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Meeting Abstracts

1016-P: Development of Highly Accurate Measurement Method of Salivary Glycated Albumin by HPLC

MASAKAZU AIHARA, NAOTO KUBOTA, TOSHIMASA YAMAUCHI
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1016-P
https://doi.org/10.2337/db24-1016-P
Published: 14 June 2024
View article titled, 1016-P: Development of Highly Accurate Measurement Method of Salivary Glycated Albumin by HPLC
Journal Articles

Overexpression of UBE2E2 in Mouse Pancreatic β-Cells Leads to Glucose Intolerance via Reduction of β-Cell Mass

Yoshitaka Sakurai, Naoto Kubota, Iseki Takamoto, Nobuhiro Wada, Masakazu Aihara, Takanori Hayashi, Tetsuya Kubota, Yuta Hiraike, Takayoshi Sasako, Harumi Nakao, Atsu Aiba, Yoko Chikaoka, Takeshi Kawamura, Takashi Kadowaki, Toshimasa Yamauchi
Journal: Diabetes
Diabetes 2024;73(3):474–489
https://doi.org/10.2337/db23-0150
Published: 08 December 2023
View article titled, Overexpression of UBE2E2 in Mouse Pancreatic β-Cells Leads to Glucose Intolerance via Reduction of β-Cell Mass
Open the PDF for Overexpression of UBE2E2 in Mouse Pancreatic β-Cells Leads to Glucose Intolerance via Reduction of β-Cell Mass in another window
Meeting Abstracts

631-P: Development of Noninvasive Diabetes Management Method Using Glycated Albumin in Tears

MASAKAZU AIHARA, NAOTO KUBOTA, TOSHIMASA YAMAUCHI
Journal: Diabetes
Diabetes 2023;72(Supplement_1):631-P
https://doi.org/10.2337/db23-631-P
Published: 20 June 2023
View article titled, 631-P: Development of Noninvasive Diabetes Management Method Using Glycated Albumin in Tears
Journal Articles

Lack of Brain Insulin Receptor Substrate-1 Causes Growth Retardation, With Decreased Expression of Growth Hormone–Releasing Hormone in the Hypothalamus

Takanori Hayashi, Tetsuya Kubota, Inoue Mariko, Iseki Takamoto, Masakazu Aihara, Yoshitaka Sakurai, Nobuhiro Wada, Takashi Miki, Toshimasa Yamauchi, Naoto Kubota, Takashi Kadowaki
Journal: Diabetes
Diabetes 2021;70(8):1640–1653
https://doi.org/10.2337/db20-0482
Published: 12 May 2021
View article titled, Lack of Brain Insulin Receptor Substrate-1 Causes Growth Retardation, With Decreased Expression of Growth Hormone–Releasing Hormone in the Hypothalamus
Open the PDF for Lack of Brain Insulin Receptor Substrate-1 Causes Growth Retardation, With Decreased Expression of Growth Hormone–Releasing Hormone in the Hypothalamus in another window
Meeting Abstracts

887-P: Development of the Noninvasive Diabetes Monitoring Method

MASAKAZU AIHARA, NAOTO KUBOTA, TAKASHI KADOWAKI
Journal: Diabetes
Diabetes 2020;69(Supplement_1):887-P
https://doi.org/10.2337/db20-887-P
Published: 01 June 2020
View article titled, 887-P: Development of the Noninvasive Diabetes Monitoring Method
Meeting Abstracts

1876-P: Gut Microbial Fermentation of Polysaccharides Impacts Insulin Resistance in Humans

TADASHI TAKEUCHI, YUMIKO NAKANISHI, KAZUTAKA IKEDA, HIROSHI TSUGAWA, WATARU SUDA, YOSHIKO MIZUNO, NOBUTAKE YAMAMICHI, MAKOTO ARITA, MASAHIRA HATTORI, NAOTO KUBOTA, TETSUYA KUBOTA, TAKASHI KADOWAKI, SHIGEO KOYASU, HIROSHI OHNO
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1876-P
https://doi.org/10.2337/db20-1876-P
Published: 01 June 2020
View article titled, 1876-P: Gut Microbial Fermentation of Polysaccharides Impacts Insulin Resistance in Humans
Meeting Abstracts

Study of the Correlation between Tear Glucose Concentrations and Blood Glucose Concentrations

MASAKAZU AIHARA, NAOTO KUBOTA, TAKASHI KADOWAKI
Journal: Diabetes
Diabetes 2018;67(Supplement_1):944-P
https://doi.org/10.2337/db18-944-P
Published: 01 July 2018
View article titled, Study of the Correlation between Tear Glucose Concentrations and Blood Glucose Concentrations
Meeting Abstracts

Impairment of M2a-Subtype Macrophage Activation by Il-4-Irs2 Pathway in Obesity

TETSUYA KUBOTA, MARIKO INOUE, NAOTO KUBOTA, ISEKI TAKAMOTO, KOHJIRO UEKI, TOSHIMASA YAMAUCHI, TAKASHI KADOWAKI
Journal: Diabetes
Diabetes 2018;67(Supplement_1):2012-P
https://doi.org/10.2337/db18-2012-P
Published: 01 July 2018
View article titled, Impairment of M2a-Subtype Macrophage Activation by Il-4-Irs2 Pathway in Obesity
Meeting Abstracts

Tofogliflozin Suppresses the Progression of Atherosclerosis and Reduces Inflammation in Macrophages of STZ-Diabetic ApoE KO Mice due to Improvement of Glucose Tolerance

MASAHIKO IWAMOTO, NAOTO KUBOTA, TETSUYA KUBOTA, YOSHITAKA SAKURAI, NOBUHIRO WADA, ISEKI TAKAMOTO, SEIJI SHIODA, TAKASHI KADOWAKI
Journal: Diabetes
Diabetes 2018;67(Supplement_1):486-P
https://doi.org/10.2337/db18-486-P
Published: 01 July 2018
View article titled, Tofogliflozin Suppresses the Progression of Atherosclerosis and Reduces Inflammation in Macrophages of STZ-Diabetic ApoE KO Mice due to Improvement of Glucose Tolerance
Meeting Abstracts

Lack of Brain Insulin Receptor Substrate-1 (IRS1) Causes Growth Retardation via Growth Hormone Releasing Hormone

TAKANORI HAYASHI, NAOTO KUBOTA, TETSUYA KUBOTA, TAKASHI KADOWAKI
Journal: Diabetes
Diabetes 2018;67(Supplement_1):1795-P
https://doi.org/10.2337/db18-1795-P
Published: 01 July 2018
View article titled, Lack of Brain Insulin Receptor Substrate-1 (IRS1) Causes Growth Retardation via Growth Hormone Releasing Hormone
Journal Articles

Dual Regulation of Gluconeogenesis by Insulin and Glucose in the Proximal Tubules of the Kidney

Motohiro Sasaki, Takayoshi Sasako, Naoto Kubota, Yoshitaka Sakurai, Iseki Takamoto, Tetsuya Kubota, Reiko Inagi, George Seki, Moritaka Goto, Kohjiro Ueki, Masaomi Nangaku, Takahito Jomori, Takashi Kadowaki
Journal: Diabetes
Diabetes 2017;66(9):2339–2350
https://doi.org/10.2337/db16-1602
Published: 17 June 2017
View article titled, Dual Regulation of Gluconeogenesis by Insulin and Glucose in the Proximal Tubules of the Kidney
Open the PDF for Dual Regulation of Gluconeogenesis by Insulin and Glucose in the Proximal Tubules of the Kidney in another window
Includes: Supplementary data
Journal Articles

Insulin Receptor Substrate-2 (Irs2) in Endothelial Cells Plays a Crucial Role in Insulin Secretion

Shinji Hashimoto, Naoto Kubota, Hiroyuki Sato, Motohiro Sasaki, Iseki Takamoto, Tetsuya Kubota, Keizo Nakaya, Mitsuhiko Noda, Kohjiro Ueki, Takashi Kadowaki
Journal: Diabetes
Diabetes 2015;64(3):876–886
https://doi.org/10.2337/db14-0432
Published: 01 October 2014
View article titled, Insulin Receptor Substrate-2 (Irs2) in Endothelial Cells Plays a Crucial Role in Insulin Secretion
Open the PDF for Insulin Receptor Substrate-2 (Irs2) in Endothelial Cells Plays a Crucial Role in Insulin Secretion in another window
Journal Articles

Vagal Hyperactivity Due to Ventromedial Hypothalamic Lesions Increases Adiponectin Production and Release

Yoko Suzuki, Hiroyuki Shimizu, Noriko Ishizuka, Naoto Kubota, Tetsuya Kubota, Akira Senoo, Haruaki Kageyama, Toshimasa Osaka, Satoshi Hirako, Hyoun-Ju Kim, Akiyo Matsumoto, Seiji Shioda, Masatomo Mori, Takashi Kadowaki, Shuji Inoue
Journal: Diabetes
Diabetes 2014;63(5):1637–1648
https://doi.org/10.2337/db13-0636
Published: 12 April 2014
View article titled, Vagal Hyperactivity Due to Ventromedial Hypothalamic Lesions Increases Adiponectin Production and Release
Open the PDF for Vagal Hyperactivity Due to Ventromedial Hypothalamic Lesions Increases Adiponectin Production and Release in another window
Includes: Supplementary data
Journal Articles

Glucokinase Activation Ameliorates ER Stress–Induced Apoptosis in Pancreatic β-Cells

Jun Shirakawa, Yu Togashi, Eri Sakamoto, Mitsuyo Kaji, Kazuki Tajima, Kazuki Orime, Hideaki Inoue, Naoto Kubota, Takashi Kadowaki, Yasuo Terauchi
Journal: Diabetes
Diabetes 2013;62(10):3448–3458
https://doi.org/10.2337/db13-0052
Published: 17 September 2013
View article titled, Glucokinase Activation Ameliorates ER Stress–Induced Apoptosis in Pancreatic β-Cells
Open the PDF for Glucokinase Activation Ameliorates ER Stress–Induced Apoptosis in Pancreatic β-Cells in another window
Includes: Supplementary data
Journal Articles

Adiponectin-Dependent and -Independent Pathways in Insulin-Sensitizing and Antidiabetic Actions of Thiazolidinediones

Naoto Kubota, Toshimasa Yamauchi, Kazuyuki Tobe, Takashi Kadowaki
Journal: Diabetes
Diabetes 2006;55(Supplement_2):S32–S38
https://doi.org/10.2337/db06-S005
Published: 01 December 2006
View article titled, Adiponectin-Dependent and -Independent Pathways in Insulin-Sensitizing and Antidiabetic Actions of Thiazolidinediones
Open the PDF for Adiponectin-Dependent and -Independent Pathways in Insulin-Sensitizing and Antidiabetic Actions of Thiazolidinediones in another window
Journal Articles

Pioglitazone Reduces Islet Triglyceride Content and Restores Impaired Glucose-Stimulated Insulin Secretion in Heterozygous Peroxisome Proliferator–Activated Receptor-γ–Deficient Mice on a High-Fat Diet

Junji Matsui, Yasuo Terauchi, Naoto Kubota, Iseki Takamoto, Kazuhiro Eto, Tokuyuki Yamashita, Kajuro Komeda, Toshimasa Yamauchi, Junji Kamon, Shunbun Kita, Mitsuhiko Noda, Takashi Kadowaki
Journal: Diabetes
Diabetes 2004;53(11):2844–2854
https://doi.org/10.2337/diabetes.53.11.2844
Published: 01 November 2004
View article titled, Pioglitazone Reduces Islet Triglyceride Content and Restores Impaired Glucose-Stimulated Insulin Secretion in Heterozygous Peroxisome Proliferator–Activated Receptor-γ–Deficient Mice on a High-Fat Diet
Open the PDF for Pioglitazone Reduces Islet Triglyceride Content and Restores Impaired Glucose-Stimulated Insulin Secretion in Heterozygous Peroxisome Proliferator–Activated Receptor-γ–Deficient Mice on a High-Fat Diet in another window
Journal Articles

Increased Serum Leptin Protects From Adiposity Despite the Increased Glucose Uptake in White Adipose Tissue in Mice Lacking p85α Phosphoinositide 3-Kinase

Yasuo Terauchi, Junji Matsui, Junji Kamon, Toshimasa Yamauchi, Naoto Kubota, Kajuro Komeda, Shinichi Aizawa, Yasuo Akanuma, Motowo Tomita, Takashi Kadowaki
Journal: Diabetes
Diabetes 2004;53(9):2261–2270
https://doi.org/10.2337/diabetes.53.9.2261
Published: 01 September 2004
View article titled, Increased Serum Leptin Protects From Adiposity Despite the Increased Glucose Uptake in White Adipose Tissue in Mice Lacking p85α Phosphoinositide 3-Kinase
Open the PDF for Increased Serum Leptin Protects From Adiposity Despite the Increased Glucose Uptake in White Adipose Tissue in Mice Lacking p85α Phosphoinositide 3-Kinase in another window
Journal Articles

Phosphatidylinositol 3-Kinase Suppresses Glucose-Stimulated Insulin Secretion by Affecting Post-Cytosolic [Ca2+] Elevation Signals

Kazuhiro Eto, Tokuyuki Yamashita, Yoshiharu Tsubamoto, Yasuo Terauchi, Kenzo Hirose, Naoto Kubota, Shigeo Yamashita, Junko Taka, Shinobu Satoh, Hisahiko Sekihara, Kazuyuki Tobe, Masamitsu Iino, Mitsuhiko Noda, Satoshi Kimura, Takashi Kadowaki
Journal: Diabetes
Diabetes 2002;51(1):87–97
https://doi.org/10.2337/diabetes.51.1.87
Published: 01 January 2002
View article titled, Phosphatidylinositol 3-Kinase Suppresses Glucose-Stimulated Insulin Secretion by Affecting Post-Cytosolic [Ca<sup>2+</sup>] Elevation Signals
Open the PDF for Phosphatidylinositol 3-Kinase Suppresses Glucose-Stimulated Insulin Secretion by Affecting Post-Cytosolic [Ca<sup>2+</sup>] Elevation Signals in another window
Journal Articles

Subcellular Localization of Insulin Receptor Substrate Family Proteins Associated With Phosphatidylinositol 3-Kinase Activity and Alterations in Lipolysis in Primary Mouse Adipocytes From IRS-1 Null Mice

Youki Tsuji, Yasushi Kaburagi, Yasuo Terauchi, Shinobu Satoh, Naoto Kubota, Hiroyuki Tamemoto, Fredric B. Kraemer, Hisahiko Sekihara, Shinichi Aizawa, Yasuo Akanuma, Kazuyuki Tobe, Satoshi Kimura, Takashi Kadowaki
Journal: Diabetes
Diabetes 2001;50(6):1455–1463
https://doi.org/10.2337/diabetes.50.6.1455
Published: 01 June 2001
View article titled, Subcellular Localization of Insulin Receptor Substrate Family Proteins Associated With Phosphatidylinositol 3-Kinase Activity and Alterations in Lipolysis in Primary Mouse Adipocytes From IRS-1 Null Mice
Open the PDF for Subcellular Localization of Insulin Receptor Substrate Family Proteins Associated With Phosphatidylinositol 3-Kinase Activity and Alterations in Lipolysis in Primary Mouse Adipocytes From IRS-1 Null Mice in another window