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Meeting Abstracts

26-OR: Meta-analyses of Genome-Wide Association Studies for Proinsulin Provide Insight into Glycemic Trait Dysregulation

Free
K. ALAINE BROADAWAY, XIANYONOG YIN, ALICE WILLIAMSON, EMMA WILSON, MAGIC INVESTIGATORS
Journal: Diabetes
Diabetes 2021;70(Supplement_1):26-OR
https://doi.org/10.2337/db21-26-OR
Published: 01 June 2021
View articletitled, 26-OR: Meta-analyses of Genome-Wide Association Studies for Proinsulin Provide Insight into Glycemic Trait Dysregulation
Journal Articles

Peripheral Blood Transcriptomic Signatures of Fasting Glucose and Insulin Concentrations

Free
Brian H. Chen, Marie-France Hivert, Marjolein J. Peters, Luke C. Pilling, John D. Hogan, Lisa M. Pham, Lorna W. Harries, Caroline S. Fox, Stefania Bandinelli, Abbas Dehghan, Dena G. Hernandez, Albert Hofman, Jaeyoung Hong, Roby Joehanes, Andrew D. Johnson, Peter J. Munson, Denis V. Rybin, Andrew B. Singleton, André G. Uitterlinden, Saixia Ying, MAGIC Investigators, David Melzer, Daniel Levy, Joyce B.J. van Meurs, Luigi Ferrucci, Jose C. Florez, Josée Dupuis, James B. Meigs, Eric D. Kolaczyk
Journal: Diabetes
Diabetes 2016;65(12):3794–3804
https://doi.org/10.2337/db16-0470
Published: 13 September 2016
View articletitled, Peripheral Blood Transcriptomic Signatures of Fasting Glucose and Insulin Concentrations
Open the PDF for Peripheral Blood Transcriptomic Signatures of Fasting Glucose and Insulin Concentrations in another window
Includes: Supplementary data
Journal Articles

Pathways Targeted by Antidiabetes Drugs Are Enriched for Multiple Genes Associated With Type 2 Diabetes Risk

Free
Ayellet V. Segrè, Nancy Wei, DIAGRAM Consortium, MAGIC Investigators, David Altshuler, Jose C. Florez
Journal: Diabetes
Diabetes 2015;64(4):1470–1483
https://doi.org/10.2337/db14-0703
Published: 03 November 2014
View articletitled, Pathways Targeted by Antidiabetes Drugs Are Enriched for Multiple Genes Associated With Type 2 Diabetes Risk
Open the PDF for Pathways Targeted by Antidiabetes Drugs Are Enriched for Multiple Genes Associated With Type 2 Diabetes Risk in another window
Includes: Supplementary data
Journal Articles

Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity

Open Access
Antigone S. Dimas, Vasiliki Lagou, Adam Barker, Joshua W. Knowles, Reedik Mägi, Marie-France Hivert, Andrea Benazzo, Denis Rybin, Anne U. Jackson, Heather M. Stringham, Ci Song, Antje Fischer-Rosinsky, Trine Welløv Boesgaard, Niels Grarup, Fahim A. Abbasi, Themistocles L. Assimes, Ke Hao, Xia Yang, Cécile Lecoeur, Inês Barroso, Lori L. Bonnycastle, Yvonne Böttcher, Suzannah Bumpstead, Peter S. Chines, Michael R. Erdos, Jurgen Graessler, Peter Kovacs, Mario A. Morken, Narisu Narisu, Felicity Payne, Alena Stancakova, Amy J. Swift, Anke Tönjes, Stefan R. Bornstein, Stéphane Cauchi, Philippe Froguel, David Meyre, Peter E.H. Schwarz, Hans-Ulrich Häring, Ulf Smith, Michael Boehnke, Richard N. Bergman, Francis S. Collins, Karen L. Mohlke, Jaakko Tuomilehto, Thomas Quertemous, Lars Lind, Torben Hansen, Oluf Pedersen, Mark Walker, Andreas F.H. Pfeiffer, Joachim Spranger, Michael Stumvoll, James B. Meigs, Nicholas J. Wareham, Johanna Kuusisto, Markku Laakso, Claudia Langenberg, Josée Dupuis, Richard M. Watanabe, Jose C. Florez, Erik Ingelsson, Mark I. McCarthy, Inga Prokopenko, on behalf of the MAGIC Investigators
Journal: Diabetes
Diabetes 2014;63(6):2158–2171
https://doi.org/10.2337/db13-0949
Published: 15 May 2014
View articletitled, Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity
Open the PDF for Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity in another window
Includes: Supplementary data
Journal Articles

Genetic Variants Associated With Glycine Metabolism and Their Role in Insulin Sensitivity and Type 2 Diabetes

Open Access
Weijia Xie, Andrew R. Wood, Valeriya Lyssenko, Michael N. Weedon, Joshua W. Knowles, Sami Alkayyali, Themistocles L. Assimes, Thomas Quertermous, Fahim Abbasi, Jussi Paananen, Hans Häring, Torben Hansen, Oluf Pedersen, Ulf Smith, Markku Laakso, the MAGIC Investigators, the DIAGRAM Consortium, the GENESIS Consortium, the RISC Consortium, Jacqueline M. Dekker, John J. Nolan, Leif Groop, Ele Ferrannini, Klaus-Peter Adam, Walter E. Gall, Timothy M. Frayling, Mark Walker
Journal: Diabetes
Diabetes 2013;62(6):2141–2150
https://doi.org/10.2337/db12-0876
Published: 17 May 2013
View articletitled, Genetic Variants Associated With Glycine Metabolism and Their Role in Insulin Sensitivity and Type 2 Diabetes
Open the PDF for Genetic Variants Associated With Glycine Metabolism and Their Role in Insulin Sensitivity and Type 2 Diabetes in another window
Includes: Supplementary data
Journal Articles

Impact of Common Variation in Bone-Related Genes on Type 2 Diabetes and Related Traits

Open Access
Liana K. Billings, Yi-Hsiang Hsu, Rachel J. Ackerman, Josée Dupuis, Benjamin F. Voight, Laura J. Rasmussen-Torvik, Serge Hercberg, Mark Lathrop, Daniel Barnes, Claudia Langenberg, Jennie Hui, Mao Fu, Nabila Bouatia-Naji, Cecile Lecoeur, Ping An, Patrik K. Magnusson, Ida Surakka, Samuli Ripatti, Lene Christiansen, Christine Dalgård, Lasse Folkersen, Elin Grundberg, the MAGIC Investigators, the DIAGRAM + Consortium, the MuTHER Consortium, the ASCOT Investigators, the GEFOS Consortium, Per Eriksson, Jaakko Kaprio, Kirsten Ohm Kyvik, Nancy L. Pedersen, Ingrid B. Borecki, Michael A. Province, Beverley Balkau, Philippe Froguel, Alan R. Shuldiner, Lyle J. Palmer, Nick Wareham, Pierre Meneton, Toby Johnson, James S. Pankow, David Karasik, James B. Meigs, Douglas P. Kiel, Jose C. Florez
Journal: Diabetes
Diabetes 2012;61(8):2176–2186
https://doi.org/10.2337/db11-1515
Published: 17 July 2012
View articletitled, Impact of Common Variation in Bone-Related Genes on Type 2 Diabetes and Related Traits
Open the PDF for Impact of Common Variation in Bone-Related Genes on Type 2 Diabetes and Related Traits in another window
Includes: Supplementary data
Journal Articles

Total Zinc Intake May Modify the Glucose-Raising Effect of a Zinc Transporter (SLC30A8) Variant: A 14-Cohort Meta-analysis

Open Access
Stavroula Kanoni, Jennifer A. Nettleton, Marie-France Hivert, Zheng Ye, Frank J.A. van Rooij, Dmitry Shungin, Emily Sonestedt, Julius S. Ngwa, Mary K. Wojczynski, Rozenn N. Lemaitre, Stefan Gustafsson, Jennifer S. Anderson, Toshiko Tanaka, George Hindy, Georgia Saylor, Frida Renstrom, Amanda J. Bennett, Cornelia M. van Duijn, Jose C. Florez, Caroline S. Fox, Albert Hofman, Ron C. Hoogeveen, Denise K. Houston, Frank B. Hu, Paul F. Jacques, Ingegerd Johansson, Lars Lind, Yongmei Liu, Nicola McKeown, Jose Ordovas, James S. Pankow, Eric J.G. Sijbrands, Ann-Christine Syvänen, André G. Uitterlinden, Mary Yannakoulia, M. Carola Zillikens, the MAGIC Investigators, Nick J. Wareham, Inga Prokopenko, Stefania Bandinelli, Nita G. Forouhi, L. Adrienne Cupples, Ruth J. Loos, Goran Hallmans, Josée Dupuis, Claudia Langenberg, Luigi Ferrucci, Stephen B. Kritchevsky, Mark I. McCarthy, Erik Ingelsson, Ingrid B. Borecki, Jacqueline C.M. Witteman, Marju Orho-Melander, David S. Siscovick, James B. Meigs, Paul W. Franks, George V. Dedoussis
Journal: Diabetes
Diabetes 2011;60(9):2407–2416
https://doi.org/10.2337/db11-0176
Published: 20 August 2011
View articletitled, Total Zinc Intake May Modify the Glucose-Raising Effect of a Zinc Transporter (SLC30A8) Variant: A 14-Cohort Meta-analysis
Open the PDF for Total Zinc Intake May Modify the Glucose-Raising Effect of a Zinc Transporter (SLC30A8) Variant: A 14-Cohort Meta-analysis in another window
Includes: Supplementary data
Journal Articles

Genetic Predisposition to Long-Term Nondiabetic Deteriorations in Glucose Homeostasis: Ten-Year Follow-Up of the GLACIER Study

Open Access
Frida Renström, Dmitry Shungin, Ingegerd Johansson, the MAGIC Investigators, Jose C. Florez, Göran Hallmans, Frank B. Hu, Paul W. Franks
Journal: Diabetes
Diabetes 2011;60(1):345–354
https://doi.org/10.2337/db10-0933
Published: 24 September 2010
View articletitled, Genetic Predisposition to Long-Term Nondiabetic Deteriorations in Glucose Homeostasis: Ten-Year Follow-Up of the GLACIER Study
Open the PDF for Genetic Predisposition to Long-Term Nondiabetic Deteriorations in Glucose Homeostasis: Ten-Year Follow-Up of the GLACIER Study in another window
Includes: Supplementary data
Journal Articles

Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans

Open Access
Erik Ingelsson, Claudia Langenberg, Marie-France Hivert, Inga Prokopenko, Valeriya Lyssenko, Josée Dupuis, Reedik Mägi, Stephen Sharp, Anne U. Jackson, Themistocles L. Assimes, Peter Shrader, Joshua W. Knowles, Björn Zethelius, Fahim A. Abbasi, Richard N. Bergman, Antje Bergmann, Christian Berne, Michael Boehnke, Lori L. Bonnycastle, Stefan R. Bornstein, Thomas A. Buchanan, Suzannah J. Bumpstead, Yvonne Böttcher, Peter Chines, Francis S. Collins, Cyrus C. Cooper, Elaine M. Dennison, Michael R. Erdos, Ele Ferrannini, Caroline S. Fox, Jürgen Graessler, Ke Hao, Bo Isomaa, Karen A. Jameson, Peter Kovacs, Johanna Kuusisto, Markku Laakso, Claes Ladenvall, Karen L. Mohlke, Mario A. Morken, Narisu Narisu, David M. Nathan, Laura Pascoe, Felicity Payne, John R. Petrie, Avan A. Sayer, Peter E. H. Schwarz, Laura J. Scott, Heather M. Stringham, Michael Stumvoll, Amy J. Swift, Ann-Christine Syvänen, Tiinamaija Tuomi, Jaakko Tuomilehto, Anke Tönjes, Timo T. Valle, Gordon H. Williams, Lars Lind, Inês Barroso, Thomas Quertermous, Mark Walker, Nicholas J. Wareham, James B. Meigs, Mark I. McCarthy, Leif Groop, Richard M. Watanabe, Jose C. Florez, on behalf of the MAGIC investigators
Journal: Diabetes
Diabetes 2010;59(5):1266–1275
https://doi.org/10.2337/db09-1568
Published: 25 February 2010
View articletitled, Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans
Open the PDF for Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans in another window
Includes: Supplementary data