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Meeting Abstracts

1778-LB: Comparing a Somatostatin Receptor 2 Antagonist (SSTR2a) to Exogenous Glucagon (EG) for the Treatment of Severe Insulin-Induced Hypoglycemia

EMILY G. HOFFMAN, NINOSCHKA DSOUZA, NADIA ALEALI, NEWSHA NOZARIASBMARZ, SAMANEH FATEHI, DORSA SHAKERI, OWEN CHAN, RICHARD LIGGINS, MICHAEL C. RIDDELL
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1778-LB
https://doi.org/10.2337/db24-1778-LB
Published: 14 June 2024
View article titled, 1778-LB: Comparing a Somatostatin Receptor 2 Antagonist (SSTR2a) to Exogenous Glucagon (EG) for the Treatment of Severe Insulin-Induced Hypoglycemia
Meeting Abstracts

1774-LB: The Glucagon Stimulating Effect in Hypoglycemia of Somatostatin Receptor 2 Antagonist (SSTR2a) Is Maintained with Repeat Dosing

NINOSCHKA DSOUZA, NADIA ALEALI, DORSA SHAKERI, SARA C. ATHERLEY, EMILY G. HOFFMAN, SINA KARIMI-CHAHARTASH, SAHEL JAVANBAKHSH, OWEN CHAN, RICHARD LIGGINS, MICHAEL C. RIDDELL
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1774-LB
https://doi.org/10.2337/db24-1774-LB
Published: 14 June 2024
View article titled, 1774-LB: The Glucagon Stimulating Effect in Hypoglycemia of Somatostatin Receptor 2 Antagonist (SSTR2a) Is Maintained with Repeat Dosing
Meeting Abstracts

1773-LB: Impact of SSTR2a Treatment in Hypoglycemia in Male (M) and Female (F) Rat Models of Type 2 Diabetes (T2D)

NINOSCHKA DSOUZA, NADIA ALEALI, DORSA SHAKERI, SARA C. ATHERLEY, EMILY G. HOFFMAN, SINA KARIMI-CHAHARTASH, SAHEL JAVANBAKHSH, OWEN CHAN, RICHARD LIGGINS, MICHAEL C. RIDDELL
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1773-LB
https://doi.org/10.2337/db24-1773-LB
Published: 14 June 2024
View article titled, 1773-LB: Impact of SSTR2a Treatment in Hypoglycemia in Male (M) and Female (F) Rat Models of Type 2 Diabetes (T2D)
Meeting Abstracts

1776-LB: Hyperglycemia Stimulates Local Lactate Production in the Hypothalamus

CHUKWUEMEKA UZO, OWEN CHAN
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1776-LB
https://doi.org/10.2337/db24-1776-LB
Published: 14 June 2024
View article titled, 1776-LB: Hyperglycemia Stimulates Local Lactate Production in the Hypothalamus
Journal Articles

Identification of Hypothalamic Glucoregulatory Neurons That Sense and Respond to Changes in Glycemia

Jennifer D. Deem, David Tingley, Anne-Mette Bjerregaard, Anna Secher, Owen Chan, Chukwuemeka Uzo, Nicole E. Richardson, Elizabeth Giering, Tammy Doan, Bao A. Phan, Brandon Wu, Jarrad M. Scarlett, Gregory J. Morton, Michael W. Schwartz
Journal: Diabetes
Diabetes 2023;72(9):1207–1213
https://doi.org/10.2337/db23-0139
Published: 22 June 2023
View article titled, Identification of Hypothalamic Glucoregulatory Neurons That Sense and Respond to Changes in Glycemia
Open the PDF for Identification of Hypothalamic Glucoregulatory Neurons That Sense and Respond to Changes in Glycemia in another window
Meeting Abstracts

2-LB: Effect of Somatostatin Receptor 2 Antagonism (SSTR2a) on Oral Glucose Tolerance (OGT) in a Rat Model of Type 2 Diabetes (T2D)

NINOSCHKA C. D'SOUZA, NADIA ALEALI, DORSA SHAKERI, EMILY G. HOFFMAN, SARA C. ATHERLEY, SABRINA CHAMPSI, MAYA EL-ZAHED, RICHARD LIGGINS, OWEN CHAN, MICHAEL C. RIDDELL
Journal: Diabetes
Diabetes 2023;72(Supplement_1):2-LB
https://doi.org/10.2337/db23-2-LB
Published: 20 June 2023
View article titled, 2-LB: Effect of Somatostatin Receptor 2 Antagonism (SSTR2a) on Oral Glucose Tolerance (OGT) in a Rat Model of Type 2 Diabetes (T2D)
Meeting Abstracts

4-LB: Norepinephrine-Stimulated Glutamate Release in the Ventromedial Hypothalamus Is Important to Enhance the Counterregulatory Response during Hypoglycemia

IRVANE E. NELSON, DANIEL A. APPADURAI, CHUKWUEMEKA UZO, OWEN CHAN
Journal: Diabetes
Diabetes 2023;72(Supplement_1):4-LB
https://doi.org/10.2337/db23-4-LB
Published: 20 June 2023
View article titled, 4-LB: Norepinephrine-Stimulated Glutamate Release in the Ventromedial Hypothalamus Is Important to Enhance the Counterregulatory Response during Hypoglycemia
Meeting Abstracts

1-LB: Evaluating the Effectiveness of the Novel Somatostatin Receptor Antagonist (SSTR2a) ZT-01 for Hypoglycemia Prevention in a Rodent Model of Type 2 Diabetes

NINOSCHKA C. D'SOUZA, JULIAN AIKEN, EMILY G. HOFFMAN, SARA C. ATHERLEY, SABRINA CHAMPSI, NADIA ALEALI, DORSA SHAKERI, MAYA EL-ZAHED, NICKY AKBARIAN, MEHRAN NEJAD-MANSOURI, RICHARD LIGGINS, OWEN CHAN, MICHAEL C. RIDDELL, PARINAZ ZAREE BAVANI
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1-LB
https://doi.org/10.2337/db23-1-LB
Published: 20 June 2023
View article titled, 1-LB: Evaluating the Effectiveness of the Novel Somatostatin Receptor Antagonist (SSTR2a) ZT-01 for Hypoglycemia Prevention in a Rodent Model of Type 2 Diabetes
Meeting Abstracts

3-LB: Effects of Sustained Somatostatin Receptor 2 Antagonism (SSTR2a) on Glycemia in Type 2 Diabetic (T2D) Male Rats—A Pilot Study

NADIA ALEALI, NINOSCHKA C. D'SOUZA, DORSA SHAKERI, ERIC SIMONSON, RICHARD LIGGINS, OWEN CHAN, MICHAEL C. RIDDELL
Journal: Diabetes
Diabetes 2023;72(Supplement_1):3-LB
https://doi.org/10.2337/db23-3-LB
Published: 20 June 2023
View article titled, 3-LB: Effects of Sustained Somatostatin Receptor 2 Antagonism (SSTR2a) on Glycemia in Type 2 Diabetic (T2D) Male Rats—A Pilot Study
Journal Articles

Astrocyte Glycogen Is a Major Source of Hypothalamic Lactate in Rats With Recurrent Hypoglycemia

Gong Su, Rawad Farhat, Anil K. Laxman, Kimberly Chapman-Natewa, Irvane E. Nelson, Owen Chan
Journal: Diabetes
Diabetes 2023;72(8):1154–1160
https://doi.org/10.2337/db22-0902
Published: 22 May 2023
View article titled, Astrocyte Glycogen Is a Major Source of Hypothalamic Lactate in Rats With Recurrent Hypoglycemia
Open the PDF for Astrocyte Glycogen Is a Major Source of Hypothalamic Lactate in Rats With Recurrent Hypoglycemia in another window
Meeting Abstracts

165-OR: Norepinephrine Acts on Glutamatergic Neurons in the Ventromedial Hypothalamus to Stimulate the Release of Counterregulatory Hormones

DANIEL A. APPADURAI, OWEN CHAN
Journal: Diabetes
Diabetes 2022;71(Supplement_1):165-OR
https://doi.org/10.2337/db22-165-OR
Published: 01 June 2022
View article titled, 165-OR: Norepinephrine Acts on Glutamatergic Neurons in the Ventromedial Hypothalamus to Stimulate the Release of Counterregulatory Hormones
Meeting Abstracts

3-LB: Glutamate Metabolism Is Coupled to Lactate Production from Astrocytes under Low-Glucose Conditions

DANIEL A. APPADURAI, OWEN CHAN
Journal: Diabetes
Diabetes 2021;70(Supplement_1):3-LB
https://doi.org/10.2337/db21-3-LB
Published: 01 June 2021
View article titled, 3-LB: Glutamate Metabolism Is Coupled to Lactate Production from Astrocytes under Low-Glucose Conditions
Meeting Abstracts

913-P: Higher Glucose Thresholds for Hypoglycemia Alarms on Continuous Glucose Monitoring Systems (CGMs) Are Associated with Less Time in Hypoglycemia in Patients with Impaired Awareness of Hypoglycemia

YU KUEI LIN, DANIELLE GROAT, OWEN CHAN, RODICA POP-BUSUI, MICHAEL VARNER, SIMON FISHER
Journal: Diabetes
Diabetes 2020;69(Supplement_1):913-P
https://doi.org/10.2337/db20-913-P
Published: 01 June 2020
View article titled, 913-P: Higher Glucose Thresholds for Hypoglycemia Alarms on Continuous Glucose Monitoring Systems (CGMs) Are Associated with Less Time in Hypoglycemia in Patients with Impaired Awareness of Hypoglycemia
Meeting Abstracts

9-LB: Novel Somatostatin Receptor 2 Antagonist ZT-01 Prevents Hypoglycemia Onset in STZ-Diabetic Rats by Improving Glucagon Secretion

JULIAN AIKEN, NINOSCHKA C. D’SOUZA, ERIC SIMONSON, RAWAD FARHAT, OWEN CHAN, RICHARD LIGGINS, MICHAEL RIDDELL
Journal: Diabetes
Diabetes 2020;69(Supplement_1):9-LB
https://doi.org/10.2337/db20-9-LB
Published: 01 June 2020
View article titled, 9-LB: Novel Somatostatin Receptor 2 Antagonist ZT-01 Prevents Hypoglycemia Onset in STZ-Diabetic Rats by Improving Glucagon Secretion
Meeting Abstracts

12-LB: Subcutaneous Administration of the Novel Somatostatin Receptor 2 Antagonist ZT-01 Restores the Glucagon Response to Hypoglycemia in STZ-Diabetic Rats to Normal Levels

RAWAD FARHAT, ERIC SIMONSON, MICHAEL RIDDELL, RICHARD LIGGINS, OWEN CHAN
Journal: Diabetes
Diabetes 2020;69(Supplement_1):12-LB
https://doi.org/10.2337/db20-12-LB
Published: 01 June 2020
View article titled, 12-LB: Subcutaneous Administration of the Novel Somatostatin Receptor 2 Antagonist ZT-01 Restores the Glucagon Response to Hypoglycemia in STZ-Diabetic Rats to Normal Levels
Meeting Abstracts

979-P: Lower Glucose Thresholds for Hyperglycemia Alarm and Narrower Threshold Range for Hyper/Hypoglycemia Alarm on Continuous Glucose Monitoring Systems Correlate with Lower Average Glucose Levels and Longer Time-in-Range

YU KUEI LIN, MAN HUNG, ANU SHARMA, OWEN CHAN, MICHAEL VARNER, DANIELLE GROAT, DANA DOPITA, SIMON FISHER
Journal: Diabetes
Diabetes 2019;68(Supplement_1):979-P
https://doi.org/10.2337/db19-979-P
Published: 01 June 2019
View article titled, 979-P: Lower Glucose Thresholds for Hyperglycemia Alarm and Narrower Threshold Range for Hyper/Hypoglycemia Alarm on Continuous Glucose Monitoring Systems Correlate with Lower Average Glucose Levels and Longer Time-in-Range
Meeting Abstracts

117-OR: Carvedilol Prevents Impairment of the Counterregulatory Response in Recurrently Hypoglycemic Diabetic Rats

RAWAD FARHAT, OWEN CHAN, GONG SU, ELIANE DE SANTANA VAN VLIET
Journal: Diabetes
Diabetes 2019;68(Supplement_1):117-OR
https://doi.org/10.2337/db19-117-OR
Published: 01 June 2019
View article titled, 117-OR: Carvedilol Prevents Impairment of the Counterregulatory Response in Recurrently Hypoglycemic Diabetic Rats
Meeting Abstracts

118-OR: Activation of Dopamine Signaling in the Brain Causes HAAF

ADRIANA VIEIRA DE ABREU, RAHUL AGRAWAL, ETHAN R. MEIER, OWEN CHAN, SIMON FISHER
Journal: Diabetes
Diabetes 2019;68(Supplement_1):118-OR
https://doi.org/10.2337/db19-118-OR
Published: 01 June 2019
View article titled, 118-OR: Activation of Dopamine Signaling in the Brain Causes HAAF
Meeting Abstracts

402-P: Higher Glucose Thresholds for Hypoglycemia Alarms on Continuous Glucose Monitoring Systems Correlate with Less Time in Hypoglycemia

YU KUEI LIN, MAN HUNG, ANU SHARMA, OWEN CHAN, MICHAEL VARNER, DANIELLE GROAT, DANA DOPITA, SIMON FISHER
Journal: Diabetes
Diabetes 2019;68(Supplement_1):402-P
https://doi.org/10.2337/db19-402-P
Published: 01 June 2019
View article titled, 402-P: Higher Glucose Thresholds for Hypoglycemia Alarms on Continuous Glucose Monitoring Systems Correlate with Less Time in Hypoglycemia
Meeting Abstracts

Glycogen Is the Major Source of Lactate in the Ventromedial Hypothalamus of Recurrently Hypoglycemic Rats

GONG SU, OWEN CHAN, RAWAD FARHAT, KIMBERLY CHAPMAN
Journal: Diabetes
Diabetes 2018;67(Supplement_1):203-OR
https://doi.org/10.2337/db18-203-OR
Published: 01 July 2018
View article titled, Glycogen Is the Major Source of Lactate in the Ventromedial Hypothalamus of Recurrently Hypoglycemic Rats