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Meeting Abstracts

20-OR: A New Model to Assess Lactate Synthetic Rate during an Oral Glucose Tolerance Test

JACOPO BONET, BRITTANY GALUPPO, NICOLA SANTORO, CHIARA DALLA MAN

Diabetes 2021;70(Supplement_1):20-OR

DOI: https://doi.org/10.2337/db21-20-OR

Published: 01 June 2021

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Meeting Abstracts

67-OR: Oral Minimal Model Testing Reveals Early Impairment of Insulin Sensitivity in Type 1 Diabetes Autoantibody Positive, Nonobese, Nondysglycemic Youth

ALFONSO GALDERISI, ANTOINETTE MORAN, CARMELLA EVANS-MOLINA, MARIANGEA MARTINO, NICOLA SANTORO, SONIA CAPRIO, CLAUDIO COBELLI

Diabetes 2021;70(Supplement_1):67-OR

DOI: https://doi.org/10.2337/db21-67-OR

Published: 01 June 2021

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Meeting Abstracts

898-P: Colonic Acetate Production in Youth with and without Obesity

BRITTANY GALUPPO, GARY CLINE, MICHELLE A. VAN NAME, CRISTIANA AGAZZI, CRAIG L. KIEN, NICOLA SANTORO

Diabetes 2021;70(Supplement_1):898-P

DOI: https://doi.org/10.2337/db21-898-P

Published: 01 June 2021

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Meeting Abstracts

921-P: Do Glucose and Lipid Metabolism Differ by Adiposity in Adolescents with Type 1 Diabetes (T1D)? Preliminary Results of a 2-Step Clamp Study

MICHELLE A. VAN NAME, STEPHAN SIEBEL, EILEEN M. TICHY, SONIA CAPRIO, WILLIAM V. TAMBORLANE, NICOLA SANTORO

Diabetes 2021;70(Supplement_1):921-P

DOI: https://doi.org/10.2337/db21-921-P

Published: 01 June 2021

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Meeting Abstracts

1819-P: Gut Microbiota and PNPLA3 RS738409 Associated with Nonalcoholic Fatty Liver Disease in Obese Youth

AYESHA MONGA KRAVETZ, TODD TESTERMAN, BRITTANY GALUPPO, JOERG GRAF, STEPHAN SIEBEL, RICHARD FEINN, NICOLA SANTORO

Diabetes 2020;69(Supplement_1):1819-P

DOI: https://doi.org/10.2337/db20-1819-P

Published: 01 June 2020

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Meeting Abstracts

61-OR: Genetic and Metabolic Determinants of the Incretin Effect in Obese Adolescent with Prediabetes

ALFONSO GALDERISI, STEPHANIE SAMUELS, BRIDGET PIERPONT, CHIARA DALLA MAN, NICOLA SANTORO, SONIA CAPRIO

Diabetes 2020;69(Supplement_1):61-OR

DOI: https://doi.org/10.2337/db20-61-OR

Published: 01 June 2020

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Meeting Abstracts

1273-P: Growth Differentiation Factor 15 (GDF15) Is Associated with Nonalcoholic Fatty Liver Disease (NAFLD) in Obese Youth

BRITTANY GALUPPO, CRISTIANA AGAZZI, BRIDGET PIERPONT, STEPHANIE SAMUELS, ELENA TARABRA, SONIA CAPRIO, NICOLA SANTORO

Diabetes 2020;69(Supplement_1):1273-P

DOI: https://doi.org/10.2337/db20-1273-P

Published: 01 June 2020

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Meeting Abstracts

128-OR: Clustering of Metabolomics, Clinical Biomarkers, and Ectopic Liver Fat in Children/Adolescents: An Integrated Network Analysis

CATHERINE E. CIOFFI, K.M. VENKAT NARAYAN, KARAN UPPAL, BRIDGET PIERPONT, SONIA CAPRIO, NICOLA SANTORO, MIRIAM B. VOS

Diabetes 2019;68(Supplement_1):128-OR

DOI: https://doi.org/10.2337/db19-128-OR

Published: 01 June 2019

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Meeting Abstracts

772-P: Effect of a Low n6/n3 PUFA Diet on Intrahepatic Fat Content in Obese Adolescents

MICHELLE A. VAN NAME, JENNIFER M. CHICK, MARY SAVOYE, BRIDGET PIERPONT, BRITTANY GALUPPO, ARIEL FELDSTEIN, NICOLA SANTORO

Diabetes 2019;68(Supplement_1):772-P

DOI: https://doi.org/10.2337/db19-772-P

Published: 01 June 2019

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Meeting Abstracts

121-OR: Insulin Clearance Is an Independent Determinant of ß-Cell Cell Function in Obese Youths

ALFONSO GALDERISI, DOMENICO TRICO, COSIMO GIANNINI, SR., NICOLA SANTORO, SONIA CAPRIO, RAM WEISS

Diabetes 2019;68(Supplement_1):121-OR

DOI: https://doi.org/10.2337/db19-121-OR

Published: 01 June 2019

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Meeting Abstracts

177-OR: Genome-Wide Association Study of Lipid Traits in Youth with Type 2 Diabetes: The ProDiGY (Progress in Diabetes Genetics in Youth) Consortium

LING CHEN, SHYLAJA SRINIVASAN, NICOLA SANTORO, JENNIFER TODD, JASMIN DIVERS, AMY SANGHAVI SHAH, SAMUEL GIDDING, BRIAN K. BURKE, MOREY W. HAYMOND, LESLIE LANGE, SANTICA M. MARCOVINA, ALAN CHAIT, JASON FLANNICK, SONIA CAPRIO, JOSE C. FLOREZ

Diabetes 2019;68(Supplement_1):177-OR

DOI: https://doi.org/10.2337/db19-177-OR

Published: 01 June 2019

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Meeting Abstracts

1317-P: Static, but Nondynamic, ß-Cell Responsiveness to Glucose Is Affected by the Risk Variant rs7903146 of TCF7L2 and Associated with a Delayed Time-to-Glucose-Peak in Obese Youths

ALFONSO GALDERISI, DOMENICO TRICO, CHIARA DALLA MAN, STEPHAN SIEBEL, NICOLA SANTORO, BRIDGET PIERPONT, CLAUDIO COBELLI, SONIA CAPRIO

Diabetes 2019;68(Supplement_1):1317-P

DOI: https://doi.org/10.2337/db19-1317-P

Published: 01 June 2019

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Journal Articles

Altered In Vivo Lipid Fluxes and Cell Dynamics in Subcutaneous Adipose Tissues Are Associated With the Unfavorable Pattern of Fat Distribution in Obese Adolescent Girls

Jessica Nouws, Mark Fitch, Mariana Mata, Nicola Santoro, Brittany Galuppo, Romy Kursawe, Deepak Narayan, Alla Vash-Margita, Bridget Pierpont, Gerald I. Shulman, Marc Hellerstein, Sonia Caprio

Diabetes 2019;68(6):1168–1177

DOI: https://doi.org/10.2337/db18-1162

Published: 01 April 2019

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Includes: Supplementary data

Meeting Abstracts

Ethnicity and Common Genetic Variants Modulate Nonalcoholic Fatty Liver Disease (NAFLD) Metabolic Phenotype in Obese Youth

DOMENICO TRICO, SONIA CAPRIO, GIUSEPPINA R. UMANO, ALFONSO GALDERISI, MARIANA M. MATA, JESSICA NOUWS, BRIDGET PIERPONT, GRACE KIM, NICOLA SANTORO

Diabetes 2018;67(Supplement_1):313-OR

DOI: https://doi.org/10.2337/db18-313-OR

Published: 01 July 2018

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Meeting Abstracts

The TCF7L2 Variant rs7903146 Affects the Risk of Youth-Onset Type 2 Diabetes by Reducing the Incretin Effect on Insulin Secretion

ALFONSO GALDERISI, BRIDGET PIERPONT, DAVID D'ALESSIO, NICOLA SANTORO, SONIA CAPRIO

Diabetes 2018;67(Supplement_1):340-OR

DOI: https://doi.org/10.2337/db18-340-OR

Published: 01 July 2018

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Journal Articles

Altered Brain Response to Drinking Glucose and Fructose in Obese Adolescents

Ania M. Jastreboff, Rajita Sinha, Jagriti Arora, Cosimo Giannini, Jessica Kubat, Saima Malik, Michelle A. Van Name, Nicola Santoro, Mary Savoye, Elvira J. Duran, Bridget Pierpont, Gary Cline, R. Todd Constable, Robert S. Sherwin, Sonia Caprio

Diabetes 2016;65(7):1929–1939

DOI: https://doi.org/10.2337/db15-1216

Published: 05 April 2016

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Includes: Supplementary data

Journal Articles

A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents

Romy Kursawe, Vishwa D. Dixit, Philipp E. Scherer, Nicola Santoro, Deepak Narayan, Ruth Gordillo, Cosimo Giannini, Ximena Lopez, Bridget Pierpont, Jessica Nouws, Gerald I. Shulman, Sonia Caprio

Diabetes 2016;65(3):610–618

DOI: https://doi.org/10.2337/db15-1478

Published: 30 December 2015

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Includes: Supplementary data

Journal Articles

Evidence for Early Defects in Insulin Sensitivity and Secretion Before the Onset of Glucose Dysregulation in Obese Youths : A Longitudinal Study

Cosimo Giannini, Ram Weiss, Anna Cali, Riccardo Bonadonna, Nicola Santoro, Bridget Pierpont, Melissa Shaw, Sonia Caprio

Diabetes 2012;61(3):606–614

DOI: https://doi.org/10.2337/db11-1111

Published: 13 February 2012

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Includes: Supplementary data

Journal Articles

Hepatic Lipase Gene Variant −514C>T Is Associated With Lipoprotein and Insulin Sensitivity Response to Regular Exercise: The HERITAGE Family Study

Margarita Teran-Garcia, Nicola Santoro, Tuomo Rankinen, Jean Bergeron, Treva Rice, Arthur S. Leon, D.C. Rao, James S. Skinner, Richard N. Bergman, Jean-Pierre Després, Claude Bouchard

Diabetes 2005;54(7):2251–2255

DOI: https://doi.org/10.2337/diabetes.54.7.2251

Published: 01 July 2005

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Journal Articles

Mutational Screening of the CART Gene in Obese Children: Identifying a Mutation (Leu34Phe) Associated With Reduced Resting Energy Expenditure and Cosegregating With Obesity Phenotype in a Large Family

Emanuele Miraglia del Giudice, Nicola Santoro, Grazia Cirillo, Luigi D’Urso, Rosario Di Toro, Laura Perrone

Diabetes 2001;50(9):2157–2160

DOI: https://doi.org/10.2337/diabetes.50.9.2157

Published: 01 September 2001

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NARROW

20-OR: A New Model to Assess Lactate Synthetic Rate during an Oral Glucose Tolerance Test

67-OR: Oral Minimal Model Testing Reveals Early Impairment of Insulin Sensitivity in Type 1 Diabetes Autoantibody Positive, Nonobese, Nondysglycemic Youth

898-P: Colonic Acetate Production in Youth with and without Obesity

921-P: Do Glucose and Lipid Metabolism Differ by Adiposity in Adolescents with Type 1 Diabetes (T1D)? Preliminary Results of a 2-Step Clamp Study

1819-P: Gut Microbiota and PNPLA3 RS738409 Associated with Nonalcoholic Fatty Liver Disease in Obese Youth

61-OR: Genetic and Metabolic Determinants of the Incretin Effect in Obese Adolescent with Prediabetes

1273-P: Growth Differentiation Factor 15 (GDF15) Is Associated with Nonalcoholic Fatty Liver Disease (NAFLD) in Obese Youth

128-OR: Clustering of Metabolomics, Clinical Biomarkers, and Ectopic Liver Fat in Children/Adolescents: An Integrated Network Analysis

772-P: Effect of a Low n6/n3 PUFA Diet on Intrahepatic Fat Content in Obese Adolescents

121-OR: Insulin Clearance Is an Independent Determinant of ß-Cell Cell Function in Obese Youths

177-OR: Genome-Wide Association Study of Lipid Traits in Youth with Type 2 Diabetes: The ProDiGY (Progress in Diabetes Genetics in Youth) Consortium

1317-P: Static, but Nondynamic, ß-Cell Responsiveness to Glucose Is Affected by the Risk Variant rs7903146 of TCF7L2 and Associated with a Delayed Time-to-Glucose-Peak in Obese Youths

Altered In Vivo Lipid Fluxes and Cell Dynamics in Subcutaneous Adipose Tissues Are Associated With the Unfavorable Pattern of Fat Distribution in Obese Adolescent Girls

Ethnicity and Common Genetic Variants Modulate Nonalcoholic Fatty Liver Disease (NAFLD) Metabolic Phenotype in Obese Youth

The TCF7L2 Variant rs7903146 Affects the Risk of Youth-Onset Type 2 Diabetes by Reducing the Incretin Effect on Insulin Secretion

Altered Brain Response to Drinking Glucose and Fructose in Obese Adolescents

A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents

Evidence for Early Defects in Insulin Sensitivity and Secretion Before the Onset of Glucose Dysregulation in Obese Youths : A Longitudinal Study

Hepatic Lipase Gene Variant −514C>T Is Associated With Lipoprotein and Insulin Sensitivity Response to Regular Exercise: The HERITAGE Family Study

Mutational Screening of the CART Gene in Obese Children: Identifying a Mutation (Leu34Phe) Associated With Reduced Resting Energy Expenditure and Cosegregating With Obesity Phenotype in a Large Family

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