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Michael R. Rickels
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Meeting Abstracts

140-OR: Durable Glycemic Control and Elimination of Exogenous Insulin Use with VX-880 in Patients with Type 1 Diabetes (T1D)—VX-880-101 (FORWARD)

Free
MICHAEL R. RICKELS, PIOTR WITKOWSKI, TREVOR W. REICHMAN, EELCO J. DE KONING, JAMES F. MARKMANN, JON S. ODORICO, MARTIN WIJKSTROM, LESLIE S. KEAN, CHANTAL MATHIEU, ANNE L. PETERS, YAOYUAN VINCENT TAN, KRISTINE VANIJCHAROENKARN, DOUGLAS MELTON, FELICIA PAGLIUCA, BOTE BRUINSMA, GAUTHAM MARIGOWDA, CAMILLO RICORDI
Journal: Diabetes
Diabetes 2025;74(Supplement_1):140-OR
https://doi.org/10.2337/db25-140-OR
Published: 20 June 2025
View articletitled, 140-OR: Durable Glycemic Control and Elimination of Exogenous Insulin Use with VX-880 in Patients with Type 1 Diabetes (T1D)—VX-880-101 (FORWARD)
Meeting Abstracts

242-OR: Effects of Automated Insulin Delivery (AID) on Impaired Awareness of Hypoglycemia (IAH) in Older Adults with Type 1 Diabetes in the AIDE Study

Free
ANIKA BILAL, DARIA A. IGUDESMAN, ROBERT HENDERSON, JORGE L. JO KAMIMOTO, KERI J. WHITAKER, SHAFAQ RAZA RIZVI, NAOMI CHAYTOR, RUTH S. WEINSTOCK, YOGISH C. KUDVA, MICHAEL R. RICKELS, RICHARD E. PRATLEY, ANNA CASU
Journal: Diabetes
Diabetes 2025;74(Supplement_1):242-OR
https://doi.org/10.2337/db25-242-OR
Published: 20 June 2025
View articletitled, 242-OR: Effects of Automated Insulin Delivery (AID) on Impaired Awareness of Hypoglycemia (IAH) in Older Adults with Type 1 Diabetes in the AIDE Study
Meeting Abstracts

370-P: Interoception Mitigates the Impact of Hypoglycemia Exposure on Symptom Recognition in Adults with Type 1 Diabetes

Free
AUSTIN M. MATUS, ANNIKA AGNI, EMILY HEPWORTH, STEPHANIE A. AMIEL, MICHAEL R. RICKELS, BARBARA RIEGEL, JAMES A. SHAW, JANE SPEIGHT, YU KUEI LIN
Journal: Diabetes
Diabetes 2025;74(Supplement_1):370-P
https://doi.org/10.2337/db25-370-P
Published: 20 June 2025
View articletitled, 370-P: Interoception Mitigates the Impact of Hypoglycemia Exposure on Symptom Recognition in Adults with Type 1 Diabetes
Meeting Abstracts

45-OR: Evaluating the Effects of Hypoglycemia on Plasma Beta Amyloid in Type 1 Diabetes (T1D)

Free
CARLEY GLASS, ANIKA BILAL, FANCHAO YI, CHARLES ROWE, YURY O. NUNEZ LOPEZ, MICHAEL R. RICKELS, RICHARD E. PRATLEY
Journal: Diabetes
Diabetes 2025;74(Supplement_1):45-OR
https://doi.org/10.2337/db25-45-OR
Published: 20 June 2025
View articletitled, 45-OR: Evaluating the Effects of Hypoglycemia on Plasma Beta Amyloid in Type 1 Diabetes (T1D)
Meeting Abstracts

605-P: Diabetes Distress Is Associated with Higher Risk of Hypoglycemia in Older Adults with Type 1 Diabetes in the AIDE Trial

Free
SHAFAQ RAZA RIZVI, ROBERT J. HENDERSON, LAUREN KANAPKA, ANNA KAHKOSKA, COREY REID, DONNA DESJARDINS, NAOMI CHAYTOR, RUTH S. WEINSTOCK, MICHAEL R. RICKELS, RICHARD E. PRATLEY, YOGISH C. KUDVA
Journal: Diabetes
Diabetes 2025;74(Supplement_1):605-P
https://doi.org/10.2337/db25-605-P
Published: 20 June 2025
View articletitled, 605-P: Diabetes Distress Is Associated with Higher Risk of Hypoglycemia in Older Adults with Type 1 Diabetes in the AIDE Trial
Meeting Abstracts

90-OR: Effects of Glucagon-Like Peptide 1 (GLP-1) Agonist Therapy on Islet Function in Adults with Pancreatic-Insufficient Cystic Fibrosis ( PI-CF) and Abnormal Glucose Tolerance (AGT)—Preliminary Results

Free
SUJATHA REDDY, RANVIR R. BHATIA, AMY PELECKIS, PAOLA ALVARADO, RACHEL WALEGA, DARKO STEFANOVSKI, ROBERT J. GALLOP, DENIS HADJILIADIS, ANNELIESE FLATT, RONALD C. RUBENSTEIN, CHRISTINE L. CHAN, ANDREA KELLY, MICHAEL R. RICKELS
Journal: Diabetes
Diabetes 2025;74(Supplement_1):90-OR
https://doi.org/10.2337/db25-90-OR
Published: 20 June 2025
View articletitled, 90-OR: Effects of Glucagon-Like Peptide 1 (GLP-1) Agonist Therapy on Islet Function in Adults with Pancreatic-Insufficient Cystic Fibrosis ( PI-CF) and Abnormal Glucose Tolerance (AGT)—Preliminary Results
Meeting Abstracts

218-OR: Time of Exercise Affects Nocturnal Hypoglycemia after Exercise in Adults with Type 1 Diabetes (T1D)—Results from the T1D Exercise Initiative (T1DEXI) Study

Free
DANIEL I. BISNO, LAUREN V. TURNER, ROBERT J. GALLOP, JORGE L. JO KAMIMOTO, SUJATHA REDDY, MICHAEL C. RIDDELL, MICHAEL R. RICKELS
Journal: Diabetes
Diabetes 2025;74(Supplement_1):218-OR
https://doi.org/10.2337/db25-218-OR
Published: 20 June 2025
View articletitled, 218-OR: Time of Exercise Affects Nocturnal Hypoglycemia after Exercise in Adults with Type 1 Diabetes (T1D)—Results from the T1D Exercise Initiative (T1DEXI) Study
Meeting Abstracts

663-P: Associations between Relationship Status and Parenting on Glycemic and Emotional Outcomes in Adults with Type 1 Diabetes (T1D) Enrolled in the GluCog Study

Free
MIRANDA S. ZUNIGA-KENNEDY, LUCIANA M. FONSECA, YOGISH C. KUDVA, SHAFAQ RAZA RIZVI, RUTH S. WEINSTOCK, JANE D. BULGER, RICHARD E. PRATLEY, MICHAEL R. RICKELS, LAURA GERMINE, NAOMI CHAYTOR
Journal: Diabetes
Diabetes 2025;74(Supplement_1):663-P
https://doi.org/10.2337/db25-663-P
Published: 20 June 2025
View articletitled, 663-P: Associations between Relationship Status and Parenting on Glycemic and Emotional Outcomes in Adults with Type 1 Diabetes (T1D) Enrolled in the GluCog Study
Journal Articles

Advances in Cell Replacement Therapies for Diabetes

Free
Bernhard J. Hering, Michael R. Rickels, Melena D. Bellin, Jeffrey R. Millman, Alice A. Tomei, Andrés J. García, Haval Shirwan, Cherie L. Stabler, Minglin Ma, Peng Yi, Xunrong Luo, Qizhi Tang, Sabarinathan Ramachandran, Jose Oberholzer, Camillo Ricordi, Timothy J. Kieffer, A.M. James Shapiro
Journal: Diabetes
Diabetes 2025;74(7):1068–1077
https://doi.org/10.2337/db25-0037
Published: 24 April 2025
View articletitled, Advances in Cell Replacement Therapies for Diabetes
Open the PDF for Advances in Cell Replacement Therapies for Diabetes in another window
Journal Articles

β-Cell Secretory Capacity Predicts Metabolic Outcomes Over 6 Years After Human Islet Transplantation

Free
Anneliese J. Flatt, Austin M. Matus, Robert J. Gallop, Eileen Markmann, Cornelia Dalton-Bakes, Amy J. Peleckis, Chengyang Liu, Ali Naji, Michael R. Rickels
Journal: Diabetes
Diabetes 2025;74(5):749–759
https://doi.org/10.2337/db24-0729
Published: 04 December 2024
View articletitled, β-Cell Secretory Capacity Predicts Metabolic Outcomes Over 6 Years After Human Islet Transplantation
Open the PDF for β-Cell Secretory Capacity Predicts Metabolic Outcomes Over 6 Years After Human Islet Transplantation in another window
Meeting Abstracts

178-OR: Assessing Hypoglycemia Awareness—Validating HypoA-Q within the T1D Exchange Registry

Free
YU KUEI LIN, WEN YE, EMILY HEPWORTH, AUSTIN M. MATUS, ANNELIESE FLATT, NICOLE DE ZOYSA, JAMES A. SHAW, MICHAEL R. RICKELS, STEPHANIE A. AMIEL, JANE SPEIGHT
Journal: Diabetes
Diabetes 2024;73(Supplement_1):178-OR
https://doi.org/10.2337/db24-178-OR
Published: 14 June 2024
View articletitled, 178-OR: Assessing Hypoglycemia Awareness—Validating HypoA-Q within the T1D Exchange Registry
Meeting Abstracts

316-OR: Interoception Predicts Impaired Awareness of Hypoglycemia (IAH) in Adults with Type 1 Diabetes (T1D)

Free
AUSTIN M. MATUS, BARBARA RIEGEL, MICHAEL R. RICKELS
Journal: Diabetes
Diabetes 2024;73(Supplement_1):316-OR
https://doi.org/10.2337/db24-316-OR
Published: 14 June 2024
View articletitled, 316-OR: Interoception Predicts Impaired Awareness of Hypoglycemia (IAH) in Adults with Type 1 Diabetes (T1D)
Meeting Abstracts

144-OR: A Randomized Clinical Trial of Automated Insulin Delivery in Elderly with Type 1 Diabetes

Free
YOGISH C. KUDVA, ROBERT HENDERSON, LAUREN KANAPKA, RUTH S. WEINSTOCK, MICHAEL R. RICKELS, RICHARD E. PRATLEY, NAOMI CHAYTOR, KAMILLE JANESS, DONNA DESJARDINS, VISHWANATH PATTAN, AMY PELECKIS, ANNA CASU, SHAFAQ RAZA RIZVI, SUZAN BZDICK, KERI J. WHITAKER, JORGE L. JO KAMIMOTO, KELLEE MILLER, ROY BECK
Journal: Diabetes
Diabetes 2024;73(Supplement_1):144-OR
https://doi.org/10.2337/db24-144-OR
Published: 14 June 2024
View articletitled, 144-OR: A Randomized Clinical Trial of Automated Insulin Delivery in Elderly with Type 1 Diabetes
Meeting Abstracts

1507-P: Mixed-Meal Tolerance Test (MMTT) C-Peptide and BETA-2 Score Predict Underlying ß-Cell Secretory Capacity following Islet Transplantation for Type 1 Diabetes (T1D)

Free
ANNELIESE FLATT, AUSTIN M. MATUS, ROBERT J. GALLOP, EILEEN M. MARKMANN, CORNELIA V. DALTON-BAKES, AMY PELECKIS, CHENGYANG LIU, ALI NAJI, MICHAEL R. RICKELS
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1507-P
https://doi.org/10.2337/db24-1507-P
Published: 14 June 2024
View articletitled, 1507-P: Mixed-Meal Tolerance Test (MMTT) C-Peptide and BETA-2 Score Predict Underlying ß-Cell Secretory Capacity following Islet Transplantation for Type 1 Diabetes (T1D)
Journal Articles

Evidence for C-Peptide as a Validated Surrogate to Predict Clinical Benefits in Trials of Disease-Modifying Therapies for Type 1 Diabetes

Free
Esther Latres, Carla J. Greenbaum, Maria L. Oyaski, Colin M. Dayan, Helen M. Colhoun, John M. Lachin, Jay S. Skyler, Michael R. Rickels, Simi T. Ahmed, Sanjoy Dutta, Kevan C. Herold, Marjana Marinac
Journal: Diabetes
Diabetes 2024;73(6):823–833
https://doi.org/10.2337/dbi23-0012
Published: 13 February 2024
View articletitled, Evidence for C-Peptide as a Validated Surrogate to Predict Clinical Benefits in Trials of Disease-Modifying Therapies for Type 1 Diabetes
Open the PDF for Evidence for C-Peptide as a Validated Surrogate to Predict Clinical Benefits in Trials of Disease-Modifying Therapies for Type 1 Diabetes in another window
Meeting Abstracts

836-P: Glucose-Dependent Insulin Production and Insulin-Independence in Type 1 Diabetes from Stem Cell–Derived, Fully Differentiated Islet Cells—Updated Data from the VX-880 Clinical Trial

Free
TREVOR W. REICHMAN, CAMILLO RICORDI, ALI NAJI, JAMES F. MARKMANN, BRUCE A. PERKINS, MARTIN WIJKSTROM, STEVEN PARASKEVAS, BOTE BRUINSMA, GAUTHAM MARIGOWDA, JUDY L. SHIH, CHENKUN WANG, DOUGLAS MELTON, FELICIA PAGLIUCA, BASTIANO SANNA, LESLIE S. KEAN, ANNE L. PETERS, PIOTR WITKOWSKI, MICHAEL R. RICKELS
Journal: Diabetes
Diabetes 2023;72(Supplement_1):836-P
https://doi.org/10.2337/db23-836-P
Published: 23 June 2023
View articletitled, 836-P: Glucose-Dependent Insulin Production and Insulin-Independence in Type 1 Diabetes from Stem Cell–Derived, Fully Differentiated Islet Cells—Updated Data from the VX-880 Clinical Trial
Meeting Abstracts

573-P: Impact of Impaired Awareness of Hypoglycemia on Glucose Changes During and After Exercise in Type 1 Diabetes—Results from the T1DEXI Study Cohort

Free
JORGE L. JO KAMIMOTO, ZOEY LI, ROBIN L. GAL, JESSICA R. CASTLE, FRANCIS J. DOYLE, III, PETER G. JACOBS, CORBY K. MARTIN, ROY BECK, PETER CALHOUN, MICHAEL RIDDELL, MICHAEL R. RICKELS
Journal: Diabetes
Diabetes 2023;72(Supplement_1):573-P
https://doi.org/10.2337/db23-573-P
Published: 20 June 2023
View articletitled, 573-P: Impact of Impaired Awareness of Hypoglycemia on Glucose Changes During and After Exercise in Type 1 Diabetes—Results from the T1DEXI Study Cohort
Meeting Abstracts

580-P: Influence of Daily Step Counts on Glucose Outcomes in Adults with Type 1 Diabetes (T1D)

Free
LAUREN TURNER, CHASE MARAK, PETER CALHOUN, ROBIN L. GAL, ZOEY LI, GAVIN YOUNG, SUSANA R. PATTON, MARK A. CLEMENTS, CORBY K. MARTIN, FRANCIS J. DOYLE, III, JESSICA R. CASTLE, MELANIE B. GILLINGHAM, MICHAEL R. RICKELS, ROY BECK, PETER G. JACOBS, MICHAEL RIDDELL
Journal: Diabetes
Diabetes 2023;72(Supplement_1):580-P
https://doi.org/10.2337/db23-580-P
Published: 20 June 2023
View articletitled, 580-P: Influence of Daily Step Counts on Glucose Outcomes in Adults with Type 1 Diabetes (T1D)
Meeting Abstracts

1548-P: GLP-1 and GIP Reduce Insulin Clearance in Individuals with Pancreatic-Insufficient Cystic Fibrosis (PI-CF)

Free
ANNELIESE FLATT, ANDRIANA DOLIBA, AMY J. PELECKIS, RONALD C. RUBENSTEIN, ANDREA KELLY, MICHAEL R. RICKELS
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1548-P
https://doi.org/10.2337/db23-1548-P
Published: 20 June 2023
View articletitled, 1548-P: GLP-1 and GIP Reduce Insulin Clearance in Individuals with Pancreatic-Insufficient Cystic Fibrosis (PI-CF)
Meeting Abstracts

65-LB: Social Determinants of Health Predict Self-Care in Type 1 Diabetes

Free
AUSTIN M. MATUS, BARBARA RIEGEL, MICHAEL R. RICKELS
Journal: Diabetes
Diabetes 2023;72(Supplement_1):65-LB
https://doi.org/10.2337/db23-65-LB
Published: 20 June 2023
View articletitled, 65-LB: Social Determinants of Health Predict Self-Care in Type 1 Diabetes