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Meeting Abstracts

1750-P: Rescuing Human Beta-Cell Dysfunction Induced by Proinflammatory Cytokines and Glucotoxicity

MARTA TESI, MARA SULEIMAN, ROBERTO SEMERARO, CARMELA DE LUCA, EMANUELE BOSI, SILVIA DEL GUERRA, ALBERTO MAGI, MIRIAM CNOP, DECIO L. EIZIRIK, LORELLA MARSELLI, PIERO MARCHETTI

Diabetes 2024;73(Supplement_1):1750-P

https://doi.org/10.2337/db24-1750-P

Published: 14 June 2024

View article titled, 1750-P: Rescuing Human Beta-Cell Dysfunction Induced by Proinflammatory Cytokines and Glucotoxicity

Meeting Abstracts

1465-P: The C1858T Polymorphism in PTPN22 Modulates the Human Pancreatic Islet Transcriptome

MARA SULEIMAN, CARMELA DE LUCA, ROBERTO SEMERARO, EMANUELE BOSI, ALBERTO MAGI, MARTA TESI, SILVIA DEL GUERRA, OLIVIA PAGLIAROSI, ANNAMARIA CUDINI, LEONARDO ROSSI, DECIO L. EIZIRIK, MIRIAM CNOP, PIERO MARCHETTI, LORELLA MARSELLI, ALESSANDRA FIERABRACCI

Diabetes 2024;73(Supplement_1):1465-P

https://doi.org/10.2337/db24-1465-P

Published: 14 June 2024

View article titled, 1465-P: The C1858T Polymorphism in PTPN22 Modulates the Human Pancreatic Islet Transcriptome

Meeting Abstracts

1471-P: Impaired Delta Opioid Receptor Function Protects against Type 2 Diabetes and Results in Enhanced Insulin Secretion—A Functional Genetic Study

AMELIE BONNEFOND, RADIO GROUP, RAPHAEL SCHARFMANN, PIERO MARCHETTI, MIRIAM CNOP, PHILIPPE FROGUEL

Diabetes 2024;73(Supplement_1):1471-P

https://doi.org/10.2337/db24-1471-P

Published: 14 June 2024

View article titled, 1471-P: Impaired Delta Opioid Receptor Function Protects against Type 2 Diabetes and Results in Enhanced Insulin Secretion—A Functional Genetic Study

Meeting Abstracts

149-OR: Genetic Modulation of HNF1A Activity via SGLT2 Deficiency Leads to Transient Intermittent Hyperglycemia: Consequences for HNF1A-MODY

ANA ACOSTA-MONTALVO, CHIARA SAPONARO, JULIEN THEVENET, MAGALI CHIRAL, ANTHONY PIRON, NATHALIE DELALLEAU, GIANNI PASQUETTI, ANAÏS CODDEVILLE, MARIA MORENO, VALERY GMYR, MIRIAM CNOP, JULIE A. KERR-CONTE, FRANCOIS PATTOU, MARCO PONTOGLIO, ADRIAN LISTON, CAROLINE BONNER

Diabetes 2022;71(Supplement_1):149-OR

https://doi.org/10.2337/db22-149-OR

Published: 01 June 2022

View article titled, 149-OR: Genetic Modulation of HNF1A Activity via SGLT2 Deficiency Leads to Transient Intermittent Hyperglycemia: Consequences for HNF1A-MODY

Journal Articles

The KINGS Ins2^+/G32S Mouse: A Novel Model of β-Cell Endoplasmic Reticulum Stress and Human Diabetes

Amazon L.F. Austin, Lydia F. Daniels Gatward, Miriam Cnop, Gabriel Santos, David Andersson, Sally Sharp, Clive Gentry, Stuart Bevan, Peter M. Jones, Aileen J.F. King

Diabetes 2020;69(12):2667–2677

https://doi.org/10.2337/db20-0570

Published: 29 September 2020

View article titled, The KINGS Ins2+/G32S Mouse: A Novel Model of β-Cell Endoplasmic Reticulum Stress and Human Diabetes

Meeting Abstracts

1900-P: HNF1A Deficiency Leads to Perturbed Glucagon Secretion in Humans

CHIARA SAPONARO, ANA ACOSTA-MONTALVO, LIA ANGUELOVA, JULIEN THEVENET, MAGALI CHIRAL, GIANNI PASQUETTI, ANTHONY PIRON, MIRIAM CNOP, VALERY GMYR, JOCHEN PREHN, JULIE A. KERR-CONTE, FRANCOIS PATTOU, MARCO PONTOGLIO, KATHARINE R. OWEN, IOANNIS SPILIOTIS, CAROLINE BONNER

Diabetes 2020;69(Supplement_1):1900-P

https://doi.org/10.2337/db20-1900-P

Published: 01 June 2020

View article titled, 1900-P: HNF1A Deficiency Leads to Perturbed Glucagon Secretion in Humans

Meeting Abstracts

2087-P: Functional Genomics of Human Islet Gluco/Lipotoxicity and Type 2 Diabetes

XIAOYAN YI, LORELLA MARSELLI, ANTHONY PIRON, MARA SULEIMAN, FLORIAN SZYMCZAK, DECIO L. EIZIRIK, PIERO MARCHETTI, MIRIAM CNOP

Diabetes 2020;69(Supplement_1):2087-P

https://doi.org/10.2337/db20-2087-P

Published: 01 June 2020

View article titled, 2087-P: Functional Genomics of Human Islet Gluco/Lipotoxicity and Type 2 Diabetes

Meeting Abstracts

2090-P: Noradrenergic Stimulus as a Potential Inducer of Human ß-Cell Dedifferentiation

FRANCESCA CINTI, FEDERICA FANTUZZI, ANDREA CARFÍ, TERESA MEZZA, CHIARA MARIA ASSUNTA CEFALO, JR., SIMONA MOFFA, GIAN PIO SORICE, ANDREA GIACCARI, MIRIAM CNOP

Diabetes 2020;69(Supplement_1):2090-P

https://doi.org/10.2337/db20-2090-P

Published: 01 June 2020

View article titled, 2090-P: Noradrenergic Stimulus as a Potential Inducer of Human ß-Cell Dedifferentiation

Journal Articles

Interindividual Heterogeneity of SGLT2 Expression and Function in Human Pancreatic Islets

Chiara Saponaro, Markus Mühlemann, Ana Acosta-Montalvo, Anthony Piron, Valery Gmyr, Nathalie Delalleau, Ericka Moerman, Julien Thévenet, Gianni Pasquetti, Anais Coddeville, Miriam Cnop, Julie Kerr-Conte, Bart Staels, François Pattou, Caroline Bonner

Diabetes 2020;69(5):902–914

https://doi.org/10.2337/db19-0888

Published: 02 January 2020

View article titled, Interindividual Heterogeneity of SGLT2 Expression and Function in Human Pancreatic Islets

Includes: Supplementary data

Meeting Abstracts

360-OR: A Novel Genetic Syndrome of Early-Onset Diabetes, Microcephaly, and Epilepsy Due to Homozygous YIPF5 Mutations

MARIA LYTRIVI, ELISA DE FRANCO, KASHYAP A. PATEL, MARIANA IGOILLO ESTEVE, CRISTINA COSENTINO, MATTHEW N. WAKELING, BELMA HALILOGLU, MELEK YILDIZ, TUSHAR GODBOLE, ANDREW T. HATTERSLEY, MIRIAM CNOP

Diabetes 2019;68(Supplement_1):360-OR

https://doi.org/10.2337/db19-360-OR

Published: 01 June 2019

View article titled, 360-OR: A Novel Genetic Syndrome of Early-Onset Diabetes, Microcephaly, and Epilepsy Due to Homozygous YIPF5 Mutations

Journal Articles

A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly

Baroj Abdulkarim, Marc Nicolino, Mariana Igoillo-Esteve, Mathilde Daures, Sophie Romero, Anne Philippi, Valérie Senée, Miguel Lopes, Daniel A. Cunha, Heather P. Harding, Céline Derbois, Nathalie Bendelac, Andrew T. Hattersley, Décio L. Eizirik, David Ron, Miriam Cnop, Cécile Julier

Diabetes 2015;64(11):3951–3962

https://doi.org/10.2337/db15-0477

Published: 09 July 2015

View article titled, A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly

Includes: Supplementary data

Journal Articles

RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate

Miriam Cnop, Baroj Abdulkarim, Guy Bottu, Daniel A. Cunha, Mariana Igoillo-Esteve, Matilde Masini, Jean-Valery Turatsinze, Thasso Griebel, Olatz Villate, Izortze Santin, Marco Bugliani, Laurence Ladriere, Lorella Marselli, Mark I. McCarthy, Piero Marchetti, Michael Sammeth, Décio L. Eizirik

Diabetes 2014;63(6):1978–1993

https://doi.org/10.2337/db13-1383

Published: 15 May 2014

View article titled, RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate

Includes: Supplementary data

Journal Articles

Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress–Mitochondrial Dialog Triggering Lipotoxic Rodent and Human β-Cell Apoptosis

Daniel A. Cunha, Mariana Igoillo-Esteve, Esteban N. Gurzov, Carla M. Germano, Najib Naamane, Ihsane Marhfour, Makiko Fukaya, Jean-Marie Vanderwinden, Conny Gysemans, Chantal Mathieu, Lorella Marselli, Piero Marchetti, Heather P. Harding, David Ron, Décio L. Eizirik, Miriam Cnop

Diabetes 2012;61(11):2763–2775

https://doi.org/10.2337/db12-0123

Published: 16 October 2012

View article titled, Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress–Mitochondrial Dialog Triggering Lipotoxic Rodent and Human β-Cell Apoptosis

Includes: Supplementary data

Journal Articles

Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB

Daniel A. Cunha, Laurence Ladrière, Fernanda Ortis, Mariana Igoillo-Esteve, Esteban N. Gurzov, Roberto Lupi, Piero Marchetti, Décio L. Eizirik, Miriam Cnop

Diabetes 2009;58(12):2851–2862

https://doi.org/10.2337/db09-0685

Published: 31 August 2009

View article titled, Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB

Includes: Supplementary data

Journal Articles

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon-γ–Induced Pancreatic β-Cell Apoptosis

Fabrice Moore, Maikel L. Colli, Miriam Cnop, Mariana Igoillo Esteve, Alessandra K. Cardozo, Daniel A. Cunha, Marco Bugliani, Piero Marchetti, Décio L. Eizirik

Diabetes 2009;58(6):1283–1291

https://doi.org/10.2337/db08-1510

Published: 26 March 2009

View article titled, PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon-γ–Induced Pancreatic β-Cell Apoptosis

Includes: Supplementary data

Journal Articles

Transcriptional Regulation of the Endoplasmic Reticulum Stress Gene Chop in Pancreatic Insulin-Producing Cells

Pierre Pirot, Fernanda Ortis, Miriam Cnop, Yanjun Ma, Linda M. Hendershot, Décio L. Eizirik, Alessandra K. Cardozo

Diabetes 2007;56(4):1069–1077

https://doi.org/10.2337/db06-1253

Published: 01 April 2007

View article titled, Transcriptional Regulation of the Endoplasmic Reticulum Stress Gene Chop in Pancreatic Insulin-Producing Cells

Includes: Supplementary data

Journal Articles

Mechanisms of Pancreatic β-Cell Death in Type 1 and Type 2 Diabetes: Many Differences, Few Similarities

Miriam Cnop, Nils Welsh, Jean-Christophe Jonas, Anne Jörns, Sigurd Lenzen, Decio L. Eizirik

Diabetes 2005;54(suppl_2):S97–S107

https://doi.org/10.2337/diabetes.54.suppl_2.S97

Published: 01 December 2005

View article titled, Mechanisms of Pancreatic β-Cell Death in Type 1 and Type 2 Diabetes: <subtitle>Many Differences, Few Similarities</subtitle>

Journal Articles

Is There a Role for Locally Produced Interleukin-1 in the Deleterious Effects of High Glucose or the Type 2 Diabetes Milieu to Human Pancreatic Islets?

Nils Welsh, Miriam Cnop, Ilham Kharroubi, Marco Bugliani, Roberto Lupi, Piero Marchetti, Décio L. Eizirik

Diabetes 2005;54(11):3238–3244

https://doi.org/10.2337/diabetes.54.11.3238

Published: 01 November 2005

View article titled, Is There a Role for Locally Produced Interleukin-1 in the Deleterious Effects of High Glucose or the Type 2 Diabetes Milieu to Human Pancreatic Islets?

Journal Articles

Increased Dietary Fat Promotes Islet Amyloid Formation and β-Cell Secretory Dysfunction in a Transgenic Mouse Model of Islet Amyloid

Rebecca L. Hull, Sofianos Andrikopoulos, C. Bruce Verchere, Josep Vidal, Feng Wang, Miriam Cnop, Ronald L. Prigeon, Steven E. Kahn

Diabetes 2003;52(2):372–379

https://doi.org/10.2337/diabetes.52.2.372

Published: 01 February 2003

View article titled, Increased Dietary Fat Promotes Islet Amyloid Formation and β-Cell Secretory Dysfunction in a Transgenic Mouse Model of Islet Amyloid

Journal Articles

The Atherogenic Lipoprotein Profile Associated With Obesity and Insulin Resistance Is Largely Attributable to Intra-Abdominal Fat

Delma J. Nieves, Miriam Cnop, Barbara Retzlaff, Carolyn E. Walden, John D. Brunzell, Robert H. Knopp, Steven E. Kahn

Diabetes 2003;52(1):172–179

https://doi.org/10.2337/diabetes.52.1.172

Published: 01 January 2003

View article titled, The Atherogenic Lipoprotein Profile Associated With Obesity and Insulin Resistance Is Largely Attributable to Intra-Abdominal Fat

NARROW

1750-P: Rescuing Human Beta-Cell Dysfunction Induced by Proinflammatory Cytokines and Glucotoxicity

1465-P: The C1858T Polymorphism in PTPN22 Modulates the Human Pancreatic Islet Transcriptome

1471-P: Impaired Delta Opioid Receptor Function Protects against Type 2 Diabetes and Results in Enhanced Insulin Secretion—A Functional Genetic Study

149-OR: Genetic Modulation of HNF1A Activity via SGLT2 Deficiency Leads to Transient Intermittent Hyperglycemia: Consequences for HNF1A-MODY

The KINGS Ins2^+/G32S Mouse: A Novel Model of β-Cell Endoplasmic Reticulum Stress and Human Diabetes

1900-P: HNF1A Deficiency Leads to Perturbed Glucagon Secretion in Humans

2087-P: Functional Genomics of Human Islet Gluco/Lipotoxicity and Type 2 Diabetes

2090-P: Noradrenergic Stimulus as a Potential Inducer of Human ß-Cell Dedifferentiation

Interindividual Heterogeneity of SGLT2 Expression and Function in Human Pancreatic Islets

360-OR: A Novel Genetic Syndrome of Early-Onset Diabetes, Microcephaly, and Epilepsy Due to Homozygous YIPF5 Mutations

A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly

RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate

Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress–Mitochondrial Dialog Triggering Lipotoxic Rodent and Human β-Cell Apoptosis

Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon-γ–Induced Pancreatic β-Cell Apoptosis

Transcriptional Regulation of the Endoplasmic Reticulum Stress Gene Chop in Pancreatic Insulin-Producing Cells

Mechanisms of Pancreatic β-Cell Death in Type 1 and Type 2 Diabetes: Many Differences, Few Similarities

Is There a Role for Locally Produced Interleukin-1 in the Deleterious Effects of High Glucose or the Type 2 Diabetes Milieu to Human Pancreatic Islets?

Increased Dietary Fat Promotes Islet Amyloid Formation and β-Cell Secretory Dysfunction in a Transgenic Mouse Model of Islet Amyloid

The Atherogenic Lipoprotein Profile Associated With Obesity and Insulin Resistance Is Largely Attributable to Intra-Abdominal Fat

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