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Muhammad Abdul-Ghani
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Meeting Abstracts

1982-LB: MPC-Directed Insulin Sensitizer MSDC-0602K Combines with Tirzepatide to Maintain Muscle Mass/Function and Restructure Adipose Tissue

Free
MOHAMED ABU-FARHA, JEHAD ABUBAKER, FAHD ALMULLA, MUHAMMAD ABDUL-GHANI, LUKE NORTON, RALPH A. DEFRONZO, JERRY R. COLCA, KYLE S. MCCOMMIS
Journal: Diabetes
Diabetes 2024;74(Supplement_1):1982-LB
https://doi.org/10.2337/db25-1982-LB
Published: 20 June 2025
View articletitled, 1982-LB: MPC-Directed Insulin Sensitizer MSDC-0602K Combines with Tirzepatide to Maintain Muscle Mass/Function and Restructure Adipose Tissue
Meeting Abstracts

162-OR: Beta-Cell Preservation with Early Oral Antidiabetic Medications in Prediabetes (PreDM)

Free
ALBERTO CHAVEZ, AURORA MEROVCI, SIVARAM NEPPALA, GOZDE BASKOY, JOHN M. ADAMS__III, ANDREA A. HANSIS-DIARTE, EUGENIO CERSOSIMO, RENATA BELFORT DE AGUIAR, MUHAMMAD ABDUL-GHANI, RALPH A. DEFRONZO
Journal: Diabetes
Diabetes 2024;74(Supplement_1):162-OR
https://doi.org/10.2337/db25-162-OR
Published: 20 June 2025
View articletitled, 162-OR: Beta-Cell Preservation with Early Oral Antidiabetic Medications in Prediabetes (PreDM)
Meeting Abstracts

1597-P: Insulin Sensitivity Dependent and Insulin Sensitivity Independent Insulin Secretion in Nondiabetic Individuals

Free
MOHAMED ABU-FARHA, ALBERTO CHAVEZ, GOZDE BASKOY, JOHN M. ADAMS__III, JEHAD ABUBAKER, THAMER ALESSA, FAHAD ALAJMI, RENATA BELFORT DE AGUIAR, RALPH A. DEFRONZO, FAHD ALMULLA, MUHAMMAD ABDUL-GHANI
Journal: Diabetes
Diabetes 2024;74(Supplement_1):1597-P
https://doi.org/10.2337/db25-1597-P
Published: 20 June 2025
View articletitled, 1597-P: Insulin Sensitivity Dependent and Insulin Sensitivity Independent Insulin Secretion in Nondiabetic Individuals
Meeting Abstracts

1586-P: Association between PCSK7 Levels and NAFLD Severity in KADEM Study

Free
MOHAMMAD QADDOUMI, JEHAD ABUBAKER, IRINA AL-KHAIRI, PREETHI T. CHERIAN, DEVARAJAN SRIRAMAN, ALPHONSE T. THANGAVEL, ARSHAD M. CHANNANATH, SR., MUHAMMAD ABDUL-GHANI, FAHD ALMULLA, MOHAMED ABU-FARHA
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1586-P
https://doi.org/10.2337/db24-1586-P
Published: 14 June 2024
View articletitled, 1586-P: Association between PCSK7 Levels and NAFLD Severity in KADEM Study
Meeting Abstracts

138-OR: Pioglitazone Amplifies the Decrease in HbA1c and Prevents the Increase in Plasma Ketone Caused by Dapagliflozin in Type 1 Diabetes Mellitus Patients

Free
MUHAMMAD ABDUL-GHANI, GOZDE BASKOY, AFIF NAKHLEH, SIHAM ABDELGANI, FAHD AL-MULLA, MOHAMED ABU-FARHA, FAHAD ALAJMI, THAMER ALESSA, RALPH A. DEFRONZO, NAIM SHEHADEH
Journal: Diabetes
Diabetes 2024;73(Supplement_1):138-OR
https://doi.org/10.2337/db24-138-OR
Published: 14 June 2024
View articletitled, 138-OR: Pioglitazone Amplifies the Decrease in HbA1c and Prevents the Increase in Plasma Ketone Caused by Dapagliflozin in Type 1 Diabetes Mellitus Patients
Meeting Abstracts

301-OR: Synergistic Effects of Dapagliflozin and Tirzepatide Combination Treatment on Weight Loss and Glucose Regulation in Diet-Induced Obese Animals

Free
MOHAMED ABU-FARHA, IRINA AL-KHAIRI, MOHAMMAD QADDOUMI, FAHAD ALAJMI, NERMEEN A. ABUKHALAF, PREETHI T. CHERIAN, HOSSEIN AREFANIAN, JEHAD ABUBAKER, MUHAMMAD ABDUL-GHANI, FAHD AL-MULLA
Journal: Diabetes
Diabetes 2024;73(Supplement_1):301-OR
https://doi.org/10.2337/db24-301-OR
Published: 14 June 2024
View articletitled, 301-OR: Synergistic Effects of Dapagliflozin and Tirzepatide Combination Treatment on Weight Loss and Glucose Regulation in Diet-Induced Obese Animals
Meeting Abstracts

139-OR: Empagliflozin Enhances Hepatic Glucose Production and Reduces Total-Body Norepinephrine Turnover Rate—A Randomized Trial

Free
SIHAM ABDELGANI, GOZDE BASKOY, JOHN M. ADAMS, II, AHMED KHATTAB, RALPH A. DEFRONZO, MUHAMMAD ABDUL-GHANI
Journal: Diabetes
Diabetes 2024;73(Supplement_1):139-OR
https://doi.org/10.2337/db24-139-OR
Published: 14 June 2024
View articletitled, 139-OR: Empagliflozin Enhances Hepatic Glucose Production and Reduces Total-Body Norepinephrine Turnover Rate—A Randomized Trial
Meeting Abstracts

68-LB: Early Pharmacological Intervention (EPIC) to Preserve Beta-Cell Function in Prediabetes (PreDM)

Free
ALBERTO CHAVEZ, AURORA MEROVCI, SIVARAM NEPPALA, LUIS A. CRUZ MORENO, GOZDE BASKOY, FRANCISCA M. ACOSTA, ANDREA A. HANSIS-DIARTE, CURTISS L. PUCKETT, JR., JOHN M. ADAMS, III, MUHAMMAD ABDUL-GHANI, CURTIS L. TRIPLITT, EUGENIO CERSOSIMO, RALPH A. DEFRONZO
Journal: Diabetes
Diabetes 2023;72(Supplement_1):68-LB
https://doi.org/10.2337/db23-68-LB
Published: 20 June 2023
View articletitled, 68-LB: Early Pharmacological Intervention (EPIC) to Preserve Beta-Cell Function in Prediabetes (PreDM)
Meeting Abstracts

211-OR: Plasma Insulin Is Required for the Increase in Plasma ANGPTL8 Concentration following Glucose Ingestion

Free
MOHAMED ABU-FARHA, JEHAD ABUBAKER, IRINA AL KHAIRI, PREETHI T. CHERIAN, CHRISTINA AGYIN, IV, SIHAM ABDELGANI, EBAA S. ALOZAIRI, JOHN M. ADAMS, II, FAHD ALMULLA, RALPH A. DEFRONZO, MUHAMMAD ABDUL-GHANI
Journal: Diabetes
Diabetes 2022;71(Supplement_1):211-OR
https://doi.org/10.2337/db22-211-OR
Published: 01 June 2022
View articletitled, 211-OR: Plasma Insulin Is Required for the Increase in Plasma ANGPTL8 Concentration following Glucose Ingestion
Meeting Abstracts

54-LB: Distinct Mechanisms Are Responsible for the Increase in Endogenous Glucose Production and Ketone Formation following Empagliflozin in T2DM Patients

Free
SIHAM ABDELGANI, JOHN M. ADAMS, III, GIUSEPPE DANIELE, FAHD ALMULLA, RALPH A. DEFRONZO, MUHAMMAD ABDUL-GHANI, MOHAMED ABU-FARHA, STEFANO DEL PRATO
Journal: Diabetes
Diabetes 2022;71(Supplement_1):54-LB
https://doi.org/10.2337/db22-54-LB
Published: 01 June 2022
View articletitled, 54-LB: Distinct Mechanisms Are Responsible for the Increase in Endogenous Glucose Production and Ketone Formation following Empagliflozin in T2DM Patients
Meeting Abstracts

644-P: Effect of PharmacologIC (EPIC) Therapy on Insulin Sensitivity and Beta-Cell Function in Prediabetes (PreDM)

Free
ALBERTO O. CHAVEZ VELAZQUEZ, EMAD ALI, AURORA MEROVCI, CHRISTINA AGYIN, IV, TOMOKO TERASAWA, MUHAMMAD ABDUL-GHANI, CURTIS L. TRIPLITT, EUGENIO CERSOSIMO, RALPH A. DEFRONZO
Journal: Diabetes
Diabetes 2022;71(Supplement_1):644-P
https://doi.org/10.2337/db22-644-P
Published: 01 June 2022
View articletitled, 644-P: Effect of PharmacologIC (EPIC) Therapy on Insulin Sensitivity and Beta-Cell Function in Prediabetes (PreDM)
Journal Articles

Adaptation of Insulin Clearance to Metabolic Demand Is a Key Determinant of Glucose Tolerance

Free
Amalia Gastaldelli, Muhammad Abdul Ghani, Ralph A. DeFronzo
Journal: Diabetes
Diabetes 2021;70(2):377–385
https://doi.org/10.2337/db19-1152
Published: 19 October 2020
View articletitled, Adaptation of Insulin Clearance to Metabolic Demand Is a Key Determinant of Glucose Tolerance
Open the PDF for Adaptation of Insulin Clearance to Metabolic Demand Is a Key Determinant of Glucose Tolerance in another window
Journal Articles

Effect of Mild Physiologic Hyperglycemia on Insulin Secretion, Insulin Clearance, and Insulin Sensitivity in Healthy Glucose-Tolerant Subjects

Free
Aurora Merovci, Devjit Tripathy, Xi Chen, Ivan Valdez, Muhammad Abdul-Ghani, Carolina Solis-Herrera, Amalia Gastaldelli, Ralph A. DeFronzo
Journal: Diabetes
Diabetes 2021;70(1):204–213
https://doi.org/10.2337/db20-0039
Published: 08 October 2020
View articletitled, Effect of Mild Physiologic Hyperglycemia on Insulin Secretion, Insulin Clearance, and Insulin Sensitivity in Healthy Glucose-Tolerant Subjects
Open the PDF for Effect of Mild Physiologic Hyperglycemia on Insulin Secretion, Insulin Clearance, and Insulin Sensitivity in Healthy Glucose-Tolerant Subjects in another window
Meeting Abstracts

352-OR: Combination Therapy with Dapagliflozin plus Exenatide on Endogenous Glucose Production: A Mechanism of Action Study

Free
MARIAM ALATRACH, CHRISTINA AGYIN, IV, JOHN M. ADAMS, II, OLGA LAVRYNENKO, NITCHAKARN LAICHUTHAI, EUGENIO CERSOSIMO, CURTIS L. TRIPLITT, AMALIA GASTALDELLI, MUHAMMAD ABDUL-GHANI, RALPH A. DEFRONZO
Journal: Diabetes
Diabetes 2020;69(Supplement_1):352-OR
https://doi.org/10.2337/db20-352-OR
Published: 01 June 2020
View articletitled, 352-OR: Combination Therapy with Dapagliflozin plus Exenatide on Endogenous Glucose Production: A Mechanism of Action Study
Meeting Abstracts

1851-P: Renal Denervation Attenuates Endogenous Glucose Production Increase with SGLT2 Inhibition in Patients with Renal Transplant Recipients and Impaired Fasting Glucose

Free
GIUSEPPE DANIELE, CAROLINA SOLIS-HERRERA, ANGELA DARDANO, ANDREA MARI, ANDREA TURA, LAURA GIUSTI, JANCY J. KURUMTHODATHU, ALEX A.G. BROCCHI, BEATRICE CAMPI, ALESSANDRO SABA, ANNA MARIA BIANCHI, CARLA TREGNAGHI, MARIA FRANCESCA EGIDI, MUHAMMAD ABDUL-GHANI, RALPH A. DEFRONZO, STEFANO DELPRATO
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1851-P
https://doi.org/10.2337/db20-1851-P
Published: 01 June 2020
View articletitled, 1851-P: Renal Denervation Attenuates Endogenous Glucose Production Increase with SGLT2 Inhibition in Patients with Renal Transplant Recipients and Impaired Fasting Glucose
Meeting Abstracts

184-OR: Liver Fibrosis Scores Do Not Predict Response to Therapy in T2DM

Free
OLGA LAVRYNENKO, MARIAM ALATRACH, MUHAMMAD ABDUL-GHANI, EUGENIO CERSOSIMO, NAIM ALKHOURI, CURTISS L. PUCKETT, JR., RALPH A. DEFRONZO, JOHN M. ADAMS, II, JUAN A. VASQUEZ, JR., GEOFFREY D. CLARKE
Journal: Diabetes
Diabetes 2020;69(Supplement_1):184-OR
https://doi.org/10.2337/db20-184-OR
Published: 01 June 2020
View articletitled, 184-OR: Liver Fibrosis Scores Do Not Predict Response to Therapy in T2DM
Meeting Abstracts

1136-P: Glucose Kinetics during Oral Glucose Challenge following Administration of Exenatide and Dapagliflozin Alone and in Combination in Type 2 Diabetes

Free
MARIAM ALATRACH, CHRISTINA AGYIN, IV, NITCHAKARN LAICHUTHAI, OLGA LAVRYNENKO, JOHN M. ADAMS, II, MUHAMMAD ABDUL-GHANI, CURTIS L. TRIPLITT, RALPH A. DEFRONZO, EUGENIO CERSOSIMO
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1136-P
https://doi.org/10.2337/db20-1136-P
Published: 01 June 2020
View articletitled, 1136-P: Glucose Kinetics during Oral Glucose Challenge following Administration of Exenatide and Dapagliflozin Alone and in Combination in Type 2 Diabetes
Journal Articles

Evidence Against an Important Role of Plasma Insulin and Glucagon Concentrations in the Increase in EGP Caused by SGLT2 Inhibitors

Free
Mariam Alatrach, Nitchakarn Laichuthai, Robert Martinez, Christina Agyin, Ali Muhammed Ali, Hussein Al-Jobori, Olga Lavynenko, John Adams, Curtis Triplitt, Ralph DeFronzo, Eugenio Cersosimo, Muhammad Abdul-Ghani
Journal: Diabetes
Diabetes 2020;69(4):681–688
https://doi.org/10.2337/db19-0770
Published: 08 January 2020
View articletitled, Evidence Against an Important Role of Plasma Insulin and Glucagon Concentrations in the Increase in EGP Caused by SGLT2 Inhibitors
Open the PDF for Evidence Against an Important Role of Plasma Insulin and Glucagon Concentrations in the Increase in EGP Caused by SGLT2 Inhibitors in another window
Includes: Supplementary data
Meeting Abstracts

246-OR: Contribution of Plasma Glucose and Hormones to the Acute Compensatory Rise in Endogenous Glucose Production (EGP) during Glucosuria in T2D Patients

Free
MARIAM ALATRACH, CHRISTINA AGYIN, IV, NITCHAKARN LAICHUTHAI, JOHN M. ADAMS, II, MUHAMMAD ABDUL-GHANI, CURTIS L. TRIPLITT, RALPH A. DEFRONZO, EUGENIO CERSOSIMO
Journal: Diabetes
Diabetes 2019;68(Supplement_1):246-OR
https://doi.org/10.2337/db19-246-OR
Published: 01 June 2019
View articletitled, 246-OR: Contribution of Plasma Glucose and Hormones to the Acute Compensatory Rise in Endogenous Glucose Production (EGP) during Glucosuria in T2D Patients
Meeting Abstracts

155-LB: The Increase in Endogenous Glucose Production with SGLT2 Inhibition Is Unchanged by Renal Denervation but Highly Correlates to Urinary Glucose Excretion

Free
CAROLINA SOLIS-HERRERA, MARIAM ALATRACH, CHRISTINA AGYIN, HENRI HONKA, RUPAL PATEL, CURTIS L. TRIPLITT, JOHN M. ADAMS, II, AMALIA GASTALDELLI, MUHAMMAD ABDUL-GHANI, EUGENIO CERSOSIMO, RALPH A. DEFRONZO
Journal: Diabetes
Diabetes 2019;68(Supplement_1):155-LB
https://doi.org/10.2337/db19-155-LB
Published: 01 June 2019
View articletitled, 155-LB: The Increase in Endogenous Glucose Production with SGLT2 Inhibition Is Unchanged by Renal Denervation but Highly Correlates to Urinary Glucose Excretion