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Journal Articles

Loss of β-cell K_ATP reduces Ca²⁺ sensitivity of insulin secretion and Trpm5 expression

Nathaniel W. York, Zihan Yan, Anna B. Osipovich, Abbie Tate, Sumit Patel, David W. Piston, Mark A. Magnuson, Maria S. Remedi, Colin G. Nichols

Diabetes db240650

https://doi.org/10.2337/db24-0650

Published: 12 December 2024

View article titled, Loss of β-cell KATP reduces Ca2+ sensitivity of insulin secretion and Trpm5 expression

Meeting Abstracts

2101-LB: Restoring ß-Cell Mass and Identity in KATP-Induced Neonatal Diabetes—The Synergy of Autophagy and Intermittent Fasting

ESMERALDA CASTELBLANCO, MARIA S. REMEDI, IRVING RAMIREZ SOTERO

Diabetes 2024;73(Supplement_1):2101-LB

https://doi.org/10.2337/db24-2101-LB

Published: 14 June 2024

View article titled, 2101-LB: Restoring ß-Cell Mass and Identity in KATP-Induced Neonatal Diabetes—The Synergy of Autophagy and Intermittent Fasting

Journal Articles

Glucokinase Inhibition: A Novel Treatment for Diabetes?

Maria S. Remedi, Colin G. Nichols

Diabetes 2023;72(2):170–174

https://doi.org/10.2337/db22-0731

Published: 20 January 2023

View article titled, Glucokinase Inhibition: A Novel Treatment for Diabetes?

Meeting Abstracts

318-OR: Intermittent Fasting Improves ß-cell Function in Nonobese KATP-Induced Neonatal Diabetes through Reduction of Cellular Stress and Enhanced Autophagy

ESMERALDA CASTELBLANCO, ZEENAT A. SHYR, ZIHAN YAN, ABHINAV DIWAN, MARIA S. REMEDI

Diabetes 2022;71(Supplement_1):318-OR

https://doi.org/10.2337/db22-318-OR

Published: 01 June 2022

View article titled, 318-OR: Intermittent Fasting Improves ß-cell Function in Nonobese KATP-Induced Neonatal Diabetes through Reduction of Cellular Stress and Enhanced Autophagy

Meeting Abstracts

1354-P: Alternate-Day Intermittent Fasting Improves Diabetes and Protects Beta-Cell Function in Polygenic Mouse Models of T2DM

SUMIT PATEL, ZIHAN YAN, MARIA S. REMEDI

Diabetes 2022;71(Supplement_1):1354-P

https://doi.org/10.2337/db22-1354-P

Published: 01 June 2022

View article titled, 1354-P: Alternate-Day Intermittent Fasting Improves Diabetes and Protects Beta-Cell Function in Polygenic Mouse Models of T2DM

Journal Articles

Genetic Reduction of Glucose Metabolism Preserves Functional β-Cell Mass in K_ATP-Induced Neonatal Diabetes

Zihan Yan, Manuela Fortunato, Zeenat A. Shyr, Amy L. Clark, Matt Fuess, Colin G. Nichols, Maria S. Remedi

Diabetes 2022;71(6):1233–1245

https://doi.org/10.2337/db21-0992

Published: 16 March 2022

View article titled, Genetic Reduction of Glucose Metabolism Preserves Functional β-Cell Mass in KATP-Induced Neonatal Diabetes

Journal Articles

ATP-Sensitive Potassium Channels in Hyperinsulinism and Type 2 Diabetes: Inconvenient Paradox or New Paradigm?

Colin G. Nichols, Nathaniel W. York, Maria S. Remedi

Diabetes 2022;71(3):367–375

https://doi.org/10.2337/db21-0755

Published: 23 February 2022

View article titled, ATP-Sensitive Potassium Channels in Hyperinsulinism and Type 2 Diabetes: Inconvenient Paradox or New Paradigm?

Meeting Abstracts

43-OR: Islet Autophagic Flux Is Impaired Prior to the Onset of Type 1 Diabetes

AMY L. CLARK, ZIHAN YAN, MARIA S. REMEDI, ABHINAV DIWAN

Diabetes 2021;70(Supplement_1):43-OR

https://doi.org/10.2337/db21-43-OR

Published: 01 June 2021

View article titled, 43-OR: Islet Autophagic Flux Is Impaired Prior to the Onset of Type 1 Diabetes

Meeting Abstracts

86-OR: High-Fat Diet Prevents Autoimmune Diabetes in NOD Mice

AMY L. CLARK, ZIHAN YAN, SOPHIA X. CHEN, MATT FUESS, GABRIELLE MCGINN, MARIA S. REMEDI

Diabetes 2020;69(Supplement_1):86-OR

https://doi.org/10.2337/db20-86-OR

Published: 01 June 2020

View article titled, 86-OR: High-Fat Diet Prevents Autoimmune Diabetes in NOD Mice

Meeting Abstracts

1789-P: Inactivation of Acyl-Protein Thioesterase 1, a Major Mediator of Palmitoylation Cycling, Promotes Insulin Secretion and ß-Cell Failure

GUIFANG DONG, XIAOCHAO WEI, LI YIN, CHU FENG, SANGEETA ADAK, ZEENAT A. SHYR, QIANG ZHANG, SHUNTARO MORIKAWA, RIE ASADA, FUMIHIKO URANO, MARIA S. REMEDI, CLAY F. SEMENKOVICH

Diabetes 2020;69(Supplement_1):1789-P

https://doi.org/10.2337/db20-1789-P

Published: 01 June 2020

View article titled, 1789-P: Inactivation of Acyl-Protein Thioesterase 1, a Major Mediator of Palmitoylation Cycling, Promotes Insulin Secretion and ß-Cell Failure

Meeting Abstracts

334-LB: Dapagliflozin, a SGLT2 Inhibitor, Therapy Improves ß-Cell Function in Neonatal Diabetes by Reducing Oxidative and ER Stress, and Loss of ß-Cell Identity

ZIHAN YAN, ZEENAT A. SHYR, MARIA S. REMEDI

Diabetes 2019;68(Supplement_1):334-LB

https://doi.org/10.2337/db19-334-LB

Published: 01 June 2019

View article titled, 334-LB: Dapagliflozin, a SGLT2 Inhibitor, Therapy Improves ß-Cell Function in Neonatal Diabetes by Reducing Oxidative and ER Stress, and Loss of ß-Cell Identity

Meeting Abstracts

Mechanisms Underlying the Progressive Loss of Beta-Cell Function and Mass in Neonatal Diabetes Are Reverted by Dapagliflozin Therapy

ZEENAT A. SHYR, ZIHAN YAN, ALESSANDRO USTIONE, MARIA S. REMEDI

Diabetes 2018;67(Supplement_1):2158-P

https://doi.org/10.2337/db18-2158-P

Published: 01 July 2018

View article titled, Mechanisms Underlying the Progressive Loss of Beta-Cell Function and Mass in Neonatal Diabetes Are Reverted by Dapagliflozin Therapy

Meeting Abstracts

Beta-Cell Glucotoxicity in K_ATP-Induced Diabetes Is Alleviated by Genetic Reduction of Glucose Metabolism

MANUELA FORTUNATO, ZIHAN YAN, ZEENAT A. SHYR, HANNAH E. CONWAY, MARIA S. REMEDI

Diabetes 2018;67(Supplement_1):327-OR

https://doi.org/10.2337/db18-327-OR

Published: 01 July 2018

View article titled, Beta-Cell Glucotoxicity in KATP-Induced Diabetes Is Alleviated by Genetic Reduction of Glucose Metabolism

Meeting Abstracts

Dextrose-Sulfonylurea Challenge as a Screening Test for Monogenic Diabetes in Patients Diagnosed with Type 1 Diabetes

AURELIA C.H. WOOD, MARIA S. REMEDI, COLIN NICHOLS, BESS A. MARSHALL

Diabetes 2018;67(Supplement_1):310-LB

https://doi.org/10.2337/db18-310-LB

Published: 01 July 2018

View article titled, Dextrose-Sulfonylurea Challenge as a Screening Test for Monogenic Diabetes in Patients Diagnosed with Type 1 Diabetes

Journal Articles

Glycogen Synthase Kinase-3 and Mammalian Target of Rapamycin Pathways Contribute to DNA Synthesis, Cell Cycle Progression, and Proliferation in Human Islets

Hui Liu, Maria S. Remedi, Kirk L. Pappan, Guim Kwon, Nidhi Rohatgi, Connie A. Marshall, Michael L. McDaniel

Diabetes 2009;58(3):663–672

https://doi.org/10.2337/db07-1208

Published: 01 March 2009

View article titled, Glycogen Synthase Kinase-3 and Mammalian Target of Rapamycin Pathways Contribute to DNA Synthesis, Cell Cycle Progression, and Proliferation in Human Islets

Journal Articles

Expression of ATP-Insensitive K_ATP Channels in Pancreatic β-Cells Underlies a Spectrum of Diabetic Phenotypes

Joseph C. Koster, Maria S. Remedi, Ricard Masia, Brian Patton, Ailing Tong, Colin G. Nichols

Diabetes 2006;55(11):2957–2964

https://doi.org/10.2337/db06-0732

Published: 01 November 2006

View article titled, Expression of ATP-Insensitive KATP Channels in Pancreatic β-Cells Underlies a Spectrum of Diabetic Phenotypes

Journal Articles

ATP-Sensitive K⁺ Channel Signaling in Glucokinase-Deficient Diabetes

Maria S. Remedi, Joseph C. Koster, Brian L. Patton, Colin G. Nichols

Diabetes 2005;54(10):2925–2931

https://doi.org/10.2337/diabetes.54.10.2925

Published: 01 October 2005

View article titled, ATP-Sensitive K+ Channel Signaling in Glucokinase-Deficient Diabetes

Journal Articles

ATP and Sulfonylurea Sensitivity of Mutant ATP-Sensitive K⁺ Channels in Neonatal Diabetes: Implications for Pharmacogenomic Therapy

Joseph C. Koster, Maria S. Remedi, Crystal Dao, Colin G. Nichols

Diabetes 2005;54(9):2645–2654

https://doi.org/10.2337/diabetes.54.9.2645

Published: 01 September 2005

View article titled, ATP and Sulfonylurea Sensitivity of Mutant ATP-Sensitive K+ Channels in Neonatal Diabetes: <subtitle>Implications for Pharmacogenomic Therapy</subtitle>

Journal Articles

Signaling Elements Involved in the Metabolic Regulation of mTOR by Nutrients, Incretins, and Growth Factors in Islets

Guim Kwon, Connie A. Marshall, Kirk L. Pappan, Maria S. Remedi, Michael L. McDaniel

Diabetes 2004;53(suppl_3):S225–S232

https://doi.org/10.2337/diabetes.53.suppl_3.S225

Published: 01 December 2004

View article titled, Signaling Elements Involved in the Metabolic Regulation of mTOR by Nutrients, Incretins, and Growth Factors in Islets

Journal Articles

Diet-Induced Glucose Intolerance in Mice With Decreased β-Cell ATP-Sensitive K⁺ Channels

Maria S. Remedi, Joseph. C. Koster, Kamelia Markova, Susumu Seino, Takashi Miki, Brian L. Patton, Michael L. McDaniel, Colin G. Nichols

Diabetes 2004;53(12):3159–3167

https://doi.org/10.2337/diabetes.53.12.3159

Published: 01 December 2004

View article titled, Diet-Induced Glucose Intolerance in Mice With Decreased β-Cell ATP-Sensitive K+ Channels

NARROW

Loss of β-cell K_ATP reduces Ca²⁺ sensitivity of insulin secretion and Trpm5 expression

2101-LB: Restoring ß-Cell Mass and Identity in KATP-Induced Neonatal Diabetes—The Synergy of Autophagy and Intermittent Fasting

Glucokinase Inhibition: A Novel Treatment for Diabetes?

318-OR: Intermittent Fasting Improves ß-cell Function in Nonobese KATP-Induced Neonatal Diabetes through Reduction of Cellular Stress and Enhanced Autophagy

1354-P: Alternate-Day Intermittent Fasting Improves Diabetes and Protects Beta-Cell Function in Polygenic Mouse Models of T2DM

Genetic Reduction of Glucose Metabolism Preserves Functional β-Cell Mass in K_ATP-Induced Neonatal Diabetes

ATP-Sensitive Potassium Channels in Hyperinsulinism and Type 2 Diabetes: Inconvenient Paradox or New Paradigm?

43-OR: Islet Autophagic Flux Is Impaired Prior to the Onset of Type 1 Diabetes

86-OR: High-Fat Diet Prevents Autoimmune Diabetes in NOD Mice

1789-P: Inactivation of Acyl-Protein Thioesterase 1, a Major Mediator of Palmitoylation Cycling, Promotes Insulin Secretion and ß-Cell Failure

334-LB: Dapagliflozin, a SGLT2 Inhibitor, Therapy Improves ß-Cell Function in Neonatal Diabetes by Reducing Oxidative and ER Stress, and Loss of ß-Cell Identity

Mechanisms Underlying the Progressive Loss of Beta-Cell Function and Mass in Neonatal Diabetes Are Reverted by Dapagliflozin Therapy

Beta-Cell Glucotoxicity in K_ATP-Induced Diabetes Is Alleviated by Genetic Reduction of Glucose Metabolism

Dextrose-Sulfonylurea Challenge as a Screening Test for Monogenic Diabetes in Patients Diagnosed with Type 1 Diabetes

Glycogen Synthase Kinase-3 and Mammalian Target of Rapamycin Pathways Contribute to DNA Synthesis, Cell Cycle Progression, and Proliferation in Human Islets

Expression of ATP-Insensitive K_ATP Channels in Pancreatic β-Cells Underlies a Spectrum of Diabetic Phenotypes

ATP-Sensitive K⁺ Channel Signaling in Glucokinase-Deficient Diabetes

ATP and Sulfonylurea Sensitivity of Mutant ATP-Sensitive K⁺ Channels in Neonatal Diabetes: Implications for Pharmacogenomic Therapy

Signaling Elements Involved in the Metabolic Regulation of mTOR by Nutrients, Incretins, and Growth Factors in Islets

Diet-Induced Glucose Intolerance in Mice With Decreased β-Cell ATP-Sensitive K⁺ Channels

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