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Masato Kasuga
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Journal Articles

Histidine Augments the Suppression of Hepatic Glucose Production by Central Insulin Action

Kumi Kimura, Yusuke Nakamura, Yuka Inaba, Michihiro Matsumoto, Yoshiaki Kido, Shun-ichiro Asahara, Tomokazu Matsuda, Hiroshi Watanabe, Akifumi Maeda, Fuyuhiko Inagaki, Chisato Mukai, Kiyoshi Takeda, Shizuo Akira, Tsuguhito Ota, Hajime Nakabayashi, Shuichi Kaneko, Masato Kasuga, Hiroshi Inoue
Journal: Diabetes
Diabetes 2013;62(7):2266–2277
https://doi.org/10.2337/db12-1701
Published: 14 June 2013
View articletitled, Histidine Augments the Suppression of Hepatic Glucose Production by Central Insulin Action
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Includes: Supplementary data
Journal Articles

Loss of Pdk1-Foxo1 Signaling in Myeloid Cells Predisposes to Adipose Tissue Inflammation and Insulin Resistance

Yoshinaga Kawano, Jun Nakae, Nobuyuki Watanabe, Shiho Fujisaka, Kristy Iskandar, Risa Sekioka, Yoshitake Hayashi, Kazuyuki Tobe, Masato Kasuga, Tetsuo Noda, Akihiko Yoshimura, Masafumi Onodera, Hiroshi Itoh
Journal: Diabetes
Diabetes 2012;61(8):1935–1948
https://doi.org/10.2337/db11-0770
Published: 17 July 2012
View articletitled, Loss of Pdk1-Foxo1 Signaling in Myeloid Cells Predisposes to Adipose Tissue Inflammation and Insulin Resistance
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Includes: Supplementary data
Journal Articles

Endoplasmic Reticulum Stress Inhibits STAT3-Dependent Suppression of Hepatic Gluconeogenesis via Dephosphorylation and Deacetylation

Kumi Kimura, Tomoko Yamada, Michihiro Matsumoto, Yoshiaki Kido, Tetsuya Hosooka, Shun-ichiro Asahara, Tomokazu Matsuda, Tsuguhito Ota, Hiroshi Watanabe, Yoshimichi Sai, Kenichi Miyamoto, Shuichi Kaneko, Masato Kasuga, Hiroshi Inoue
Journal: Diabetes
Diabetes 2012;61(1):61–73
https://doi.org/10.2337/db10-1684
Published: 12 December 2011
View articletitled, Endoplasmic Reticulum Stress Inhibits STAT3-Dependent Suppression of Hepatic Gluconeogenesis via Dephosphorylation and Deacetylation
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Includes: Supplementary data
Journal Articles

Role of KLF15 in Regulation of Hepatic Gluconeogenesis and Metformin Action

Mototsugu Takashima, Wataru Ogawa, Kumiko Hayashi, Hiroshi Inoue, Shinichi Kinoshita, Yasuo Okamoto, Hiroshi Sakaue, Yu Wataoka, Aki Emi, Yoko Senga, Yasushi Matsuki, Eijiro Watanabe, Ryuji Hiramatsu, Masato Kasuga
Journal: Diabetes
Diabetes 2010;59(7):1608–1615
https://doi.org/10.2337/db09-1679
Published: 14 April 2010
View articletitled, Role of KLF15 in Regulation of Hepatic Gluconeogenesis and Metformin Action
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Includes: Supplementary data
Journal Articles

Frequency of the G/G Genotype of Resistin Single Nucleotide Polymorphism at −420 Appears to Be Increased in Younger-Onset Type 2 Diabetes

Masaaki Ochi, Haruhiko Osawa, Yushi Hirota, Kazuo Hara, Yasuharu Tabara, Yoshiharu Tokuyama, Ikki Shimizu, Azuma Kanatsuka, Yasuhisa Fujii, Jun Ohashi, Tetsuro Miki, Naoto Nakamura, Takashi Kadowaki, Mitsuo Itakura, Masato Kasuga, Hideichi Makino
Journal: Diabetes
Diabetes 2007;56(11):2834–2838
https://doi.org/10.2337/db06-1157
Published: 01 November 2007
View articletitled, Frequency of the G/G Genotype of Resistin Single Nucleotide Polymorphism at −420 Appears to Be Increased in Younger-Onset Type 2 Diabetes
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Includes: Supplementary data
Journal Articles

Restoration of Glucokinase Expression in the Liver Normalizes Postprandial Glucose Disposal in Mice With Hepatic Deficiency of PDK1

Yasuo Okamoto, Wataru Ogawa, Akihiko Nishizawa, Hiroshi Inoue, Kiyoshi Teshigawara, Shinichi Kinoshita, Yasushi Matsuki, Eijiro Watanabe, Ryuji Hiramatsu, Hiroshi Sakaue, Tetsuo Noda, Masato Kasuga
Journal: Diabetes
Diabetes 2007;56(4):1000–1009
https://doi.org/10.2337/db06-1322
Published: 01 April 2007
View articletitled, Restoration of Glucokinase Expression in the Liver Normalizes Postprandial Glucose Disposal in Mice With Hepatic Deficiency of PDK1
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Journal Articles

Association Studies of Variants in the Genes Involved in Pancreatic β-Cell Function in Type 2 Diabetes in Japanese Subjects

Norihide Yokoi, Masao Kanamori, Yukio Horikawa, Jun Takeda, Tokio Sanke, Hiroto Furuta, Kishio Nanjo, Hiroyuki Mori, Masato Kasuga, Kazuo Hara, Takashi Kadowaki, Yukio Tanizawa, Yoshitomo Oka, Yukiko Iwami, Hisako Ohgawara, Yuichiro Yamada, Yutaka Seino, Hideki Yano, Nancy J. Cox, Susumu Seino
Journal: Diabetes
Diabetes 2006;55(8):2379–2386
https://doi.org/10.2337/db05-1203
Published: 01 August 2006
View articletitled, Association Studies of Variants in the Genes Involved in Pancreatic β-Cell Function in Type 2 Diabetes in Japanese Subjects
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Includes: Supplementary data
Journal Articles

A Polymorphism in the AMPKα2 Subunit Gene Is Associated With Insulin Resistance and Type 2 Diabetes in the Japanese Population

Momoko Horikoshi, Kazuo Hara, Jun Ohashi, Kazuaki Miyake, Katsushi Tokunaga, Chikako Ito, Masato Kasuga, Ryozo Nagai, Takashi Kadowaki
Journal: Diabetes
Diabetes 2006;55(4):919–923
https://doi.org/10.2337/diabetes.55.04.06.db05-0727
Published: 01 April 2006
View articletitled, A Polymorphism in the AMPKα2 Subunit Gene Is Associated With Insulin Resistance and Type 2 Diabetes in the Japanese Population
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Includes: Supplementary data
Journal Articles

Role of Peroxisome Proliferator-Activated Receptor-γ in Maintenance of the Characteristics of Mature 3T3-L1 Adipocytes

Yoshikazu Tamori, Jiro Masugi, Naonobu Nishino, Masato Kasuga
Journal: Diabetes
Diabetes 2002;51(7):2045–2055
https://doi.org/10.2337/diabetes.51.7.2045
Published: 01 July 2002
View articletitled, Role of Peroxisome Proliferator-Activated Receptor-γ in Maintenance of the Characteristics of Mature 3T3-L1 Adipocytes
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Journal Articles

Role of the Insulin Receptor Substrate 1 and Phosphatidylinositol 3-Kinase Signaling Pathway in Insulin-Induced Expression of Sterol Regulatory Element Binding Protein 1c and Glucokinase Genes in Rat Hepatocytes

Michihiro Matsumoto, Wataru Ogawa, Kiyoshi Teshigawara, Hiroshi Inoue, Kazuaki Miyake, Hiroshi Sakaue, Masato Kasuga
Journal: Diabetes
Diabetes 2002;51(6):1672–1680
https://doi.org/10.2337/diabetes.51.6.1672
Published: 01 June 2002
View articletitled, Role of the Insulin Receptor Substrate 1 and Phosphatidylinositol 3-Kinase Signaling Pathway in Insulin-Induced Expression of Sterol Regulatory Element Binding Protein 1c and Glucokinase Genes in Rat Hepatocytes
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Journal Articles

Fas/Fas Ligand Interactions Play an Essential Role in the Initiation of Murine Autoimmune Diabetes

Maki Nakayama, Masao Nagata, Hisafumi Yasuda, Kenji Arisawa, Reiko Kotani, Katsumi Yamada, Shahead Ali Chowdhury, Sagarika Chakrabarty, Zhen Zi Jin, Hideo Yagita, Koichi Yokono, Masato Kasuga
Journal: Diabetes
Diabetes 2002;51(5):1391–1397
https://doi.org/10.2337/diabetes.51.5.1391
Published: 01 May 2002
View articletitled, Fas/Fas Ligand Interactions Play an Essential Role in the Initiation of Murine Autoimmune Diabetes
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Journal Articles

Modest Overexpression of Neuropeptide Y in the Brain Leads to Obesity After High-Sucrose Feeding

Toshihiro Kaga, Akio Inui, Minoru Okita, Akihiro Asakawa, Naohiko Ueno, Masato Kasuga, Mineko Fujimiya, Noriyasu Nishimura, Rika Dobashi, Yasuo Morimoto, I-Min Liu, Juei-Tang Cheng
Journal: Diabetes
Diabetes 2001;50(5):1206–1210
https://doi.org/10.2337/diabetes.50.5.1206
Published: 01 May 2001
View articletitled, Modest Overexpression of Neuropeptide Y in the Brain Leads to Obesity After High-Sucrose Feeding
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Journal Articles

The Pro12→Ala Substitution in PPAR-γ Is Associated With Resistance to Development of Diabetes in the General Population: Possible Involvement in Impairment of Insulin Secretion in Individuals With Type 2 Diabetes

Hiroyuki Mori, Hiroshi Ikegami, Yoshihiko Kawaguchi, Susumu Seino, Norihide Yokoi, Jun Takeda, Ituro Inoue, Yutaka Seino, Koichiro Yasuda, Toshiaki Hanafusa, Kazuya Yamagata, Takuya Awata, Takashi Kadowaki, Kazuo Hara, Nobuhiro Yamada, Takanari Gotoda, Naoko Iwasaki, Yasuhiko Iwamoto, Tokio Sanke, Kishio Nanjo, Yoshitomo Oka, Akira Matsutani, Eiichi Maeda, Masato Kasuga
Journal: Diabetes
Diabetes 2001;50(4):891–894
https://doi.org/10.2337/diabetes.50.4.891
Published: 01 April 2001
View articletitled, The Pro12→Ala Substitution in PPAR-γ Is Associated With Resistance to Development of Diabetes in the General Population: Possible Involvement in Impairment of Insulin Secretion in Individuals With Type 2 Diabetes
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Journal Articles

No Coding Mutations Are Detected in the Peroxisome Proliferator-Activated Receptor-γ Gene in Japanese Patients with Lipoatrophic Diabetes

Hideki Okazawa, Hiroyuki Mori, Yoshikazu Tamori, Satoshi Araki, Toshiharu Niki, Jiro Masugi, Masatoshi Kawanishi, Takanori Kubota, Hiroaki Shinoda, Masato Kasuga
Journal: Diabetes
Diabetes 1997;46(11):1904–1906
https://doi.org/10.2337/diab.46.11.1904
Published: 01 November 1997
View articletitled, No Coding Mutations Are Detected in the Peroxisome Proliferator-Activated Receptor-γ Gene in Japanese Patients with Lipoatrophic Diabetes
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Journal Articles

Human Obese Gene: Molecular Screening in Japanese and Asian Indian NIDDM Patients Associated With Obesity

Toshiharu Niki, Hiroyuki Mori, Yoshikazu Tamori, Miyako Kishimoto-Hashirmoto, Hirohisa Ueno, Satoshi Araki, Jiro Masugi, Nitin Sawant, Hemali R Majithia, Nadeem Rais, Mitsuru Hashiramoto, Hiroshi Taniguchi, Masato Kasuga
Journal: Diabetes
Diabetes 1996;45(5):675–678
https://doi.org/10.2337/diab.45.5.675
Published: 01 May 1996
View articletitled, Human Obese Gene: Molecular Screening in Japanese and Asian Indian NIDDM Patients Associated With Obesity
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Journal Articles

Expression of Intercellular Adhesion Molecule 1 on Pancreatic β-Cells Accelerates β-Cell Destruction by Cytotoxic T-Cells in Murine Autoimmune Diabetes

Nrorio Yagi, Koichi Yokono, Kazuhiko Amano, Masao Nagata, Kazuya Tsukamoto, Yutaka Hasegawa, Ryoji Yoneda, Naoko Okamoto, Hiroaki Moriyama, Masatoshi Miki, Yoichi Tominaga, Jun-ich Miyazaki, Hideo Yagita, Ko Okumura, Akira Mizoguchi, Akinori Miki, Chizuka Ide, Sakan Maeda, Masato Kasuga
Journal: Diabetes
Diabetes 1995;44(7):744–752
https://doi.org/10.2337/diab.44.7.744
Published: 01 July 1995
View articletitled, Expression of Intercellular Adhesion Molecule 1 on Pancreatic β-Cells Accelerates β-Cell Destruction by Cytotoxic T-Cells in Murine Autoimmune Diabetes
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Journal Articles

Enzyme-Linked Immunosorbent Assay Method for Human Autophosphorylated Insulin Receptor: Applicability to Insulin-Resistant States

Haruhiko Hagino, Kozui Shii, Koichi Yokono, Hiroshi Matsuba, Masaki Yoshida, Yoichi Hosomi, Yumi Okada, Miyako Kishimoto, Toshiki Hozumi, Yoshihiko Ishida, Tsutomu Kazumi, Ryuichiro Nishimura, Masato Kasuga, Shigeaki Baba
Journal: Diabetes
Diabetes 1994;43(2):274–280
https://doi.org/10.2337/diab.43.2.274
Published: 01 February 1994
View articletitled, Enzyme-Linked Immunosorbent Assay Method for Human Autophosphorylated Insulin Receptor: Applicability to Insulin-Resistant States
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Journal Articles

Trial of Insulinlike Growth Factor I Therapy for Patients With Extreme Insulin Resistance Syndromes

Hideshi Kuzuya, Nobuo Matsuura, Michiyo Sakamoto, Hideichi Makino, Yoshikazu Sakamoto, Takashi Kadowaki, Yoshimi Suzuki, Masashi Kobayashi, Yoshiharu Akazawa, Makoto Nomura, Yasunao Yoshimasa, Masato Kasuga, Katsumi Goji, Shigenobu Nagataki, Hitoshi Oyasu, Hiroo Imura
Journal: Diabetes
Diabetes 1993;42(5):696–705
https://doi.org/10.2337/diab.42.5.696
Published: 01 May 1993
View articletitled, Trial of Insulinlike Growth Factor I Therapy for Patients With Extreme Insulin Resistance Syndromes
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Journal Articles

Immunological Detection of Phosphotyrosine-Containing Proteins in Rat Livers After Insulin Injection

Kazuyuki Tobe, Osamu Koshio, Yuko Tashiro-Hashimoto, Fumimaro Takaku, Yasuo Akanuma, Masato Kasuga
Journal: Diabetes
Diabetes 1990;39(5):528–533
https://doi.org/10.2337/diab.39.5.528
Published: 01 May 1990
View articletitled, Immunological Detection of Phosphotyrosine-Containing Proteins in Rat Livers After Insulin Injection
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Journal Articles

Characteristics of Insulin Receptors and Insulin Action in Human Myelogenous Leukemia Cell Line K-562

Toshikazu Yamanouchi, Toshio Tsushima, Yasuo Akanuma, Masato Kasuga, Hideaki Mizoguchi, Fumimaro Takaku
Journal: Diabetes
Diabetes 1985;34(4):347–352
https://doi.org/10.2337/diab.34.4.347
Published: 01 April 1985
View articletitled, Characteristics of Insulin Receptors and Insulin Action in Human Myelogenous Leukemia Cell Line K-562
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