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Journal Articles

Longitudinal Pattern of First-Phase Insulin Response Is Associated With Genetic Variants Outside the Class II HLA Region in Children With Multiple Autoantibodies

Maarit K. Koskinen, Mari-Liis Mikk, Antti-Pekka Laine, Johanna Lempainen, Eliisa Löyttyniemi, Paula Vähäsalo, Anne Hekkala, Taina Härkönen, Minna Kiviniemi, Olli Simell, Mikael Knip, Riitta Veijola, Jorma Ilonen, Jorma Toppari

Diabetes 2020;69(1):12–19

https://doi.org/10.2337/db19-0329

Published: 07 October 2019

View article titled, Longitudinal Pattern of First-Phase Insulin Response Is Associated With Genetic Variants Outside the Class II HLA Region in Children With Multiple Autoantibodies

Journal Articles

Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity

Jill M. Norris, Hye-Seung Lee, Brittni Frederiksen, Iris Erlund, Ulla Uusitalo, Jimin Yang, Åke Lernmark, Olli Simell, Jorma Toppari, Marian Rewers, Anette-G. Ziegler, Jin-Xiong She, Suna Onengut-Gumuscu, Wei-Min Chen, Stephen S. Rich, Jouko Sundvall, Beena Akolkar, Jeffrey Krischer, Suvi M. Virtanen, William Hagopian, The TEDDY Study Group, Marian Rewers, Kimberly Bautista, Judith Baxter, Ruth Bedoy, Daniel Felipe-Morales, Kimberly Driscoll, Brigitte I. Frohnert, Patricia Gesualdo, Michelle Hoffman, Rachel Karban, Edwin Liu, Jill Norris, Adela Samper-Imaz, Andrea Steck, Kathleen Waugh, Hali Wright, Jorma Toppari, Olli G. Simell, Annika Adamsson, Suvi Ahonen, Heikki Hyöty, Jorma Ilonen, Sanna Jokipuu, Tiina Kallio, Leena Karlsson, Miia Kähönen, Mikael Knip, Lea Kovanen, Mirva Koreasalo, Kalle Kurppa, Tiina Latva-aho, Maria Lönnrot, Elina Mäntymäki, Katja Multasuo, Juha Mykkänen, Tiina Niininen, Sari Niinistö, Mia Nyblom, Petra Rajala, Jenna Rautanen, Anne Riikonen, Mika Riikonen, Jenni Rouhiainen, Minna Romo, Tuula Simell, Ville Simell, Maija Sjöberg, Aino Stenius, Maria Leppänen, Sini Vainionpää, Eeva Varjonen, Riitta Veijola, Suvi M. Virtanen, Mari Vähä-Mäkilä, Mari Åkerlund, Katri Lindfors, Jin-Xiong She, Desmond Schatz, Diane Hopkins, Leigh Steed, Jamie Thomas, Janey Adams, Katherine Silvis, Michael Haller, Melissa Gardiner, Richard McIndoe, Ashok Sharma, Joshua Williams, Gabriela Young, Stephen W. Anderson, Laura Jacobsen, Anette G. Ziegler, Andreas Beyerlein, Ezio Bonifacio, Michael Hummel, Sandra Hummel, Kristina Foterek, Nicole Janz, Mathilde Kersting, Annette Knopff, Sibylle Koletzko, Claudia Peplow, Roswith Roth, Marlon Scholz, Joanna Stock, Katharina Warncke, Lorena Wendel, Christiane Winkler, Åke Lernmark, Daniel Agardh, Carin Andrén Aronsson, Maria Ask, Jenny Bremer, Ulla-Marie Carlsson, Corrado Cilio, Emelie Ericson-Hallström, Lina Fransson, Thomas Gard, Joanna Gerardsson, Rasmus Bennet, Monica Hansen, Gertie Hansson, Susanne Hyberg, Fredrik Johansen, Berglind Jonsdottir, Helena Elding Larsson, Marielle Lindström, Markus Lundgren, Maria Månsson-Martinez, Maria Markan, Jessica Melin, Zeliha Mestan, Karin Ottosson, Kobra Rahmati, Anita Ramelius, Falastin Salami, Sara Sibthorpe, Birgitta Sjöberg, Ulrica Swartling, Evelyn Tekum Amboh, Carina Törn, Anne Wallin, Åsa Wimar, Sofie Åberg, William A. Hagopian, Michael Killian, Claire Cowen Crouch, Jennifer Skidmore, Josephine Carson, Maria Dalzell, Kayleen Dunson, Rachel Hervey, Corbin Johnson, Rachel Lyons, Arlene Meyer, Denise Mulenga, Alexander Tarr, Morgan Uland, John Willis, Dorothy Becker, Margaret Franciscus, MaryEllen Dalmagro-Elias Smith, Ashi Daftary, Mary Beth Klein, Chrystal Yates, Jeffrey P. Krischer, Michael Abbondondolo, Sarah Austin-Gonzalez, Maryouri Avendano, Sandra Baethke, Rasheedah Brown, Brant Burkhardt, Martha Butterworth, Joanna Clasen, David Cuthbertson, Christopher Eberhard, Steven Fiske, Dena Garcia, Jennifer Garmeson, Veena Gowda, Kathleen Heyman, Francisco Perez Laras, Hye-Seung Lee, Shu Liu, Xiang Liu, Kristian Lynch, Jamie Malloy, Cristina McCarthy, Steven Meulemans, Hemang Parikh, Chris Shaffer, Laura Smith, Susan Smith, Noah Sulman, Roy Tamura, Ulla Uusitalo, Kendra Vehik, Ponni Vijayakandipan, Keith Wood, Jimin Yang, Beena Akolkar, Kasia Bourcier, Thomas Briese, Suzanne Bennett Johnson, Eric Triplett, Liping Yu, Dongmei Miao, Polly Bingley, Alistair Williams, Kyla Chandler, Saba Rokni, Claire Williams, Rebecca Wyatt, Gifty George, Sian Grace, Iris Erlund, Irma Salminen, Jouko Sundvall, Jaana Leiviskä, Nina Kangas, Petra Arohonka, Henry Erlich, Steven J. Mack, Anna Lisa Fear, Sandra Ke, Niveen Mulholland, Stephen S. Rich, Wei-Min Chen, Suna Onengut-Gumuscu, Emily Farber, Rebecca Roche Pickin, Jordan Davis, Dan Gallo, Jessica Bonnie, Paul Campolieto

Diabetes 2018;67(1):146–154

https://doi.org/10.2337/db17-0802

Published: 23 October 2017

View article titled, Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity

Includes: Supplementary data

Journal Articles

Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: The Environmental Determinants of Diabetes in the Young Study

Helena Elding Larsson, Kendra Vehik, Michael J. Haller, Xiang Liu, Beena Akolkar, William Hagopian, Jeffrey Krischer, Åke Lernmark, Jin-Xiong She, Olli Simell, Jorma Toppari, Anette-G. Ziegler, Marian Rewers, for the TEDDY Study Group

Diabetes 2016;65(7):1988–1995

https://doi.org/10.2337/db15-1180

Published: 23 March 2016

View article titled, Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: The Environmental Determinants of Diabetes in the Young Study

Includes: Supplementary data

Journal Articles

Serum Proteomes Distinguish Children Developing Type 1 Diabetes in a Cohort With HLA-Conferred Susceptibility

Robert Moulder, Santosh D. Bhosale, Timo Erkkilä, Essi Laajala, Jussi Salmi, Elizabeth V. Nguyen, Henna Kallionpää, Juha Mykkänen, Mari Vähä-Mäkilä, Heikki Hyöty, Riitta Veijola, Jorma Ilonen, Tuula Simell, Jorma Toppari, Mikael Knip, David R. Goodlett, Harri Lähdesmäki, Olli Simell, Riitta Lahesmaa

Diabetes 2015;64(6):2265–2278

https://doi.org/10.2337/db14-0983

Published: 23 January 2015

View article titled, Serum Proteomes Distinguish Children Developing Type 1 Diabetes in a Cohort With HLA-Conferred Susceptibility

Includes: Supplementary data

Journal Articles

HbA_1c Predicts Time to Diagnosis of Type 1 Diabetes in Children at Risk

Olli Helminen, Susanna Aspholm, Tytti Pokka, Milla-Riikka Hautakangas, Nora Haatanen, Johanna Lempainen, Jorma Ilonen, Olli Simell, Mikael Knip, Riitta Veijola

Diabetes 2015;64(5):1719–1727

https://doi.org/10.2337/db14-0497

Published: 18 December 2014

View article titled, HbA1c Predicts Time to Diagnosis of Type 1 Diabetes in Children at Risk

Journal Articles

Role of Type 1 Diabetes–Associated SNPs on Risk of Autoantibody Positivity in the TEDDY Study

Diabetes 2015;64(5):1818–1829

https://doi.org/10.2337/db14-1497

Published: 24 November 2014

View article titled, Role of Type 1 Diabetes–Associated SNPs on Risk of Autoantibody Positivity in the TEDDY Study

Includes: Supplementary data

Journal Articles

Innate Immune Activity Is Detected Prior to Seroconversion in Children With HLA-Conferred Type 1 Diabetes Susceptibility

Henna Kallionpää, Laura L. Elo, Essi Laajala, Juha Mykkänen, Isis Ricaño-Ponce, Matti Vaarma, Teemu D. Laajala, Heikki Hyöty, Jorma Ilonen, Riitta Veijola, Tuula Simell, Cisca Wijmenga, Mikael Knip, Harri Lähdesmäki, Olli Simell, Riitta Lahesmaa

Diabetes 2014;63(7):2402–2414

https://doi.org/10.2337/db13-1775

Published: 14 June 2014

View article titled, Innate Immune Activity Is Detected Prior to Seroconversion in Children With HLA-Conferred Type 1 Diabetes Susceptibility

Includes: Supplementary data

Journal Articles

Coxsackievirus B1 Is Associated With Induction of β-Cell Autoimmunity That Portends Type 1 Diabetes

Olli H. Laitinen, Hanna Honkanen, Outi Pakkanen, Sami Oikarinen, Minna M. Hankaniemi, Heini Huhtala, Tanja Ruokoranta, Valérie Lecouturier, Philippe André, Raimo Harju, Suvi M. Virtanen, Jussi Lehtonen, Jeffrey W. Almond, Tuula Simell, Olli Simell, Jorma Ilonen, Riitta Veijola, Mikael Knip, Heikki Hyöty

Diabetes 2014;63(2):446–455

https://doi.org/10.2337/db13-0619

Published: 16 January 2014

View article titled, Coxsackievirus B1 Is Associated With Induction of β-Cell Autoimmunity That Portends Type 1 Diabetes

Includes: Supplementary data

Journal Articles

Patterns of β-Cell Autoantibody Appearance and Genetic Associations During the First Years of Life

Jorma Ilonen, Anna Hammais, Antti-Pekka Laine, Johanna Lempainen, Outi Vaarala, Riitta Veijola, Olli Simell, Mikael Knip

Diabetes 2013;62(10):3636–3640

https://doi.org/10.2337/db13-0300

Published: 17 September 2013

View article titled, Patterns of β-Cell Autoantibody Appearance and Genetic Associations During the First Years of Life

Includes: Supplementary data

Journal Articles

Cord Serum Lipidome in Prediction of Islet Autoimmunity and Type 1 Diabetes

Matej Orešič, Peddinti Gopalacharyulu, Juha Mykkänen, Niina Lietzen, Marjaana Mäkinen, Heli Nygren, Satu Simell, Ville Simell, Heikki Hyöty, Riitta Veijola, Jorma Ilonen, Marko Sysi-Aho, Mikael Knip, Tuulia Hyötyläinen, Olli Simell

Diabetes 2013;62(9):3268–3274

https://doi.org/10.2337/db13-0159

Published: 15 August 2013

View article titled, Cord Serum Lipidome in Prediction of Islet Autoimmunity and Type 1 Diabetes

Journal Articles

Effect of the PTPN22 and INS Risk Genotypes on the Progression to Clinical Type 1 Diabetes After the Initiation of β-Cell Autoimmunity

Johanna Lempainen, Robert Hermann, Riitta Veijola, Olli Simell, Mikael Knip, Jorma Ilonen

Diabetes 2012;61(4):963–966

https://doi.org/10.2337/db11-0386

Published: 14 March 2012

View article titled, Effect of the PTPN22 and INS Risk Genotypes on the Progression to Clinical Type 1 Diabetes After the Initiation of β-Cell Autoimmunity

Journal Articles

Enterovirus RNA in Blood Is Linked to the Development of Type 1 Diabetes

Sami Oikarinen, Mika Martiskainen, Sisko Tauriainen, Heini Huhtala, Jorma Ilonen, Riitta Veijola, Olli Simell, Mikael Knip, Heikki Hyöty

Diabetes 2011;60(1):276–279

https://doi.org/10.2337/db10-0186

Published: 13 October 2010

View article titled, Enterovirus RNA in Blood Is Linked to the Development of Type 1 Diabetes

Journal Articles

Effect of HLA Class I and Class II Alleles on Progression From Autoantibody Positivity to Overt Type 1 Diabetes in Children With Risk-Associated Class II Genotypes

Kati Lipponen, Zsofia Gombos, Minna Kiviniemi, Heli Siljander, Johanna Lempainen, Robert Hermann, Riitta Veijola, Olli Simell, Mikael Knip, Jorma Ilonen

Diabetes 2010;59(12):3253–3256

https://doi.org/10.2337/db10-0167

Published: 25 August 2010

View article titled, Effect of HLA Class I and Class II Alleles on Progression From Autoantibody Positivity to Overt Type 1 Diabetes in Children With Risk-Associated Class II Genotypes

Journal Articles

Predictive Characteristics of Diabetes-Associated Autoantibodies Among Children With HLA-Conferred Disease Susceptibility in the General Population

Heli T.A. Siljander, Satu Simell, Anne Hekkala, Jyrki Lähde, Tuula Simell, Paula Vähäsalo, Riitta Veijola, Jorma Ilonen, Olli Simell, Mikael Knip

Diabetes 2009;58(12):2835–2842

https://doi.org/10.2337/db08-1305

Published: 15 September 2009

View article titled, Predictive Characteristics of Diabetes-Associated Autoantibodies Among Children With HLA-Conferred Disease Susceptibility in the General Population

Includes: Supplementary data

Journal Articles

Lack of Association of PAX4 Gene With Type 1 Diabetes in the Finnish and Hungarian Populations

Robert Hermann, Jussi Mantere, Kati Lipponen, Riitta Veijola, Gyula Soltesz, Timo Otonkoski, Olli Simell, Mikael Knip, Jorma Ilonen

Diabetes 2005;54(9):2816–2819

https://doi.org/10.2337/diabetes.54.9.2816

Published: 01 September 2005

View article titled, Lack of Association of PAX4 Gene With Type 1 Diabetes in the Finnish and Hungarian Populations

Journal Articles

Genetic Risk Determines the Emergence of Diabetes-Associated Autoantibodies in Young Children

Antti Kupila, Päivi Keskinen, Tuula Simell, Satu Erkkilä, Paula Arvilommi, Sari Korhonen, Teija Kimpimäki, Minna Sjöroos, Matti Ronkainen, Jorma Ilonen, Mikael Knip, Olli Simell

Diabetes 2002;51(3):646–651

https://doi.org/10.2337/diabetes.51.3.646

Published: 01 March 2002

View article titled, Genetic Risk Determines the Emergence of Diabetes-Associated Autoantibodies in Young Children

Journal Articles

Mucosa-Associated (βT-integrin^high) Lymphocytes Accumulate Early in the Pancreas of NOD Mice and Show Aberrant Recirculation Behavior

Arno Hänninen, Marko Salmi, Olli Simell, Sirpa Jalkanen

Diabetes 1996;45(9):1173–1180

https://doi.org/10.2337/diab.45.9.1173

Published: 01 September 1996

View article titled, Mucosa-Associated (βT-integrinhigh) Lymphocytes Accumulate Early in the Pancreas of NOD Mice and Show Aberrant Recirculation Behavior

Journal Articles

Endothelial Cell-Binding Properties of Lymphocytes Infiltrated Into Human Diabetic Pancreas: Implications for Pathogenesis of IDDM

Arno Hänninen, Marko Salmi, Olli Simell, Sirpa Jalkanen

Diabetes 1993;42(11):1656–1662

https://doi.org/10.2337/diab.42.11.1656

Published: 01 November 1993

View article titled, Endothelial Cell-Binding Properties of Lymphocytes Infiltrated Into Human Diabetic Pancreas: Implications for Pathogenesis of IDDM

Journal Articles

Effects of Growth Hormone and Insulin-Like Growth Factor I on Endocrine Function of Human Fetal Islet-Like Cell Clusters During Long-Term Tissue Culture

Timo Otonkoski, Mikael Knip, Inés Wong, Olli Simell

Diabetes 1988;37(12):1678–1683

https://doi.org/10.2337/diab.37.12.1678

Published: 01 December 1988

View article titled, Effects of Growth Hormone and Insulin-Like Growth Factor I on Endocrine Function of Human Fetal Islet-Like Cell Clusters During Long-Term Tissue Culture

Journal Articles

Maturation of Insulin Response to Glucose During Human Fetal and Neonatal Development: Studies with Perifusion of Pancreatic Isletlike Cell Clusters

Timo Otonkoski, Sture Andersson, Mikael Knip, Olli Simell

Diabetes 1988;37(3):286–291

https://doi.org/10.2337/diab.37.3.286

Published: 01 March 1988

View article titled, Maturation of Insulin Response to Glucose During Human Fetal and Neonatal Development: Studies with Perifusion of Pancreatic Isletlike Cell Clusters

NARROW

Longitudinal Pattern of First-Phase Insulin Response Is Associated With Genetic Variants Outside the Class II HLA Region in Children With Multiple Autoantibodies

Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity

Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: The Environmental Determinants of Diabetes in the Young Study

Serum Proteomes Distinguish Children Developing Type 1 Diabetes in a Cohort With HLA-Conferred Susceptibility

HbA_1c Predicts Time to Diagnosis of Type 1 Diabetes in Children at Risk

Role of Type 1 Diabetes–Associated SNPs on Risk of Autoantibody Positivity in the TEDDY Study

Innate Immune Activity Is Detected Prior to Seroconversion in Children With HLA-Conferred Type 1 Diabetes Susceptibility

Coxsackievirus B1 Is Associated With Induction of β-Cell Autoimmunity That Portends Type 1 Diabetes

Patterns of β-Cell Autoantibody Appearance and Genetic Associations During the First Years of Life

Cord Serum Lipidome in Prediction of Islet Autoimmunity and Type 1 Diabetes

Effect of the PTPN22 and INS Risk Genotypes on the Progression to Clinical Type 1 Diabetes After the Initiation of β-Cell Autoimmunity

Enterovirus RNA in Blood Is Linked to the Development of Type 1 Diabetes

Effect of HLA Class I and Class II Alleles on Progression From Autoantibody Positivity to Overt Type 1 Diabetes in Children With Risk-Associated Class II Genotypes

Predictive Characteristics of Diabetes-Associated Autoantibodies Among Children With HLA-Conferred Disease Susceptibility in the General Population

Lack of Association of PAX4 Gene With Type 1 Diabetes in the Finnish and Hungarian Populations

Genetic Risk Determines the Emergence of Diabetes-Associated Autoantibodies in Young Children

Mucosa-Associated (βT-integrin^high) Lymphocytes Accumulate Early in the Pancreas of NOD Mice and Show Aberrant Recirculation Behavior

Endothelial Cell-Binding Properties of Lymphocytes Infiltrated Into Human Diabetic Pancreas: Implications for Pathogenesis of IDDM

Effects of Growth Hormone and Insulin-Like Growth Factor I on Endocrine Function of Human Fetal Islet-Like Cell Clusters During Long-Term Tissue Culture

Maturation of Insulin Response to Glucose During Human Fetal and Neonatal Development: Studies with Perifusion of Pancreatic Isletlike Cell Clusters

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