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Meeting Abstracts

1515-P: Pyruvate Kinase Amplifies Insulin Secretion Downstream of the ß-Cell GLP1 Receptor

HANNAH R. FOSTER, SOPHIE L. LEWANDOWSKI, RACHEL KIRCHNER, MEGAN CAPOZZI, JONATHAN CAMPBELL, MATTHEW J. MERRINS

Diabetes 2024;73(Supplement_1):1515-P

https://doi.org/10.2337/db24-1515-P

Published: 14 June 2024

View article titled, 1515-P: Pyruvate Kinase Amplifies Insulin Secretion Downstream of the ß-Cell GLP1 Receptor

Meeting Abstracts

1483-P: Identifying Conditional Dependence of Proteins Regulating Islet Biology with Machine Learning

CHRISTOPHER EMFINGER, ELYSE FREIBERGER, MARY RABAGLIA, JELENA KOLIC, SHANE SIMONETT, MICHAEL SHORTREED, LAUREN CLARK, DONNIE STAPLETON, KATHRYN SCHUELER, KELLY MITOK, TARA R. PRICE, JOSHUA J. COON, LLOYD SMITH, MATTHEW J. MERRINS, JAMES D. JOHNSON, MARK KELLER, ALAN D. ATTIE

Diabetes 2024;73(Supplement_1):1483-P

https://doi.org/10.2337/db24-1483-P

Published: 14 June 2024

View article titled, 1483-P: Identifying Conditional Dependence of Proteins Regulating Islet Biology with Machine Learning

Meeting Abstracts

103-OR: Signaling Mechanisms Underlying Islet Compensation in a Novel Mouse Model of ß-Cell Replication Deficiency

HANNAH R. FOSTER, SOPHIA SDAO, MELISSA ADAMS, BARAK BLUM, MATTHEW J. MERRINS

Diabetes 2024;73(Supplement_1):103-OR

https://doi.org/10.2337/db24-103-OR

Published: 14 June 2024

View article titled, 103-OR: Signaling Mechanisms Underlying Islet Compensation in a Novel Mouse Model of ß-Cell Replication Deficiency

Meeting Abstracts

1739-P: Genetic Deletion of Mitochondrial PEP Carboxykinase (PCK2) in Pancreatic α-Cells Increases Amino Acid-Stimulated Ca²⁺ Influx

ERLI JIN, HANNAH R. FOSTER, EVGENIY POTAPENKO, EMILY R. KNUTH, MATTHEW J. MERRINS

Diabetes 2024;73(Supplement_1):1739-P

https://doi.org/10.2337/db24-1739-P

Published: 14 June 2024

View article titled, 1739-P: Genetic Deletion of Mitochondrial PEP Carboxykinase (PCK2) in Pancreatic α-Cells Increases Amino Acid-Stimulated Ca2+ Influx

Meeting Abstracts

1732-P: ATP Dynamics in ß-Cell Primary Cilia Depend on Bidirectional Signaling from Ciliary Glycolysis to Mitochondria

SHIH MING HUANG, HANNAH R. FOSTER, JING HUGHES, MATTHEW J. MERRINS

Diabetes 2024;73(Supplement_1):1732-P

https://doi.org/10.2337/db24-1732-P

Published: 14 June 2024

View article titled, 1732-P: ATP Dynamics in ß-Cell Primary Cilia Depend on Bidirectional Signaling from Ciliary Glycolysis to Mitochondria

Journal Articles

Leucine Suppresses α-Cell cAMP and Glucagon Secretion via a Combination of Cell-Intrinsic and Islet Paracrine Signaling

Emily R. Knuth, Hannah R. Foster, Erli Jin, Maia H. Ekstrand, Jakob G. Knudsen, Matthew J. Merrins

Diabetes 2024;73(9):1426–1439

https://doi.org/10.2337/db23-1013

Published: 13 June 2024

View article titled, Leucine Suppresses α-Cell cAMP and Glucagon Secretion via a Combination of Cell-Intrinsic and Islet Paracrine Signaling

Journal Articles

Glucose Regulation of β-Cell K_ATP Channels: It Is Time for a New Model!

Matthew J. Merrins, Richard G. Kibbey

Diabetes 2024;73(6):856–863

https://doi.org/10.2337/dbi23-0032

Published: 19 April 2024

View article titled, Glucose Regulation of β-Cell KATP Channels: It Is Time for a New Model!

Meeting Abstracts

1747-P: Islet Ca2+ Dynamics, Heterogeneity, and Consistency in Three Dimensions with Activators of Pyruvate Kinase

JENNIFER BRIGGS, ERLI JIN, MATTHEW J. MERRINS, RICHARD K. BENNINGER

Diabetes 2023;72(Supplement_1):1747-P

https://doi.org/10.2337/db23-1747-P

Published: 20 June 2023

View article titled, 1747-P: Islet Ca2+ Dynamics, Heterogeneity, and Consistency in Three Dimensions with Activators of Pyruvate Kinase

Meeting Abstracts

316-OR: Genetic Deletion of Beta-Cell Pkm1, Pkm2, and Pck2 Identifies PEP as an Essential Signal for Compartmentalized KATP Closure and Cycling of the Insulin Secretory Pathway

HANNAH R. FOSTER, THUONG HO, EVGENIY POTAPENKO, REBECCA L. CARDONE, RICHARD KIBBEY, IV, MATTHEW J. MERRINS

Diabetes 2022;71(Supplement_1):316-OR

https://doi.org/10.2337/db22-316-OR

Published: 01 June 2022

View article titled, 316-OR: Genetic Deletion of Beta-Cell Pkm1, Pkm2, and Pck2 Identifies PEP as an Essential Signal for Compartmentalized KATP Closure and Cycling of the Insulin Secretory Pathway

Journal Articles

What Regulates Basal Insulin Secretion and Causes Hyperinsulinemia?

Barbara E. Corkey, Jude T. Deeney, Matthew J. Merrins

Diabetes 2021;70(10):2174–2182

https://doi.org/10.2337/dbi21-0009

Published: 27 September 2021

View article titled, What Regulates Basal Insulin Secretion and Causes Hyperinsulinemia?

Journal Articles

β-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High-Fat Diet–Fed Mice

Haopeng Lin, Nancy Smith, Aliya F. Spigelman, Kunimasa Suzuki, Mourad Ferdaoussi, Tamadher A. Alghamdi, Sophie L. Lewandowski, Yaxing Jin, Austin Bautista, Ying Wayne Wang, Jocelyn E. Manning Fox, Matthew J. Merrins, Jean Buteau, Patrick E. MacDonald

Diabetes 2021;70(11):2626–2638

https://doi.org/10.2337/db20-1235

Published: 30 August 2021

View article titled, β-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High-Fat Diet–Fed Mice

Meeting Abstracts

1254-P: ß-Cell Cdk1 Deletion Reveals a- and ß-Cell Compensatory Mechanisms for Hypoplasia

SOPHIA SDAO, MELISSA ADAMS, HANNAH R. FOSTER, BARAK BLUM, MATTHEW J. MERRINS

Diabetes 2021;70(Supplement_1):1254-P

https://doi.org/10.2337/db21-1254-P

Published: 01 June 2021

View article titled, 1254-P: ß-Cell Cdk1 Deletion Reveals a- and ß-Cell Compensatory Mechanisms for Hypoplasia

Meeting Abstracts

127-OR: In Vivo Genetic Evidence That the Pyruvate Kinase Isoforms PKM1 and PKM2 Differentially Control Beta-Cell Fuel Sensing

HANNAH R. FOSTER, THUONG HO, EVGENIY POTAPENKO, SOPHIE L. LEWANDOWSKI, SOPHIA SDAO, HALENA R. VANDEUSEN, REBECCA L. CARDONE, RICHARD KIBBEY, IV, MATTHEW J. MERRINS

Diabetes 2021;70(Supplement_1):127-OR

https://doi.org/10.2337/db21-127-OR

Published: 01 June 2021

View article titled, 127-OR: In Vivo Genetic Evidence That the Pyruvate Kinase Isoforms PKM1 and PKM2 Differentially Control Beta-Cell Fuel Sensing

Meeting Abstracts

129-OR: Glycolytic Enzymes and Creatine Kinase Locally Regulate KATP Channel Activity in Both ß- and a-Cells

THUONG HO, EVGENIY POTAPENKO, MATTHEW J. MERRINS

Diabetes 2021;70(Supplement_1):129-OR

https://doi.org/10.2337/db21-129-OR

Published: 01 June 2021

View article titled, 129-OR: Glycolytic Enzymes and Creatine Kinase Locally Regulate KATP Channel Activity in Both ß- and a-Cells

Meeting Abstracts

Cdk2-Dependent Activation of ß-Cell Metabolism Is Eclipsed by Its Inhibitory Effect on Plasma Membrane Excitability and Insulin Secretion

SOPHIA SDAO, CHETAN POUDEL, KARA M. MORTENSEN, MATTHEW J. MERRINS

Diabetes 2018;67(Supplement_1):2140-P

https://doi.org/10.2337/db18-2140-P

Published: 01 July 2018

View article titled, Cdk2-Dependent Activation of ß-Cell Metabolism Is Eclipsed by Its Inhibitory Effect on Plasma Membrane Excitability and Insulin Secretion

Meeting Abstracts

Glucose Oxidation Depletes Cytosolic Citrate and Glutamate in the Amplifying Pathways of Insulin Secretion

SOPHIE L. LEWANDOWSKI, MATTHEW J. MERRINS

Diabetes 2018;67(Supplement_1):2152-P

https://doi.org/10.2337/db18-2152-P

Published: 01 July 2018

View article titled, Glucose Oxidation Depletes Cytosolic Citrate and Glutamate in the Amplifying Pathways of Insulin Secretion

Journal Articles

Radiomanganese PET Detects Changes in Functional β-Cell Mass in Mouse Models of Diabetes

Reinier Hernandez, Stephen A. Graves, Trillian Gregg, Halena R. VanDeusen, Rachel J. Fenske, Haley N. Wienkes, Christopher G. England, Hector F. Valdovinos, Justin J. Jeffery, Todd E. Barnhart, Gregory W. Severin, Robert J. Nickles, Michelle E. Kimple, Matthew J. Merrins, Weibo Cai

Diabetes 2017;66(8):2163–2174

https://doi.org/10.2337/db16-1285

Published: 17 May 2017

View article titled, Radiomanganese PET Detects Changes in Functional β-Cell Mass in Mouse Models of Diabetes

Includes: Supplementary data

Journal Articles

Enriching Islet Phospholipids With Eicosapentaenoic Acid Reduces Prostaglandin E₂ Signaling and Enhances Diabetic β-Cell Function

Joshua C. Neuman, Michael D. Schaid, Allison L. Brill, Rachel J. Fenske, Carly R. Kibbe, Danielle A. Fontaine, Sophia M. Sdao, Harpreet K. Brar, Kelsey M. Connors, Haley N. Wienkes, Kevin W. Eliceiri, Matthew J. Merrins, Dawn B. Davis, Michelle E. Kimple

Diabetes 2017;66(6):1572–1585

https://doi.org/10.2337/db16-1362

Published: 13 February 2017

View article titled, Enriching Islet Phospholipids With Eicosapentaenoic Acid Reduces Prostaglandin E2 Signaling and Enhances Diabetic β-Cell Function

Includes: Supplementary data

Journal Articles

Pancreatic β-Cells From Mice Offset Age-Associated Mitochondrial Deficiency With Reduced K_ATP Channel Activity

Trillian Gregg, Chetan Poudel, Brian A. Schmidt, Rashpal S. Dhillon, Sophia M. Sdao, Nathan A. Truchan, Emma L. Baar, Luis A. Fernandez, John M. Denu, Kevin W. Eliceiri, Jeremy D. Rogers, Michelle E. Kimple, Dudley W. Lamming, Matthew J. Merrins

Diabetes 2016;65(9):2700–2710

https://doi.org/10.2337/db16-0432

Published: 09 June 2016

View article titled, Pancreatic β-Cells From Mice Offset Age-Associated Mitochondrial Deficiency With Reduced KATP Channel Activity

Includes: Supplementary data

NARROW

1515-P: Pyruvate Kinase Amplifies Insulin Secretion Downstream of the ß-Cell GLP1 Receptor

1483-P: Identifying Conditional Dependence of Proteins Regulating Islet Biology with Machine Learning

103-OR: Signaling Mechanisms Underlying Islet Compensation in a Novel Mouse Model of ß-Cell Replication Deficiency

1739-P: Genetic Deletion of Mitochondrial PEP Carboxykinase (PCK2) in Pancreatic α-Cells Increases Amino Acid-Stimulated Ca²⁺ Influx

1732-P: ATP Dynamics in ß-Cell Primary Cilia Depend on Bidirectional Signaling from Ciliary Glycolysis to Mitochondria

Leucine Suppresses α-Cell cAMP and Glucagon Secretion via a Combination of Cell-Intrinsic and Islet Paracrine Signaling

Glucose Regulation of β-Cell K_ATP Channels: It Is Time for a New Model!

1747-P: Islet Ca2+ Dynamics, Heterogeneity, and Consistency in Three Dimensions with Activators of Pyruvate Kinase

316-OR: Genetic Deletion of Beta-Cell Pkm1, Pkm2, and Pck2 Identifies PEP as an Essential Signal for Compartmentalized KATP Closure and Cycling of the Insulin Secretory Pathway

What Regulates Basal Insulin Secretion and Causes Hyperinsulinemia?

β-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High-Fat Diet–Fed Mice

1254-P: ß-Cell Cdk1 Deletion Reveals a- and ß-Cell Compensatory Mechanisms for Hypoplasia

127-OR: In Vivo Genetic Evidence That the Pyruvate Kinase Isoforms PKM1 and PKM2 Differentially Control Beta-Cell Fuel Sensing

129-OR: Glycolytic Enzymes and Creatine Kinase Locally Regulate KATP Channel Activity in Both ß- and a-Cells

Cdk2-Dependent Activation of ß-Cell Metabolism Is Eclipsed by Its Inhibitory Effect on Plasma Membrane Excitability and Insulin Secretion

Glucose Oxidation Depletes Cytosolic Citrate and Glutamate in the Amplifying Pathways of Insulin Secretion

Radiomanganese PET Detects Changes in Functional β-Cell Mass in Mouse Models of Diabetes

Enriching Islet Phospholipids With Eicosapentaenoic Acid Reduces Prostaglandin E₂ Signaling and Enhances Diabetic β-Cell Function

Pancreatic β-Cells From Mice Offset Age-Associated Mitochondrial Deficiency With Reduced K_ATP Channel Activity

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