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Nobuhiro Yamada
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Journal Articles

Elovl6 Deficiency Improves Glycemic Control in Diabetic db/db Mice by Expanding β-Cell Mass and Increasing Insulin Secretory Capacity

Hui Zhao, Takashi Matsuzaka, Yuta Nakano, Kaori Motomura, Nie Tang, Tomotaka Yokoo, Yuka Okajima, Song-iee Han, Yoshinori Takeuchi, Yuichi Aita, Hitoshi Iwasaki, Shigeru Yatoh, Hiroaki Suzuki, Motohiro Sekiya, Naoya Yahagi, Yoshimi Nakagawa, Hirohito Sone, Nobuhiro Yamada, Hitoshi Shimano
Journal: Diabetes
Diabetes 2017;66(7):1833–1846
https://doi.org/10.2337/db16-1277
Published: 01 May 2017
View article titled, Elovl6 Deficiency Improves Glycemic Control in Diabetic <em>db</em>/<em>db</em> Mice by Expanding β-Cell Mass and Increasing Insulin Secretory Capacity
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Includes: Supplementary data
Journal Articles

Palmitate Impairs and Eicosapentaenoate Restores Insulin Secretion Through Regulation of SREBP-1c in Pancreatic Islets

Toyonori Kato, Hitoshi Shimano, Takashi Yamamoto, Mayumi Ishikawa, Shin Kumadaki, Takashi Matsuzaka, Yoshimi Nakagawa, Naoya Yahagi, Masanori Nakakuki, Alyssa H. Hasty, Yoshinori Takeuchi, Kazuto Kobayashi, Akimitsu Takahashi, Shigeru Yatoh, Hiroaki Suzuki, Hirohito Sone, Nobuhiro Yamada
Journal: Diabetes
Diabetes 2008;57(9):2382–2392
https://doi.org/10.2337/db06-1806
Published: 01 September 2008
View article titled, Palmitate Impairs and Eicosapentaenoate Restores Insulin Secretion Through Regulation of SREBP-1c in Pancreatic Islets
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Includes: Supplementary data
Journal Articles

Identification of a Novel Member of the Carboxylesterase Family That Hydrolyzes Triacylglycerol : A Potential Role in Adipocyte Lipolysis

Hiroaki Okazaki, Masaki Igarashi, Makiko Nishi, Makiko Tajima, Motohiro Sekiya, Sachiko Okazaki, Naoya Yahagi, Ken Ohashi, Kazuhisa Tsukamoto, Michiyo Amemiya-Kudo, Takashi Matsuzaka, Hitoshi Shimano, Nobuhiro Yamada, Junken Aoki, Rei Morikawa, Yasukazu Takanezawa, Hiroyuki Arai, Ryozo Nagai, Takashi Kadowaki, Jun-ichi Osuga, Shun Ishibashi
Journal: Diabetes
Diabetes 2006;55(7):2091–2097
https://doi.org/10.2337/db05-0585
Published: 01 July 2006
View article titled, Identification of a Novel Member of the Carboxylesterase Family That Hydrolyzes Triacylglycerol : <subtitle>A Potential Role in Adipocyte Lipolysis</subtitle>
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Journal Articles

Transgenic Mice Overexpressing Nuclear SREBP-1c in Pancreatic β-Cells

Akimitsu Takahashi, Kaori Motomura, Toyonori Kato, Tomohiro Yoshikawa, Yoshimi Nakagawa, Naoya Yahagi, Hirohito Sone, Hiroaki Suzuki, Hideo Toyoshima, Nobuhiro Yamada, Hitoshi Shimano
Journal: Diabetes
Diabetes 2005;54(2):492–499
https://doi.org/10.2337/diabetes.54.2.492
Published: 01 February 2005
View article titled, Transgenic Mice Overexpressing Nuclear SREBP-1c in Pancreatic β-Cells
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Journal Articles

Insulin-Independent Induction of Sterol Regulatory Element-Binding Protein-1c Expression in the Livers of Streptozotocin-Treated Mice

Takashi Matsuzaka, Hitoshi Shimano, Naoya Yahagi, Michiyo Amemiya-Kudo, Hiroaki Okazaki, Yoshiaki Tamura, Yoko Iizuka, Ken Ohashi, Sachiko Tomita, Motohiro Sekiya, Alyssa Hasty, Yoshimi Nakagawa, Hirohito Sone, Hideo Toyoshima, Shun Ishibashi, Jun-ichi Osuga, Nobuhiro Yamada
Journal: Diabetes
Diabetes 2004;53(3):560–569
https://doi.org/10.2337/diabetes.53.3.560
Published: 01 March 2004
View article titled, Insulin-Independent Induction of Sterol Regulatory Element-Binding Protein-1c Expression in the Livers of Streptozotocin-Treated Mice
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Journal Articles

Hepatic Akt Activation Induces Marked Hypoglycemia, Hepatomegaly, and Hypertriglyceridemia With Sterol Regulatory Element Binding Protein Involvement

Hiraku Ono, Hitoshi Shimano, Hideki Katagiri, Naoya Yahagi, Hideyuki Sakoda, Yukiko Onishi, Motonobu Anai, Takehide Ogihara, Midori Fujishiro, Amelia Y.I. Viana, Yasushi Fukushima, Miho Abe, Nobuhiro Shojima, Masatoshi Kikuchi, Nobuhiro Yamada, Yoshitomo Oka, Tomoichiro Asano
Journal: Diabetes
Diabetes 2003;52(12):2905–2913
https://doi.org/10.2337/diabetes.52.12.2905
Published: 01 December 2003
View article titled, Hepatic Akt Activation Induces Marked Hypoglycemia, Hepatomegaly, and Hypertriglyceridemia With Sterol Regulatory Element Binding Protein Involvement
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Journal Articles

Lipolysis in the Absence of Hormone-Sensitive Lipase: Evidence for a Common Mechanism Regulating Distinct Lipases

Hiroaki Okazaki, Jun-ichi Osuga, Yoshiaki Tamura, Naoya Yahagi, Sachiko Tomita, Futoshi Shionoiri, Yoko Iizuka, Ken Ohashi, Kenji Harada, Satoshi Kimura, Takanari Gotoda, Hitoshi Shimano, Nobuhiro Yamada, Shun Ishibashi
Journal: Diabetes
Diabetes 2002;51(12):3368–3375
https://doi.org/10.2337/diabetes.51.12.3368
Published: 01 December 2002
View article titled, Lipolysis in the Absence of Hormone-Sensitive Lipase: <subtitle>Evidence for a Common Mechanism Regulating Distinct Lipases </subtitle>
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Journal Articles

The Pro12→Ala Substitution in PPAR-γ Is Associated With Resistance to Development of Diabetes in the General Population: Possible Involvement in Impairment of Insulin Secretion in Individuals With Type 2 Diabetes

Hiroyuki Mori, Hiroshi Ikegami, Yoshihiko Kawaguchi, Susumu Seino, Norihide Yokoi, Jun Takeda, Ituro Inoue, Yutaka Seino, Koichiro Yasuda, Toshiaki Hanafusa, Kazuya Yamagata, Takuya Awata, Takashi Kadowaki, Kazuo Hara, Nobuhiro Yamada, Takanari Gotoda, Naoko Iwasaki, Yasuhiko Iwamoto, Tokio Sanke, Kishio Nanjo, Yoshitomo Oka, Akira Matsutani, Eiichi Maeda, Masato Kasuga
Journal: Diabetes
Diabetes 2001;50(4):891–894
https://doi.org/10.2337/diabetes.50.4.891
Published: 01 April 2001
View article titled, The Pro<sup>12</sup>→Ala Substitution in PPAR-γ Is Associated With Resistance to Development of Diabetes in the General Population: <subtitle>Possible Involvement in Impairment of Insulin Secretion in Individuals With Type 2 Diabetes</subtitle>
Open the PDF for The Pro<sup>12</sup>→Ala Substitution in PPAR-γ Is Associated With Resistance to Development of Diabetes in the General Population: <subtitle>Possible Involvement in Impairment of Insulin Secretion in Individuals With Type 2 Diabetes</subtitle> in another window
Journal Articles

Transgenic Mouse and Gene Therapy

Kenji Harada, Hitoshi Shimano, Shun Ishibashi, Nobuhiro Yamada
Journal: Diabetes
Diabetes 1996;45(Supplement_3):S129–S132
https://doi.org/10.2337/diab.45.3.S129
Published: 01 July 1996
View article titled, Transgenic Mouse and Gene Therapy
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Journal Articles

Enhanced Expression of Platelet-Derived Growth Factor-β Receptor by High Glucose Involvement of Platelet-Derived Growth Factor in Diabetic Angiopathy

Toshimori Inaba, Shun Ishibashi, Takanari Gotoda, Masako Kawamura, Noritsugu Morino, Yoshihisa Nojima, Masanobu Kawakami, Yoshio Yazaki, Nobuhiro Yamada
Journal: Diabetes
Diabetes 1996;45(4):507–512
https://doi.org/10.2337/diab.45.4.507
Published: 01 April 1996
View article titled, Enhanced Expression of Platelet-Derived Growth Factor-β Receptor by High Glucose Involvement of Platelet-Derived Growth Factor in Diabetic Angiopathy
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Journal Articles

Overexpression of Apolipoprotein E Prevents Development of Diabetic Hyperlipidemia in Transgenic Mice

Koji Yamamoto, Hitoshi Shimano, Masako Shimada, Masako Kawamura, Takanari Gotoda, Kenji Harada, Jun-ichi Ohsuga, Yoshi Yazaki, Nobuhiro Yamada
Journal: Diabetes
Diabetes 1995;44(5):580–585
https://doi.org/10.2337/diab.44.5.580
Published: 01 May 1995
View article titled, Overexpression of Apolipoprotein E Prevents Development of Diabetic Hyperlipidemia in Transgenic Mice
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