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Journal Articles

Astrocyte glycogen is a major source of hypothalamic lactate in rats with recurrent hypoglycemia.

Gong Su, Rawad Farhat, Anil K. Laxman, Kimberly Chapman-Natewa, Irvane E. Nelson, Owen Chan

Diabetes db220902

DOI: https://doi.org/10.2337/db22-0902

Published: 22 May 2023

View article titled, Astrocyte glycogen is a major source of hypothalamic lactate in rats with recurrent hypoglycemia.

Meeting Abstracts

165-OR: Norepinephrine Acts on Glutamatergic Neurons in the Ventromedial Hypothalamus to Stimulate the Release of Counterregulatory Hormones

DANIEL A. APPADURAI, OWEN CHAN

Diabetes 2022;71(Supplement_1):165-OR

DOI: https://doi.org/10.2337/db22-165-OR

Published: 01 June 2022

View article titled, 165-OR: Norepinephrine Acts on Glutamatergic Neurons in the Ventromedial Hypothalamus to Stimulate the Release of Counterregulatory Hormones

Meeting Abstracts

3-LB: Glutamate Metabolism Is Coupled to Lactate Production from Astrocytes under Low-Glucose Conditions

DANIEL A. APPADURAI, OWEN CHAN

Diabetes 2021;70(Supplement_1):3-LB

DOI: https://doi.org/10.2337/db21-3-LB

Published: 01 June 2021

View article titled, 3-LB: Glutamate Metabolism Is Coupled to Lactate Production from Astrocytes under Low-Glucose Conditions

Meeting Abstracts

913-P: Higher Glucose Thresholds for Hypoglycemia Alarms on Continuous Glucose Monitoring Systems (CGMs) Are Associated with Less Time in Hypoglycemia in Patients with Impaired Awareness of Hypoglycemia

YU KUEI LIN, DANIELLE GROAT, OWEN CHAN, RODICA POP-BUSUI, MICHAEL VARNER, SIMON FISHER

Diabetes 2020;69(Supplement_1):913-P

DOI: https://doi.org/10.2337/db20-913-P

Published: 01 June 2020

View article titled, 913-P: Higher Glucose Thresholds for Hypoglycemia Alarms on Continuous Glucose Monitoring Systems (CGMs) Are Associated with Less Time in Hypoglycemia in Patients with Impaired Awareness of Hypoglycemia

Meeting Abstracts

9-LB: Novel Somatostatin Receptor 2 Antagonist ZT-01 Prevents Hypoglycemia Onset in STZ-Diabetic Rats by Improving Glucagon Secretion

JULIAN AIKEN, NINOSCHKA C. D’SOUZA, ERIC SIMONSON, RAWAD FARHAT, OWEN CHAN, RICHARD LIGGINS, MICHAEL RIDDELL

Diabetes 2020;69(Supplement_1):9-LB

DOI: https://doi.org/10.2337/db20-9-LB

Published: 01 June 2020

View article titled, 9-LB: Novel Somatostatin Receptor 2 Antagonist ZT-01 Prevents Hypoglycemia Onset in STZ-Diabetic Rats by Improving Glucagon Secretion

Meeting Abstracts

12-LB: Subcutaneous Administration of the Novel Somatostatin Receptor 2 Antagonist ZT-01 Restores the Glucagon Response to Hypoglycemia in STZ-Diabetic Rats to Normal Levels

RAWAD FARHAT, ERIC SIMONSON, MICHAEL RIDDELL, RICHARD LIGGINS, OWEN CHAN

Diabetes 2020;69(Supplement_1):12-LB

DOI: https://doi.org/10.2337/db20-12-LB

Published: 01 June 2020

View article titled, 12-LB: Subcutaneous Administration of the Novel Somatostatin Receptor 2 Antagonist ZT-01 Restores the Glucagon Response to Hypoglycemia in STZ-Diabetic Rats to Normal Levels

Meeting Abstracts

979-P: Lower Glucose Thresholds for Hyperglycemia Alarm and Narrower Threshold Range for Hyper/Hypoglycemia Alarm on Continuous Glucose Monitoring Systems Correlate with Lower Average Glucose Levels and Longer Time-in-Range

YU KUEI LIN, MAN HUNG, ANU SHARMA, OWEN CHAN, MICHAEL VARNER, DANIELLE GROAT, DANA DOPITA, SIMON FISHER

Diabetes 2019;68(Supplement_1):979-P

DOI: https://doi.org/10.2337/db19-979-P

Published: 01 June 2019

View article titled, 979-P: Lower Glucose Thresholds for Hyperglycemia Alarm and Narrower Threshold Range for Hyper/Hypoglycemia Alarm on Continuous Glucose Monitoring Systems Correlate with Lower Average Glucose Levels and Longer Time-in-Range

Meeting Abstracts

117-OR: Carvedilol Prevents Impairment of the Counterregulatory Response in Recurrently Hypoglycemic Diabetic Rats

RAWAD FARHAT, OWEN CHAN, GONG SU, ELIANE DE SANTANA VAN VLIET

Diabetes 2019;68(Supplement_1):117-OR

DOI: https://doi.org/10.2337/db19-117-OR

Published: 01 June 2019

View article titled, 117-OR: Carvedilol Prevents Impairment of the Counterregulatory Response in Recurrently Hypoglycemic Diabetic Rats

Meeting Abstracts

118-OR: Activation of Dopamine Signaling in the Brain Causes HAAF

ADRIANA VIEIRA DE ABREU, RAHUL AGRAWAL, ETHAN R. MEIER, OWEN CHAN, SIMON FISHER

Diabetes 2019;68(Supplement_1):118-OR

DOI: https://doi.org/10.2337/db19-118-OR

Published: 01 June 2019

View article titled, 118-OR: Activation of Dopamine Signaling in the Brain Causes HAAF

Meeting Abstracts

402-P: Higher Glucose Thresholds for Hypoglycemia Alarms on Continuous Glucose Monitoring Systems Correlate with Less Time in Hypoglycemia

YU KUEI LIN, MAN HUNG, ANU SHARMA, OWEN CHAN, MICHAEL VARNER, DANIELLE GROAT, DANA DOPITA, SIMON FISHER

Diabetes 2019;68(Supplement_1):402-P

DOI: https://doi.org/10.2337/db19-402-P

Published: 01 June 2019

View article titled, 402-P: Higher Glucose Thresholds for Hypoglycemia Alarms on Continuous Glucose Monitoring Systems Correlate with Less Time in Hypoglycemia

Meeting Abstracts

Long-Term Use of GLP-1 Receptor Agonists Alter GLP-1 Receptor mRNA Expression in Hindbrain Pathways That Regulate Gastric Motility in Mice

PEILI WANG, RAMANAIAH MAMILLAPALLI, WANLING ZHU, OWEN CHAN

Diabetes 2018;67(Supplement_1):1088-P

DOI: https://doi.org/10.2337/db18-1088-P

Published: 01 July 2018

View article titled, Long-Term Use of GLP-1 Receptor Agonists Alter GLP-1 Receptor mRNA Expression in Hindbrain Pathways That Regulate Gastric Motility in Mice

Meeting Abstracts

Carvedilol Prevents Counterregulatory Failure in Recurrently Hypoglycemic Rats

RAWAD FARHAT, GONG SU, OWEN CHAN

Diabetes 2018;67(Supplement_1):200-OR

DOI: https://doi.org/10.2337/db18-200-OR

Published: 01 July 2018

View article titled, Carvedilol Prevents Counterregulatory Failure in Recurrently Hypoglycemic Rats

Meeting Abstracts

Glycogen Is the Major Source of Lactate in the Ventromedial Hypothalamus of Recurrently Hypoglycemic Rats

GONG SU, OWEN CHAN, RAWAD FARHAT, KIMBERLY CHAPMAN

Diabetes 2018;67(Supplement_1):203-OR

DOI: https://doi.org/10.2337/db18-203-OR

Published: 01 July 2018

View article titled, Glycogen Is the Major Source of Lactate in the Ventromedial Hypothalamus of Recurrently Hypoglycemic Rats

Meeting Abstracts

Somatostatin Receptor II Antagonism Improves Glucagon Counterregulatory Responses to Recurrent Hypoglycemia in Male Sprague-Dawley Rats

MICHAEL RIDDELL, MAHSA JAHANGIRIESMAILI, ERIN R. MANDEL, CAYLEE A. GREENBERG, AOIBHE M. PASIEKA, TREVOR TEICH, OWEN CHAN, RICHARD T. LIGGINS

Diabetes 2018;67(Supplement_1):394-P

DOI: https://doi.org/10.2337/db18-394-P

Published: 01 July 2018

View article titled, Somatostatin Receptor II Antagonism Improves Glucagon Counterregulatory Responses to Recurrent Hypoglycemia in Male Sprague-Dawley Rats

Journal Articles

Impaired Glutamatergic Neurotransmission in the Ventromedial Hypothalamus May Contribute to Defective Counterregulation in Recurrently Hypoglycemic Rats

Golam M.I. Chowdhury, Peili Wang, Alisha Ciardi, Ramanaiah Mamillapalli, Justin Johnson, Wanling Zhu, Tore Eid, Kevin Behar, Owen Chan

Diabetes 2017;66(7):1979–1989

DOI: https://doi.org/10.2337/db16-1589

Published: 17 April 2017

View article titled, Impaired Glutamatergic Neurotransmission in the Ventromedial Hypothalamus May Contribute to Defective Counterregulation in Recurrently Hypoglycemic Rats

Includes: Supplementary data

Journal Articles

Reduction in SGLT1 mRNA Expression in the Ventromedial Hypothalamus Improves the Counterregulatory Responses to Hypoglycemia in Recurrently Hypoglycemic and Diabetic Rats

Xiaoning Fan, Owen Chan, Yuyan Ding, Wanling Zhu, Jason Mastaitis, Robert Sherwin

Diabetes 2015;64(10):3564–3572

DOI: https://doi.org/10.2337/db15-0022

Published: 30 June 2015

View article titled, Reduction in SGLT1 mRNA Expression in the Ventromedial Hypothalamus Improves the Counterregulatory Responses to Hypoglycemia in Recurrently Hypoglycemic and Diabetic Rats

Journal Articles

Is There Cross Talk Between Portal and Hypothalamic Glucose-Sensing Circuits?

Owen Chan, Robert S. Sherwin

Diabetes 2014;63(8):2617–2619

DOI: https://doi.org/10.2337/db14-0755

Published: 17 July 2014

View article titled, Is There Cross Talk Between Portal and Hypothalamic Glucose-Sensing Circuits?

Journal Articles

Lactate-Induced Release of GABA in the Ventromedial Hypothalamus Contributes to Counterregulatory Failure in Recurrent Hypoglycemia and Diabetes

Owen Chan, Sachin A. Paranjape, Adam Horblitt, Wanling Zhu, Robert S. Sherwin

Diabetes 2013;62(12):4239–4246

DOI: https://doi.org/10.2337/db13-0770

Published: 16 November 2013

View article titled, Lactate-Induced Release of GABA in the Ventromedial Hypothalamus Contributes to Counterregulatory Failure in Recurrent Hypoglycemia and Diabetes

Includes: Supplementary data

Journal Articles

Hypothalamic Regulation of Glucose-Stimulated Insulin Secretion

Owen Chan, Robert S. Sherwin

Diabetes 2012;61(3):564–565

DOI: https://doi.org/10.2337/db11-1846

Published: 13 February 2012

View article titled, Hypothalamic Regulation of Glucose-Stimulated Insulin Secretion

Journal Articles

Modulation of β-Adrenergic Receptors in the Ventromedial Hypothalamus Influences Counterregulatory Responses to Hypoglycemia

Barbara Szepietowska, Wanling Zhu, Owen Chan, Adam Horblitt, James Dziura, Robert S. Sherwin

Diabetes 2011;60(12):3154–3158

DOI: https://doi.org/10.2337/db11-0432

Published: 13 November 2011

View article titled, Modulation of β-Adrenergic Receptors in the Ventromedial Hypothalamus Influences Counterregulatory Responses to Hypoglycemia

NARROW

Astrocyte glycogen is a major source of hypothalamic lactate in rats with recurrent hypoglycemia.

165-OR: Norepinephrine Acts on Glutamatergic Neurons in the Ventromedial Hypothalamus to Stimulate the Release of Counterregulatory Hormones

3-LB: Glutamate Metabolism Is Coupled to Lactate Production from Astrocytes under Low-Glucose Conditions

913-P: Higher Glucose Thresholds for Hypoglycemia Alarms on Continuous Glucose Monitoring Systems (CGMs) Are Associated with Less Time in Hypoglycemia in Patients with Impaired Awareness of Hypoglycemia

9-LB: Novel Somatostatin Receptor 2 Antagonist ZT-01 Prevents Hypoglycemia Onset in STZ-Diabetic Rats by Improving Glucagon Secretion

12-LB: Subcutaneous Administration of the Novel Somatostatin Receptor 2 Antagonist ZT-01 Restores the Glucagon Response to Hypoglycemia in STZ-Diabetic Rats to Normal Levels

979-P: Lower Glucose Thresholds for Hyperglycemia Alarm and Narrower Threshold Range for Hyper/Hypoglycemia Alarm on Continuous Glucose Monitoring Systems Correlate with Lower Average Glucose Levels and Longer Time-in-Range

117-OR: Carvedilol Prevents Impairment of the Counterregulatory Response in Recurrently Hypoglycemic Diabetic Rats

118-OR: Activation of Dopamine Signaling in the Brain Causes HAAF

402-P: Higher Glucose Thresholds for Hypoglycemia Alarms on Continuous Glucose Monitoring Systems Correlate with Less Time in Hypoglycemia

Long-Term Use of GLP-1 Receptor Agonists Alter GLP-1 Receptor mRNA Expression in Hindbrain Pathways That Regulate Gastric Motility in Mice

Carvedilol Prevents Counterregulatory Failure in Recurrently Hypoglycemic Rats

Glycogen Is the Major Source of Lactate in the Ventromedial Hypothalamus of Recurrently Hypoglycemic Rats

Somatostatin Receptor II Antagonism Improves Glucagon Counterregulatory Responses to Recurrent Hypoglycemia in Male Sprague-Dawley Rats

Impaired Glutamatergic Neurotransmission in the Ventromedial Hypothalamus May Contribute to Defective Counterregulation in Recurrently Hypoglycemic Rats

Reduction in SGLT1 mRNA Expression in the Ventromedial Hypothalamus Improves the Counterregulatory Responses to Hypoglycemia in Recurrently Hypoglycemic and Diabetic Rats

Is There Cross Talk Between Portal and Hypothalamic Glucose-Sensing Circuits?

Lactate-Induced Release of GABA in the Ventromedial Hypothalamus Contributes to Counterregulatory Failure in Recurrent Hypoglycemia and Diabetes

Hypothalamic Regulation of Glucose-Stimulated Insulin Secretion

Modulation of β-Adrenergic Receptors in the Ventromedial Hypothalamus Influences Counterregulatory Responses to Hypoglycemia

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