAI, JING CHEN, PAUL N. EPSTEIN, LU CAI, KUPPER A. WINTERGERST, YAN QIAN, YI TAN
Journal: Diabetes
Diabetes 2018;67(Supplement_1):471-P
https://doi.org/10.2337/db18-471-P
Published: 01 July 2018
View article titled, CXCR7 Agonist TC14012 Improves Angiogenic Function of Endothelial Progenitor Cells in Diabetic Limb Ischemia
Journal Articles

Metallothionein Preserves Akt2 Activity and Cardiac Function via Inhibiting TRB3 in Diabetic Hearts

Junlian Gu, Xiaoqing Yan, Xiaozhen Dai, Yuehui Wang, Qian Lin, Jian Xiao, Shanshan Zhou, Jian Zhang, Kai Wang, Jun Zeng, Ying Xin, Michelle T. Barati, Chi Zhang, Yang Bai, Yan Li, Paul N. Epstein, Kupper A. Wintergerst, Xiaokun Li, Yi Tan, Lu Cai
Journal: Diabetes
Diabetes 2018;67(3):507–517
https://doi.org/10.2337/db17-0219
Published: 27 October 2017
View article titled, Metallothionein Preserves Akt2 Activity and Cardiac Function via Inhibiting TRB3 in Diabetic Hearts
Open the PDF for Metallothionein Preserves Akt2 Activity and Cardiac Function via Inhibiting TRB3 in Diabetic Hearts in another window
Includes: Supplementary data
Journal Articles

Metallothionein Is Downstream of Nrf2 and Partially Mediates Sulforaphane Prevention of Diabetic Cardiomyopathy

Junlian Gu, Yanli Cheng, Hao Wu, Lili Kong, Shudong Wang, Zheng Xu, Zhiguo Zhang, Yi Tan, Bradley B. Keller, Honglan Zhou, Yuehui Wang, Zhonggao Xu, Lu Cai
Journal: Diabetes
Diabetes 2017;66(2):529–542
https://doi.org/10.2337/db15-1274
Published: 30 November 2016
View article titled, Metallothionein Is Downstream of Nrf2 and Partially Mediates Sulforaphane Prevention of Diabetic Cardiomyopathy
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Includes: Supplementary data
Journal Articles

Inhibition of JNK Phosphorylation by a Novel Curcumin Analog Prevents High Glucose–Induced Inflammation and Apoptosis in Cardiomyocytes and the Development of Diabetic Cardiomyopathy

Yong Pan, Yi Wang, Yunjie Zhao, Kesong Peng, Weixin Li, Yonggang Wang, Jingjing Zhang, Shanshan Zhou, Quan Liu, Xiaokun Li, Lu Cai, Guang Liang
Journal: Diabetes
Diabetes 2014;63(10):3497–3511
https://doi.org/10.2337/db13-1577
Published: 15 September 2014
View article titled, Inhibition of JNK Phosphorylation by a Novel Curcumin Analog Prevents High Glucose–Induced Inflammation and Apoptosis in Cardiomyocytes and the Development of Diabetic Cardiomyopathy
Open the PDF for Inhibition of JNK Phosphorylation by a Novel Curcumin Analog Prevents High Glucose–Induced Inflammation and Apoptosis in Cardiomyocytes and the Development of Diabetic Cardiomyopathy in another window
Includes: Supplementary data
Journal Articles

A Novel Mechanism by Which SDF-1β Protects Cardiac Cells From Palmitate-Induced Endoplasmic Reticulum Stress and Apoptosis via CXCR7 and AMPK/p38 MAPK-Mediated Interleukin-6 Generation

Yuguang Zhao, Yi Tan, Shugang Xi, Yunqian Li, Cai Li, Jiuwei Cui, Xiaoqing Yan, Xiaokun Li, Guanjun Wang, Wei Li, Lu Cai
Journal: Diabetes
Diabetes 2013;62(7):2545–2558
https://doi.org/10.2337/db12-1233
Published: 14 June 2013
View article titled, A Novel Mechanism by Which SDF-1β Protects Cardiac Cells From Palmitate-Induced Endoplasmic Reticulum Stress and Apoptosis via CXCR7 and AMPK/p38 MAPK-Mediated Interleukin-6 Generation
Open the PDF for A Novel Mechanism by Which SDF-1β Protects Cardiac Cells From Palmitate-Induced Endoplasmic Reticulum Stress and Apoptosis via CXCR7 and AMPK/p38 MAPK-Mediated Interleukin-6 Generation in another window
Includes: Supplementary data
Journal Articles

Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress–Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo

Yi Tan, Tomonaga Ichikawa, Jinqing Li, Qiusheng Si, Huaitao Yang, Xiangbai Chen, Curtis S. Goldblatt, Colin J. Meyer, Xiaokun Li, Lu Cai, Taixing Cui
Journal: Diabetes
Diabetes 2011;60(2):625–633
https://doi.org/10.2337/db10-1164
Published: 21 January 2011
View article titled, Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress–Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo
Open the PDF for Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress–Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo in another window
Includes: Supplementary data
Journal Articles

Inactivation of GSK-3β by Metallothionein Prevents Diabetes-Related Changes in Cardiac Energy Metabolism, Inflammation, Nitrosative Damage, and Remodeling

Yuehui Wang, Wenke Feng, Wanli Xue, Yi Tan, David W. Hein, Xiao-Kun Li, Lu Cai
Journal: Diabetes
Diabetes 2009;58(6):1391–1402
https://doi.org/10.2337/db08-1697
Published: 26 March 2009
View article titled, Inactivation of GSK-3β by Metallothionein Prevents Diabetes-Related Changes in Cardiac Energy Metabolism, Inflammation, Nitrosative Damage, and Remodeling
Open the PDF for Inactivation of GSK-3β by Metallothionein Prevents Diabetes-Related Changes in Cardiac Energy Metabolism, Inflammation, Nitrosative Damage, and Remodeling in another window
Journal Articles

Inhibition of Superoxide Generation and Associated Nitrosative Damage Is Involved in Metallothionein Prevention of Diabetic Cardiomyopathy

Lu Cai, Jianxun Wang, Yan Li, Xuihua Sun, Lipeng Wang, Zhanxiang Zhou, Y. James Kang
Journal: Diabetes
Diabetes 2005;54(6):1829–1837
https://doi.org/10.2337/diabetes.54.6.1829
Published: 01 June 2005
View article titled, Inhibition of Superoxide Generation and Associated Nitrosative Damage Is Involved in Metallothionein Prevention of Diabetic Cardiomyopathy
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Journal Articles

Hyperglycemia-Induced Apoptosis in Mouse Myocardium: Mitochondrial Cytochrome c–Mediated Caspase-3 Activation Pathway

Lu Cai, Wei Li, Guangwu Wang, Luping Guo, Youchun Jiang, Y. James Kang
Journal: Diabetes
Diabetes 2002;51(6):1938–1948
https://doi.org/10.2337/diabetes.51.6.1938
Published: 01 June 2002
View article titled, Hyperglycemia-Induced Apoptosis in Mouse Myocardium: <subtitle>Mitochondrial Cytochrome <em>c</em>–Mediated Caspase-3 Activation Pathway </subtitle>
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Journal Articles

Flux Through the Hexosamine Pathway Is a Determinant of Nuclear Factor κB– Dependent Promoter Activation

Leighton R. James, Damu Tang, Alistair Ingram, Hao Ly, Kerri Thai, Lu Cai, James W. Scholey
Journal: Diabetes
Diabetes 2002;51(4):1146–1156
https://doi.org/10.2337/diabetes.51.4.1146
Published: 01 April 2002
View article titled, Flux Through the Hexosamine Pathway Is a Determinant of Nuclear Factor κB– Dependent Promoter Activation
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