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Meeting Abstracts

2039-LB: Insulin Sensitivity Is Impaired Independent of Changes in Body Weight in Liver-Specific GDF15 Knockout Mice

JAKE KASTROLL, MICHAEL J. JURCZAK, JONATHAN ALDER, AMBER VANDEVENDER, NIKOLAOS DEDOUSIS, IAN J. SIPULA

Diabetes 2024;73(Supplement_1):2039-LB

https://doi.org/10.2337/db24-2039-LB

Published: 14 June 2024

View article titled, 2039-LB: Insulin Sensitivity Is Impaired Independent of Changes in Body Weight in Liver-Specific GDF15 Knockout Mice

Journal Articles

Role of Cardiorespiratory Fitness and Mitochondrial Oxidative Capacity in Reduced Walk Speed of Older Adults With Diabetes

Diabetes 2024;73(7):1048–1057

https://doi.org/10.2337/db23-0827

Published: 29 March 2024

View article titled, Role of Cardiorespiratory Fitness and Mitochondrial Oxidative Capacity in Reduced Walk Speed of Older Adults With Diabetes

Journal Articles

Assessment of Tissue-Specific Glucose Uptake: Teaching an Old 2-DOG New Tricks

Max C. Petersen, Michael J. Jurczak

Diabetes 2024;73(3):355–356

https://doi.org/10.2337/db23-0816

Published: 20 February 2024

View article titled, Assessment of Tissue-Specific Glucose Uptake: Teaching an Old 2-DOG New Tricks

Meeting Abstracts

1572-P: USP30 Regulates Hepatic Mitophagy and Mitochondrial Function

OLAYEMI G. FAGUNLOYE, FIONA BELLO, AMBER VANDEVENDER, IAN J. SIPULA, MICHAEL J. JURCZAK

Diabetes 2023;72(Supplement_1):1572-P

https://doi.org/10.2337/db23-1572-P

Published: 20 June 2023

View article titled, 1572-P: USP30 Regulates Hepatic Mitophagy and Mitochondrial Function

Meeting Abstracts

261-LB: Hepatocyte Gdf15 Protects against CCL4-Induced Liver Injury Independent of Changes in Feeding and Inflammation

JAKE KASTROLL, MICHAEL J. JURCZAK, FIONA BELLO, AMBER VANDEVENDER, IAN J. SIPULA, JONATHAN ALDER

Diabetes 2023;72(Supplement_1):261-LB

https://doi.org/10.2337/db23-261-LB

Published: 20 June 2023

View article titled, 261-LB: Hepatocyte Gdf15 Protects against CCL4-Induced Liver Injury Independent of Changes in Feeding and Inflammation

Meeting Abstracts

1368-P: Skeletal Muscle Mitochondrial Dysfunction Contributes to Increased GDF15 Levels in Aged Mice with Insulin Resistance and Sarcopenia

JEFFREY CHEN, FIONA BELLO, JAKE KASTROLL, AMBER VANDEVENDER, MARTHA PANGBURN, AGUSTIN A. GIL SILVA, IAN J. SIPULA, JONATHAN ALDER, MICHAEL J. JURCZAK

Diabetes 2022;71(Supplement_1):1368-P

https://doi.org/10.2337/db22-1368-P

Published: 01 June 2022

View article titled, 1368-P: Skeletal Muscle Mitochondrial Dysfunction Contributes to Increased GDF15 Levels in Aged Mice with Insulin Resistance and Sarcopenia

Meeting Abstracts

224-LB: Mitochondrial Capacity of Skeletal Muscle in Older Adults with Diabetes

SOFHIA V. RAMOS, GIOVANNA DISTEFANO, PEGGY CAWTHON, STEPHANIE M. MARSHALL, PHILIP KRAMER, ANTHONY MOLINA, MICHAEL J. JURCZAK, FREDERICO TOLEDO, BRET H. GOODPASTER, PAUL M. COEN

Diabetes 2022;71(Supplement_1):224-LB

https://doi.org/10.2337/db22-224-LB

Published: 01 June 2022

View article titled, 224-LB: Mitochondrial Capacity of Skeletal Muscle in Older Adults with Diabetes

Meeting Abstracts

1337-P: Sex-Specific Variation in Lipid Metabolism in Response to Nutritional Stress Is Associated with Differences in NASH Progression

MACKENZIE MOON, ANJANA MURALI, FIONA BELLO, JIEBIAO WANG, MICHAEL J. JURCZAK

Diabetes 2022;71(Supplement_1):1337-P

https://doi.org/10.2337/db22-1337-P

Published: 01 June 2022

View article titled, 1337-P: Sex-Specific Variation in Lipid Metabolism in Response to Nutritional Stress Is Associated with Differences in NASH Progression

Meeting Abstracts

3-OR: Hepatocyte Gdf15 Is Sufficient for Increased Plasma GDF15 Levels and Body Weight Constraint during High-Fat–Diet Feeding and Restores Insulin Sensitivity in a Liver-Specific Manner

BINGXIAN XIE, ANJANA MURALI, AMBER VANDEVENDER, AGUSTIN A. GIL SILVA, FIONA BELLO, IAN J. SIPULA, NIKOLAOS DEDOUSIS, JONATHAN ALDER, MICHAEL J. JURCZAK

Diabetes 2022;71(Supplement_1):3-OR

https://doi.org/10.2337/db22-3-OR

Published: 01 June 2022

View article titled, 3-OR: Hepatocyte Gdf15 Is Sufficient for Increased Plasma GDF15 Levels and Body Weight Constraint during High-Fat–Diet Feeding and Restores Insulin Sensitivity in a Liver-Specific Manner

Meeting Abstracts

1175-P: Inhibition of FBXO48 Improves Metabolic Changes Associated with NAFLD by Inhibiting Proteasomal Degradation of Phosphorylated AMPKa

ANJANA MURALI, LIA R. EDMUNDS, BINGXIAN XIE, BILL CHEN, YUAN LIU, MICHAEL J. JURCZAK

Diabetes 2021;70(Supplement_1):1175-P

https://doi.org/10.2337/db21-1175-P

Published: 01 June 2021

View article titled, 1175-P: Inhibition of FBXO48 Improves Metabolic Changes Associated with NAFLD by Inhibiting Proteasomal Degradation of Phosphorylated AMPKa

Meeting Abstracts

371-OR: Reduced Hepatic Expression of the Mitochondrial Quality Control Factor PARKIN Hastens the Progression of NAFLD in Mice and Is Associated with NASH in Patients

RAMYA UNDAMATLA, LIA R. EDMUNDS, BINGXIAN XIE, AMANDA MILLS, IAN J. SIPULA, SATDARSHAN P. MONGA, MICHAEL J. JURCZAK

Diabetes 2020;69(Supplement_1):371-OR

https://doi.org/10.2337/db20-371-OR

Published: 01 June 2020

View article titled, 371-OR: Reduced Hepatic Expression of the Mitochondrial Quality Control Factor PARKIN Hastens the Progression of NAFLD in Mice and Is Associated with NASH in Patients

Meeting Abstracts

1882-P: Liver-Specific Deletion of the Mitochondrial Quality Control E3 Ligase Parkin Is Associated with Increased Hepatic Steatosis and Markers of NAFLD in Diet-Induced Obese Mice

LIA R. EDMUNDS, AMANDA MILLS, MICHAEL J. JURCZAK

Diabetes 2019;68(Supplement_1):1882-P

https://doi.org/10.2337/db19-1882-P

Published: 01 June 2019

View article titled, 1882-P: Liver-Specific Deletion of the Mitochondrial Quality Control E3 Ligase Parkin Is Associated with Increased Hepatic Steatosis and Markers of NAFLD in Diet-Induced Obese Mice

Journal Articles

Hepatocyte-Specific Ablation or Whole-Body Inhibition of Xanthine Oxidoreductase in Mice Corrects Obesity-Induced Systemic Hyperuricemia Without Improving Metabolic Abnormalities

Daniel B. Harmon, W. Kyle Mandler, Ian J. Sipula, Nikolaos Dedousis, Sara E. Lewis, Jeremy T. Eckels, Jianhai Du, Yekai Wang, Brydie R. Huckestein, Patrick J. Pagano, Eugenia Cifuentes-Pagano, Gregg E. Homanics, Thomas J. Van’t Erve, Maja Stefanovic-Racic, Michael J. Jurczak, Robert M. O’Doherty, Eric E. Kelley

Diabetes 2019;68(6):1221–1229

https://doi.org/10.2337/db18-1198

Published: 01 April 2019

View article titled, Hepatocyte-Specific Ablation or Whole-Body Inhibition of Xanthine Oxidoreductase in Mice Corrects Obesity-Induced Systemic Hyperuricemia Without Improving Metabolic Abnormalities

Includes: Supplementary data

Journal Articles

Skeletal Muscle–Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node That Regulates Obesity-Induced Insulin Resistance

Ahmed Lawan, Kisuk Min, Lei Zhang, Alberto Canfran-Duque, Michael J. Jurczak, Joao Paulo G. Camporez, Yaohui Nie, Timothy P. Gavin, Gerald I. Shulman, Carlos Fernandez-Hernando, Anton M. Bennett

Diabetes 2018;67(4):624–635

https://doi.org/10.2337/db17-0826

Published: 09 January 2018

View article titled, Skeletal Muscle–Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node That Regulates Obesity-Induced Insulin Resistance

Includes: Supplementary data

Journal Articles

Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling

Kevin C. Corbit, João Paulo G. Camporez, Lia R. Edmunds, Jennifer L. Tran, Nicholas B. Vera, Derek M. Erion, Rahul C. Deo, Rachel J. Perry, Gerald I. Shulman, Michael J. Jurczak, Ethan J. Weiss

Diabetes 2018;67(2):208–221

https://doi.org/10.2337/db17-0524

Published: 04 December 2017

View article titled, Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling

Includes: Supplementary data

Journal Articles

Mitochondrial-Targeted Catalase Protects Against High-Fat Diet–Induced Muscle Insulin Resistance by Decreasing Intramuscular Lipid Accumulation

Hui-Young Lee, Jae Sung Lee, Tiago Alves, Warren Ladiges, Peter S. Rabinovitch, Michael J. Jurczak, Cheol Soo Choi, Gerald I. Shulman, Varman T. Samuel

Diabetes 2017;66(8):2072–2081

https://doi.org/10.2337/db16-1334

Published: 05 May 2017

View article titled, Mitochondrial-Targeted Catalase Protects Against High-Fat Diet–Induced Muscle Insulin Resistance by Decreasing Intramuscular Lipid Accumulation

Includes: Supplementary data

Journal Articles

Targeting Pyruvate Carboxylase Reduces Gluconeogenesis and Adiposity and Improves Insulin Resistance

Diabetes 2013;62(7):2183–2194

https://doi.org/10.2337/db12-1311

Published: 14 June 2013

View article titled, Targeting Pyruvate Carboxylase Reduces Gluconeogenesis and Adiposity and Improves Insulin Resistance

Includes: Supplementary data

Journal Articles

Tumor Progression Locus 2 (TPL2) Regulates Obesity-Associated Inflammation and Insulin Resistance

James W. Perfield, II, Yunkyoung Lee, Gerald I. Shulman, Varman T. Samuel, Michael J. Jurczak, Eugene Chang, Chen Xie, Phillip N. Tsichlis, Martin S. Obin, Andrew S. Greenberg

Diabetes 2011;60(4):1168–1176

https://doi.org/10.2337/db10-0715

Published: 22 March 2011

View article titled, Tumor Progression Locus 2 (TPL2) Regulates Obesity-Associated Inflammation and Insulin Resistance

Includes: Supplementary data

Journal Articles

SGLT2 Deletion Improves Glucose Homeostasis and Preserves Pancreatic β-Cell Function

Michael J. Jurczak, Hui-Young Lee, Andreas L. Birkenfeld, Francois R. Jornayvaz, David W. Frederick, Rebecca L. Pongratz, Xiaoxian Zhao, Gilbert W. Moeckel, Varman T. Samuel, Jean M. Whaley, Gerald I. Shulman, Richard G. Kibbey

Diabetes 2011;60(3):890–898

https://doi.org/10.2337/db10-1328

Published: 21 February 2011

View article titled, SGLT2 Deletion Improves Glucose Homeostasis and Preserves Pancreatic β-Cell Function

Includes: Supplementary data

NARROW

2039-LB: Insulin Sensitivity Is Impaired Independent of Changes in Body Weight in Liver-Specific GDF15 Knockout Mice

Role of Cardiorespiratory Fitness and Mitochondrial Oxidative Capacity in Reduced Walk Speed of Older Adults With Diabetes

Assessment of Tissue-Specific Glucose Uptake: Teaching an Old 2-DOG New Tricks

1572-P: USP30 Regulates Hepatic Mitophagy and Mitochondrial Function

261-LB: Hepatocyte Gdf15 Protects against CCL4-Induced Liver Injury Independent of Changes in Feeding and Inflammation

1368-P: Skeletal Muscle Mitochondrial Dysfunction Contributes to Increased GDF15 Levels in Aged Mice with Insulin Resistance and Sarcopenia

224-LB: Mitochondrial Capacity of Skeletal Muscle in Older Adults with Diabetes

1337-P: Sex-Specific Variation in Lipid Metabolism in Response to Nutritional Stress Is Associated with Differences in NASH Progression

3-OR: Hepatocyte Gdf15 Is Sufficient for Increased Plasma GDF15 Levels and Body Weight Constraint during High-Fat–Diet Feeding and Restores Insulin Sensitivity in a Liver-Specific Manner

1175-P: Inhibition of FBXO48 Improves Metabolic Changes Associated with NAFLD by Inhibiting Proteasomal Degradation of Phosphorylated AMPKa

371-OR: Reduced Hepatic Expression of the Mitochondrial Quality Control Factor PARKIN Hastens the Progression of NAFLD in Mice and Is Associated with NASH in Patients

1882-P: Liver-Specific Deletion of the Mitochondrial Quality Control E3 Ligase Parkin Is Associated with Increased Hepatic Steatosis and Markers of NAFLD in Diet-Induced Obese Mice

Hepatocyte-Specific Ablation or Whole-Body Inhibition of Xanthine Oxidoreductase in Mice Corrects Obesity-Induced Systemic Hyperuricemia Without Improving Metabolic Abnormalities

Skeletal Muscle–Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node That Regulates Obesity-Induced Insulin Resistance

Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling

Mitochondrial-Targeted Catalase Protects Against High-Fat Diet–Induced Muscle Insulin Resistance by Decreasing Intramuscular Lipid Accumulation

Targeting Pyruvate Carboxylase Reduces Gluconeogenesis and Adiposity and Improves Insulin Resistance

Tumor Progression Locus 2 (TPL2) Regulates Obesity-Associated Inflammation and Insulin Resistance

SGLT2 Deletion Improves Glucose Homeostasis and Preserves Pancreatic β-Cell Function

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