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Meeting Abstracts

1554-P: Insights Into Insulin Synthesis and Turnover Using ¹³C₅¹⁵N-Valine to Label C-Peptide in Humans

AOIFE M. EGAN, ROY B. DYER, MARCELLO C. LAURENTI, CHIARA DALLA MAN, ADRIAN VELLA

Diabetes 2024;73(Supplement_1):1554-P

https://doi.org/10.2337/db24-1554-P

Published: 14 June 2024

View article titled, 1554-P: Insights Into Insulin Synthesis and Turnover Using 13C515N-Valine to Label C-Peptide in Humans

Meeting Abstracts

1618-P: Progression to Glucose Intolerance Is Characterized by Glucagon Secretion Inappropriate for Circulating Glucose

SNEHA MOHAN, HANNAH E. CHRISTIE, MARCELLO C. LAURENTI, AOIFE M. EGAN, ADRIAN VELLA, CHIARA DALLA MAN

Diabetes 2024;73(Supplement_1):1618-P

https://doi.org/10.2337/db24-1618-P

Published: 14 June 2024

View article titled, 1618-P: Progression to Glucose Intolerance Is Characterized by Glucagon Secretion Inappropriate for Circulating Glucose

Journal Articles

The Longitudinal Effect of Diabetes-Associated Variation in TCF7L2 on Islet Function in Humans

Maya Zeini, Marcello C. Laurenti, Aoife M. Egan, Kalpana Muthusamy, Anisha Ramar, Emma Vella, Kent R. Bailey, Claudio Cobelli, Chiara Dalla Man, Adrian Vella

Diabetes 2024;73(9):1440–1446

https://doi.org/10.2337/db24-0192

Published: 13 June 2024

View article titled, The Longitudinal Effect of Diabetes-Associated Variation in TCF7L2 on Islet Function in Humans

Meeting Abstracts

36-OR: The Effect of Glucagon-Like Peptide-1 Receptor Blockade on the ß-Cell Response to Glucagon Bolus in People With and Without Type 2 Diabetes

AOIFE M. EGAN, MAYA ZEINI, ANDREW A. WELCH, RAHELE A. FARAHANI, MARCELLO C. LAURENTI, CLAUDIO COBELLI, CHIARA DALLA MAN, ADRIAN VELLA

Diabetes 2023;72(Supplement_1):36-OR

https://doi.org/10.2337/db23-36-OR

Published: 20 June 2023

View article titled, 36-OR: The Effect of Glucagon-Like Peptide-1 Receptor Blockade on the ß-Cell Response to Glucagon Bolus in People With and Without Type 2 Diabetes

Meeting Abstracts

1564-P: Impaired Insulin Secretion Increases Glucagon Action on the Liver

ALESSIO TONELLO, MARCELLO C. LAURENTI, CLAUDIO COBELLI, ADRIAN VELLA, CHIARA DALLA MAN

Diabetes 2023;72(Supplement_1):1564-P

https://doi.org/10.2337/db23-1564-P

Published: 20 June 2023

View article titled, 1564-P: Impaired Insulin Secretion Increases Glucagon Action on the Liver

Meeting Abstracts

1646-P: The Effect of Glucagon-Like Peptide-1 Receptor Blockade and Acute Insulin Resistance on Islet Function and Glucose Metabolism in People without Diabetes

MAYA ZEINI, RAHELE A. FARAHANI, ANDREW A. WELCH, MARCELLO C. LAURENTI, CLAUDIO COBELLI, CHIARA DALLA MAN, AOIFE M. EGAN, ADRIAN VELLA

Diabetes 2023;72(Supplement_1):1646-P

https://doi.org/10.2337/db23-1646-P

Published: 20 June 2023

View article titled, 1646-P: The Effect of Glucagon-Like Peptide-1 Receptor Blockade and Acute Insulin Resistance on Islet Function and Glucose Metabolism in People without Diabetes

Meeting Abstracts

1645-P: Diabetes-Associated Variation in TCF7L2 Is Associated with a Longitudinal Decline in Glucose Tolerance Accompanied by Impaired Suppression of Postprandial Glucagon Secretion

MAYA ZEINI, KALPANA MUTHUSAMY, AOIFE M. EGAN, MARCELLO C. LAURENTI, CLAUDIO COBELLI, CHIARA DALLA MAN, ADRIAN VELLA

Diabetes 2023;72(Supplement_1):1645-P

https://doi.org/10.2337/db23-1645-P

Published: 20 June 2023

View article titled, 1645-P: Diabetes-Associated Variation in TCF7L2 Is Associated with a Longitudinal Decline in Glucose Tolerance Accompanied by Impaired Suppression of Postprandial Glucagon Secretion

Meeting Abstracts

1547-P: The Differential Effect of Glucagon-Like Peptide-1 Receptor Blockade on Glucose Metabolism in People With and Without Type 2 Diabetes

ANDREW A. WELCH, RAHELE A. FARAHANI, MAYA ZEINI, AOIFE M. EGAN, MARCELLO C. LAURENTI, CLAUDIO COBELLI, CHIARA DALLA MAN, ADRIAN VELLA

Diabetes 2023;72(Supplement_1):1547-P

https://doi.org/10.2337/db23-1547-P

Published: 20 June 2023

View article titled, 1547-P: The Differential Effect of Glucagon-Like Peptide-1 Receptor Blockade on Glucose Metabolism in People With and Without Type 2 Diabetes

Journal Articles

The Effect of Glucagon-Like Peptide 1 Receptor Blockade on Glucagon-Induced Stimulation of Insulin Secretion

Rahele A. Farahani, Aoife M. Egan, Andrew A. Welch, Marcello C. Laurenti, Claudio Cobelli, Chiara Dalla Man, Adrian Vella

Diabetes 2023;72(4):449–454

https://doi.org/10.2337/db22-0709

Published: 23 December 2022

View article titled, The Effect of Glucagon-Like Peptide 1 Receptor Blockade on Glucagon-Induced Stimulation of Insulin Secretion

Meeting Abstracts

1376-P: Comparison of a-Cell Response to Intravenous or Oral Glucose in Nondiabetic Humans

MARCELLO C. LAURENTI, ARMANDO MANDUCA, CLAUDIO COBELLI, CHIARA DALLA MAN, ADRIAN VELLA

Diabetes 2022;71(Supplement_1):1376-P

https://doi.org/10.2337/db22-1376-P

Published: 01 June 2022

View article titled, 1376-P: Comparison of a-Cell Response to Intravenous or Oral Glucose in Nondiabetic Humans

Meeting Abstracts

1325-P: Modulation of Overnight Free Fatty Acid and Glucose Concentrations and Their Effect on Postprandial Islet Function and Glucose Metabolism

ANDREW A. WELCH, DANIEL SCHEMBRI WISMAYER, AOIFE M. EGAN, RAHELE A. FARAHANI, MARCELLO C. LAURENTI, CLAUDIO COBELLI, CHIARA DALLA MAN, ADRIAN VELLA

Diabetes 2022;71(Supplement_1):1325-P

https://doi.org/10.2337/db22-1325-P

Published: 01 June 2022

View article titled, 1325-P: Modulation of Overnight Free Fatty Acid and Glucose Concentrations and Their Effect on Postprandial Islet Function and Glucose Metabolism

Meeting Abstracts

358-OR: The Effect of Glucagon-Like Peptide-1 Receptor Blockade on Glucagon-Induced Stimulation of Insulin Secretion

RAHELE A. FARAHANI, AOIFE M. EGAN, ANDREW A. WELCH, MARCELLO C. LAURENTI, CLAUDIO COBELLI, CHIARA DALLA MAN, ADRIAN VELLA

Diabetes 2022;71(Supplement_1):358-OR

https://doi.org/10.2337/db22-358-OR

Published: 01 June 2022

View article titled, 358-OR: The Effect of Glucagon-Like Peptide-1 Receptor Blockade on Glucagon-Induced Stimulation of Insulin Secretion

Meeting Abstracts

259-OR: The Effect of Impaired Glucagon Suppression on Endogenous Glucose Production Is Independent of Insulin Action

MARCELLO C. LAURENTI, AOIFE M. EGAN, DANIEL SCHEMBRI WISMAYER, CLAUDIO COBELLI, CHIARA DALLA MAN, ADRIAN VELLA

Diabetes 2021;70(Supplement_1):259-OR

https://doi.org/10.2337/db21-259-OR

Published: 01 June 2021

View article titled, 259-OR: The Effect of Impaired Glucagon Suppression on Endogenous Glucose Production Is Independent of Insulin Action

Meeting Abstracts

263-OR: Higher Glycemic Threshold for Glucagon Suppression in Impaired Fasting Glucose and Impaired Glucose Tolerance

JACOB D. KOHLENBERG, MARCELLO C. LAURENTI, AOIFE M. EGAN, CLAUDIO COBELLI, CHIARA DALLA MAN, ADRIAN VELLA

Diabetes 2021;70(Supplement_1):263-OR

https://doi.org/10.2337/db21-263-OR

Published: 01 June 2021

View article titled, 263-OR: Higher Glycemic Threshold for Glucagon Suppression in Impaired Fasting Glucose and Impaired Glucose Tolerance

Meeting Abstracts

1791-P: The Threshold for Fasting Insulin Secretion Is Independent of the Beta-Cell Secretory Response to Glucose in Nondiabetic Humans

JACOB D. KOHLENBERG, MARCELLO C. LAURENTI, AOIFE M. EGAN, CHIARA DALLA MAN, ROBERT A. RIZZA, CLAUDIO COBELLI, ADRIAN VELLA

Diabetes 2020;69(Supplement_1):1791-P

https://doi.org/10.2337/db20-1791-P

Published: 01 June 2020

View article titled, 1791-P: The Threshold for Fasting Insulin Secretion Is Independent of the Beta-Cell Secretory Response to Glucose in Nondiabetic Humans

Meeting Abstracts

1787-P: Insulin Pulse Characteristics Do Not Alter Hepatic Glucose Metabolism and Insulin Action

MARCELLO C. LAURENTI, CHIARA DALLA MAN, RON T. VARGHESE, JOHN JONES, CRISTINA BAROSA, ROBERT A. RIZZA, ALEKSEY MATVEYENKO, GIUSEPPE DE NICOLAO, CLAUDIO COBELLI, ADRIAN VELLA

Diabetes 2020;69(Supplement_1):1787-P

https://doi.org/10.2337/db20-1787-P

Published: 01 June 2020

View article titled, 1787-P: Insulin Pulse Characteristics Do Not Alter Hepatic Glucose Metabolism and Insulin Action

Meeting Abstracts

1902-P: Insulin Pulses Do Not Inhibit Glucagon Secretion in Nondiabetic Humans

MARCELLO C. LAURENTI, CHIARA DALLA MAN, RON T. VARGHESE, ROBERT A. RIZZA, ALEKSEY MATVEYENKO, CLAUDIO COBELLI, ADRIAN VELLA

Diabetes 2020;69(Supplement_1):1902-P

https://doi.org/10.2337/db20-1902-P

Published: 01 June 2020

View article titled, 1902-P: Insulin Pulses Do Not Inhibit Glucagon Secretion in Nondiabetic Humans

Meeting Abstracts

1836-P: Derivation of Glucagon Kinetics to Reconstruct Glucagon Secretion in Nondiabetic Humans

MARCELLO C. LAURENTI, CHIARA DALLA MAN, J.D. ADAMS, AOIFE M. EGAN, CLAUDIO COBELLI, ADRIAN VELLA

Diabetes 2019;68(Supplement_1):1836-P

https://doi.org/10.2337/db19-1836-P

Published: 01 June 2019

View article titled, 1836-P: Derivation of Glucagon Kinetics to Reconstruct Glucagon Secretion in Nondiabetic Humans

Meeting Abstracts

1831-P: Delayed Glucagon Suppression Contributes to Postprandial Hyperglycemia Independently of the Degree of Insulin Secretion

J.D. ADAMS, MARCELLO C. LAURENTI, ROBERT A. RIZZA, AOIFE M. EGAN, CLAUDIO COBELLI, CHIARA DALLA MAN, ADRIAN VELLA

Diabetes 2019;68(Supplement_1):1831-P

https://doi.org/10.2337/db19-1831-P

Published: 01 June 2019

View article titled, 1831-P: Delayed Glucagon Suppression Contributes to Postprandial Hyperglycemia Independently of the Degree of Insulin Secretion

Meeting Abstracts

1839-P: GLP-1 Receptor Antagonism Using Exendin-9,39 in the Fasting State Modulates a-Cell Function in Humans with Type 2 Diabetes

MARIA D. HURTADO, AOIFE M. EGAN, MARCELLO C. LAURENTI, J.D. ADAMS, ROBERT A. RIZZA, CLAUDIO COBELLI, ALEKSEY MATVEYENKO, CHIARA DALLA MAN, ADRIAN VELLA

Diabetes 2019;68(Supplement_1):1839-P

https://doi.org/10.2337/db19-1839-P

Published: 01 June 2019

View article titled, 1839-P: GLP-1 Receptor Antagonism Using Exendin-9,39 in the Fasting State Modulates a-Cell Function in Humans with Type 2 Diabetes

NARROW

1554-P: Insights Into Insulin Synthesis and Turnover Using ¹³C₅¹⁵N-Valine to Label C-Peptide in Humans

1618-P: Progression to Glucose Intolerance Is Characterized by Glucagon Secretion Inappropriate for Circulating Glucose

The Longitudinal Effect of Diabetes-Associated Variation in TCF7L2 on Islet Function in Humans

36-OR: The Effect of Glucagon-Like Peptide-1 Receptor Blockade on the ß-Cell Response to Glucagon Bolus in People With and Without Type 2 Diabetes

1564-P: Impaired Insulin Secretion Increases Glucagon Action on the Liver

1646-P: The Effect of Glucagon-Like Peptide-1 Receptor Blockade and Acute Insulin Resistance on Islet Function and Glucose Metabolism in People without Diabetes

1645-P: Diabetes-Associated Variation in TCF7L2 Is Associated with a Longitudinal Decline in Glucose Tolerance Accompanied by Impaired Suppression of Postprandial Glucagon Secretion

1547-P: The Differential Effect of Glucagon-Like Peptide-1 Receptor Blockade on Glucose Metabolism in People With and Without Type 2 Diabetes

The Effect of Glucagon-Like Peptide 1 Receptor Blockade on Glucagon-Induced Stimulation of Insulin Secretion

1376-P: Comparison of a-Cell Response to Intravenous or Oral Glucose in Nondiabetic Humans

1325-P: Modulation of Overnight Free Fatty Acid and Glucose Concentrations and Their Effect on Postprandial Islet Function and Glucose Metabolism

358-OR: The Effect of Glucagon-Like Peptide-1 Receptor Blockade on Glucagon-Induced Stimulation of Insulin Secretion

259-OR: The Effect of Impaired Glucagon Suppression on Endogenous Glucose Production Is Independent of Insulin Action

263-OR: Higher Glycemic Threshold for Glucagon Suppression in Impaired Fasting Glucose and Impaired Glucose Tolerance

1791-P: The Threshold for Fasting Insulin Secretion Is Independent of the Beta-Cell Secretory Response to Glucose in Nondiabetic Humans

1787-P: Insulin Pulse Characteristics Do Not Alter Hepatic Glucose Metabolism and Insulin Action

1902-P: Insulin Pulses Do Not Inhibit Glucagon Secretion in Nondiabetic Humans

1836-P: Derivation of Glucagon Kinetics to Reconstruct Glucagon Secretion in Nondiabetic Humans

1831-P: Delayed Glucagon Suppression Contributes to Postprandial Hyperglycemia Independently of the Degree of Insulin Secretion

1839-P: GLP-1 Receptor Antagonism Using Exendin-9,39 in the Fasting State Modulates a-Cell Function in Humans with Type 2 Diabetes

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