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Journal Articles

Cisplatin exposure dysregulates insulin secretion in male and female mice

Lahari Basu, Lili Grieco-St-Pierre, Ma. Enrica Angela Ching, John D. H. Stead, Antonio A. Hanson, Jana Palaniyandi, Erin P. van Zyl, Myriam P. Hoyeck, Kelsea S. McKay, Kyle A. van Allen, Hyojin Lee, Xiao-Qing Dai, Austin Bautista, Evgenia Fadzeyeva, Erin E. Mulvihill, Carole L. Yauk, Jan A. Mennigen, Patrick E. MacDonald, Jennifer E. Bruin

Diabetes db240419

https://doi.org/10.2337/db24-0419

Published: 14 January 2025

View article titled, Cisplatin exposure dysregulates insulin secretion in male and female mice

Journal Articles

RFX6 Maintains Gene Expression and Function of Adult Human Islet α-Cells

Vy M.N. Coykendall, Mollie F. Qian, Krissie Tellez, Austin Bautista, Romina J. Bevacqua, Xueying Gu, Yan Hang, Martin Neukam, Weichen Zhao, Charles Chang, Patrick E. MacDonald, Seung K. Kim

Diabetes 2024;73(3):448–460

https://doi.org/10.2337/db23-0483

Published: 08 December 2023

View article titled, RFX6 Maintains Gene Expression and Function of Adult Human Islet α-Cells

Journal Articles

Deletion of Carboxypeptidase E in β-Cells Disrupts Proinsulin Processing but Does Not Lead to Spontaneous Development of Diabetes in Mice

Yi-Chun Chen, Austin J. Taylor, James M. Fulcher, Adam C. Swensen, Xiao-Qing Dai, Mitsuhiro Komba, Kenzie L.C. Wrightson, Kenny Fok, Annette E. Patterson, Ramon I. Klein Geltink, Patrick E. MacDonald, Wei-Jun Qian, C. Bruce Verchere

Diabetes 2023;72(9):1277–1288

https://doi.org/10.2337/db22-0945

Published: 26 June 2023

View article titled, Deletion of Carboxypeptidase E in β-Cells Disrupts Proinsulin Processing but Does Not Lead to Spontaneous Development of Diabetes in Mice

Journal Articles

Ca²⁺ Oscillations, Waves, and Networks in Islets From Human Donors With and Without Type 2 Diabetes

Marko Gosak, Richard Yan-Do, Haopeng Lin, Patrick E. MacDonald, Andraž Stožer

Diabetes 2022;71(12):2584–2596

https://doi.org/10.2337/db22-0004

Published: 06 September 2022

View article titled, Ca<sup>2+</sup> Oscillations, Waves, and Networks in Islets From Human Donors With and Without Type 2 Diabetes

Journal Articles

β-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High-Fat Diet–Fed Mice

Haopeng Lin, Nancy Smith, Aliya F. Spigelman, Kunimasa Suzuki, Mourad Ferdaoussi, Tamadher A. Alghamdi, Sophie L. Lewandowski, Yaxing Jin, Austin Bautista, Ying Wayne Wang, Jocelyn E. Manning Fox, Matthew J. Merrins, Jean Buteau, Patrick E. MacDonald

Diabetes 2021;70(11):2626–2638

https://doi.org/10.2337/db20-1235

Published: 30 August 2021

View article titled, β-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High-Fat Diet–Fed Mice

Journal Articles

Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction

Jianyang Fu, Xiaoqing Dai, Gregory Plummer, Kunimasa Suzuki, Austin Bautista, John M. Githaka, Laura Senior, Mette Jensen, Dafna Greitzer-Antes, Jocelyn E. Manning Fox, Herbert Y. Gaisano, Christopher B. Newgard, Nicolas Touret, Patrick E. MacDonald

Diabetes 2017;66(7):1890–1900

https://doi.org/10.2337/db16-1170

Published: 15 June 2017

View article titled, Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction

Includes: Supplementary data

Journal Articles

A Glycine-Insulin Autocrine Feedback Loop Enhances Insulin Secretion From Human β-Cells and Is Impaired in Type 2 Diabetes

Richard Yan-Do, Eric Duong, Jocelyn E. Manning Fox, Xiaoqing Dai, Kunimasa Suzuki, Shara Khan, Austin Bautista, Mourad Ferdaoussi, James Lyon, Xichen Wu, Stephen Cheley, Patrick E. MacDonald, Matthias Braun

Diabetes 2016;65(8):2311–2321

https://doi.org/10.2337/db15-1272

Published: 03 May 2016

View article titled, A Glycine-Insulin Autocrine Feedback Loop Enhances Insulin Secretion From Human β-Cells and Is Impaired in Type 2 Diabetes

Includes: Supplementary data

Journal Articles

Antiaging Glycopeptide Protects Human Islets Against Tacrolimus-Related Injury and Facilitates Engraftment in Mice

Boris L. Gala-Lopez, Andrew R. Pepper, Rena L. Pawlick, Doug O’Gorman, Tatsuya Kin, Antonio Bruni, Nasser Abualhassan, Mariusz Bral, Austin Bautista, Jocelyn E. Manning Fox, Lachlan G. Young, Patrick E. MacDonald, A.M. James Shapiro

Diabetes 2016;65(2):451–462

https://doi.org/10.2337/db15-0764

Published: 18 November 2015

View article titled, Antiaging Glycopeptide Protects Human Islets Against Tacrolimus-Related Injury and Facilitates Engraftment in Mice

Journal Articles

In Vivo Role of Focal Adhesion Kinase in Regulating Pancreatic β-Cell Mass and Function Through Insulin Signaling, Actin Dynamics, and Granule Trafficking

Erica P. Cai, Marina Casimir, Stephanie A. Schroer, Cynthia T. Luk, Sally Yu Shi, Diana Choi, Xiao Qing Dai, Catherine Hajmrle, Aliya F. Spigelman, Dan Zhu, Herbert Y. Gaisano, Patrick E. MacDonald, Minna Woo

Diabetes 2012;61(7):1708–1718

https://doi.org/10.2337/db11-1344

Published: 15 June 2012

View article titled, In Vivo Role of Focal Adhesion Kinase in Regulating Pancreatic β-Cell Mass and Function Through Insulin Signaling, Actin Dynamics, and Granule Trafficking

Journal Articles

Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules

Janine K. Kruit, Nadeeja Wijesekara, Jocelyn E. Manning Fox, Xiao-Qing Dai, Liam R. Brunham, Gavin J. Searle, Garry P. Morgan, Adam J. Costin, Renmei Tang, Alpana Bhattacharjee, James D. Johnson, Peter E. Light, Brad J. Marsh, Patrick E. MacDonald, C. Bruce Verchere, Michael R. Hayden

Diabetes 2011;60(12):3186–3196

https://doi.org/10.2337/db11-0081

Published: 13 November 2011

View article titled, Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules

Includes: Supplementary data

Journal Articles

SUMOylation Regulates Insulin Exocytosis Downstream of Secretory Granule Docking in Rodents and Humans

Xiao-Qing Dai, Greg Plummer, Marina Casimir, Youhou Kang, Catherine Hajmrle, Herbert Y. Gaisano, Jocelyn E. Manning Fox, Patrick E. MacDonald

Diabetes 2011;60(3):838–847

https://doi.org/10.2337/db10-0440

Published: 21 February 2011

View article titled, SUMOylation Regulates Insulin Exocytosis Downstream of Secretory Granule Docking in Rodents and Humans

Journal Articles

TRP-ing Down the Path to Insulin Secretion

Patrick E. MacDonald

Diabetes 2011;60(1):28–29

https://doi.org/10.2337/db10-1402

Published: 01 January 2011

View article titled, TRP-ing Down the Path to Insulin Secretion

Journal Articles

Inhibition of β-Cell Sodium-Calcium Exchange Enhances Glucose-Dependent Elevations in Cytoplasmic Calcium and Insulin Secretion

Kevin S.C. Hamming, Daniel Soliman, Nicola J. Webster, Gavin J. Searle, Laura C. Matemisz, David A. Liknes, Xiao-Qing Dai, Thomas Pulinilkunnil, Michael J. Riedel, Jason R.B. Dyck, Patrick E. MacDonald, Peter E. Light

Diabetes 2010;59(7):1686–1693

https://doi.org/10.2337/db09-0630

Published: 22 April 2010

View article titled, Inhibition of β-Cell Sodium-Calcium Exchange Enhances Glucose-Dependent Elevations in Cytoplasmic Calcium and Insulin Secretion

Journal Articles

Insulin Granule Recruitment and Exocytosis Is Dependent on p110γ in Insulinoma and Human β-Cells

Gary M. Pigeau, Jelena Kolic, Brandon J. Ball, Michael B. Hoppa, Ying W. Wang, Thomas Rückle, Minna Woo, Jocelyn E. Manning Fox, Patrick E. MacDonald

Diabetes 2009;58(9):2084–2092

https://doi.org/10.2337/db08-1371

Published: 23 June 2009

View article titled, Insulin Granule Recruitment and Exocytosis Is Dependent on p110γ in Insulinoma and Human β-Cells

Journal Articles

Regulated Exocytosis and Kiss-and-Run of Synaptic-Like Microvesicles in INS-1 and Primary Rat β-Cells

Patrick E. MacDonald, Stefanie Obermüller, Jenny Vikman, Juris Galvanovskis, Patrik Rorsman, Lena Eliasson

Diabetes 2005;54(3):736–743

https://doi.org/10.2337/diabetes.54.3.736

Published: 01 March 2005

View article titled, Regulated Exocytosis and Kiss-and-Run of Synaptic-Like Microvesicles in INS-1 and Primary Rat β-Cells

Journal Articles

The Multiple Actions of GLP-1 on the Process of Glucose-Stimulated Insulin Secretion

Patrick E. MacDonald, Wasim El-kholy, Michael J. Riedel, Anne Marie F. Salapatek, Peter E. Light, Michael B. Wheeler

Diabetes 2002;51(suppl_3):S434–S442

https://doi.org/10.2337/diabetes.51.2007.S434

Published: 01 December 2002

View article titled, The Multiple Actions of GLP-1 on the Process of Glucose-Stimulated Insulin Secretion

Journal Articles

Glucagon-Like Peptide-1 Receptor Activation Antagonizes Voltage-Dependent Repolarizing K⁺ Currents in β-Cells: A Possible Glucose-Dependent Insulinotropic Mechanism

Patrick E. MacDonald, Anne Marie F. Salapatek, Michael B. Wheeler

Diabetes 2002;51(suppl_3):S443–S447

https://doi.org/10.2337/diabetes.51.2007.S443

Published: 01 December 2002

View article titled, Glucagon-Like Peptide-1 Receptor Activation Antagonizes Voltage-Dependent Repolarizing K<sup>+</sup> Currents in β-Cells: <subtitle>A Possible Glucose-Dependent Insulinotropic Mechanism </subtitle>

NARROW

Cisplatin exposure dysregulates insulin secretion in male and female mice

RFX6 Maintains Gene Expression and Function of Adult Human Islet α-Cells

Deletion of Carboxypeptidase E in β-Cells Disrupts Proinsulin Processing but Does Not Lead to Spontaneous Development of Diabetes in Mice

Ca²⁺ Oscillations, Waves, and Networks in Islets From Human Donors With and Without Type 2 Diabetes

β-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High-Fat Diet–Fed Mice

Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction

A Glycine-Insulin Autocrine Feedback Loop Enhances Insulin Secretion From Human β-Cells and Is Impaired in Type 2 Diabetes

Antiaging Glycopeptide Protects Human Islets Against Tacrolimus-Related Injury and Facilitates Engraftment in Mice

In Vivo Role of Focal Adhesion Kinase in Regulating Pancreatic β-Cell Mass and Function Through Insulin Signaling, Actin Dynamics, and Granule Trafficking

Islet Cholesterol Accumulation Due to Loss of ABCA1 Leads to Impaired Exocytosis of Insulin Granules

SUMOylation Regulates Insulin Exocytosis Downstream of Secretory Granule Docking in Rodents and Humans

TRP-ing Down the Path to Insulin Secretion

Inhibition of β-Cell Sodium-Calcium Exchange Enhances Glucose-Dependent Elevations in Cytoplasmic Calcium and Insulin Secretion

Insulin Granule Recruitment and Exocytosis Is Dependent on p110γ in Insulinoma and Human β-Cells

Regulated Exocytosis and Kiss-and-Run of Synaptic-Like Microvesicles in INS-1 and Primary Rat β-Cells

The Multiple Actions of GLP-1 on the Process of Glucose-Stimulated Insulin Secretion

Glucagon-Like Peptide-1 Receptor Activation Antagonizes Voltage-Dependent Repolarizing K⁺ Currents in β-Cells: A Possible Glucose-Dependent Insulinotropic Mechanism

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