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Patrik Rorsman
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Journal Articles

Metabolic and paracrine heterogeneity of pancreatic glucagon-secreting α-cells

Haiqiang Dou, Caroline Miranda, Johan Tolö, Cristiano Santos, Rui Gao, Nikhil R. Gandasi, Thomas G. Hill, Lakshmi Kothegala, Andrei I. Tarasov, Quan Zhang, Patrik Rorsman
Journal: Diabetes
Diabetes db241053
https://doi.org/10.2337/db24-1053
Published: 04 April 2025
View articletitled, Metabolic and paracrine heterogeneity of pancreatic glucagon-secreting α-cells
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Journal Articles

Nicotinic Signaling Stimulates Glucagon Secretion in Mouse and Human Pancreatic α-Cells

Alexander Hamilton, Quan Zhang, Rui Gao, Thomas G. Hill, Albert Salehi, Jakob G. Knudsen, Matthew B. Draper, Paul R.V. Johnson, Patrik Rorsman, Andrei I. Tarasov
Journal: Diabetes
Diabetes 2025;74(1):53–64
https://doi.org/10.2337/db23-0809
Published: 30 October 2024
View articletitled, Nicotinic Signaling Stimulates Glucagon Secretion in Mouse and Human Pancreatic α-Cells
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Journal Articles

Electrophysiological Characterization of Inducible Pluripotent Stem Cell–Derived Human β-Like Cells and an SLC30A8 Disease Model

Manon Jaffredo, Nicole A.J. Krentz, Benoite Champon, Claire E. Duff, Sameena Nawaz, Nicola Beer, Christian Honore, Anne Clark, Patrik Rorsman, Jochen Lang, Anna L. Gloyn, Matthieu Raoux, Benoit Hastoy
Journal: Diabetes
Diabetes 2024;73(8):1255–1265
https://doi.org/10.2337/db23-0776
Published: 22 May 2024
View articletitled, Electrophysiological Characterization of Inducible Pluripotent Stem Cell–Derived Human β-Like Cells and an SLC30A8 Disease Model
Open the PDF for Electrophysiological Characterization of Inducible Pluripotent Stem Cell–Derived Human β-Like Cells and an SLC30A8 Disease Model in another window
Journal Articles

Glucose Controls Glucagon Secretion by Regulating Fatty Acid Oxidation in Pancreatic α-Cells

Sarah L. Armour, Alexander Frueh, Margarita V. Chibalina, Haiqiang Dou, Lidia Argemi-Muntadas, Alexander Hamilton, Georgios Katzilieris-Petras, Peter Carmeliet, Benjamin Davies, Thomas Moritz, Lena Eliasson, Patrik Rorsman, Jakob G. Knudsen
Journal: Diabetes
Diabetes 2023;72(10):1446–1459
https://doi.org/10.2337/db23-0056
Published: 26 July 2023
View articletitled, Glucose Controls Glucagon Secretion by Regulating Fatty Acid Oxidation in Pancreatic α-Cells
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Meeting Abstracts

199-OR: Optogenetic Control of Pancreatic Delta Cells Reveals Their Central Role in Hormone Release from Pancreatic Islets

HAIQIANG DOU, CAROLINE A. MIRANDA, JOHAN TOLÖ, QUAN ZHANG, PATRIK RORSMAN
Journal: Diabetes
Diabetes 2023;72(Supplement_1):199-OR
https://doi.org/10.2337/db23-199-OR
Published: 20 June 2023
View articletitled, 199-OR: Optogenetic Control of Pancreatic Delta Cells Reveals Their Central Role in Hormone Release from Pancreatic Islets
Meeting Abstracts

1772-P: Alpha-Cell Heterogeneity Contributes to Phasic Glucagon Release

CAROLINE A. MIRANDA, HAIQIANG DOU, JOHAN TOLÖ, ANDREI I. TARASOV, PATRIK RORSMAN
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1772-P
https://doi.org/10.2337/db23-1772-P
Published: 20 June 2023
View articletitled, 1772-P: Alpha-Cell Heterogeneity Contributes to Phasic Glucagon Release
Journal Articles

Response to Comment on Satin et al. “Take Me To Your Leader”: An Electrophysiological Appraisal of the Role of Hub Cells in Pancreatic Islets. Diabetes 2020;69:830–836

Leslie S. Satin, Patrik Rorsman
Journal: Diabetes
Diabetes 2020;69(9):e12–e13
https://doi.org/10.2337/dbi20-0027
Published: 14 August 2020
View articletitled, Response to Comment on Satin et al. “Take Me To Your Leader”: An Electrophysiological Appraisal of the Role of Hub Cells in Pancreatic Islets. Diabetes 2020;69:830–836
Open the PDF for Response to Comment on Satin et al. “Take Me To Your Leader”: An Electrophysiological Appraisal of the Role of Hub Cells in Pancreatic Islets. Diabetes 2020;69:830–836 in another window
Journal Articles

A Variation on the Theme: SGLT2 Inhibition and Glucagon Secretion in Human Islets

David J. Hodson, Patrik Rorsman
Journal: Diabetes
Diabetes 2020;69(5):864–866
https://doi.org/10.2337/dbi19-0035
Published: 13 April 2020
View articletitled, A Variation on the Theme: SGLT2 Inhibition and Glucagon Secretion in Human Islets
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Journal Articles

“Take Me To Your Leader”: An Electrophysiological Appraisal of the Role of Hub Cells in Pancreatic Islets

Leslie S. Satin, Quan Zhang, Patrik Rorsman
Journal: Diabetes
Diabetes 2020;69(5):830–836
https://doi.org/10.2337/dbi19-0012
Published: 13 April 2020
View articletitled, “Take Me To Your Leader”: An Electrophysiological Appraisal of the Role of Hub Cells in Pancreatic Islets
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Meeting Abstracts

1866-P: Peripancreatic Adipose Tissue Protects against Ectopic Fat Accumulation in the Liver

BELÉN CHANCLÓN, PETER MICALLEF, ELIN BANKE NORDBECK, YANLING WU, BJÖRN WILDER, JULIA KANERVA, PATRIK RORSMAN, INGRID WERNSTEDT ASTERHOLM
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1866-P
https://doi.org/10.2337/db19-1866-P
Published: 01 June 2019
View articletitled, 1866-P: Peripancreatic Adipose Tissue Protects against Ectopic Fat Accumulation in the Liver
Meeting Abstracts

1975-P: Increased Pancreatic a Cell Ca2+ Oscillations Explain Hyperglucagonemia in High-Fat Diet-Fed Mice

JOELY KELLARD, LINFORD BRIANT, JAKOB G. KNUDSEN, PATRIK RORSMAN
Journal: Diabetes
Diabetes 2019;68(Supplement_1):1975-P
https://doi.org/10.2337/db19-1975-P
Published: 01 June 2019
View articletitled, 1975-P: Increased Pancreatic a Cell Ca2+ Oscillations Explain Hyperglucagonemia in High-Fat Diet-Fed Mice
Meeting Abstracts

340-LB: Optogenetic Control of a-Cell Electrical Activity and Glucagon Secretion in Intact Islets

CAROLINE A. MIRANDA, HAIQIANG DOU, JOHAN TOLö, ANDREI I. TARASOV, PATRIK RORSMAN
Journal: Diabetes
Diabetes 2019;68(Supplement_1):340-LB
https://doi.org/10.2337/db19-340-LB
Published: 01 June 2019
View articletitled, 340-LB: Optogenetic Control of a-Cell Electrical Activity and Glucagon Secretion in Intact Islets
Meeting Abstracts

339-LB: Modulation of Insulin and Glucagon Secretion by Optogenetic Control of Delta-Cell Electrical Activity in Pancreatic Islets

HAIQIANG DOU, CAROLINE A. MIRANDA, QUAN ZHANG, PATRIK RORSMAN, JOHAN TOLö
Journal: Diabetes
Diabetes 2019;68(Supplement_1):339-LB
https://doi.org/10.2337/db19-339-LB
Published: 01 June 2019
View articletitled, 339-LB: Modulation of Insulin and Glucagon Secretion by Optogenetic Control of Delta-Cell Electrical Activity in Pancreatic Islets
Meeting Abstracts

Pancreatic Alpha-Cell Function and Identity in Human T2D

XIAOQING DAI, JOAN CAMUNAS SOLER, SR., LINFORD BRIANT, ALIYA F. SPIGELMAN, YAN HANG, PATRIK RORSMAN, SEUNG KIM, PATRICK MACDONALD
Journal: Diabetes
Diabetes 2018;67(Supplement_1):315-LB
https://doi.org/10.2337/db18-315-LB
Published: 01 July 2018
View articletitled, Pancreatic Alpha-Cell Function and Identity in Human T2D
Meeting Abstracts

Adiponectin Increases Glucose-Dependent Electrical Activity and Insulin Secretion in Mouse Pancreatic ß Cells

JOANA I. REAL, BELEN CHANCLON GARCIA, INGRID WERNSTEDT ASTERHOLM, PATRIK RORSMAN
Journal: Diabetes
Diabetes 2018;67(Supplement_1):329-OR
https://doi.org/10.2337/db18-329-OR
Published: 01 July 2018
View articletitled, Adiponectin Increases Glucose-Dependent Electrical Activity and Insulin Secretion in Mouse Pancreatic ß Cells
Meeting Abstracts

Pancreatic Adipose Tissue in Diet-Induced Type 2 Diabetes

BELEN CHANCLON GARCIA, YANLING WU, ELIN BANKE NORDBECK, SALIHA MUSOVIC, CHARLOTTA S. OLOFSSON, PATRIK RORSMAN, INGRID WERNSTEDT ASTERHOLM
Journal: Diabetes
Diabetes 2018;67(Supplement_1):2431-PUB
https://doi.org/10.2337/db18-2431-PUB
Published: 01 July 2018
View articletitled, Pancreatic Adipose Tissue in Diet-Induced Type 2 Diabetes
Journal Articles

Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+ Mobilization From Acidic Stores in Pancreatic α-Cells

Alexander Hamilton, Quan Zhang, Albert Salehi, Mara Willems, Jakob G. Knudsen, Anna K. Ringgaard, Caroline E. Chapman, Alejandro Gonzalez-Alvarez, Nicoletta C. Surdo, Manuela Zaccolo, Davide Basco, Paul R.V. Johnson, Reshma Ramracheya, Guy A. Rutter, Antony Galione, Patrik Rorsman, Andrei I. Tarasov
Journal: Diabetes
Diabetes 2018;67(6):1128–1139
https://doi.org/10.2337/db17-1102
Published: 21 March 2018
View articletitled, Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+ Mobilization From Acidic Stores in Pancreatic α-Cells
Open the PDF for Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+ Mobilization From Acidic Stores in Pancreatic α-Cells in another window
Includes: Supplementary data
Journal Articles

Increased Expression of the Diabetes Gene SOX4 Reduces Insulin Secretion by Impaired Fusion Pore Expansion

Stephan C. Collins, Hyun Woong Do, Benoit Hastoy, Alison Hugill, Julie Adam, Margarita V. Chibalina, Juris Galvanovskis, Mahdieh Godazgar, Sheena Lee, Michelle Goldsworthy, Albert Salehi, Andrei I. Tarasov, Anders H. Rosengren, Roger Cox, Patrik Rorsman
Journal: Diabetes
Diabetes 2016;65(7):1952–1961
https://doi.org/10.2337/db15-1489
Published: 18 March 2016
View articletitled, Increased Expression of the Diabetes Gene SOX4 Reduces Insulin Secretion by Impaired Fusion Pore Expansion
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Includes: Supplementary data
Journal Articles

Reduced Insulin Exocytosis in Human Pancreatic β-Cells With Gene Variants Linked to Type 2 Diabetes

Anders H. Rosengren, Matthias Braun, Taman Mahdi, Sofia A. Andersson, Mary E. Travers, Makoto Shigeto, Enming Zhang, Peter Almgren, Claes Ladenvall, Annika S. Axelsson, Anna Edlund, Morten Gram Pedersen, Anna Jonsson, Reshma Ramracheya, Yunzhao Tang, Jonathan N. Walker, Amy Barrett, Paul R.V. Johnson, Valeriya Lyssenko, Mark I. McCarthy, Leif Groop, Albert Salehi, Anna L. Gloyn, Erik Renström, Patrik Rorsman, Lena Eliasson
Journal: Diabetes
Diabetes 2012;61(7):1726–1733
https://doi.org/10.2337/db11-1516
Published: 15 June 2012
View articletitled, Reduced Insulin Exocytosis in Human Pancreatic β-Cells With Gene Variants Linked to Type 2 Diabetes
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Includes: Supplementary data
Journal Articles

Membrane Potential-Dependent Inactivation of Voltage-Gated Ion Channels in α-Cells Inhibits Glucagon Secretion From Human Islets

Reshma Ramracheya, Caroline Ward, Makoto Shigeto, Jonathan N. Walker, Stefan Amisten, Quan Zhang, Paul R. Johnson, Patrik Rorsman, Matthias Braun
Journal: Diabetes
Diabetes 2010;59(9):2198–2208
https://doi.org/10.2337/db09-1505
Published: 14 June 2010
View articletitled, Membrane Potential-Dependent Inactivation of Voltage-Gated Ion Channels in α-Cells Inhibits Glucagon Secretion From Human Islets
Open the PDF for Membrane Potential-Dependent Inactivation of Voltage-Gated Ion Channels in α-Cells Inhibits Glucagon Secretion From Human Islets in another window
Includes: Supplementary data