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Journal Articles

Immune and Metabolic Effects of Antigen-Specific Immunotherapy Using Multiple β-Cell Peptides in Type 1 Diabetes

Yuk-Fun Liu, Jake Powrie, Sefina Arif, Jennie H.M. Yang, Evangelia Williams, Leena Khatri, Mamta Joshi, Loic Lhuillier, Nikolaos Fountoulakis, Emma Smith, Craig Beam, Anna Lorenc, Mark Peakman, Timothy Tree

Diabetes 2022;71(4):722–732

https://doi.org/10.2337/db21-0728

Published: 24 January 2022

View article titled, Immune and Metabolic Effects of Antigen-Specific Immunotherapy Using Multiple β-Cell Peptides in Type 1 Diabetes

Journal Articles

Low-Dose Anti-Thymocyte Globulin Preserves C-Peptide, Reduces HbA_1c, and Increases Regulatory to Conventional T-Cell Ratios in New-Onset Type 1 Diabetes: Two-Year Clinical Trial Data

Michael J. Haller, S. Alice Long, J. Lori Blanchfield, Desmond A. Schatz, Jay S. Skyler, Jeffrey P. Krischer, Brian N. Bundy, Susan M. Geyer, Megan V. Warnock, Jessica L. Miller, Mark A. Atkinson, Dorothy J. Becker, David A. Baidal, Linda A. DiMeglio, Stephen E. Gitelman, Robin Goland, Peter A. Gottlieb, Kevan C. Herold, Jennifer B. Marks, Antoinette Moran, Henry Rodriguez, William E. Russell, Darrell M. Wilson, Carla J. Greenbaum, Type 1 Diabetes TrialNet ATG-GCSF Study Group, Carla J. Greenbaum, Mark A. Atkinson, David A. Baidal, Manuela Battaglia, Dorothy Becker, Penelope Bingley, Emanuele Bosi, Jane Buckner, Mark Clements, Peter G. Colman, Linda DiMeglio, Carmella Evans-Molina, Stephen E. Gitelman, Robin Goland, Peter Gottlieb, Kevan Herold, Mikael Knip, Jeffrey P. Krischer, Ake Lernmark, Wayne Moore, Antoinette Moran, Andrew Muir, Jerry Palmer, Mark Peakman, Louis Philipson, Philip Raskin, Maria Redondo, Henry Rodriguez, William Russell, Desmond A. Schatz, Jay M. Sosenko, Lisa Spain, John Wentworth, Diane Wherrett, Darrell M. Wilson, William Winter, Anette Ziegler, Mark Anderson, Peter Antinozzi, Richard Insel, Thomas Kay, Jennifer B. Marks, Alberto Pugliese, Bart Roep, Jay S. Skyler, Jorma Toppari, Carla J. Greenbaum, Jeffrey P. Krischer, Ellen Leschek, Lisa Spain, Katarzyna Bourcier, Richard Insel, John Ridge, Jay S. Skyler, Carla J. Greenbaum, Lisa Rafkin, Jay M. Sosenko, Jay S. Skyler, Irene Santiago, Jeffrey P. Krischer, Brian Bundy, Michael Abbondondolo, Timothy Adams, Ilma Asif, Jenna Bjellquist, Matthew Boonstra, Cristina Burroughs, Mario Cleves, David Cuthbertson, Meagan DeSalvatore, Christopher Eberhard, Steve Fiske, Julie Ford, Jennifer Garmeson, Susan Geyer, Brian Hays, Courtney Henderson, Martha Henry, Kathleen Heyman, Belinda Hsiao, Christina Karges, Beata-Gabriela Koziol, Lindsay Lane, Shu Liu, Jennifer Lloyd, Kristin Maddox, Jamie Malloy, Julie Martin, Cameron McNeill, Margaret Moore, Sarah Muller, Thuy Nguyen, Jodie Nunez, Ryan O’Donnell, Melissa Parker, M.J. Pereyra, Amy Roberts, Kelly Sadler, Christine Sullivan, Roy Tamura, Elon Walker-Veras, Megan V. Warnock, Keith Wood, Rebecca Wood, Ping Xu, Vanessa Yanek, Kenneth Young, Darlene Amado, Amanda Kinderman, Ashley Leinbach, Jessica Miller, Nichole Reed, Tina Stavros, Ellen Leschek, Lisa Spain, Emily Blumberg, Sean Aas, Gerald Beck, Rose Gubitosi-Klug, Lori Laffel, Robert Vigersky, Dennis Wallace, David Brillon, Robert Veatch, Brett Loechelt, Lindsey Baden, Peter Gottlieb, Michael Green, Ellen Leschek, Adriana Weinberg, Santica Marcovina, Jerry P. Palmer, Jay Tischfield, Adriana Weinberg, William Winter, Liping Yu, Annie Shultz, Emily Batts, Arielle Pagryzinski, Mary Ramey, Meghan Tobin, Kristin Fitzpatrick, Randy Guerra, Melita Romasco, Christopher Webb, Peter Gottlieb, Maya Barr, Mary Drye, Jordan Lykens, Aaron Michels, Allison Schauwecker, Andrea Steck, Paul Wadwa, Carla J. Greenbaum, Jane Buckner, Wei Hao, Sandra Lord, Marli McCulloch-Olson, Mary Ramey, Elaine Sachter, Jenna Snavely, Meghan Tobin, Corinna Tordillos, Dana VanBuecken, Robin Goland, Analia Alvarez, Magdalena Bogun, Rachelle Gandica, Natasha Leibel, Sarah Pollak, Barney Softness, Kristen Williams, Bryce Nelson, James Amrhein, Lisa Looper, Elaine Moreland, Andrew Smith, Beth Weir, Lori Wise, Linda DiMeglio, Carmella Evans-Molina, Manasa Mantravadi, Maureen Mullen, Vanessa Patrick, Maria Spall, Stephanie Woerner, Darrell M. Wilson, Nora Arrizon-Ruiz, Tandy Aye, Laura Bachrach, Karen Barahona, Trudy Esrey, Laura Nally, Stephen E. Gitelman, Mark Anderson, Glenna Auerback, Jeanne Buchanan, Christine T. Ferrara, Karen Ko, Srinath Sanda, Christine Torok, Rebecca Wesch, Michael J. Haller, Anastasia Albanese-O'Neill, Todd Brusko, Miriam Cintron, Jennifer Hosford, Laura M. Jacobsen, Henry Rohrs, Desmond A. Schatz, Janet Silverstein, Paula Towe, David A. Baidal, Carlos Blaschke, Della Matheson, Janine Sanchez, Natalia Sanders-Branca, Jay S. Skyler, Jay M. Sosenko, Antoinette Moran, Janice Leschyshyn, Jennifer McVean, Brandon Nathan, Brittney Nelson, Beth Pappenfus, Jessica Ruedy, Anne Street, Muna Sunni, Darcy Weingartner, Dorothy Becker, Kelli DeLallo, Ana Diaz, David Groscost, Mary Beth Klein, Ingrid Libman, Karen Riley, Henry Rodriguez, Sureka Bollepalli, Rachel Brownstein, Emily Eyth, Danielle Henson, Michele Laine, Dorothy Shulman, William Russell, Faith Brendle, Anne Brown, Brenna Dixon, Justin Gregory, Dan Moore, James Thomas, Kevan Herold, Laurie Feldman, William Tamborlane

Diabetes 2019;68(6):1267–1276

https://doi.org/10.2337/db19-0057

Published: 09 April 2019

View article titled, Low-Dose Anti-Thymocyte Globulin Preserves C-Peptide, Reduces HbA1c, and Increases Regulatory to Conventional T-Cell Ratios in New-Onset Type 1 Diabetes: Two-Year Clinical Trial Data

Includes: Supplementary data

Meeting Abstracts

The MultiPepT1De Study—Examining the Safety of Peptide Immunotherapy Using Multiple Islet Antigens in Recent-Onset Type 1 Diabetes

YUK-FUN LIU, JAKE K. POWRIE, SEFINA ARIF, NIKOLAOS FOUNTOULAKIS, MAMTA JOSHI, EMMA L. SMITH, FOTEINI STRIMENOPOULOU, MOIRA THOMSON, MARK PEAKMAN

Diabetes 2018;67(Supplement_1):1733-P

https://doi.org/10.2337/db18-1733-P

Published: 01 July 2018

View article titled, The MultiPepT1De Study—Examining the Safety of Peptide Immunotherapy Using Multiple Islet Antigens in Recent-Onset Type 1 Diabetes

Journal Articles

Molecular Pathways for Immune Recognition of Preproinsulin Signal Peptide in Type 1 Diabetes

Deborah Kronenberg-Versteeg, Martin Eichmann, Mark A. Russell, Arnoud de Ru, Beate Hehn, Norkhairin Yusuf, Peter A. van Veelen, Sarah J. Richardson, Noel G. Morgan, Marius K. Lemberg, Mark Peakman

Diabetes 2018;67(4):687–696

https://doi.org/10.2337/db17-0021

Published: 17 January 2018

View article titled, Molecular Pathways for Immune Recognition of Preproinsulin Signal Peptide in Type 1 Diabetes

Includes: Supplementary data

Journal Articles

Discovery of a Selective Islet Peptidome Presented by the Highest-Risk HLA-DQ8trans Molecule

Menno van Lummel, Peter A. van Veelen, Arnoud H. de Ru, Jos Pool, Tatjana Nikolic, Sandra Laban, Antoinette Joosten, Jan W. Drijfhout, Iria Gómez-Touriño, Sefina Arif, Henk J. Aanstoot, Mark Peakman, Bart O. Roep

Diabetes 2016;65(3):732–741

https://doi.org/10.2337/db15-1031

Published: 30 December 2015

View article titled, Discovery of a Selective Islet Peptidome Presented by the Highest-Risk HLA-DQ8trans Molecule

Includes: Supplementary data

Journal Articles

Erratum. Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes. Diabetes 2014;63: 3835–3845

Sefina Arif, Pia Leete, Vy Nguyen, Katherine Marks, Nurhanani Mohamed Nor, Megan Estorninho, Deborah Kronenberg-Versteeg, Polly J. Bingley, John A. Todd, Catherine Guy, David B. Dunger, Jake Powrie, Abby Willcox, Alan K. Foulis, Sarah J. Richardson, Emanuele de Rinaldis, Noel G. Morgan, Anna Lorenc, Mark Peakman

Diabetes 2015;64(9):3334

https://doi.org/10.2337/db15-er09a

Published: 13 August 2015

View article titled, Erratum. Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes. Diabetes 2014;63: 3835–3845

Journal Articles

Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes

Diabetes 2014;63(11):3835–3845

https://doi.org/10.2337/db14-0365

Published: 13 October 2014

View article titled, Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes

Includes: Supplementary data

Journal Articles

β-Cell–Specific CD8 T Cell Phenotype in Type 1 Diabetes Reflects Chronic Autoantigen Exposure

Ania Skowera, Kristin Ladell, James E. McLaren, Garry Dolton, Katherine K. Matthews, Emma Gostick, Deborah Kronenberg-Versteeg, Martin Eichmann, Robin R. Knight, Susanne Heck, Jake Powrie, Polly J. Bingley, Colin M. Dayan, John J. Miles, Andrew K. Sewell, David A. Price, Mark Peakman

Diabetes 2015;64(3):916–925

https://doi.org/10.2337/db14-0332

Published: 22 September 2014

View article titled, β-Cell–Specific CD8 T Cell Phenotype in Type 1 Diabetes Reflects Chronic Autoantigen Exposure

Includes: Supplementary data

Journal Articles

Reduction in CD4 Central Memory T-Cell Subset in Costimulation Modulator Abatacept-Treated Patients With Recent-Onset Type 1 Diabetes Is Associated With Slower C-Peptide Decline

Tihamer Orban, Craig A. Beam, Ping Xu, Keith Moore, Qi Jiang, Jun Deng, Sarah Muller, Peter Gottlieb, Lisa Spain, Mark Peakman, the Type 1 Diabetes TrialNet Abatacept Study Group

Diabetes 2014;63(10):3449–3457

https://doi.org/10.2337/db14-0047

Published: 15 September 2014

View article titled, Reduction in CD4 Central Memory T-Cell Subset in Costimulation Modulator Abatacept-Treated Patients With Recent-Onset Type 1 Diabetes Is Associated With Slower C-Peptide Decline

Journal Articles

Posttranslational Modification of HLA-DQ Binding Islet Autoantigens in Type 1 Diabetes

Menno van Lummel, Gaby Duinkerken, Peter A. van Veelen, Arnoud de Ru, Robert Cordfunke, Arnaud Zaldumbide, Iria Gomez-Touriño, Sefina Arif, Mark Peakman, Jan W. Drijfhout, Bart O. Roep

Diabetes 2014;63(1):237–247

https://doi.org/10.2337/db12-1214

Published: 13 December 2013

View article titled, Posttranslational Modification of HLA-DQ Binding Islet Autoantigens in Type 1 Diabetes

Includes: Supplementary data

Journal Articles

Human β-Cell Killing by Autoreactive Preproinsulin-Specific CD8 T Cells Is Predominantly Granule-Mediated With the Potency Dependent Upon T-Cell Receptor Avidity

Robin R. Knight, Deborah Kronenberg, Min Zhao, Guo Cai Huang, Martin Eichmann, Anna Bulek, Linda Wooldridge, David K. Cole, Andrew K. Sewell, Mark Peakman, Ania Skowera

Diabetes 2013;62(1):205–213

https://doi.org/10.2337/db12-0315

Published: 13 December 2012

View article titled, Human β-Cell Killing by Autoreactive Preproinsulin-Specific CD8 T Cells Is Predominantly Granule-Mediated With the Potency Dependent Upon T-Cell Receptor Avidity

Includes: Supplementary data

Journal Articles

Circulating Preproinsulin Signal Peptide–Specific CD8 T Cells Restricted by the Susceptibility Molecule HLA-A24 Are Expanded at Onset of Type 1 Diabetes and Kill β-Cells

Deborah Kronenberg, Robin R. Knight, Megan Estorninho, Richard J. Ellis, Michel G. Kester, Arnoud de Ru, Martin Eichmann, Guo C. Huang, Jake Powrie, Colin M. Dayan, Ania Skowera, Peter A. van Veelen, Mark Peakman

Diabetes 2012;61(7):1752–1759

https://doi.org/10.2337/db11-1520

Published: 15 June 2012

View article titled, Circulating Preproinsulin Signal Peptide–Specific CD8 T Cells Restricted by the Susceptibility Molecule HLA-A24 Are Expanded at Onset of Type 1 Diabetes and Kill β-Cells

Includes: Supplementary data

Journal Articles

Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated β-Cell Death

Sefina Arif, Fabrice Moore, Katherine Marks, Thomas Bouckenooghe, Colin M. Dayan, Raquel Planas, Marta Vives-Pi, Jake Powrie, Timothy Tree, Piero Marchetti, Guo Cai Huang, Esteban N. Gurzov, Ricardo Pujol-Borrell, Decio L. Eizirik, Mark Peakman

Diabetes 2011;60(8):2112–2119

https://doi.org/10.2337/db10-1643

Published: 18 July 2011

View article titled, Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated β-Cell Death

Includes: Supplementary data

Journal Articles

Antigen-Specific Immunotherapy for Type 1 Diabetes: Maximizing the Potential

Mark Peakman, Matthias von Herrath

Diabetes 2010;59(9):2087–2093

https://doi.org/10.2337/db10-0630

Published: 01 September 2010

View article titled, Antigen-Specific Immunotherapy for Type 1 Diabetes: Maximizing the Potential

Journal Articles

Simultaneous Detection of Circulating Autoreactive CD8⁺ T-Cells Specific for Different Islet Cell–Associated Epitopes Using Combinatorial MHC Multimers

Jurjen H. Velthuis, Wendy W. Unger, Joana R.F. Abreu, Gaby Duinkerken, Kees Franken, Mark Peakman, Arnold H. Bakker, Sine Reker-Hadrup, Bart Keymeulen, Jan Wouter Drijfhout, Ton N. Schumacher, Bart O. Roep

Diabetes 2010;59(7):1721–1730

https://doi.org/10.2337/db09-1486

Published: 31 March 2010

View article titled, Simultaneous Detection of Circulating Autoreactive CD8+ T-Cells Specific for Different Islet Cell–Associated Epitopes Using Combinatorial MHC Multimers

Includes: Supplementary data

Journal Articles

Naturally Arising Human CD4 T-Cells That Recognize Islet Autoantigens and Secrete Interleukin-10 Regulate Proinflammatory T-Cell Responses via Linked Suppression

Timothy I.M. Tree, Jennifer Lawson, Hannah Edwards, Ania Skowera, Sefina Arif, Bart O. Roep, Mark Peakman

Diabetes 2010;59(6):1451–1460

https://doi.org/10.2337/db09-0503

Published: 18 March 2010

View article titled, Naturally Arising Human CD4 T-Cells That Recognize Islet Autoantigens and Secrete Interleukin-10 Regulate Proinflammatory T-Cell Responses via Linked Suppression

Includes: Supplementary data

Journal Articles

Validity and Reproducibility of Measurement of Islet Autoreactivity by T-Cell Assays in Subjects With Early Type 1 Diabetes

Kevan C. Herold, Barbara Brooks-Worrell, Jerry Palmer, H. Michael Dosch, Mark Peakman, Peter Gottlieb, Helena Reijonen, Sefina Arif, Lisa M. Spain, Clinton Thompson, John M. Lachin, the Type 1 Diabetes TrialNet Research Group

Diabetes 2009;58(11):2588–2595

https://doi.org/10.2337/db09-0249

Published: 12 August 2009

View article titled, Validity and Reproducibility of Measurement of Islet Autoreactivity by T-Cell Assays in Subjects With Early Type 1 Diabetes

Includes: Supplementary data

Journal Articles

Plasmacytoid Dendritic Cells Are Proportionally Expanded at Diagnosis of Type 1 Diabetes and Enhance Islet Autoantigen Presentation to T-Cells Through Immune Complex Capture

Jennifer S. Allen, Karl Pang, Ania Skowera, Richard Ellis, Chloe Rackham, Biliana Lozanoska-Ochser, Timothy Tree, R. David G. Leslie, Jennifer M. Tremble, Colin M. Dayan, Mark Peakman

Diabetes 2009;58(1):138–145

https://doi.org/10.2337/db08-0964

Published: 01 January 2009

View article titled, Plasmacytoid Dendritic Cells Are Proportionally Expanded at Diagnosis of Type 1 Diabetes and Enhance Islet Autoantigen Presentation to T-Cells Through Immune Complex Capture

Includes: Supplementary data

Journal Articles

Atorvastatin Fails to Prevent the Development of Autoimmune Diabetes Despite Inhibition of Pathogenic β-Cell–Specific CD8 T-Cells

Biliana Lozanoska-Ochser, Francesca Barone, Costantino Pitzalis, Mark Peakman

Diabetes 2006;55(4):1004–1010

https://doi.org/10.2337/diabetes.55.04.06.db05-1261

Published: 01 April 2006

View article titled, Atorvastatin Fails to Prevent the Development of Autoimmune Diabetes Despite Inhibition of Pathogenic β-Cell–Specific CD8 T-Cells

Journal Articles

Defective Suppressor Function in CD4⁺CD25⁺ T-Cells From Patients With Type 1 Diabetes

Shelley Lindley, Colin M. Dayan, Amanda Bishop, Bart O. Roep, Mark Peakman, Timothy I.M. Tree

Diabetes 2005;54(1):92–99

https://doi.org/10.2337/diabetes.54.1.92

Published: 01 January 2005

View article titled, Defective Suppressor Function in CD4+CD25+ T-Cells From Patients With Type 1 Diabetes

NARROW

Immune and Metabolic Effects of Antigen-Specific Immunotherapy Using Multiple β-Cell Peptides in Type 1 Diabetes

Low-Dose Anti-Thymocyte Globulin Preserves C-Peptide, Reduces HbA_1c, and Increases Regulatory to Conventional T-Cell Ratios in New-Onset Type 1 Diabetes: Two-Year Clinical Trial Data

The MultiPepT1De Study—Examining the Safety of Peptide Immunotherapy Using Multiple Islet Antigens in Recent-Onset Type 1 Diabetes

Molecular Pathways for Immune Recognition of Preproinsulin Signal Peptide in Type 1 Diabetes

Discovery of a Selective Islet Peptidome Presented by the Highest-Risk HLA-DQ8trans Molecule

Erratum. Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes. Diabetes 2014;63: 3835–3845

Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes

β-Cell–Specific CD8 T Cell Phenotype in Type 1 Diabetes Reflects Chronic Autoantigen Exposure

Reduction in CD4 Central Memory T-Cell Subset in Costimulation Modulator Abatacept-Treated Patients With Recent-Onset Type 1 Diabetes Is Associated With Slower C-Peptide Decline

Posttranslational Modification of HLA-DQ Binding Islet Autoantigens in Type 1 Diabetes

Human β-Cell Killing by Autoreactive Preproinsulin-Specific CD8 T Cells Is Predominantly Granule-Mediated With the Potency Dependent Upon T-Cell Receptor Avidity

Circulating Preproinsulin Signal Peptide–Specific CD8 T Cells Restricted by the Susceptibility Molecule HLA-A24 Are Expanded at Onset of Type 1 Diabetes and Kill β-Cells

Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated β-Cell Death

Antigen-Specific Immunotherapy for Type 1 Diabetes: Maximizing the Potential

Simultaneous Detection of Circulating Autoreactive CD8⁺ T-Cells Specific for Different Islet Cell–Associated Epitopes Using Combinatorial MHC Multimers

Naturally Arising Human CD4 T-Cells That Recognize Islet Autoantigens and Secrete Interleukin-10 Regulate Proinflammatory T-Cell Responses via Linked Suppression

Validity and Reproducibility of Measurement of Islet Autoreactivity by T-Cell Assays in Subjects With Early Type 1 Diabetes

Plasmacytoid Dendritic Cells Are Proportionally Expanded at Diagnosis of Type 1 Diabetes and Enhance Islet Autoantigen Presentation to T-Cells Through Immune Complex Capture

Atorvastatin Fails to Prevent the Development of Autoimmune Diabetes Despite Inhibition of Pathogenic β-Cell–Specific CD8 T-Cells

Defective Suppressor Function in CD4⁺CD25⁺ T-Cells From Patients With Type 1 Diabetes

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