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Meeting Abstracts

1563-P: High Fat and Fructose Feeding Severely Impairs Hepatic Glucose Effectiveness but Not Insulin Action Under Euglycemic Conditions

DALE S. EDGERTON, GUILLAUME KRAFT, HANNAH L. WATERMAN, BEN FARMER, KALISHA YANKEY, MARTA S. SMITH, JON R. HASTINGS, MELANIE SCOTT, ALAN D. CHERRINGTON

Diabetes 2024;73(Supplement_1):1563-P

https://doi.org/10.2337/db24-1563-P

Published: 14 June 2024

View article titled, 1563-P: High Fat and Fructose Feeding Severely Impairs Hepatic Glucose Effectiveness but Not Insulin Action Under Euglycemic Conditions

Meeting Abstracts

1597-P: High Fat and Fructose Diet Dysregulates Postprandial Gut and Hepatic Metabolism in a Canine Model

GUILLAUME KRAFT, MELANIE SCOTT, BEN FARMER, KALISHA YANKEY, DALE S. EDGERTON, HARITH RAJAGOPALAN, EMILY COZZI, KATHERINE GIBSON-CORLEY, CHARLES R. FLYNN, ALAN D. CHERRINGTON

Diabetes 2024;73(Supplement_1):1597-P

https://doi.org/10.2337/db24-1597-P

Published: 14 June 2024

View article titled, 1597-P: High Fat and Fructose Diet Dysregulates Postprandial Gut and Hepatic Metabolism in a Canine Model

Meeting Abstracts

1600-P: Duration of Morning Hyperinsulinemia Is Key to the Enhancement of Hepatic Glucose Uptake Later in the Day

HANNAH L. WATERMAN, MARTA S. SMITH, BEN FARMER, GUILLAUME KRAFT, MELANIE SCOTT, DALE S. EDGERTON, ALAN D. CHERRINGTON, MARY C. MOORE

Diabetes 2023;72(Supplement_1):1600-P

https://doi.org/10.2337/db23-1600-P

Published: 20 June 2023

View article titled, 1600-P: Duration of Morning Hyperinsulinemia Is Key to the Enhancement of Hepatic Glucose Uptake Later in the Day

Meeting Abstracts

1560-P: Combining Glucagon with Insulin Can Lessen the Hypoglycemic Potential of Insulin

GUILLAUME KRAFT, MELANIE SCOTT, MARTA S. SMITH, BEN FARMER, DALE S. EDGERTON, ALAN D. CHERRINGTON

Diabetes 2023;72(Supplement_1):1560-P

https://doi.org/10.2337/db23-1560-P

Published: 20 June 2023

View article titled, 1560-P: Combining Glucagon with Insulin Can Lessen the Hypoglycemic Potential of Insulin

Journal Articles

Profound Sensitivity of the Liver to the Direct Effect of Insulin Allows Peripheral Insulin Delivery to Normalize Hepatic but Not Muscle Glucose Uptake in the Healthy Dog

Guillaume Kraft, Katie C. Coate, Marta Smith, Ben Farmer, Melanie Scott, Jon Hastings, Alan D. Cherrington, Dale S. Edgerton

Diabetes 2023;72(2):196–209

https://doi.org/10.2337/db22-0471

Published: 24 October 2022

View article titled, Profound Sensitivity of the Liver to the Direct Effect of Insulin Allows Peripheral Insulin Delivery to Normalize Hepatic but Not Muscle Glucose Uptake in the Healthy Dog

Meeting Abstracts

1341-P: Dietary Fat and Fructose Impair Glucagon-Stimulated Liver Glucose Metabolism

DALE S. EDGERTON, GUILLAUME KRAFT, KATIE C. COATE, BEN FARMER, MARTA S. SMITH, MELANIE SCOTT, JON R. HASTINGS, MARY C. MOORE, ALAN D. CHERRINGTON

Diabetes 2022;71(Supplement_1):1341-P

https://doi.org/10.2337/db22-1341-P

Published: 01 June 2022

View article titled, 1341-P: Dietary Fat and Fructose Impair Glucagon-Stimulated Liver Glucose Metabolism

Journal Articles

The Importance of the Mechanisms by Which Insulin Regulates Meal-Associated Liver Glucose Uptake in the Dog

Guillaume Kraft, Katie C. Coate, Marta Smith, Ben Farmer, Melanie Scott, Alan D. Cherrington, Dale S. Edgerton

Diabetes 2021;70(6):1292–1302

https://doi.org/10.2337/db20-1271

Published: 23 March 2021

View article titled, The Importance of the Mechanisms by Which Insulin Regulates Meal-Associated Liver Glucose Uptake in the Dog

Meeting Abstracts

367-OR: High-Fat and Fructose Feeding Severely Impairs Hepatic Glucose Effectiveness

DALE S. EDGERTON, GUILLAUME KRAFT, BEN FARMER, MELANIE SCOTT, MARTA S. SMITH, ALAN D. CHERRINGTON

Diabetes 2020;69(Supplement_1):367-OR

https://doi.org/10.2337/db20-367-OR

Published: 01 June 2020

View article titled, 367-OR: High-Fat and Fructose Feeding Severely Impairs Hepatic Glucose Effectiveness

Journal Articles

Sympathetic Denervation of the Common Hepatic Artery Lessens Glucose Intolerance in the Fat- and Fructose-Fed Dog

Guillaume Kraft, Anthony Vrba, Melanie Scott, Eric Allen, Dale S. Edgerton, Phil E. Williams, Scott B. Vafai, Bobak R. Azamian, Alan D. Cherrington

Diabetes 2019;68(6):1143–1155

https://doi.org/10.2337/db18-1209

Published: 01 April 2019

View article titled, Sympathetic Denervation of the Common Hepatic Artery Lessens Glucose Intolerance in the Fat- and Fructose-Fed Dog

Meeting Abstracts

Incretin Hormone Release Does Not Involve Hepatic Portal Vein Glucose Sensors

DALE S. EDGERTON, GUILLAUME KRAFT, MARTA S. SMITH, L. MERKLE MOORE, BEN FARMER, HEATHER SARA, MELANIE SCOTT, MARY MOORE, MICHAEL A. NAUCK, ALAN D. CHERRINGTON

Diabetes 2018;67(Supplement_1):1961-P

https://doi.org/10.2337/db18-1961-P

Published: 01 July 2018

View article titled, Incretin Hormone Release Does Not Involve Hepatic Portal Vein Glucose Sensors

Journal Articles

Changes in Glucose and Fat Metabolism in Response to the Administration of a Hepato-Preferential Insulin Analog

Dale S. Edgerton, Mary C. Moore, Jason J. Winnick, Melanie Scott, Ben Farmer, Helle Naver, Claus B. Jeppesen, Peter Madsen, Thomas B. Kjeldsen, Erica Nishimura, Christian L. Brand, Alan D. Cherrington

Diabetes 2014;63(11):3946–3954

https://doi.org/10.2337/db14-0266

Published: 13 October 2014

View article titled, Changes in Glucose and Fat Metabolism in Response to the Administration of a Hepato-Preferential Insulin Analog

Journal Articles

Inhibition of Dipeptidyl Peptidase-4 by Vildagliptin During Glucagon-Like Peptide 1 Infusion Increases Liver Glucose Uptake in the Conscious Dog

Dale S. Edgerton, Kathryn M.S. Johnson, Doss W. Neal, Melanie Scott, Charles H. Hobbs, Xia Zhang, Alokesh Duttaroy, Alan D. Cherrington

Diabetes 2009;58(1):243–249

https://doi.org/10.2337/db08-0515

Published: 01 January 2009

View article titled, Inhibition of Dipeptidyl Peptidase-4 by Vildagliptin During Glucagon-Like Peptide 1 Infusion Increases Liver Glucose Uptake in the Conscious Dog

Journal Articles

Inhalation of Human Insulin (Exubera) Augments the Efficiency of Muscle Glucose Uptake In Vivo

Dale S. Edgerton, Alan D. Cherrington, Phillip Williams, Doss W. Neal, Melanie Scott, Larry Bowen, Warren Wilson, Charles H. Hobbs, Chet Leach, Mei-chang Kuo, Thomas R. Strack

Diabetes 2006;55(12):3604–3610

https://doi.org/10.2337/db06-0718

Published: 01 December 2006

View article titled, Inhalation of Human Insulin (Exubera) Augments the Efficiency of Muscle Glucose Uptake In Vivo

Journal Articles

Inhalation of Insulin (Exubera) Is Associated With Augmented Disposal of Portally Infused Glucose in Dogs

Dale S. Edgerton, Doss W. Neal, Melanie Scott, Larry Bowen, Warren Wilson, Charles H. Hobbs, Chet Leach, Shantha Sivakumaran, Thomas R. Strack, Alan D. Cherrington

Diabetes 2005;54(4):1164–1170

https://doi.org/10.2337/diabetes.54.4.1164

Published: 01 April 2005

View article titled, Inhalation of Insulin (Exubera) Is Associated With Augmented Disposal of Portally Infused Glucose in Dogs

NARROW

1563-P: High Fat and Fructose Feeding Severely Impairs Hepatic Glucose Effectiveness but Not Insulin Action Under Euglycemic Conditions

1597-P: High Fat and Fructose Diet Dysregulates Postprandial Gut and Hepatic Metabolism in a Canine Model

1600-P: Duration of Morning Hyperinsulinemia Is Key to the Enhancement of Hepatic Glucose Uptake Later in the Day

1560-P: Combining Glucagon with Insulin Can Lessen the Hypoglycemic Potential of Insulin

Profound Sensitivity of the Liver to the Direct Effect of Insulin Allows Peripheral Insulin Delivery to Normalize Hepatic but Not Muscle Glucose Uptake in the Healthy Dog

1341-P: Dietary Fat and Fructose Impair Glucagon-Stimulated Liver Glucose Metabolism

The Importance of the Mechanisms by Which Insulin Regulates Meal-Associated Liver Glucose Uptake in the Dog

367-OR: High-Fat and Fructose Feeding Severely Impairs Hepatic Glucose Effectiveness

Sympathetic Denervation of the Common Hepatic Artery Lessens Glucose Intolerance in the Fat- and Fructose-Fed Dog

Incretin Hormone Release Does Not Involve Hepatic Portal Vein Glucose Sensors

Changes in Glucose and Fat Metabolism in Response to the Administration of a Hepato-Preferential Insulin Analog

Inhibition of Dipeptidyl Peptidase-4 by Vildagliptin During Glucagon-Like Peptide 1 Infusion Increases Liver Glucose Uptake in the Conscious Dog

Inhalation of Human Insulin (Exubera) Augments the Efficiency of Muscle Glucose Uptake In Vivo

Inhalation of Insulin (Exubera) Is Associated With Augmented Disposal of Portally Infused Glucose in Dogs

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