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Meeting Abstracts

105-OR: Single-Cell Multiomic Analysis of the Effect of GIP and GIP-1 Mono- and Multi-agonism on the Hypothalamus and Hindbrain

ROBERT M. GUTGESELL, GANDHARI MAITY-KUMAR, CRISTINA GARCIA CACERES, MATTHIAS H. TSCHÖP, TIMO D. MÜLLER

Diabetes 2024;73(Supplement_1):105-OR

https://doi.org/10.2337/db24-105-OR

Published: 14 June 2024

View article titled, 105-OR: Single-Cell Multiomic Analysis of the Effect of GIP and GIP-1 Mono- and Multi-agonism on the Hypothalamus and Hindbrain

Meeting Abstracts

69-LB: Sex-Specific Dynamics of GLP-1R and GIPR Expression in the Hypothalamus and the Amygdala of Mice

SUSANNA M. HOFMANN, SHIQI ZHANG, ROBBY TOM, TIMO D. MÜLLER, MATTHIAS H. TSCHÖP

Diabetes 2023;72(Supplement_1):69-LB

https://doi.org/10.2337/db23-69-LB

Published: 20 June 2023

View article titled, 69-LB: Sex-Specific Dynamics of GLP-1R and GIPR Expression in the Hypothalamus and the Amygdala of Mice

Meeting Abstracts

936-P: Plasma Proteomic Profiling Delineates Treatment Efficacy of a GLP-1/GIP Coagonist in Female and Male Mice

SUSANNA M. HOFMANN, NICOLAI J. WEWER ALBRECHTSEN, MATTHIAS H. TSCHÖP, ANNETTE FEUCHTINGER, MARKUS BRIELMEIER, BRIAN FINAN, RICHARD DIMARCHI, MAXIMILIAN KLEINERT, STEPHAN SACHS, TIMO D. MÜLLER, KERSTIN STEMMER, MATTHIAS MANN

Diabetes 2020;69(Supplement_1):936-P

https://doi.org/10.2337/db20-936-P

Published: 01 June 2020

View article titled, 936-P: Plasma Proteomic Profiling Delineates Treatment Efficacy of a GLP-1/GIP Coagonist in Female and Male Mice

Journal Articles

The Iminosugar AMP-DNM Improves Satiety and Activates Brown Adipose Tissue Through GLP1

Diabetes 2019;68(12):2223–2234

https://doi.org/10.2337/db19-0049

Published: 02 October 2019

View article titled, The Iminosugar AMP-DNM Improves Satiety and Activates Brown Adipose Tissue Through GLP1

Includes: Supplementary data

Journal Articles

Long-Acting Neurotensin Synergizes With Liraglutide to Reverse Obesity Through a Melanocortin-Dependent Pathway

Cecilia Ratner, Zhenyan He, Kaare V. Grunddal, Louise J. Skov, Bolette Hartmann, Fa Zhang, Annette Feuchtinger, Anette Bjerregaard, Christina Christoffersen, Matthias H. Tschöp, Brian Finan, Richard D. DiMarchi, Gina M. Leinninger, Kevin W. Williams, Christoffer Clemmensen, Birgitte Holst

Diabetes 2019;68(6):1329–1340

https://doi.org/10.2337/db18-1009

Published: 01 April 2019

View article titled, Long-Acting Neurotensin Synergizes With Liraglutide to Reverse Obesity Through a Melanocortin-Dependent Pathway

Includes: Supplementary data

Journal Articles

Erratum. Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1. Diabetes 2018;67: 2456–2465

Diabetes 2019;68(3):676

https://doi.org/10.2337/db19-er03a

Published: 13 February 2019

View article titled, Erratum. Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1. Diabetes 2018;67: 2456–2465

Journal Articles

Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1

Diabetes 2018;67(11):2456–2465

https://doi.org/10.2337/db18-0146

Published: 28 August 2018

View article titled, Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1

Includes: Supplementary data

Journal Articles

Erratum. Adipocyte Glucocorticoid Receptor Deficiency Attenuates Aging- and HFD-Induced Obesity and Impairs the Feeding-Fasting Transition. Diabetes 2017;66: 272–286

Kristina M. Mueller, Kerstin Hartmann, Doris Kaltenecker, Sabine Vettorazzi, Mandy Bauer, Lea Mauser, Sabine Amann, Sigrid Jall, Katrin Fischer, Harald Esterbauer, Timo D. Müller, Matthias H. Tschöp, Christoph Magnes, Johannes Haybaeck, Thomas Scherer, Natalie Bordag, Jan P. Tuckermann, Richard Moriggl

Diabetes 2018;67(2):343–344

https://doi.org/10.2337/db18-er02a

Published: 16 November 2017

View article titled, Erratum. Adipocyte Glucocorticoid Receptor Deficiency Attenuates Aging- and HFD-Induced Obesity and Impairs the Feeding-Fasting Transition. Diabetes 2017;66: 272–286

Journal Articles

Erratum. Direct Substrate Delivery Into Mitochondrial Fission–Deficient Pancreatic Islets Rescues Insulin Secretion. Diabetes 2017;66: 1247–1257

Uma D. Kabra, Katrin Pfuhlmann, Adriana Migliorini, Susanne Keipert, Daniel Lamp, Olle Korsgren, Moritz Gegg, Stephen C. Woods, Paul T. Pfluger, Heiko Lickert, Charles Affourtit, Matthias H. Tschöp, Martin Jastroch

Diabetes 2017;66(12):3144

https://doi.org/10.2337/db17-er12d

Published: 12 October 2017

View article titled, Erratum. Direct Substrate Delivery Into Mitochondrial Fission–Deficient Pancreatic Islets Rescues Insulin Secretion. Diabetes 2017;66: 1247–1257

Journal Articles

Disruption of Lipid Uptake in Astroglia Exacerbates Diet-Induced Obesity

Yuanqing Gao, Clarita Layritz, Beata Legutko, Thomas O. Eichmann, Elise Laperrousaz, Valentine S. Moullé, Celine Cruciani-Guglielmacci, Christophe Magnan, Serge Luquet, Stephen C. Woods, Robert H. Eckel, Chun-Xia Yi, Cristina Garcia-Caceres, Matthias H. Tschöp

Diabetes 2017;66(10):2555–2563

https://doi.org/10.2337/db16-1278

Published: 14 July 2017

View article titled, Disruption of Lipid Uptake in Astroglia Exacerbates Diet-Induced Obesity

Includes: Supplementary data

Journal Articles

Endothelial HIF-1α Enables Hypothalamic Glucose Uptake to Drive POMC Neurons

Luis Varela, Shigetomo Suyama, Yan Huang, Marya Shanabrough, Matthias H. Tschöp, Xiao-Bing Gao, Frank J. Giordano, Tamas L. Horvath

Diabetes 2017;66(6):1511–1520

https://doi.org/10.2337/db16-1106

Published: 14 March 2017

View article titled, Endothelial HIF-1α Enables Hypothalamic Glucose Uptake to Drive POMC Neurons

Includes: Supplementary data

Journal Articles

Direct Substrate Delivery Into Mitochondrial Fission–Deficient Pancreatic Islets Rescues Insulin Secretion

Diabetes 2017;66(5):1247–1257

https://doi.org/10.2337/db16-1088

Published: 07 February 2017

View article titled, Direct Substrate Delivery Into Mitochondrial Fission–Deficient Pancreatic Islets Rescues Insulin Secretion

Includes: Supplementary data

Journal Articles

Adipocyte Glucocorticoid Receptor Deficiency Attenuates Aging- and HFD-Induced Obesity and Impairs the Feeding-Fasting Transition

Diabetes 2017;66(2):272–286

https://doi.org/10.2337/db16-0381

Published: 20 September 2016

View article titled, Adipocyte Glucocorticoid Receptor Deficiency Attenuates Aging- and HFD-Induced Obesity and Impairs the Feeding-Fasting Transition

Includes: Supplementary data

Journal Articles

Hypothalamic Injury: Fish Oil to the Rescue!

Cristina García-Cáceres, Matthias H. Tschöp

Diabetes 2016;65(3):551–553

https://doi.org/10.2337/dbi15-0036

Published: 13 February 2016

View article titled, Hypothalamic Injury: Fish Oil to the Rescue!

Journal Articles

Acute Administration of Unacylated Ghrelin Has No Effect on Basal or Stimulated Insulin Secretion in Healthy Humans

Jenny Tong, Harold W. Davis, Suzanne Summer, Stephen C. Benoit, Ahrar Haque, Martin Bidlingmaier, Matthias H. Tschöp, David D’Alessio

Diabetes 2014;63(7):2309–2319

https://doi.org/10.2337/db13-1598

Published: 14 June 2014

View article titled, Acute Administration of Unacylated Ghrelin Has No Effect on Basal or Stimulated Insulin Secretion in Healthy Humans

Journal Articles

GLP-1/Glucagon Coagonism Restores Leptin Responsiveness in Obese Mice Chronically Maintained on an Obesogenic Diet

Christoffer Clemmensen, Joseph Chabenne, Brian Finan, Lorraine Sullivan, Katrin Fischer, Daniela Küchler, Laura Sehrer, Teja Ograjsek, Susanna M. Hofmann, Sonja C. Schriever, Paul T. Pfluger, Jason Pinkstaff, Matthias H. Tschöp, Richard DiMarchi, Timo D. Müller

Diabetes 2014;63(4):1422–1427

https://doi.org/10.2337/db13-1609

Published: 13 March 2014

View article titled, GLP-1/Glucagon Coagonism Restores Leptin Responsiveness in Obese Mice Chronically Maintained on an Obesogenic Diet

Includes: Supplementary data

Journal Articles

GLP-1R Responsiveness Predicts Individual Gastric Bypass Efficacy on Glucose Tolerance in Rats

Kirk M. Habegger, Kristy M. Heppner, Sarah E. Amburgy, Nickki Ottaway, Jenna Holland, Christine Raver, Erin Bartley, Timo D. Müller, Paul T. Pfluger, Jose Berger, Mouhamadoul Toure, Stephen C. Benoit, Richard D. DiMarchi, Diego Perez-Tilve, David A. D’Alessio, Randy J. Seeley, Matthias H. Tschöp

Diabetes 2014;63(2):505–513

https://doi.org/10.2337/db13-0511

Published: 16 January 2014

View article titled, GLP-1R Responsiveness Predicts Individual Gastric Bypass Efficacy on Glucose Tolerance in Rats

Includes: Supplementary data

Journal Articles

Both Acyl and Des-Acyl Ghrelin Regulate Adiposity and Glucose Metabolism via Central Nervous System Ghrelin Receptors

Kristy M. Heppner, Carolin L. Piechowski, Anne Müller, Nickki Ottaway, Stephanie Sisley, David L. Smiley, Kirk M. Habegger, Paul T. Pfluger, Richard DiMarchi, Heike Biebermann, Matthias H. Tschöp, Darleen A. Sandoval, Diego Perez-Tilve

Diabetes 2014;63(1):122–131

https://doi.org/10.2337/db13-0414

Published: 13 December 2013

View article titled, Both Acyl and Des-Acyl Ghrelin Regulate Adiposity and Glucose Metabolism via Central Nervous System Ghrelin Receptors

Journal Articles

GLP-1R Agonism Enhances Adjustable Gastric Banding in Diet-Induced Obese Rats

Kirk M. Habegger, Henriette Kirchner, Chun-Xia Yi, Kristy M. Heppner, Dan Sweeney, Nickki Ottaway, Jenna Holland, Sarah Amburgy, Christine Raver, Radhakrishna Krishna, Timo D. Müller, Diego Perez-Tilve, Paul T. Pfluger, Silvana Obici, Richard D. DiMarchi, David A. D’Alessio, Randy J. Seeley, Matthias H. Tschöp

Diabetes 2013;62(9):3261–3267

https://doi.org/10.2337/db13-0117

Published: 15 August 2013

View article titled, GLP-1R Agonism Enhances Adjustable Gastric Banding in Diet-Induced Obese Rats

Journal Articles

Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions

Diabetes 2013;62(5):1453–1463

https://doi.org/10.2337/db12-1116

Published: 16 April 2013

View article titled, Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions

Includes: Supplementary data

NARROW

105-OR: Single-Cell Multiomic Analysis of the Effect of GIP and GIP-1 Mono- and Multi-agonism on the Hypothalamus and Hindbrain

69-LB: Sex-Specific Dynamics of GLP-1R and GIPR Expression in the Hypothalamus and the Amygdala of Mice

936-P: Plasma Proteomic Profiling Delineates Treatment Efficacy of a GLP-1/GIP Coagonist in Female and Male Mice

The Iminosugar AMP-DNM Improves Satiety and Activates Brown Adipose Tissue Through GLP1

Long-Acting Neurotensin Synergizes With Liraglutide to Reverse Obesity Through a Melanocortin-Dependent Pathway

Erratum. Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1. Diabetes 2018;67: 2456–2465

Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1

Erratum. Adipocyte Glucocorticoid Receptor Deficiency Attenuates Aging- and HFD-Induced Obesity and Impairs the Feeding-Fasting Transition. Diabetes 2017;66: 272–286

Erratum. Direct Substrate Delivery Into Mitochondrial Fission–Deficient Pancreatic Islets Rescues Insulin Secretion. Diabetes 2017;66: 1247–1257

Disruption of Lipid Uptake in Astroglia Exacerbates Diet-Induced Obesity

Endothelial HIF-1α Enables Hypothalamic Glucose Uptake to Drive POMC Neurons

Direct Substrate Delivery Into Mitochondrial Fission–Deficient Pancreatic Islets Rescues Insulin Secretion

Adipocyte Glucocorticoid Receptor Deficiency Attenuates Aging- and HFD-Induced Obesity and Impairs the Feeding-Fasting Transition

Hypothalamic Injury: Fish Oil to the Rescue!

Acute Administration of Unacylated Ghrelin Has No Effect on Basal or Stimulated Insulin Secretion in Healthy Humans

GLP-1/Glucagon Coagonism Restores Leptin Responsiveness in Obese Mice Chronically Maintained on an Obesogenic Diet

GLP-1R Responsiveness Predicts Individual Gastric Bypass Efficacy on Glucose Tolerance in Rats

Both Acyl and Des-Acyl Ghrelin Regulate Adiposity and Glucose Metabolism via Central Nervous System Ghrelin Receptors

GLP-1R Agonism Enhances Adjustable Gastric Banding in Diet-Induced Obese Rats

Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions

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