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Matthijs K.C. Hesselink
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Journal Articles

Evidence for a Direct Effect of the NAD+ Precursor Acipimox on Muscle Mitochondrial Function in Humans

Tineke van de Weijer, Esther Phielix, Lena Bilet, Evan G. Williams, Eduardo R. Ropelle, Alessandra Bierwagen, Roshan Livingstone, Peter Nowotny, Lauren M. Sparks, Sabina Paglialunga, Julia Szendroedi, Bas Havekes, Norman Moullan, Eija Pirinen, Jong-Hee Hwang, Vera B. Schrauwen-Hinderling, Matthijs K.C. Hesselink, Johan Auwerx, Michael Roden, Patrick Schrauwen
Journal: Diabetes
Diabetes 2015;64(4):1193–1201
https://doi.org/10.2337/db14-0667
Published: 28 October 2014
View article titled, Evidence for a Direct Effect of the NAD<sup>+</sup> Precursor Acipimox on Muscle Mitochondrial Function in Humans
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Includes: Supplementary data
Journal Articles

Reduced Incorporation of Fatty Acids Into Triacylglycerol in Myotubes From Obese Individuals With Type 2 Diabetes

Lauren M. Sparks, Madeleen Bosma, Bram Brouwers, Tineke van de Weijer, Lena Bilet, Gert Schaart, Esther Moonen-Kornips, Thomas O. Eichmann, Achim Lass, Matthijs K.C. Hesselink, Patrick Schrauwen
Journal: Diabetes
Diabetes 2014;63(5):1583–1593
https://doi.org/10.2337/db13-1123
Published: 12 April 2014
View article titled, Reduced Incorporation of Fatty Acids Into Triacylglycerol in Myotubes From Obese Individuals With Type 2 Diabetes
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Includes: Supplementary data
Journal Articles

Blocking the Entrance to Open the Gate

Patrick Schrauwen, Silvie Timmers, Matthijs K.C. Hesselink
Journal: Diabetes
Diabetes 2013;62(3):703–705
https://doi.org/10.2337/db12-1663
Published: 14 February 2013
View article titled, Blocking the Entrance to Open the Gate
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Journal Articles

Perilipin 2 Improves Insulin Sensitivity in Skeletal Muscle Despite Elevated Intramuscular Lipid Levels

Madeleen Bosma, Matthijs K.C. Hesselink, Lauren M. Sparks, Silvie Timmers, Maria João Ferraz, Frits Mattijssen, Denis van Beurden, Gert Schaart, Marc H. de Baets, Fons K. Verheyen, Sander Kersten, Patrick Schrauwen
Journal: Diabetes
Diabetes 2012;61(11):2679–2690
https://doi.org/10.2337/db11-1402
Published: 16 October 2012
View article titled, Perilipin 2 Improves Insulin Sensitivity in Skeletal Muscle Despite Elevated Intramuscular Lipid Levels
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Includes: Supplementary data
Journal Articles

High Oxidative Capacity Due to Chronic Exercise Training Attenuates Lipid-Induced Insulin Resistance

Esther Phielix, Ruth Meex, D. Margriet Ouwens, Lauren Sparks, Joris Hoeks, Gert Schaart, Esther Moonen-Kornips, Matthijs K.C. Hesselink, Patrick Schrauwen
Journal: Diabetes
Diabetes 2012;61(10):2472–2478
https://doi.org/10.2337/db11-1832
Published: 13 September 2012
View article titled, High Oxidative Capacity Due to Chronic Exercise Training Attenuates Lipid-Induced Insulin Resistance
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Includes: Supplementary data
Journal Articles

Prolonged Fasting Identifies Skeletal Muscle Mitochondrial Dysfunction as Consequence Rather Than Cause of Human Insulin Resistance

Joris Hoeks, Noud A. van Herpen, Marco Mensink, Esther Moonen-Kornips, Denis van Beurden, Matthijs K.C. Hesselink, Patrick Schrauwen
Journal: Diabetes
Diabetes 2010;59(9):2117–2125
https://doi.org/10.2337/db10-0519
Published: 23 June 2010
View article titled, Prolonged Fasting Identifies Skeletal Muscle Mitochondrial Dysfunction as Consequence Rather Than Cause of Human Insulin Resistance
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Journal Articles

Restoration of Muscle Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes by Exercise Training Is Paralleled by Increased Myocellular Fat Storage and Improved Insulin Sensitivity

Ruth C.R. Meex, Vera B. Schrauwen-Hinderling, Esther Moonen-Kornips, Gert Schaart, Marco Mensink, Esther Phielix, Tineke van de Weijer, Jean-Pierre Sels, Patrick Schrauwen, Matthijs K.C. Hesselink
Journal: Diabetes
Diabetes 2010;59(3):572–579
https://doi.org/10.2337/db09-1322
Published: 22 December 2009
View article titled, Restoration of Muscle Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes by Exercise Training Is Paralleled by Increased Myocellular Fat Storage and Improved Insulin Sensitivity
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Journal Articles

Lower Intrinsic ADP-Stimulated Mitochondrial Respiration Underlies In Vivo Mitochondrial Dysfunction in Muscle of Male Type 2 Diabetic Patients

Esther Phielix, Vera B. Schrauwen-Hinderling, Marco Mensink, Ellen Lenaers, Ruth Meex, Joris Hoeks, Marianne Eline Kooi, Esther Moonen-Kornips, Jean-Pierre Sels, Matthijs K.C. Hesselink, Patrick Schrauwen
Journal: Diabetes
Diabetes 2008;57(11):2943–2949
https://doi.org/10.2337/db08-0391
Published: 01 November 2008
View article titled, Lower Intrinsic ADP-Stimulated Mitochondrial Respiration Underlies In Vivo Mitochondrial Dysfunction in Muscle of Male Type 2 Diabetic Patients
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Journal Articles

Oxidative Capacity, Lipotoxicity, and Mitochondrial Damage in Type 2 Diabetes

Patrick Schrauwen, Matthijs K.C. Hesselink
Journal: Diabetes
Diabetes 2004;53(6):1412–1417
https://doi.org/10.2337/diabetes.53.6.1412
Published: 01 June 2004
View article titled, Oxidative Capacity, Lipotoxicity, and Mitochondrial Damage in Type 2 Diabetes
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Journal Articles

Uncoupling Protein 3 Content Is Decreased in Skeletal Muscle of Patients With Type 2 Diabetes

Patrick Schrauwen, Matthijs K.C. Hesselink, Ellen E. Blaak, Lars B. Borghouts, Gert Schaart, Wim H.M. Saris, Hans A. Keizer
Journal: Diabetes
Diabetes 2001;50(12):2870–2873
https://doi.org/10.2337/diabetes.50.12.2870
Published: 01 December 2001
View article titled, Uncoupling Protein 3 Content Is Decreased in Skeletal Muscle of Patients With Type 2 Diabetes
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