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Mark A Magnuson
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Journal Articles

An Enhancer Within Abcb11 Regulates G6pc2 in C57BL/6 Mouse Pancreatic Islets

Mark P. Keller, Emily M. Hawes, Kathryn L. Schueler, Donnie S. Stapleton, Kelly A. Mitok, Shane P. Simonett, James K. Oeser, Leesa L. Sampson, Alan D. Attie, Mark A. Magnuson, Richard M. O’Brien
Journal: Diabetes
Diabetes 2023;72(11):1621–1628
https://doi.org/10.2337/db23-0215
Published: 08 August 2023
View article titled, An Enhancer Within <em>Abcb11</em> Regulates <em>G6pc2</em> in C57BL/6 Mouse Pancreatic Islets
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Journal Articles

Franz Matschinsky, MD (1931–2022): Paragon of Scientific Rigor and Curiosity Who Discovered Glucokinase as the Pancreatic Glucose Sensor

Mitchell A. Lazar, Mark A. Magnuson, Klaus H. Kaestner
Journal: Diabetes
Diabetes 2022;71(10):2078–2083
https://doi.org/10.2337/dbi22-0017
Published: 12 September 2022
View article titled, Franz Matschinsky, MD (1931–2022): Paragon of Scientific Rigor and Curiosity Who Discovered Glucokinase as the Pancreatic Glucose Sensor
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Journal Articles

Glucose Regulates Microtubule Disassembly and the Dose of Insulin Secretion via Tau Phosphorylation

Kung-Hsien Ho, Xiaodun Yang, Anna B. Osipovich, Over Cabrera, Mansuo L. Hayashi, Mark A. Magnuson, Guoqiang Gu, Irina Kaverina
Journal: Diabetes
Diabetes 2020;69(9):1936–1947
https://doi.org/10.2337/db19-1186
Published: 15 June 2020
View article titled, Glucose Regulates Microtubule Disassembly and the Dose of Insulin Secretion via Tau Phosphorylation
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Journal Articles

Excitotoxicity and Overnutrition Additively Impair Metabolic Function and Identity of Pancreatic β-Cells

Anna B. Osipovich, Jennifer S. Stancill, Jean-Philippe Cartailler, Karrie D. Dudek, Mark A. Magnuson
Journal: Diabetes
Diabetes 2020;69(7):1476–1491
https://doi.org/10.2337/db19-1145
Published: 24 April 2020
View article titled, Excitotoxicity and Overnutrition Additively Impair Metabolic Function and Identity of Pancreatic β-Cells
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Journal Articles

The Pdx1-Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet β-Cell Function

Jason M. Spaeth, Jin-Hua Liu, Daniel Peters, Min Guo, Anna B. Osipovich, Fardin Mohammadi, Nilotpal Roy, Anil Bhushan, Mark A. Magnuson, Matthias Hebrok, Christopher V.E. Wright, Roland Stein
Journal: Diabetes
Diabetes 2019;68(9):1806–1818
https://doi.org/10.2337/db19-0349
Published: 14 June 2019
View article titled, The Pdx1-Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet β-Cell Function
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Includes: Supplementary data
Journal Articles

Defining a Novel Role for the Pdx1 Transcription Factor in Islet β-Cell Maturation and Proliferation During Weaning

Jason M. Spaeth, Manisha Gupte, Mark Perelis, Yu-Ping Yang, Holly Cyphert, Shuangli Guo, Jin-Hua Liu, Min Guo, Joseph Bass, Mark A. Magnuson, Christopher Wright, Roland Stein
Journal: Diabetes
Diabetes 2017;66(11):2830–2839
https://doi.org/10.2337/db16-1516
Published: 13 July 2017
View article titled, Defining a Novel Role for the Pdx1 Transcription Factor in Islet β-Cell Maturation and Proliferation During Weaning
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Includes: Supplementary data
Journal Articles

Chronic β-Cell Depolarization Impairs β-Cell Identity by Disrupting a Network of Ca2+-Regulated Genes

Jennifer S. Stancill, Jean-Philippe Cartailler, Hannah W. Clayton, James T. O’Connor, Matthew T. Dickerson, Prasanna K. Dadi, Anna B. Osipovich, David A. Jacobson, Mark A. Magnuson
Journal: Diabetes
Diabetes 2017;66(8):2175–2187
https://doi.org/10.2337/db16-1355
Published: 26 May 2017
View article titled, Chronic β-Cell Depolarization Impairs β-Cell Identity by Disrupting a Network of Ca<sup>2+</sup>-Regulated Genes
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Includes: Supplementary data
Journal Articles

Activation of FoxM1 Revitalizes the Replicative Potential of Aged β-Cells in Male Mice and Enhances Insulin Secretion

Maria L. Golson, Jennifer C. Dunn, Matthew F. Maulis, Prasanna K. Dadi, Anna B. Osipovich, Mark A. Magnuson, David A. Jacobson, Maureen Gannon
Journal: Diabetes
Diabetes 2015;64(11):3829–3838
https://doi.org/10.2337/db15-0465
Published: 06 August 2015
View article titled, Activation of FoxM1 Revitalizes the Replicative Potential of Aged β-Cells in Male Mice and Enhances Insulin Secretion
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Includes: Supplementary data
Journal Articles

Response to Comment on: Kumar et al. Fat Cell–Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism. Diabetes 2010;59:1397–1406

Anil Kumar, Susanna R. Keller, Jason K. Kim, Mark A. Magnuson, Thurl E. Harris
Journal: Diabetes
Diabetes 2011;60(4):e15
https://doi.org/10.2337/db11-0135
Published: 22 March 2011
View article titled, Response to Comment on: Kumar et al. Fat Cell–Specific Ablation of <em>Rictor</em> in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism. Diabetes 2010;59:1397–1406
Open the PDF for Response to Comment on: Kumar et al. Fat Cell–Specific Ablation of <em>Rictor</em> in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism. Diabetes 2010;59:1397–1406 in another window
Journal Articles

Rictor/mTORC2 Is Essential for Maintaining a Balance Between β-Cell Proliferation and Cell Size

Yanyun Gu, Jill Lindner, Anil Kumar, Weiping Yuan, Mark A. Magnuson
Journal: Diabetes
Diabetes 2011;60(3):827–837
https://doi.org/10.2337/db10-1194
Published: 21 February 2011
View article titled, Rictor/mTORC2 Is Essential for Maintaining a Balance Between β-Cell Proliferation and Cell Size
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Includes: Supplementary data
Journal Articles

MafA and MafB Regulate Genes Critical to β-Cells in a Unique Temporal Manner

Isabella Artner, Yan Hang, Magdalena Mazur, Tsunehiko Yamamoto, Min Guo, Jill Lindner, Mark A. Magnuson, Roland Stein
Journal: Diabetes
Diabetes 2010;59(10):2530–2539
https://doi.org/10.2337/db10-0190
Published: 13 July 2010
View article titled, MafA and MafB Regulate Genes Critical to β-Cells in a Unique Temporal Manner
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Includes: Supplementary data
Journal Articles

Fat Cell–Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism

Anil Kumar, John C. Lawrence, Jr., Dae Young Jung, Hwi Jin Ko, Susanna R. Keller, Jason K. Kim, Mark A. Magnuson, Thurl E. Harris
Journal: Diabetes
Diabetes 2010;59(6):1397–1406
https://doi.org/10.2337/db09-1061
Published: 23 March 2010
View article titled, Fat Cell–Specific Ablation of <em>Rictor</em> in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism
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Includes: Supplementary data
Journal Articles

The Network of Glucokinase-Expressing Cells in Glucose Homeostasis and the Potential of Glucokinase Activators for Diabetes Therapy

Franz M. Matschinsky, Mark A. Magnuson, Dorothy Zelent, Tom L. Jetton, Nicolai Doliba, Yi Han, Rebecca Taub, Joseph Grimsby
Journal: Diabetes
Diabetes 2006;55(1):1–12
https://doi.org/10.2337/diabetes.55.01.06.db05-0926
Published: 01 January 2006
View article titled, The Network of Glucokinase-Expressing Cells in Glucose Homeostasis and the Potential of Glucokinase Activators for Diabetes Therapy
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Journal Articles

Targeted Inactivation of Hepatocyte Growth Factor Receptor c-met in β-Cells Leads to Defective Insulin Secretion and GLUT-2 Downregulation Without Alteration of β-Cell Mass

Jennifer Roccisana, Vasumathi Reddy, Rupangi C. Vasavada, Jose A. Gonzalez-Pertusa, Mark A. Magnuson, Adolfo Garcia-Ocaña
Journal: Diabetes
Diabetes 2005;54(7):2090–2102
https://doi.org/10.2337/diabetes.54.7.2090
Published: 01 July 2005
View article titled, Targeted Inactivation of Hepatocyte Growth Factor Receptor c-met in β-Cells Leads to Defective Insulin Secretion and GLUT-2 Downregulation Without Alteration of β-Cell Mass
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Journal Articles

Insights Into the Biochemical and Genetic Basis of Glucokinase Activation From Naturally Occurring Hypoglycemia Mutations

Anna L. Gloyn, Kees Noordam, Michèl A.A.P. Willemsen, Sian Ellard, Wayne W.K. Lam, Ian W. Campbell, Paula Midgley, Chyio Shiota, Carol Buettger, Mark A. Magnuson, Franz M. Matschinsky, Andrew T. Hattersley
Journal: Diabetes
Diabetes 2003;52(9):2433–2440
https://doi.org/10.2337/diabetes.52.9.2433
Published: 01 September 2003
View article titled, Insights Into the Biochemical and Genetic Basis of Glucokinase Activation From Naturally Occurring Hypoglycemia Mutations
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Journal Articles

Mechanisms by Which Liver-Specific PEPCK Knockout Mice Preserve Euglycemia During Starvation

Pengxiang She, Shawn C. Burgess, Masakazu Shiota, Paul Flakoll, E. Patrick Donahue, Craig R. Malloy, A. Dean Sherry, Mark A. Magnuson
Journal: Diabetes
Diabetes 2003;52(7):1649–1654
https://doi.org/10.2337/diabetes.52.7.1649
Published: 01 July 2003
View article titled, Mechanisms by Which Liver-Specific PEPCK Knockout Mice Preserve Euglycemia During Starvation
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Journal Articles

The Second Activating Glucokinase Mutation (A456V): Implications for Glucose Homeostasis and Diabetes Therapy

Henrik B.T. Christesen, Bendt B. Jacobsen, Stella Odili, Carol Buettger, Antonio Cuesta-Munoz, Torben Hansen, Klaus Brusgaard, Ornella Massa, Mark A. Magnuson, Chiyo Shiota, Franz M. Matschinsky, Fabrizio Barbetti
Journal: Diabetes
Diabetes 2002;51(4):1240–1246
https://doi.org/10.2337/diabetes.51.4.1240
Published: 01 April 2002
View article titled, The Second Activating Glucokinase Mutation (A456V): <subtitle>Implications for Glucose Homeostasis and Diabetes Therapy </subtitle>
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Journal Articles

Glucokinase Gene Locus Transgenic Mice Are Resistant to the Development of Obesity-Induced Type 2 Diabetes

Masakazu Shiota, Catherine Postic, Yuka Fujimoto, Thomas L. Jetton, Kathryn Dixon, Danhua Pan, Joseph Grimsby, Joseph F. Grippo, Mark A. Magnuson, Alan D. Cherrington
Journal: Diabetes
Diabetes 2001;50(3):622–629
https://doi.org/10.2337/diabetes.50.3.622
Published: 01 March 2001
View article titled, Glucokinase Gene Locus Transgenic Mice Are Resistant to the Development of Obesity-Induced Type 2 Diabetes
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Journal Articles

Effects of Glucose on Insulin Secretion, Glucokinase Activity, and Transgene Expression in Transgenic Mouse Islets Containing an Upstream Glucokinase Promoter-Human Growth Hormone Fusion Gene

Yin Liang, Thomas L Jetton, Elisabeth C Zimmerman, Habiba Najafi, Donna K Berner, Franz M Matschinsky, Mark A Magnuson
Journal: Diabetes
Diabetes 1994;43(9):1138–1145
https://doi.org/10.2337/diab.43.9.1138
Published: 01 September 1994
View article titled, Effects of Glucose on Insulin Secretion, Glucokinase Activity, and Transgene Expression in Transgenic Mouse Islets Containing an Upstream Glucokinase Promoter-Human Growth Hormone Fusion Gene
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Journal Articles

Concordant Glucose Induction of Glucokinase, Glucose Usage, and Glucose-Stimulated Insulin Release in Pancreatic Islets Maintained in Organ Culture

Yin Liang, Habiba Najafi, Robert M Smith, Elisabeth C Zimmerman, Mark A Magnuson, Michael Tal, Franz M Matschinsky
Journal: Diabetes
Diabetes 1992;41(7):792–806
https://doi.org/10.2337/diab.41.7.792
Published: 01 July 1992
View article titled, Concordant Glucose Induction of Glucokinase, Glucose Usage, and Glucose-Stimulated Insulin Release in Pancreatic Islets Maintained in Organ Culture
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