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Meeting Abstracts

213-OR: Widespread Age-Associated Changes in the Chromatin Architecture of Skeletal Muscle Cell Types

Free
KEAGAN G. MOO, RICARDO D'OLIVEIRA ALBANUS, ARUSHI VARSHNEY, PETER ORCHARD, NANDINI MANICKAM, MARKKU LAAKSO, SR., JAAKKO TUOMILEHTO, TIMO A. LAKKA, KAREN L. MOHLKE, MICHAEL BOEHNKE, LAURA SCOTT, HEIKKI A. KOISTINEN, FRANCIS S. COLLINS, STEPHEN PARKER
Journal: Diabetes
Diabetes 2024;73(Supplement_1):213-OR
https://doi.org/10.2337/db24-213-OR
Published: 14 June 2024
View articletitled, 213-OR: Widespread Age-Associated Changes in the Chromatin Architecture of Skeletal Muscle Cell Types
Meeting Abstracts

212-OR: Differential Cell-Type - Specific Gene Expression and Chromatin Accessibility by Type 2 Diabetes Status and Physical Activity Levels in Human Skeletal Muscle

Free
DAN CIOTLOS, SARAH HANKS, ARUSHI VARSHNEY, MICHAEL ERDOS, NANDINI MANICKAM, HEATHER M. STRINGHAM, ERIN HILL-BURNS, PETER ORCHARD, NARISU NARISU, LORI L. BONNYCASTLE, MICHAEL D. SWEENEY, MARKKU LAAKSO, SR., JAAKKO TUOMILEHTO, TIMO A. LAKKA, KAREN L. MOHLKE, MICHAEL BOEHNKE, HEIKKI A. KOISTINEN, FRANCIS S. COLLINS, STEPHEN PARKER, LAURA SCOTT
Journal: Diabetes
Diabetes 2024;73(Supplement_1):212-OR
https://doi.org/10.2337/db24-212-OR
Published: 14 June 2024
View articletitled, 212-OR: Differential Cell-Type - Specific Gene Expression and Chromatin Accessibility by Type 2 Diabetes Status and Physical Activity Levels in Human Skeletal Muscle
Meeting Abstracts

210-OR: ADA Presidents' Select Abstract: Discovering Stimulatory State-Specific Type 2 Diabetes GWAS Mechanisms with Single-Cell Multiomics on iPSC-Derived Fibro-adipogenic Progenitor Cell Villages

Free
CHRISTA VENTRESCA, ARUSHI VARSHNEY, PETER ORCHARD, YAO-CHANG TSAN, ANDRE MONTEIRO DA ROCHA, MARKKU LAAKSO, SR., JAAKKO TUOMILEHTO, TIMO A. LAKKA, KAREN L. MOHLKE, MICHAEL BOEHNKE, LAURA SCOTT, HEIKKI A. KOISTINEN, FRANCIS S. COLLINS, TODD J. HERRON, STEPHANIE BIELAS, STEPHEN PARKER
Journal: Diabetes
Diabetes 2024;73(Supplement_1):210-OR
https://doi.org/10.2337/db24-210-OR
Published: 14 June 2024
View articletitled, 210-OR: ADA Presidents' Select Abstract: Discovering Stimulatory State-Specific Type 2 Diabetes GWAS Mechanisms with Single-Cell Multiomics on iPSC-Derived Fibro-adipogenic Progenitor Cell Villages
Meeting Abstracts

278-OR: Single-Nucleus Multiomics Profiling across 49 Individuals of Hispanic Ancestry Reveals Cell-Specific Skeletal Muscle Insulin-Responsive Gene Regulatory Signatures

Free
BENJAMIN LI, ARUSHI VARSHNEY, ADELAIDE TOVAR, NANDINI MANICKAM, PETER ORCHARD, RALPH A. DEFRONZO, LUKE NORTON, STEPHEN PARKER
Journal: Diabetes
Diabetes 2024;73(Supplement_1):278-OR
https://doi.org/10.2337/db24-278-OR
Published: 14 June 2024
View articletitled, 278-OR: Single-Nucleus Multiomics Profiling across 49 Individuals of Hispanic Ancestry Reveals Cell-Specific Skeletal Muscle Insulin-Responsive Gene Regulatory Signatures
Meeting Abstracts

274-OR: Population-Scale Single-Nucleus Skeletal Muscle Chromatin Dynamics and Nucleosome Positioning in the Context of Type 2 Diabetes

Free
XIAOOU WANG, CASSIE ROBERTSON, ARUSHI VARSHNEY, NANDINI MANICKAM, PETER ORCHARD, MARKKU LAAKSO, SR., JAAKKO TUOMILEHTO, TIMO A. LAKKA, KAREN L. MOHLKE, MICHAEL BOEHNKE, LAURA SCOTT, HEIKKI A. KOISTINEN, FRANCIS S. COLLINS, STEPHEN PARKER
Journal: Diabetes
Diabetes 2024;73(Supplement_1):274-OR
https://doi.org/10.2337/db24-274-OR
Published: 14 June 2024
View articletitled, 274-OR: Population-Scale Single-Nucleus Skeletal Muscle Chromatin Dynamics and Nucleosome Positioning in the Context of Type 2 Diabetes
Meeting Abstracts

2000-LB: Multiome Profiling of Human Islets Nominates Beta-Cell–Specific Cytokine Response Profiles Underlying Type 1 Diabetes

Free
CASSIE ROBERTSON, XIAOOU WANG, PETER ORCHARD, JERRY MENG, VLADISLAV DOLGACHEV, NANDINI MANICKAM, NARISU NARISU, MICHAEL ERDOS, FRANCIS S. COLLINS, SHUIBING CHEN, STEPHEN C. PARKER
Journal: Diabetes
Diabetes 2024;73(Supplement_1):2000-LB
https://doi.org/10.2337/db24-2000-LB
Published: 14 June 2024
View articletitled, 2000-LB: Multiome Profiling of Human Islets Nominates Beta-Cell–Specific Cytokine Response Profiles Underlying Type 1 Diabetes
Meeting Abstracts

1998-LB: Previously Frozen Beta-Cell Transcriptional Response to Cytokine Treatment Mirrors That of Fresh Beta Cells

Free
PETER ORCHARD, XIAOOU WANG, TINGFEN YAN, NARISU NARISU, CASSIE ROBERTSON, MICHAEL ERDOS, JERRY MENG, FRANCIS S. COLLINS, SHUIBING CHEN, STEPHEN C. PARKER
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1998-LB
https://doi.org/10.2337/db24-1998-LB
Published: 14 June 2024
View articletitled, 1998-LB: Previously Frozen Beta-Cell Transcriptional Response to Cytokine Treatment Mirrors That of Fresh Beta Cells
Meeting Abstracts

2013-LB: Population-Scale Skeletal Muscle Single-Nucleus Multiomic Profiling Reveals Extensive Context-Specific Genetic Regulation

Free
ARUSHI VARSHNEY, NANDINI MANICKAM, PETER ORCHARD, ADELAIDE TOVAR, ZHENHAO ZHANG, FAN FENG, TIMO A. LAKKA, MARKKU LAAKSO, SR., JAAKKO TUOMILEHTO, KAREN L. MOHLKE, JACOB KITZMAN, HEIKKI A. KOISTINEN, JIE LIU, MICHAEL BOEHNKE, FRANCIS S. COLLINS, LAURA SCOTT, STEPHEN C. PARKER
Journal: Diabetes
Diabetes 2024;73(Supplement_1):2013-LB
https://doi.org/10.2337/db24-2013-LB
Published: 14 June 2024
View articletitled, 2013-LB: Population-Scale Skeletal Muscle Single-Nucleus Multiomic Profiling Reveals Extensive Context-Specific Genetic Regulation
Meeting Abstracts

2012-LB: Type 2 Diabetes GWAS Signal C2CD4A/B Insulin Resistance Mechanisms in Skeletal Muscle

Free
IBIERE L. EPELLE, ARUSHI VARSHNEY, PETER ORCHARD, ZHENHAO ZHANG, FAN FENG, MARKKU LAAKSO, SR., JAAKKO TUOMILEHTO, TIMO A. LAKKA, KAREN L. MOHLKE, MICHAEL BOEHNKE, LAURA SCOTT, HEIKKI A. KOISTINEN, FRANCIS S. COLLINS, JIE LIU, STEPHEN C. PARKER
Journal: Diabetes
Diabetes 2024;73(Supplement_1):2012-LB
https://doi.org/10.2337/db24-2012-LB
Published: 14 June 2024
View articletitled, 2012-LB: Type 2 Diabetes GWAS Signal C2CD4A/B Insulin Resistance Mechanisms in Skeletal Muscle
Meeting Abstracts

2009-LB: Deep Learning Enhances Chromatin Accessibility Signals and Discovers Links with Genetic Variations in Skeletal Muscle Rare Cells

Free
HA T.H. VU, ARUSHI VARSHNEY, PETER ORCHARD, MARKKU LAAKSO, SR., JAAKKO TUOMILEHTO, TIMO A. LAKKA, KAREN L. MOHLKE, MICHAEL BOEHNKE, LAURA SCOTT, HEIKKI A. KOISTINEN, FRANCIS S. COLLINS, STEPHEN C. PARKER
Journal: Diabetes
Diabetes 2024;73(Supplement_1):2009-LB
https://doi.org/10.2337/db24-2009-LB
Published: 14 June 2024
View articletitled, 2009-LB: Deep Learning Enhances Chromatin Accessibility Signals and Discovers Links with Genetic Variations in Skeletal Muscle Rare Cells
Meeting Abstracts

2005-LB: Optimization of Single Nuclei Isolation from Frozen Human Skeletal Muscle and Pancreatic Tissue Samples for Single Nuclei Multiome ATAC + Gene Expression

Free
VLADISLAV DOLGACHEV, ARUSHI VARSHNEY, KEAGAN G. MOO, XIAOOU WANG, PETER ORCHARD, DIANE C. SAUNDERS, MARCELA BRISSOVA, STEPHEN C. PARKER
Journal: Diabetes
Diabetes 2024;73(Supplement_1):2005-LB
https://doi.org/10.2337/db24-2005-LB
Published: 14 June 2024
View articletitled, 2005-LB: Optimization of Single Nuclei Isolation from Frozen Human Skeletal Muscle and Pancreatic Tissue Samples for Single Nuclei Multiome ATAC + Gene Expression
Journal Articles

A Transcription Start Site Map in Human Pancreatic Islets Reveals Functional Regulatory Signatures

Free
Arushi Varshney, Yasuhiro Kyono, Venkateswaran Ramamoorthi Elangovan, Collin Wang, Michael R. Erdos, Narisu Narisu, Ricardo D’Oliveira Albanus, Peter Orchard, Michael L. Stitzel, Francis S. Collins, Jacob O. Kitzman, Stephen C.J. Parker
Journal: Diabetes
Diabetes 2021;70(7):1581–1591
https://doi.org/10.2337/db20-1087
Published: 13 April 2021
View articletitled, A Transcription Start Site Map in Human Pancreatic Islets Reveals Functional Regulatory Signatures
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