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Meeting Abstracts

74-OR: ADA Presidents' Select Abstract: CGM Metrics from Five Studies Identify Participants at High Risk of Imminent Type 1 Diabetes (T1D) Development

PETER CALHOUN, CHARLEY SPANBAUER, ANDREA STECK, BRIGITTE I. FROHNERT, MARK A. HERMAN, BART KEYMEULEN, SR., RIITTA VEIJOLA, JORMA TOPPARI, ASTER DESOUTER, FRANS K. GORUS, MARK A. ATKINSON, DARRELL M. WILSON, SUSAN PIETROPAOLO, ROY BECK

Diabetes 2024;73(Supplement_1):74-OR

https://doi.org/10.2337/db24-74-OR

Published: 21 June 2024

View article titled, 74-OR: ADA Presidents' Select Abstract: CGM Metrics from Five Studies Identify Participants at High Risk of Imminent Type 1 Diabetes (T1D) Development

Meeting Abstracts

1960-LB: A 3D Analysis of CD8+ Leukocytic Infiltration in Human Endocrine and Exocrine Pancreas at Type 1 Diabetes Onset

ALEXANDRA RIPPA, DENISE M. DROTAR, AMANDA POSGAI, MAIGAN A. HULME, CLIVE WASSERFALL, IRINA KUSMARTSEVA, MARTHA CAMPBELL-THOMPSON, MARK A. ATKINSON

Diabetes 2024;73(Supplement_1):1960-LB

https://doi.org/10.2337/db24-1960-LB

Published: 14 June 2024

View article titled, 1960-LB: A 3D Analysis of CD8+ Leukocytic Infiltration in Human Endocrine and Exocrine Pancreas at Type 1 Diabetes Onset

Meeting Abstracts

98-OR: ß-Cell Dysfunction and Mitochondrial Loss Occur Independently of Insulitis in Type 1 Diabetes Pathogenesis

MOLLIE HUBER, ADRIENNE WIDENER, DYLAN SMURLICK, HELMUT HILLER, SR., MARIA BEERY, ELLEN VERNEY, IRINA KUSMARTSEVA, MARTHA CAMPBELL-THOMPSON, MARK A. ATKINSON, CLAYTON E. MATHEWS, EDWARD PHELPS

Diabetes 2024;73(Supplement_1):98-OR

https://doi.org/10.2337/db24-98-OR

Published: 14 June 2024

View article titled, 98-OR: ß-Cell Dysfunction and Mitochondrial Loss Occur Independently of Insulitis in Type 1 Diabetes Pathogenesis

Meeting Abstracts

1455-P: The Oral Disposition Index (ODI) and Its Components during the Progression of Autoantibody-Positive (Ab+) Individuals to Type 1 Diabetes (T1D)

HEBA M. ISMAIL, DAVID D. CUTHBERTSON, LAURA M. JACOBSEN, MARK A. ATKINSON, INGRID LIBMAN, MARIA J. REDONDO, JAY SOSENKO

Diabetes 2024;73(Supplement_1):1455-P

https://doi.org/10.2337/db24-1455-P

Published: 14 June 2024

View article titled, 1455-P: The Oral Disposition Index (ODI) and Its Components during the Progression of Autoantibody-Positive (Ab+) Individuals to Type 1 Diabetes (T1D)

Meeting Abstracts

1318-P: Postprandial C-Peptide (pCP) in Provider-Diagnosed Pediatric Type 1 Diabetes (T1D) and Type 2 Diabetes (T2D)

MARIA J. REDONDO, KYLIE K. HARRALL, SARAH M. BIRD, MUSTAFA TOSUR, SERIFE UYSAL, ALEJANDRO F. SILLER, HORACIO J. VELASQUEZ, ANDREW MUIR, KENDRA VEHIK, TODD M. BRUSKO, MARK A. ATKINSON, DANA DABELEA, WILLIAM HAGOPIAN, RICHARD A. ORAM

Diabetes 2024;73(Supplement_1):1318-P

https://doi.org/10.2337/db24-1318-P

Published: 14 June 2024

View article titled, 1318-P: Postprandial C-Peptide (pCP) in Provider-Diagnosed Pediatric Type 1 Diabetes (T1D) and Type 2 Diabetes (T2D)

Meeting Abstracts

1997-LB: Curation of an AI-Ready Dataset Using Domain-Informed Features Derived from Type 1 Diabetes TrialNet Studies

ERIN M. TALLON, MELANIE R. SHAPIRO, AMEY SHRIKRISHNA WAGHMODE, RYAN MERRITT, CLIVE WASSERFALL, RHONDA BACHER, BRENT LOCKEE, CRAIG VANDERVELDEN, KELSEY PANFIL, WAYNE V. MOORE, MARK A. ATKINSON, TODD M. BRUSKO, MARK A. CLEMENTS

Diabetes 2024;73(Supplement_1):1997-LB

https://doi.org/10.2337/db24-1997-LB

Published: 14 June 2024

View article titled, 1997-LB: Curation of an AI-Ready Dataset Using Domain-Informed Features Derived from Type 1 Diabetes TrialNet Studies

Journal Articles

Bridging the Gap: Pancreas Tissue Slices From Organ and Tissue Donors for the Study of Diabetes Pathogenesis

Christian M. Cohrs, Chunguang Chen, Mark A. Atkinson, Denise M. Drotar, Stephan Speier

Diabetes 2024;73(1):11–22

https://doi.org/10.2337/dbi20-0018

Published: 20 December 2023

View article titled, Bridging the Gap: Pancreas Tissue Slices From Organ and Tissue Donors for the Study of Diabetes Pathogenesis

Meeting Abstracts

1298-P: Independent Associations of GAD65, IA2, and ZnT8 Autoantibody (Ab) Positivity with C-Peptide (CPep) in a Diverse Cohort of Youth with Diabetes (DM)

MARIA J. REDONDO, KYLIE K. HARRALL, DEBORAH H. GLUECK, MUSTAFA TOSUR, SERIFE UYSAL, ANDREW MUIR, KENDRA VEHIK, TODD M. BRUSKO, MARK A. ATKINSON, RICHARD A. ORAM, DANA DABELEA, WILLIAM HAGOPIAN, DISCOVER STUDY GROUP

Diabetes 2023;72(Supplement_1):1298-P

https://doi.org/10.2337/db23-1298-P

Published: 20 June 2023

View article titled, 1298-P: Independent Associations of GAD65, IA2, and ZnT8 Autoantibody (Ab) Positivity with C-Peptide (CPep) in a Diverse Cohort of Youth with Diabetes (DM)

Journal Articles

Incidence Trends of New-Onset Diabetes in Children and Adolescents Before and During the COVID-19 Pandemic: Findings From Florida

Yi Guo, Jiang Bian, Aokun Chen, Fei Wang, Amanda L. Posgai, Desmond A. Schatz, Elizabeth A. Shenkman, Mark A. Atkinson

Diabetes 2022;71(12):2702–2706

https://doi.org/10.2337/db22-0549

Published: 12 September 2022

View article titled, Incidence Trends of New-Onset Diabetes in Children and Adolescents Before and During the COVID-19 Pandemic: Findings From Florida

Meeting Abstracts

253-LB: Ethnic Differences in Pancreatic Hormone Secretion in Health and T2D

NICOLAI M. DOLIBA, JEFFREY ROMAN, ANDREA V. ROZO, WEI QIN, CHENGYANG LIU, ALI NAJI, MICHAEL R. RICKELS, MARK A. ATKINSON, ALVIN C. POWERS, MARCELA BRISSOVA, KLAUS H. KAESTNER, DORIS A. STOFFERS

Diabetes 2022;71(Supplement_1):253-LB

https://doi.org/10.2337/db22-253-LB

Published: 01 June 2022

View article titled, 253-LB: Ethnic Differences in Pancreatic Hormone Secretion in Health and T2D

Meeting Abstracts

1024-P: Identification of Sex-Specific Cytokine and Viral Infection Profiles in Type 1 Diabetes Patients

KHYATI GIRDHAR, ALEJANDRA PINA, JELENA MOMIROV, MARK A. ATKINSON, JASON LADNER, EMRAH ALTINDIS

Diabetes 2022;71(Supplement_1):1024-P

https://doi.org/10.2337/db22-1024-P

Published: 01 June 2022

View article titled, 1024-P: Identification of Sex-Specific Cytokine and Viral Infection Profiles in Type 1 Diabetes Patients

Meeting Abstracts

296-OR: Single-Cell Multiomic Analysis of the Human Pancreas in Type 1 Diabetes

REBECCA MELTON, ELISHA BEEBE, CHUN ZENG, MICHAEL T. MILLER, GAOWEI WANG, CAROLYN MCGRAIL, HANNAH MUMMEY, IRINA KUSMARTSEVA, MARK A. ATKINSON, SEBASTIAN PREISSL, MAIKE SANDER, KYLE J. GAULTON

Diabetes 2022;71(Supplement_1):296-OR

https://doi.org/10.2337/db22-296-OR

Published: 01 June 2022

View article titled, 296-OR: Single-Cell Multiomic Analysis of the Human Pancreas in Type 1 Diabetes

Meeting Abstracts

825-P: Composite Glucose and C-Peptide Endpoints Show Early Efficacy in Recent-Onset Type 1 Diabetes (T1D) Clinical Trials

LAURA M. JACOBSEN, DAVID D. CUTHBERTSON, MICHAEL J. HALLER, HEBA M. ISMAIL, EMILY K. SIMS, STEPHEN E. GITELMAN, DIANE K. WHERRETT, ANTOINETTE MORAN, MARK A. ATKINSON, ALBERTO PUGLIESE, PETER GOTTLIEB, JAY SOSENKO

Diabetes 2022;71(Supplement_1):825-P

https://doi.org/10.2337/db22-825-P

Published: 01 June 2022

View article titled, 825-P: Composite Glucose and C-Peptide Endpoints Show Early Efficacy in Recent-Onset Type 1 Diabetes (T1D) Clinical Trials

Meeting Abstracts

187-OR: Declines in ß-Cell Glucose Responsiveness Correlate with Loss of Glucose Metabolism during T1D Pathogenesis

MOLLIE HUBER, MARJAN SLAK RUPNIK, DENISE M. DROTAR, HELMUT HILLER, SR., MARIA BEERY, IRINA KUSMARTSEVA, MARK A. ATKINSON, EDWARD PHELPS, CLAYTON E. MATHEWS

Diabetes 2022;71(Supplement_1):187-OR

https://doi.org/10.2337/db22-187-OR

Published: 01 June 2022

View article titled, 187-OR: Declines in ß-Cell Glucose Responsiveness Correlate with Loss of Glucose Metabolism during T1D Pathogenesis

Meeting Abstracts

63-OR: A Model-Based Clinical Trial Simulation Tool to Optimize Clinical Trial Designs for Type 1 Diabetes Prevention Studies

JUAN F. MORALES, RHODA MUSE, JAGDEEP PODICHETTY, JACKSON BURTON, SARAH DAVID, FRANCIS MARTIN, MARK A. ATKINSON, MICHAEL J. HALLER, MARTHA CAMPBELL-THOMPSON, KLAUS ROMERO, INISH O'DOHERTY, STEPHAN SCHMIDT, SARAH KIM

Diabetes 2022;71(Supplement_1):63-OR

https://doi.org/10.2337/db22-63-OR

Published: 01 June 2022

View article titled, 63-OR: A Model-Based Clinical Trial Simulation Tool to Optimize Clinical Trial Designs for Type 1 Diabetes Prevention Studies

Meeting Abstracts

1229-P: Participation of Hispanic (Hisp) and African-American (AA) Youth in an Observational Study in Diabetes

MARIA J. REDONDO, MUSTAFA TOSUR, SERIFE UYSAL, ANDREW B. MUIR, SANIA IFTEKHAR, SAIMA DEEN, DANIEL J. PERRY, KYLIE K. HARRALL, DEBORAH H. GLUECK, KENDRA VEHIK, RICHARD A. ORAM, WILLIAM HAGOPIAN, DANA DABELEA, MARK A. ATKINSON, RACE (DISCOVER) DIABETES STUDY IN CHILDREN OF DIVERSE ETHNICITY

Diabetes 2022;71(Supplement_1):1229-P

https://doi.org/10.2337/db22-1229-P

Published: 01 June 2022

View article titled, 1229-P: Participation of Hispanic (Hisp) and African-American (AA) Youth in an Observational Study in Diabetes

Meeting Abstracts

11-OR: Transcriptome Heterogeneity in Insulin-Positive Insulitic vs. Noninsulitic Human Islets in Type 1 Diabetes (T1D)

ALYSSA M. DYE, GRACE ASHBERY, NATALIYA I. LENCHIK, MARK A. ATKINSON, CLAYTON E. MATHEWS, MARTHA CAMPBELL-THOMPSON, IVAN C. GERLING

Diabetes 2022;71(Supplement_1):11-OR

https://doi.org/10.2337/db22-11-OR

Published: 01 June 2022

View article titled, 11-OR: Transcriptome Heterogeneity in Insulin-Positive Insulitic vs. Noninsulitic Human Islets in Type 1 Diabetes (T1D)

Meeting Abstracts

9-OR: ADA Presidents' Select Abstract: m6A mRNA Methylation Regulates the Innate Immune Response in Human Beta Cells

DARIO F. DE JESUS, ZIJIE ZHANG, NATALIE K. BROWN, GIORGIO BASILE, LING XIAO, SEVIM KAHRAMAN, CLAYTON E. MATHEWS, ALVIN C. POWERS, MARK A. ATKINSON, DECIO L. EIZIRIK, ROHIT KULKARNI

Diabetes 2022;71(Supplement_1):9-OR

https://doi.org/10.2337/db22-9-OR

Published: 01 June 2022

View article titled, 9-OR: ADA Presidents' Select Abstract: m6A mRNA Methylation Regulates the Innate Immune Response in Human Beta Cells

Meeting Abstracts

1257-P: Associations of Five-Year Type 1 Diabetes (T1D) Risk with Predictors Using Cross-Sample Validation

HEBA M. ISMAIL, DAVID D. CUTHBERTSON, MARK A. ATKINSON, MARIA J. REDONDO, JAY SOSENKO, TYPE 1 DIABETES TRIALNET

Diabetes 2022;71(Supplement_1):1257-P

https://doi.org/10.2337/db22-1257-P

Published: 01 June 2022

View article titled, 1257-P: Associations of Five-Year Type 1 Diabetes (T1D) Risk with Predictors Using Cross-Sample Validation

Meeting Abstracts

1262-P: Developing a Computable Phenotype Algorithm for Identification of Children and Adolescents with Diabetes Using Electronic Health Records

Diabetes 2022;71(Supplement_1):1262-P

https://doi.org/10.2337/db22-1262-P

Published: 01 June 2022

View article titled, 1262-P: Developing a Computable Phenotype Algorithm for Identification of Children and Adolescents with Diabetes Using Electronic Health Records

NARROW

74-OR: ADA Presidents' Select Abstract: CGM Metrics from Five Studies Identify Participants at High Risk of Imminent Type 1 Diabetes (T1D) Development

1960-LB: A 3D Analysis of CD8+ Leukocytic Infiltration in Human Endocrine and Exocrine Pancreas at Type 1 Diabetes Onset

98-OR: ß-Cell Dysfunction and Mitochondrial Loss Occur Independently of Insulitis in Type 1 Diabetes Pathogenesis

1455-P: The Oral Disposition Index (ODI) and Its Components during the Progression of Autoantibody-Positive (Ab+) Individuals to Type 1 Diabetes (T1D)

1318-P: Postprandial C-Peptide (pCP) in Provider-Diagnosed Pediatric Type 1 Diabetes (T1D) and Type 2 Diabetes (T2D)

1997-LB: Curation of an AI-Ready Dataset Using Domain-Informed Features Derived from Type 1 Diabetes TrialNet Studies

Bridging the Gap: Pancreas Tissue Slices From Organ and Tissue Donors for the Study of Diabetes Pathogenesis

1298-P: Independent Associations of GAD65, IA2, and ZnT8 Autoantibody (Ab) Positivity with C-Peptide (CPep) in a Diverse Cohort of Youth with Diabetes (DM)

Incidence Trends of New-Onset Diabetes in Children and Adolescents Before and During the COVID-19 Pandemic: Findings From Florida

253-LB: Ethnic Differences in Pancreatic Hormone Secretion in Health and T2D

1024-P: Identification of Sex-Specific Cytokine and Viral Infection Profiles in Type 1 Diabetes Patients

296-OR: Single-Cell Multiomic Analysis of the Human Pancreas in Type 1 Diabetes

825-P: Composite Glucose and C-Peptide Endpoints Show Early Efficacy in Recent-Onset Type 1 Diabetes (T1D) Clinical Trials

187-OR: Declines in ß-Cell Glucose Responsiveness Correlate with Loss of Glucose Metabolism during T1D Pathogenesis

63-OR: A Model-Based Clinical Trial Simulation Tool to Optimize Clinical Trial Designs for Type 1 Diabetes Prevention Studies

1229-P: Participation of Hispanic (Hisp) and African-American (AA) Youth in an Observational Study in Diabetes

11-OR: Transcriptome Heterogeneity in Insulin-Positive Insulitic vs. Noninsulitic Human Islets in Type 1 Diabetes (T1D)

9-OR: ADA Presidents' Select Abstract: m6A mRNA Methylation Regulates the Innate Immune Response in Human Beta Cells

1257-P: Associations of Five-Year Type 1 Diabetes (T1D) Risk with Predictors Using Cross-Sample Validation

1262-P: Developing a Computable Phenotype Algorithm for Identification of Children and Adolescents with Diabetes Using Electronic Health Records

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