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Meeting Abstracts

266-OR: Retatrutide, an Agonist of GIP, GLP-1, and Glucagon Receptors, Improves Markers of Pancreatic Beta-Cell Function and Insulin Sensitivity

JULIO ROSENSTOCK, TAMER COSKUN, MARK L. HARTMAN, JITONG LOU, QIWEI WU, YU DU, SIREL GURBUZ, KIEREN J. MATHER, ZVONKO MILICEVIC, MELISSA K. THOMAS

Diabetes 2024;73(Supplement_1):266-OR

https://doi.org/10.2337/db24-266-OR

Published: 14 June 2024

View articletitled, 266-OR: Retatrutide, an Agonist of GIP, GLP-1, and Glucagon Receptors, Improves Markers of Pancreatic Beta-Cell Function and Insulin Sensitivity

Meeting Abstracts

771-P: Tirzepatide Reduces HbA1c and Body Weight Significantly More than Placebo or Semaglutide Irrespective of Baseline Beta-Cell Function—Post Hoc Analysis from SURPASS-1 and SURPASS-2

JUAN M. MALDONADO, CHRISTOPHE DE BLOCK, JUAN P. FRIAS, CLARE LEE, KATELYN BROWN, HUI WANG, MELISSA K. THOMAS

Diabetes 2023;72(Supplement_1):771-P

https://doi.org/10.2337/db23-771-P

Published: 20 June 2023

View articletitled, 771-P: Tirzepatide Reduces HbA1c and Body Weight Significantly More than Placebo or Semaglutide Irrespective of Baseline Beta-Cell Function—Post Hoc Analysis from SURPASS-1 and SURPASS-2

Meeting Abstracts

783-P: Baseline HOMA2-B Can Predict Tirzepatide Efficacy—Post Hoc Analysis of the SURPASS-1 and SURPASS-2 Studies

STANLEY H. HSIA, MELISSA K. THOMAS, CHANTAL MATHIEU, HUI WANG, JENNIFER PELESHOK

Diabetes 2023;72(Supplement_1):783-P

https://doi.org/10.2337/db23-783-P

Published: 20 June 2023

View articletitled, 783-P: Baseline HOMA2-B Can Predict Tirzepatide Efficacy—Post Hoc Analysis of the SURPASS-1 and SURPASS-2 Studies

Meeting Abstracts

1588-P: Translatable Modeling of Glucagon Actions in Human iPSC-Derived Hepatocytes Uniquely Predicts Differential Clinical Responses to Glucagon Analog Agonist Molecules

WILLIAM ROELL, AJIT REGMI, CHARLES T. BENSON, TAMER COSKUN, JULIE S. MOYERS, JORGE ALSINA-FERNANDEZ, MELISSA K. THOMAS

Diabetes 2023;72(Supplement_1):1588-P

https://doi.org/10.2337/db23-1588-P

Published: 20 June 2023

View articletitled, 1588-P: Translatable Modeling of Glucagon Actions in Human iPSC-Derived Hepatocytes Uniquely Predicts Differential Clinical Responses to Glucagon Analog Agonist Molecules

Meeting Abstracts

722-P: Tirzepatide Improves Multiple Aspects of Beta-Cell Function

ANDREA MARI, JING LI, SHWETA URVA, TIM HEISE, J. HANS DE VRIES, EDWARD J. PRATT, ROBERT J. HEINE, MELISSA K. THOMAS, ZVONKO MILICEVIC, KIEREN J. MATHER

Diabetes 2022;71(Supplement_1):722-P

https://doi.org/10.2337/db22-722-P

Published: 01 June 2022

View articletitled, 722-P: Tirzepatide Improves Multiple Aspects of Beta-Cell Function

Meeting Abstracts

338-OR: Tirzepatide Reduces Appetite, Energy Intake, and Fat Mass in People with T2D

TIM HEISE, J. HANS DE VRIES, TAMER COSKUN, SHWETA URVA, JING LI, EDWARD J. PRATT, MELISSA K. THOMAS, KIEREN J. MATHER, JULIA P. DUNN, AXEL HAUPT, ZVONKO MILICEVIC

Diabetes 2022;71(Supplement_1):338-OR

https://doi.org/10.2337/db22-338-OR

Published: 01 June 2022

View articletitled, 338-OR: Tirzepatide Reduces Appetite, Energy Intake, and Fat Mass in People with T2D

Meeting Abstracts

337-OR: Tirzepatide Improved Markers of Islet-Cell Function (Fasting Glucagon and HOMA2-B) and Insulin Sensitivity (Fasting Insulin and HOMA2-IR) Compared with Semaglutide in People with Type 2 Diabetes

KATELYN BROWN, LAURA FERNANDEZ LANDO, BRANDON BERGMAN, MELISSA K. THOMAS, BING LIU, CLARE LEE

Diabetes 2022;71(Supplement_1):337-OR

https://doi.org/10.2337/db22-337-OR

Published: 01 June 2022

View articletitled, 337-OR: Tirzepatide Improved Markers of Islet-Cell Function (Fasting Glucagon and HOMA2-B) and Insulin Sensitivity (Fasting Insulin and HOMA2-IR) Compared with Semaglutide in People with Type 2 Diabetes

Meeting Abstracts

715-P: Tirzepatide as Monotherapy Improved Markers of Beta-Cell Function and Insulin Sensitivity in People with Type 2 Diabetes (SURPASS-1)

CLARE LEE, HUZHANG MAO, VIVIAN THIEU, MELISSA K. THOMAS

Diabetes 2022;71(Supplement_1):715-P

https://doi.org/10.2337/db22-715-P

Published: 01 June 2022

View articletitled, 715-P: Tirzepatide as Monotherapy Improved Markers of Beta-Cell Function and Insulin Sensitivity in People with Type 2 Diabetes (SURPASS-1)

Meeting Abstracts

714-P: Greater Improvement in Insulin Sensitivity Per Unit Weight Loss with Tirzepatide Compared with Selective GLP-1 Receptor Agonism

KIEREN J. MATHER, ANDREA MARI, JING LI, TIM HEISE, J. HANS DE VRIES, SHWETA URVA, TAMER COSKUN, ZVONKO MILICEVIC, AXEL HAUPT, MELISSA K. THOMAS

Diabetes 2022;71(Supplement_1):714-P

https://doi.org/10.2337/db22-714-P

Published: 01 June 2022

View articletitled, 714-P: Greater Improvement in Insulin Sensitivity Per Unit Weight Loss with Tirzepatide Compared with Selective GLP-1 Receptor Agonism

Meeting Abstracts

333-OR: Oxyntomodulin Analog LY3305677 (LY) Improves Glycemic Control and Weight Loss in Healthy Volunteers and Subjects with Type 2 Diabetes (T2D)

CHARLES BENSON, LAI-SAN THAM, YU DU, SIREL GURBUZ, DEBORAH A. ROBINS, KIEREN J. MATHER, CHENG CAI TANG, MELISSA K. THOMAS

Diabetes 2022;71(Supplement_1):333-OR

https://doi.org/10.2337/db22-333-OR

Published: 01 June 2022

View articletitled, 333-OR: Oxyntomodulin Analog LY3305677 (LY) Improves Glycemic Control and Weight Loss in Healthy Volunteers and Subjects with Type 2 Diabetes (T2D)

Journal Articles

Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study

Andrea Tura, Eleonora Grespan, Christian S. Göbl, Robert W. Koivula, Paul W. Franks, Ewan R. Pearson, Mark Walker, Ian M. Forgie, Giuseppe N. Giordano, Imre Pavo, Hartmut Ruetten, Emmanouil T. Dermitzakis, Mark I. McCarthy, Oluf Pedersen, Jochen M. Schwenk, Jerzy Adamski, Federico De Masi, Konstantinos D. Tsirigos, Søren Brunak, Ana Viñuela, Anubha Mahajan, Timothy J. McDonald, Tarja Kokkola, Jagadish Vangipurapu, Henna Cederberg, Markku Laakso, Femke Rutters, Petra J.M. Elders, Anitra D.M. Koopman, Joline W. Beulens, Martin Ridderstråle, Tue H. Hansen, Kristine H. Allin, Torben Hansen, Henrik Vestergaard, Andrea Mari, IMI DIRECT Consortium, Leen M. 't Hart, Moustafa Abdalla, Jonathan Adam, Jerzy Adamski, Kofi Adragni, Rosa L. Allesøe, Kristine H. Allin, Manimozhiyan Arumugam, Naeimeh Atabaki Pasdar, Tania Baltauss, Karina Banasik, Patrick Baum, Jimmy D. Bell, Margit Bergstrom, Joline W. Beulens, Susaana Bianzano, Roberto Bizzotto, Amelie Bonneford, Caroline Anna Brorsson, Andrew A. Brown, Søren Brunak, Louise Cabrelli, Robert Caiazzo, Mickael Canouil, Henna Cederberg, Matilda Dale, David Davtian, Adem Y. Dawed, Federico De Masi, Nathalie de Preville, Koen F. Dekkers, Emmanouil T. Dermitzakis, Harshal A. Deshmukh, Christiane Dings, Louise Donnelly, Avirup Dutta, Beate Ehrhardt, Petra J. M. Elders, Line Engelbrechtsen, Rebeca Eriksen, Yong Fan, Juan Fernandez, Jorge Ferrer, Hugo Fitipaldi, Ian M. Forgie, Annemette Forman, Paul W. Franks, Francesca Frau, Andreas Fritsche, Philippe Froguel, Gary Frost, Johann Gassenhuber, Giuseppe N. Giordano, Toni Giorgino, Stephen Gough, Ulrike Graefe-Mody, Harald Grallert, Rolf Grempler, Lenka Groeneveld, Leif Groop, Valborg Gudmundsdóttir, Ramneek Gupta, Mark Haid, Torben Hansen, Tue H. Hansen, Andrew T. Hattersley, Ragna Haussler, Alison J. Heggie, Anita M. Hennige, Anita V. Hill, Reinhard W. Holl, Mun-gwan Hong, Michelle Hudson, Bernd Jablonka, Christopher Jennison, Yunlong Jiao, Joachim Johansen, Angus G. Jones, Anna Jonsson, Tugce Karaderi, Jane Kaye, Maria Klintenberg, Robert W. Koivula, Tarja Kokkola, Anitra D. M. Koopman, Azra Kurbasic, Teemu Kuulasmaa, Markku Laakso, Thorsten Lehr, Heather Loftus, Agnete T. Lundgaard, Anubha Mahajan, Andrea Mari, Gianluca Mazzoni, Mark I. McCarthy, Timothy J. McDonald, Donna McEvoy, Nicky McRobert, Ian McVittie, Miranda Mourby, Petra Musholt, Pascal Mutie, Rachel Nice, Claudia Nicolay, Agnes Martine Nielsen, Birgitte Nilsson, Giel Nijpels, Colin N. Palmer, Francois Pattou, Imre Pavo, Ewan R. Pearson, Oluf Pedersen, Helle K. Pedersen, Mandy H. Perry, Hugo Pomares-Millan, Anna Ramisch, Simon Rasmussen, Violeta Raverdi, Martin Ridderstråle, Neil Robertson, Slieker Roderick, Marianne Rodriquez, Hartmut Ruetten, Femke Rutters, Peter Sackett, Nina Scherer, Jochen M. Schwenk, Nisha Shah, Sapna Sharma, Iryna Sihinevich, Nadja B. Sondertoft, Hans-Henrik Staerfeldt, Birgit Steckel-Hamann, Harriet Teare, Cecilia Engel Thomas, Melissa K. Thomas, Louise Thomas, Henrik S. Thomsen, Barbara Thorand, Claire E. Thorne, Joachim Tillner, Martina Troll, Konstantinos D. Tsirigos, Andrea Tura, Mathias Uhlen, Jagadish Vangipurapu, Nienke van Leeuwen, Sabine van Oort, Helene Verkindt, Henrik Vestergaard, Ana Viñuela, Josef K. Vogt, Peter Wad Sackett, Dianne Wake, Mark Walker, Agata Wesolowska-Andersen, Brandon Whitcher, Margaret W. White, Han Wu

Diabetes 2021;70(9):2092–2106

https://doi.org/10.2337/db21-0227

Published: 07 July 2021

View articletitled, Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study

Meeting Abstracts

682-P: Novel Dual Glucagon and Glucagon-Like Peptide-1 Receptor Agonist LY3305677 Improves Glucose Control, Reduces Body Weight, and Increases Energy Expenditure in Mice

YANYUN CHEN, ADAM MEZO, TAMER COSKUN, MIN SONG, WILLIAM C. ROELL, KRISTER B. BOKVIST, JULIE S. MOYERS, MELISSA K. THOMAS, FRANCISCO VALENZUELA, HONGCHANG QU

Diabetes 2021;70(Supplement_1):682-P

https://doi.org/10.2337/db21-682-P

Published: 01 June 2021

View articletitled, 682-P: Novel Dual Glucagon and Glucagon-Like Peptide-1 Receptor Agonist LY3305677 Improves Glucose Control, Reduces Body Weight, and Increases Energy Expenditure in Mice

Meeting Abstracts

1216-P: Plasma Amino Acid Profile as a Predictive Biomarker for Visceral Adiposity in Japanese Americans

ANH TRAN, PANDORA WANDER, MELISSA K. THOMAS, STEVEN E. KAHN, WILFRED Y. FUJIMOTO, EDWARD J. BOYKO

Diabetes 2021;70(Supplement_1):1216-P

https://doi.org/10.2337/db21-1216-P

Published: 01 June 2021

View articletitled, 1216-P: Plasma Amino Acid Profile as a Predictive Biomarker for Visceral Adiposity in Japanese Americans

Meeting Abstracts

106-OR: A First-in-Human Single Ascending Dose Study of Oxyntomodulin Analog LY3305677 in Healthy Subjects

LAI-SAN THAM, MELISSA K. THOMAS, CHARLES BENSON, ROSS BRAY, CHENG CAI TANG, CORINA LOGHIN

Diabetes 2021;70(Supplement_1):106-OR

https://doi.org/10.2337/db21-106-OR

Published: 01 June 2021

View articletitled, 106-OR: A First-in-Human Single Ascending Dose Study of Oxyntomodulin Analog LY3305677 in Healthy Subjects

Meeting Abstracts

104-OR: Novel GIP/GLP-1/Glucagon Receptor Agonist LY3437943: A First-in-Human Dose Study in Healthy Subjects

SHWETA URVA, YU DU, MELISSA K. THOMAS, ZVONKO MILICEVIC, TAMER COSKUN, CHARLES BENSON, CORINA LOGHIN

Diabetes 2021;70(Supplement_1):104-OR

https://doi.org/10.2337/db21-104-OR

Published: 01 June 2021

View articletitled, 104-OR: Novel GIP/GLP-1/Glucagon Receptor Agonist LY3437943: A First-in-Human Dose Study in Healthy Subjects

Meeting Abstracts

980-P: Tirzepatide, a Dual GIP and GLP-1 Receptor Agonist, Improves Markers of Beta-Cell Function and Insulin Sensitivity in Type 2 Diabetes Patients

MELISSA K. THOMAS, AMIR NIKOOIENEJAD, ROSS BRAY, XUEWEI CUI, JONATHAN M. WILSON, KEVIN L. DUFFIN, ZVONKO MILICEVIC, AXEL HAUPT, DEBORAH A. ROBINS

Diabetes 2019;68(Supplement_1):980-P

https://doi.org/10.2337/db19-980-P

Published: 01 June 2019

View articletitled, 980-P: Tirzepatide, a Dual GIP and GLP-1 Receptor Agonist, Improves Markers of Beta-Cell Function and Insulin Sensitivity in Type 2 Diabetes Patients

Meeting Abstracts

20-OR: GPR142 Agonists Increase Glucose-Dependent Insulin Secretion and Differentially Regulate Hormone Secretion in Preclinical and Phase 1 Studies

EDWARD J. PRATT, TOMONORI OURA, XIAOSU MA, HUA V. LIN, TIANWEI MA, ALEXANDER M. EFANOV, MELISSA K. THOMAS

Diabetes 2019;68(Supplement_1):20-OR

https://doi.org/10.2337/db19-20-OR

Published: 01 June 2019

View articletitled, 20-OR: GPR142 Agonists Increase Glucose-Dependent Insulin Secretion and Differentially Regulate Hormone Secretion in Preclinical and Phase 1 Studies

Meeting Abstracts

GIP Signaling Integrates with Insulin Signaling to Regulate Glucose and Lipid Metabolism in Human Adipocytes

AJIT REGMI, MELISSA K. THOMAS, M. DODSON MICHAEL, WILLIAM C. ROELL

Diabetes 2018;67(Supplement_1):37-OR

https://doi.org/10.2337/db18-37-OR

Published: 01 July 2018

View articletitled, GIP Signaling Integrates with Insulin Signaling to Regulate Glucose and Lipid Metabolism in Human Adipocytes

Journal Articles

Stromal Cell–Derived Factor-1 (SDF-1)/CXCL12 Attenuates Diabetes in Mice and Promotes Pancreatic β-Cell Survival by Activation of the Prosurvival Kinase Akt

Tatsuya Yano, Zhengyu Liu, Jennifer Donovan, Melissa K. Thomas, Joel F. Habener

Diabetes 2007;56(12):2946–2957

https://doi.org/10.2337/db07-0291

Published: 01 December 2007

View articletitled, Stromal Cell–Derived Factor-1 (SDF-1)/CXCL12 Attenuates Diabetes in Mice and Promotes Pancreatic β-Cell Survival by Activation of the Prosurvival Kinase Akt

Includes: Supplementary data

Journal Articles

Multipotential Nestin-Positive Stem Cells Isolated From Adult Pancreatic Islets Differentiate Ex Vivo Into Pancreatic Endocrine, Exocrine, and Hepatic Phenotypes

Henryk Zulewski, Elizabeth J. Abraham, Melissa J. Gerlach, Philip B. Daniel, Wolfgang Moritz, Beat Müller, Mario Vallejo, Melissa K. Thomas, Joel F. Habener

Diabetes 2001;50(3):521–533

https://doi.org/10.2337/diabetes.50.3.521

Published: 01 March 2001

View articletitled, Multipotential Nestin-Positive Stem Cells Isolated From Adult Pancreatic Islets Differentiate Ex Vivo Into Pancreatic Endocrine, Exocrine, and Hepatic Phenotypes

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266-OR: Retatrutide, an Agonist of GIP, GLP-1, and Glucagon Receptors, Improves Markers of Pancreatic Beta-Cell Function and Insulin Sensitivity

771-P: Tirzepatide Reduces HbA1c and Body Weight Significantly More than Placebo or Semaglutide Irrespective of Baseline Beta-Cell Function—Post Hoc Analysis from SURPASS-1 and SURPASS-2

783-P: Baseline HOMA2-B Can Predict Tirzepatide Efficacy—Post Hoc Analysis of the SURPASS-1 and SURPASS-2 Studies

1588-P: Translatable Modeling of Glucagon Actions in Human iPSC-Derived Hepatocytes Uniquely Predicts Differential Clinical Responses to Glucagon Analog Agonist Molecules

722-P: Tirzepatide Improves Multiple Aspects of Beta-Cell Function

338-OR: Tirzepatide Reduces Appetite, Energy Intake, and Fat Mass in People with T2D

337-OR: Tirzepatide Improved Markers of Islet-Cell Function (Fasting Glucagon and HOMA2-B) and Insulin Sensitivity (Fasting Insulin and HOMA2-IR) Compared with Semaglutide in People with Type 2 Diabetes

715-P: Tirzepatide as Monotherapy Improved Markers of Beta-Cell Function and Insulin Sensitivity in People with Type 2 Diabetes (SURPASS-1)

714-P: Greater Improvement in Insulin Sensitivity Per Unit Weight Loss with Tirzepatide Compared with Selective GLP-1 Receptor Agonism

333-OR: Oxyntomodulin Analog LY3305677 (LY) Improves Glycemic Control and Weight Loss in Healthy Volunteers and Subjects with Type 2 Diabetes (T2D)

Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study

682-P: Novel Dual Glucagon and Glucagon-Like Peptide-1 Receptor Agonist LY3305677 Improves Glucose Control, Reduces Body Weight, and Increases Energy Expenditure in Mice

1216-P: Plasma Amino Acid Profile as a Predictive Biomarker for Visceral Adiposity in Japanese Americans

106-OR: A First-in-Human Single Ascending Dose Study of Oxyntomodulin Analog LY3305677 in Healthy Subjects

104-OR: Novel GIP/GLP-1/Glucagon Receptor Agonist LY3437943: A First-in-Human Dose Study in Healthy Subjects

980-P: Tirzepatide, a Dual GIP and GLP-1 Receptor Agonist, Improves Markers of Beta-Cell Function and Insulin Sensitivity in Type 2 Diabetes Patients

20-OR: GPR142 Agonists Increase Glucose-Dependent Insulin Secretion and Differentially Regulate Hormone Secretion in Preclinical and Phase 1 Studies

GIP Signaling Integrates with Insulin Signaling to Regulate Glucose and Lipid Metabolism in Human Adipocytes

Stromal Cell–Derived Factor-1 (SDF-1)/CXCL12 Attenuates Diabetes in Mice and Promotes Pancreatic β-Cell Survival by Activation of the Prosurvival Kinase Akt

Multipotential Nestin-Positive Stem Cells Isolated From Adult Pancreatic Islets Differentiate Ex Vivo Into Pancreatic Endocrine, Exocrine, and Hepatic Phenotypes

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