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Meeting Abstracts

1526-P: Alpha Cells Facilitate Neuronally-Stimulated Insulin Secretion at Fasting Glucose

KELLY TRIMIGLIOZZI, SOPHIA J. WIEDEMANN, DANIEL T. MEIER, MARIANNE BOENI-SCHNETZLER, MARC Y. DONATH
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1526-P
https://doi.org/10.2337/db24-1526-P
Published: 14 June 2024
View article titled, 1526-P: Alpha Cells Facilitate Neuronally-Stimulated Insulin Secretion at Fasting Glucose
Meeting Abstracts

1560-P: Inflammation in the Exocrine Pancreas Impairs Insulin Secretion

LAURA STEIGER, DANIEL T. MEIER, LEILA RACHID, HELENE MEREAU, MARC Y. DONATH, AXEL DE BAAT, MARIANNE BOENI-SCHNETZLER
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1560-P
https://doi.org/10.2337/db24-1560-P
Published: 14 June 2024
View article titled, 1560-P: Inflammation in the Exocrine Pancreas Impairs Insulin Secretion
Meeting Abstracts

1556-P: Glucocorticoid-Induced Insulin Secretion via the Hypothalamic–Pituitary–Adrenal–Islet Axis Is Needed for Proper Body Weight Regulation and Pancreas Development

DANIEL T. MEIER, LEILA RACHID, MARC Y. DONATH
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1556-P
https://doi.org/10.2337/db24-1556-P
Published: 14 June 2024
View article titled, 1556-P: Glucocorticoid-Induced Insulin Secretion via the Hypothalamic–Pituitary–Adrenal–Islet Axis Is Needed for Proper Body Weight Regulation and Pancreas Development
Meeting Abstracts

1526-P: Cephalic Phase Insulin Release Requires Alpha Cells

KELLY A. TRIMIGLIOZZI, SOPHIA J. WIEDEMANN, DANIEL T. MEIER, LEILA RACHID, HELENE MEREAU, MARIANNE BÖNI-SCHNETZLER, MARC Y. DONATH
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1526-P
https://doi.org/10.2337/db23-1526-P
Published: 20 June 2023
View article titled, 1526-P: Cephalic Phase Insulin Release Requires Alpha Cells
Meeting Abstracts

1793-P: C-Peptide Kinetics: The Van Cauter Population Model May Not Be Applicable to Post–Gastric Bypass Adults with Postprandial Hyperinsulinemic Hypoglycemia

MICHELE SCHIAVON, DAVID HERZIG, MATTHIAS HEPPRICH, MARC Y. DONATH, CHRISTOPH STETTLER, LIA BALLY, CHIARA DALLA MAN
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1793-P
https://doi.org/10.2337/db20-1793-P
Published: 01 June 2020
View article titled, 1793-P: C-Peptide Kinetics: The Van Cauter Population Model May Not Be Applicable to Post–Gastric Bypass Adults with Postprandial Hyperinsulinemic Hypoglycemia
Meeting Abstracts

1955-P: Interleukin-1ß Orchestrates Non–Glucose Dependent Cephalic Phase Insulin Release in Health and Obesity

SOPHIA J. WIEDEMANN, EREZ DROR, DANIEL T. MEIER, KELLY TRIMIGLIOZZI, JOSE ALBERTO MOLINA-TIJERAS, FRIEDERIKE SCHULZE, LEILA RACHID, STÉPHANIE P. HÄUSELMANN, THERESA V. ROHM, HELENE MEREAU, CHRISTOPHE MAGNAN, MARIANNE BOENI-SCHNETZLER, MARC Y. DONATH
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1955-P
https://doi.org/10.2337/db20-1955-P
Published: 01 June 2020
View article titled, 1955-P: Interleukin-1ß Orchestrates Non–Glucose Dependent Cephalic Phase Insulin Release in Health and Obesity
Meeting Abstracts

1830-P: Empagliflozin as Well as Anakinra Reduces Symptomatic Postprandial Hypoglycemia after Gastric Bypass

MATTHIAS HEPPRICH, BENJAMIN SCHELKER, SOPHIA J. WIEDEMANN, BECKEY TRINH, MARIANNE BÖNI-SCHNETZLER, MARC Y. DONATH
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1830-P
https://doi.org/10.2337/db19-1830-P
Published: 01 June 2019
View article titled, 1830-P: Empagliflozin as Well as Anakinra Reduces Symptomatic Postprandial Hypoglycemia after Gastric Bypass
Journal Articles

IL-6–Type Cytokine Signaling in Adipocytes Induces Intestinal GLP-1 Secretion

Stephan Wueest, Céline I. Laesser, Marianne Böni-Schnetzler, Flurin Item, Fabrizio C. Lucchini, Marcela Borsigova, Werner Müller, Marc Y. Donath, Daniel Konrad
Journal: Diabetes
Diabetes 2018;67(1):36–45
https://doi.org/10.2337/db17-0637
Published: 24 October 2017
View article titled, IL-6–Type Cytokine Signaling in Adipocytes Induces Intestinal GLP-1 Secretion
Open the PDF for IL-6–Type Cytokine Signaling in Adipocytes Induces Intestinal GLP-1 Secretion in another window
Includes: Supplementary data
Journal Articles

Expression of Concern. Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein–Mediated β-Cell Proliferation in Human Pancreatic Islets. Diabetes 2006;55:2713–2722; DOI: 10.2337/db05-1430

Kathrin Maedler, Desiree M. Schumann, Nadine Sauter, Helga Ellingsgaard, Domenico Bosco, Reto Baertschiger, Yoichiro Iwakura, José Oberholzer, Claes B. Wollheim, Benoit R. Gauthier, Marc Y. Donath
Journal: Diabetes
Diabetes 2016;65(8):2462
https://doi.org/10.2337/db16-ec08a
Published: 12 July 2016
View article titled, Expression of Concern. Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein–Mediated β-Cell Proliferation in Human Pancreatic Islets. Diabetes 2006;55:2713–2722; DOI: 10.2337/db05-1430
Open the PDF for Expression of Concern. Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein–Mediated β-Cell Proliferation in Human Pancreatic Islets. Diabetes 2006;55:2713–2722; DOI: 10.2337/db05-1430 in another window
Journal Articles

Bimodal Effect on Pancreatic β-Cells of Secretory Products From Normal or Insulin-Resistant Human Skeletal Muscle. Diabetes 2011;60: 1111–1121

Karim Bouzakri, Peter Plomgaard, Thierry Berney, Marc Y. Donath, Bente Karlund Pedersen, Philippe A. Halban
Journal: Diabetes
Diabetes 2015;64(1):312
https://doi.org/10.2337/db15-er01a
Published: 16 December 2014
View article titled, Bimodal Effect on Pancreatic β-Cells of Secretory Products From Normal or Insulin-Resistant Human Skeletal Muscle. Diabetes 2011;60: 1111–1121
Open the PDF for Bimodal Effect on Pancreatic β-Cells of Secretory Products From Normal or Insulin-Resistant Human Skeletal Muscle. Diabetes 2011;60: 1111–1121 in another window
Journal Articles

Angiotensin II Induces Interleukin-1β–Mediated Islet Inflammation and β-Cell Dysfunction Independently of Vasoconstrictive Effects

Nadine S. Sauter, Constanze Thienel, Yuliya Plutino, Kapil Kampe, Erez Dror, Shuyang Traub, Katharina Timper, Benoit Bédat, Francois Pattou, Julie Kerr-Conte, Andreas W. Jehle, Marianne Böni-Schnetzler, Marc Y. Donath
Journal: Diabetes
Diabetes 2015;64(4):1273–1283
https://doi.org/10.2337/db14-1282
Published: 28 October 2014
View article titled, Angiotensin II Induces Interleukin-1β–Mediated Islet Inflammation and β-Cell Dysfunction Independently of Vasoconstrictive Effects
Open the PDF for Angiotensin II Induces Interleukin-1β–Mediated Islet Inflammation and β-Cell Dysfunction Independently of Vasoconstrictive Effects in another window
Journal Articles

Bimodal Effect on Pancreatic β-Cells of Secretory Products From Normal or Insulin-Resistant Human Skeletal Muscle

Karim Bouzakri, Peter Plomgaard, Thierry Berney, Marc Y. Donath, Bente Karlund Pedersen, Philippe A. Halban
Journal: Diabetes
Diabetes 2011;60(4):1111–1121
https://doi.org/10.2337/db10-1178
Published: 22 March 2011
View article titled, Bimodal Effect on Pancreatic β-Cells of Secretory Products From Normal or Insulin-Resistant Human Skeletal Muscle
Open the PDF for Bimodal Effect on Pancreatic β-Cells of Secretory Products From Normal or Insulin-Resistant Human Skeletal Muscle in another window
Journal Articles

Increased Number of Islet-Associated Macrophages in Type 2 Diabetes

Jan A. Ehses, Aurel Perren, Elisabeth Eppler, Pascale Ribaux, John A. Pospisilik, Ranit Maor-Cahn, Xavier Gueripel, Helga Ellingsgaard, Marten K.J. Schneider, Gregoire Biollaz, Adriano Fontana, Manfred Reinecke, Francoise Homo-Delarche, Marc Y. Donath
Journal: Diabetes
Diabetes 2007;56(9):2356–2370
https://doi.org/10.2337/db06-1650
Published: 01 September 2007
View article titled, Increased Number of Islet-Associated Macrophages in Type 2 Diabetes
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Journal Articles

Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein–Mediated β-Cell Proliferation in Human Pancreatic Islets

Kathrin Maedler, Desiree M. Schumann, Nadine Sauter, Helga Ellingsgaard, Domenico Bosco, Reto Baertschiger, Yoichiro Iwakura, José Oberholzer, Claes B. Wollheim, Benoit R. Gauthier, Marc Y. Donath
Journal: Diabetes
Diabetes 2006;55(10):2713–2722
https://doi.org/10.2337/db05-1430
Published: 01 October 2006
View article titled, Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein–Mediated β-Cell Proliferation in Human Pancreatic Islets
Open the PDF for Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein–Mediated β-Cell Proliferation in Human Pancreatic Islets in another window
Journal Articles

Aging Correlates With Decreased β-Cell Proliferative Capacity and Enhanced Sensitivity to Apoptosis: A Potential Role for Fas and Pancreatic Duodenal Homeobox-1

Kathrin Maedler, Desiree M. Schumann, Fabienne Schulthess, José Oberholzer, Domenico Bosco, Thierry Berney, Marc Y. Donath
Journal: Diabetes
Diabetes 2006;55(9):2455–2462
https://doi.org/10.2337/db05-1586
Published: 01 September 2006
View article titled, Aging Correlates With Decreased β-Cell Proliferative Capacity and Enhanced Sensitivity to Apoptosis: <subtitle>A Potential Role for Fas and Pancreatic Duodenal Homeobox-1</subtitle>
Open the PDF for Aging Correlates With Decreased β-Cell Proliferative Capacity and Enhanced Sensitivity to Apoptosis: <subtitle>A Potential Role for Fas and Pancreatic Duodenal Homeobox-1</subtitle> in another window
Journal Articles

Mechanisms of β-Cell Death in Type 2 Diabetes

Marc Y. Donath, Jan A. Ehses, Kathrin Maedler, Desiree M. Schumann, Helga Ellingsgaard, Elisabeth Eppler, Manfred Reinecke
Journal: Diabetes
Diabetes 2005;54(suppl_2):S108–S113
https://doi.org/10.2337/diabetes.54.suppl_2.S108
Published: 01 December 2005
View article titled, Mechanisms of β-Cell Death in Type 2 Diabetes
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Journal Articles

Psammomys Obesus, a Model for Environment-Gene Interactions in Type 2 Diabetes

Nurit Kaiser, Rafael Nesher, Marc Y. Donath, Merav Fraenkel, Vered Behar, Christophe Magnan, Alain Ktorza, Erol Cerasi, Gil Leibowitz
Journal: Diabetes
Diabetes 2005;54(suppl_2):S137–S144
https://doi.org/10.2337/diabetes.54.suppl_2.S137
Published: 01 December 2005
View article titled, <em>Psammomys Obesus</em>, a Model for Environment-Gene Interactions in Type 2 Diabetes
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Journal Articles

Dynamic Changes in β-Cell Mass and Pancreatic Insulin During the Evolution of Nutrition-Dependent Diabetes in Psammomys obesus: Impact of Glycemic Control

Nurit Kaiser, Michal Yuli, Gökhan Üçkaya, Andrei I. Oprescu, Marie-France Berthault, Catherine Kargar, Marc Y. Donath, Erol Cerasi, Alain Ktorza
Journal: Diabetes
Diabetes 2005;54(1):138–145
https://doi.org/10.2337/diabetes.54.1.138
Published: 01 January 2005
View article titled, Dynamic Changes in β-Cell Mass and Pancreatic Insulin During the Evolution of Nutrition-Dependent Diabetes in <em>Psammomys obesus</em>: <subtitle>Impact of Glycemic Control</subtitle>
Open the PDF for Dynamic Changes in β-Cell Mass and Pancreatic Insulin During the Evolution of Nutrition-Dependent Diabetes in <em>Psammomys obesus</em>: <subtitle>Impact of Glycemic Control</subtitle> in another window
Journal Articles

Glucose- and Interleukin-1β-Induced β-Cell Apoptosis Requires Ca2+ Influx and Extracellular Signal-Regulated Kinase (ERK) 1/2 Activation and Is Prevented by a Sulfonylurea Receptor 1/Inwardly Rectifying K+ Channel 6.2 (SUR/Kir6.2) Selective Potassium Channel Opener in Human Islets

Kathrin Maedler, Joachim Størling, Jeppe Sturis, Richard A. Zuellig, Giatgen A. Spinas, Per O.G. Arkhammar, Thomas Mandrup-Poulsen, Marc Y. Donath
Journal: Diabetes
Diabetes 2004;53(7):1706–1713
https://doi.org/10.2337/diabetes.53.7.1706
Published: 01 July 2004
View article titled, Glucose- and Interleukin-1β-Induced β-Cell Apoptosis Requires Ca<sup>2+</sup> Influx and Extracellular Signal-Regulated Kinase (ERK) 1/2 Activation and Is Prevented by a Sulfonylurea Receptor 1/Inwardly Rectifying K<sup>+</sup> Channel 6.2 (SUR/Kir6.2) Selective Potassium Channel Opener in Human Islets
Open the PDF for Glucose- and Interleukin-1β-Induced β-Cell Apoptosis Requires Ca<sup>2+</sup> Influx and Extracellular Signal-Regulated Kinase (ERK) 1/2 Activation and Is Prevented by a Sulfonylurea Receptor 1/Inwardly Rectifying K<sup>+</sup> Channel 6.2 (SUR/Kir6.2) Selective Potassium Channel Opener in Human Islets in another window
Journal Articles

Monounsaturated Fatty Acids Prevent the Deleterious Effects of Palmitate and High Glucose on Human Pancreatic β-Cell Turnover and Function

Kathrin Maedler, José Oberholzer, Pascal Bucher, Giatgen A. Spinas, Marc Y. Donath
Journal: Diabetes
Diabetes 2003;52(3):726–733
https://doi.org/10.2337/diabetes.52.3.726
Published: 01 March 2003
View article titled, Monounsaturated Fatty Acids Prevent the Deleterious Effects of Palmitate and High Glucose on Human Pancreatic β-Cell Turnover and Function
Open the PDF for Monounsaturated Fatty Acids Prevent the Deleterious Effects of Palmitate and High Glucose on Human Pancreatic β-Cell Turnover and Function in another window