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Meeting Abstracts

2130-LB: Novel Insulin Gene Variants in Antibody-Negative Adult-Onset Diabetes

Free
DAVID BROOME, KRISTIN A. MALONEY, SIRI ATMA W. GREELEY, SOO YOUNG PARK, EMILY D. SZMUILOWICZ, LIANA K. BILLINGS, LOUIS H. PHILIPSON, STEVEN E. KAHN, PETER ARVAN, NEDA RASOULI, TONI I. POLLIN, RADIANT STUDY GROUP
Journal: Diabetes
Diabetes 2024;74(Supplement_1):2130-LB
https://doi.org/10.2337/db25-2130-LB
Published: 13 June 2025
View articletitled, 2130-LB: Novel Insulin Gene Variants in Antibody-Negative Adult-Onset Diabetes
Journal Articles

An Essential Role of IER3IP1 in β-Cell Development and Proinsulin Trafficking

Free
Wenli Feng, Peter Arvan, Ming Liu
Journal: Diabetes
Diabetes 2025;74(4):455–457
https://doi.org/10.2337/dbi24-0045
Published: 20 March 2025
View articletitled, An Essential Role of IER3IP1 in β-Cell Development and Proinsulin Trafficking
Open the PDF for An Essential Role of IER3IP1 in β-Cell Development and Proinsulin Trafficking in another window
Journal Articles

Role of Sec61α2 Translocon in Insulin Biosynthesis

Available to Purchase
Xiaoxi Xu, Thomas W. Bell, Truc Le, Ivy Zhao, Emily Walker, Yiqing Wang, Ning Xu, Scott A. Soleimanpour, Holger A. Russ, Ling Qi, Billy Tsai, Ming Liu, Peter Arvan
Journal: Diabetes
Diabetes 2024;73(12):2034–2044
https://doi.org/10.2337/db24-0115
Published: 26 September 2024
View articletitled, Role of Sec61α2 Translocon in Insulin Biosynthesis
Open the PDF for Role of Sec61α2 Translocon in Insulin Biosynthesis in another window
Meeting Abstracts

1555-P: Novel Imaging Platform Highlights the Disconnect between ß-Cell Mass and Glucose Control in the Onset of Type 1 Diabetes

Free
CORENTIN CRAS-MÉNEUR, RANDY J. SEELEY, PETER ARVAN
Journal: Diabetes
Diabetes 2023;72(Supplement_1):1555-P
https://doi.org/10.2337/db23-1555-P
Published: 20 June 2023
View articletitled, 1555-P: Novel Imaging Platform Highlights the Disconnect between ß-Cell Mass and Glucose Control in the Onset of Type 1 Diabetes
Journal Articles

Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity

Free
Mei-Ling Yang, Sean E. Connolly, Renelle J. Gee, TuKiet T. Lam, Jean Kanyo, Jian Peng, Perrin Guyer, Farooq Syed, Hubert M. Tse, Steven G. Clarke, Catherine F. Clarke, Eddie A. James, Cate Speake, Carmella Evans-Molina, Peter Arvan, Kevan C. Herold, Li Wen, Mark J. Mamula
Journal: Diabetes
Diabetes 2022;71(9):1979–1993
https://doi.org/10.2337/db21-0989
Published: 22 June 2022
View articletitled, Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity
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Meeting Abstracts

1461-P: Quantifying Proinsulin Misfolding in the Endoplasmic Reticulum

Free
ANOOP ARUNAGIRI, MD MAROOF ALAM, LEENA HAATAJA, PRAVEEN J. SAMY, SCOTT SOLEIMANPOUR, LESLIE S. SATIN, PAMELA ITKIN-ANSARI, MING LIU, PETER ARVAN
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1461-P
https://doi.org/10.2337/db22-1461-P
Published: 01 June 2022
View articletitled, 1461-P: Quantifying Proinsulin Misfolding in the Endoplasmic Reticulum
Meeting Abstracts

200-OR: IER3IP1 Is Critical for Maintaining Glucose Homeostasis through Regulating the Endoplasmic Reticulum Function and Survival of ß-Cells

Free
JING YANG, JINYANG ZHEN, WENLI FENG, ZHENQIAN FAN, YUMENG HUANG, HUA SHU, XIN LI, JINGTING QIAO, YUXIN FAN, JINHONG SUN, NA LI, TENGLI LIU, SHUSEN WANG, XIAONA ZHANG, PETER ARVAN, MING LIU
Journal: Diabetes
Diabetes 2022;71(Supplement_1):200-OR
https://doi.org/10.2337/db22-200-OR
Published: 01 June 2022
View articletitled, 200-OR: IER3IP1 Is Critical for Maintaining Glucose Homeostasis through Regulating the Endoplasmic Reticulum Function and Survival of ß-Cells
Journal Articles

Erratum. Predisposition to Proinsulin Misfolding as a Genetic Risk to Diet-Induced Diabetes. Diabetes 2021;70:2580–2594

Free
Maroof Alam, Anoop Arunagiri, Leena Haataja, Mauricio Torres, Dennis Larkin, John Kappler, Niyun Jin, Peter Arvan
Journal: Diabetes
Diabetes 2022;71(4):870
https://doi.org/10.2337/db22-er04a
Published: 07 January 2022
View articletitled, Erratum. Predisposition to Proinsulin Misfolding as a Genetic Risk to Diet-Induced Diabetes. Diabetes 2021;70:2580–2594
Open the PDF for Erratum. Predisposition to Proinsulin Misfolding as a Genetic Risk to Diet-Induced Diabetes. Diabetes 2021;70:2580–2594 in another window
Journal Articles

The Role of TRAPγ/SSR3 in Preproinsulin Translocation Into the Endoplasmic Reticulum

Free
Xiaoxi Xu, Yumeng Huang, Xin Li, Peter Arvan, Ming Liu
Journal: Diabetes
Diabetes 2022;71(3):440–452
https://doi.org/10.2337/db21-0638
Published: 02 December 2021
View articletitled, The Role of TRAPγ/SSR3 in Preproinsulin Translocation Into the Endoplasmic Reticulum
Open the PDF for The Role of TRAPγ/SSR3 in Preproinsulin Translocation Into the Endoplasmic Reticulum in another window
Journal Articles

Predisposition to Proinsulin Misfolding as a Genetic Risk to Diet-Induced Diabetes

Free
Maroof Alam, Anoop Arunagiri, Leena Haataja, Mauricio Torres, Dennis Larkin, John Kappler, Niyun Jin, Peter Arvan
Journal: Diabetes
Diabetes 2021;70(11):2580–2594
https://doi.org/10.2337/db21-0422
Published: 30 August 2021
View articletitled, Predisposition to Proinsulin Misfolding as a Genetic Risk to Diet-Induced Diabetes
Open the PDF for Predisposition to Proinsulin Misfolding as a Genetic Risk to Diet-Induced Diabetes in another window
Meeting Abstracts

39-OR: Pancreatic Beta Cell SERCA2 Deficiency Impacts ER-Golgi Vesicle Trafficking and Ceramide Metabolism

Free
TATSUYOSHI KONO, HITOSHI IIDA, CHIH-CHUN LEE, PREETHI KRISHNAN, PETER ARVAN, IRIS LINDBERG, CARMELLA EVANS-MOLINA
Journal: Diabetes
Diabetes 2021;70(Supplement_1):39-OR
https://doi.org/10.2337/db21-39-OR
Published: 01 June 2021
View articletitled, 39-OR: Pancreatic Beta Cell SERCA2 Deficiency Impacts ER-Golgi Vesicle Trafficking and Ceramide Metabolism
Meeting Abstracts

292-OR: Inflammatory Cytokines Rewire the Proinsulin Interaction Network in Human Islets

Free
DUC T. TRAN, SALVATORE LOGUERCIO, KOUTA LEE, ANITA POTTEKAT, WILLIAM E. BALCH, PETER ARVAN, RANDAL J. KAUFMAN, PAMELA ITKIN-ANSARI
Journal: Diabetes
Diabetes 2021;70(Supplement_1):292-OR
https://doi.org/10.2337/db21-292-OR
Published: 01 June 2021
View articletitled, 292-OR: Inflammatory Cytokines Rewire the Proinsulin Interaction Network in Human Islets
Journal Articles

Altered β-Cell Prohormone Processing and Secretion in Type 1 Diabetes

Free
Teresa Rodriguez-Calvo, Yi-Chun Chen, C. Bruce Verchere, Leena Haataja, Peter Arvan, Pia Leete, Sarah J. Richardson, Noel G. Morgan, Wei-Jun Qian, Alberto Pugliese, Mark Atkinson, Carmella Evans-Molina, Emily K. Sims
Journal: Diabetes
Diabetes 2021;70(5):1038–1050
https://doi.org/10.2337/dbi20-0034
Published: 19 May 2021
View articletitled, Altered β-Cell Prohormone Processing and Secretion in Type 1 Diabetes
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Meeting Abstracts

47-OR: A Reference Map of the Human Proinsulin Biosynthetic Interaction Network

Free
DUC T. TRAN, PETER ARVAN, RANDAL J. KAUFMAN, PAMELA ITKIN-ANSARI
Journal: Diabetes
Diabetes 2020;69(Supplement_1):47-OR
https://doi.org/10.2337/db20-47-OR
Published: 01 June 2020
View articletitled, 47-OR: A Reference Map of the Human Proinsulin Biosynthetic Interaction Network
Meeting Abstracts

1893-P: The Integrative Role of ER Protein Quality Control Pathways (ERQC) in Prohormone Maturation

Free
GUOJUN SHI, XUYA PAN, HETING WANG, PETER ARVAN, LING QI
Journal: Diabetes
Diabetes 2020;69(Supplement_1):1893-P
https://doi.org/10.2337/db20-1893-P
Published: 01 June 2020
View articletitled, 1893-P: The Integrative Role of ER Protein Quality Control Pathways (ERQC) in Prohormone Maturation
Meeting Abstracts

49-OR: Synergistic Effect of ERAD and Autophagy in Preventing Proinsulin Aggregation and Promoting Beta-Cell Survival

Free
NEHA SHRESTHA, RACHEL B. REINERT, PETER ARVAN, LING QI
Journal: Diabetes
Diabetes 2020;69(Supplement_1):49-OR
https://doi.org/10.2337/db20-49-OR
Published: 01 June 2020
View articletitled, 49-OR: Synergistic Effect of ERAD and Autophagy in Preventing Proinsulin Aggregation and Promoting Beta-Cell Survival
Meeting Abstracts

48-OR: Pancreatic ß Cell SERCA2 Deficiency Leads to Impaired Proinsulin Processing and Reduced ER to Golgi Protein Trafficking

Free
TATSUYOSHI KONO, HITOSHI IIDA, TIMOTHY S. JARVELA, CHIH-CHUN LEE, XIN TONG, PETER ARVAN, IRIS LINDBERG, CARMELLA EVANS-MOLINA
Journal: Diabetes
Diabetes 2020;69(Supplement_1):48-OR
https://doi.org/10.2337/db20-48-OR
Published: 01 June 2020
View articletitled, 48-OR: Pancreatic ß Cell SERCA2 Deficiency Leads to Impaired Proinsulin Processing and Reduced ER to Golgi Protein Trafficking
Journal Articles

Unbiased Profiling of the Human Proinsulin Biosynthetic Interaction Network Reveals a Role for Peroxiredoxin 4 in Proinsulin Folding

Free
Duc T. Tran, Anita Pottekat, Saiful A. Mir, Salvatore Loguercio, Insook Jang, Alexandre Rosa Campos, Kathleen M. Scully, Reyhaneh Lahmy, Ming Liu, Peter Arvan, William E. Balch, Randal J. Kaufman, Pamela Itkin-Ansari
Journal: Diabetes
Diabetes 2020;69(8):1723–1734
https://doi.org/10.2337/db20-0245
Published: 26 May 2020
View articletitled, Unbiased Profiling of the Human Proinsulin Biosynthetic Interaction Network Reveals a Role for Peroxiredoxin 4 in Proinsulin Folding
Open the PDF for Unbiased Profiling of the Human Proinsulin Biosynthetic Interaction Network Reveals a Role for Peroxiredoxin 4 in Proinsulin Folding in another window
Journal Articles

Role of Proinsulin Self-Association in Mutant INS Gene–Induced Diabetes of Youth

Free
Jinhong Sun, Yi Xiong, Xin Li, Leena Haataja, Wei Chen, Saiful A. Mir, Li Lv, Rachel Madley, Dennis Larkin, Arfah Anjum, Balamurugan Dhayalan, Nischay Rege, Nalinda P. Wickramasinghe, Michael A. Weiss, Pamela Itkin-Ansari, Randal J. Kaufman, David A. Ostrov, Peter Arvan, Ming Liu
Journal: Diabetes
Diabetes 2020;69(5):954–964
https://doi.org/10.2337/db19-1106
Published: 05 March 2020
View articletitled, Role of Proinsulin Self-Association in Mutant INS Gene–Induced Diabetes of Youth
Open the PDF for Role of Proinsulin Self-Association in Mutant INS Gene–Induced Diabetes of Youth in another window
Includes: Supplementary data
Meeting Abstracts

2166-P: Sel1L-Hrd1 ERAD Is a Key Regulator of Beta-Cell Function and Identity

Free
NEHA SHRESTHA, XIN LI, YEWEI JI, RACHEL B. REINERT, PETER ARVAN, LING QI
Journal: Diabetes
Diabetes 2019;68(Supplement_1):2166-P
https://doi.org/10.2337/db19-2166-P
Published: 01 June 2019
View articletitled, 2166-P: Sel1L-Hrd1 ERAD Is a Key Regulator of Beta-Cell Function and Identity