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Philipp E. Scherer
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Journal Articles

GIPR Agonism Enhances TZD-Induced Insulin Sensitivity in Obese IR Mice

Ellen C. Furber, Karissa Hyatt, Kyla Collins, Xinxin Yu, Brian A. Droz, Adrienne Holland, Jessica L. Friedrich, Samantha Wojnicki, Debra L. Konkol, Libbey S. O’Farrell, Hana E. Baker, Tamer Coskun, Philipp E. Scherer, Christine M. Kusminski, Michael E. Christe, Kyle W. Sloop, Ricardo J. Samms
Journal: Diabetes
Diabetes 2024;73(2):292–305
https://doi.org/10.2337/db23-0172
Published: 07 November 2023
View article titled, GIPR Agonism Enhances TZD-Induced Insulin Sensitivity in Obese IR Mice
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Journal Articles

Leptin Reduction as a Required Component for Weight Loss

Shangang Zhao, Na Li, Wei Xiong, Guannan Li, Sijia He, Zhuzhen Zhang, Qingzhang Zhu, Nisi Jiang, Christian Ikejiofor, Yi Zhu, May-Yun Wang, Xianlin Han, Ningyang Zhang, Carolina Solis-Herrera, Christine Kusminski, Zhiqiang An, Joel K. Elmquist, Philipp E. Scherer
Journal: Diabetes
Diabetes 2024;73(2):197–210
https://doi.org/10.2337/db23-0571
Published: 07 November 2023
View article titled, Leptin Reduction as a Required Component for Weight Loss
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Meeting Abstracts

212-OR: Leptin Reduction as a Required Component for Weight Loss

SHANGANG ZHAO, PHILIPP E. SCHERER
Journal: Diabetes
Diabetes 2023;72(Supplement_1):212-OR
https://doi.org/10.2337/db23-212-OR
Published: 20 June 2023
View article titled, 212-OR: Leptin Reduction as a Required Component for Weight Loss
Journal Articles

Deficient Caveolin-1 Synthesis in Adipocytes Stimulates Systemic Insulin-Independent Glucose Uptake via Extracellular Vesicles

Clair Crewe, Shiuhwei Chen, Dawei Bu, Christy M. Gliniak, Ingrid Wernstedt Asterholm, Xin Xin Yu, Nolwenn Joffin, Camila O. de Souza, Jan-Bernd Funcke, Da Young Oh, Oleg Varlamov, Jacob J. Robino, Ruth Gordillo, Philipp E. Scherer
Journal: Diabetes
Diabetes 2022;71(12):2496–2512
https://doi.org/10.2337/db22-0035
Published: 26 July 2022
View article titled, Deficient Caveolin-1 Synthesis in Adipocytes Stimulates Systemic Insulin-Independent Glucose Uptake via Extracellular Vesicles
Open the PDF for Deficient Caveolin-1 Synthesis in Adipocytes Stimulates Systemic Insulin-Independent Glucose Uptake via Extracellular Vesicles in another window
Journal Articles

A Novel Model of Diabetic Complications: Adipocyte Mitochondrial Dysfunction Triggers Massive β-Cell Hyperplasia

Christine M. Kusminski, Alexandra L. Ghaben, Thomas S. Morley, Ricardo J. Samms, Andrew C. Adams, Yu An, Joshua A. Johnson, Nolwenn Joffin, Toshiharu Onodera, Clair Crewe, William L. Holland, Ruth Gordillo, Philipp E. Scherer
Journal: Diabetes
Diabetes 2020;69(3):313–330
https://doi.org/10.2337/db19-0327
Published: 27 December 2020
View article titled, A Novel Model of Diabetic Complications: Adipocyte Mitochondrial Dysfunction Triggers Massive β-Cell Hyperplasia
Open the PDF for A Novel Model of Diabetic Complications: Adipocyte Mitochondrial Dysfunction Triggers Massive β-Cell Hyperplasia in another window
Includes: Supplementary data
Journal Articles

Leptin: Less Is More

Shangang Zhao, Christine M. Kusminski, Joel K. Elmquist, Philipp E. Scherer
Journal: Diabetes
Diabetes 2020;69(5):823–829
https://doi.org/10.2337/dbi19-0018
Published: 13 April 2020
View article titled, Leptin: Less Is More
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Journal Articles

Cellular Origins of Beige Fat Cells Revisited

Mengle Shao, Qiong A. Wang, Anying Song, Lavanya Vishvanath, Napoleon C. Busbuso, Philipp E. Scherer, Rana K. Gupta
Journal: Diabetes
Diabetes 2019;68(10):1874–1885
https://doi.org/10.2337/db19-0308
Published: 16 September 2019
View article titled, Cellular Origins of Beige Fat Cells Revisited
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Meeting Abstracts

180-OR: Tissue-Specific Functions of PPARα Overexpression in Liver, Adipose, and Pancreatic ß Cells

RISHENG YE, PHILIPP E. SCHERER
Journal: Diabetes
Diabetes 2019;68(Supplement_1):180-OR
https://doi.org/10.2337/db19-180-OR
Published: 01 June 2019
View article titled, 180-OR: Tissue-Specific Functions of PPARα Overexpression in Liver, Adipose, and Pancreatic ß Cells
Meeting Abstracts

140-OR: Dermal Adipose Tissue—A Unique Fat Pad Undergoes Dynamic Changes by Reversible Dedifferentiation

ZHUZHEN ZHANG, MENGLE SHAO, RANA K. GUPTA, PHILIPP E. SCHERER
Journal: Diabetes
Diabetes 2019;68(Supplement_1):140-OR
https://doi.org/10.2337/db19-140-OR
Published: 01 June 2019
View article titled, 140-OR: Dermal Adipose Tissue—A Unique Fat Pad Undergoes Dynamic Changes by Reversible Dedifferentiation
Meeting Abstracts

316-OR: Suppressing Adipose Tissue Inflammation Promotes Insulin Resistance in Mice

QINGZHANG ZHU, PHILIPP E. SCHERER
Journal: Diabetes
Diabetes 2019;68(Supplement_1):316-OR
https://doi.org/10.2337/db19-316-OR
Published: 01 June 2019
View article titled, 316-OR: Suppressing Adipose Tissue Inflammation Promotes Insulin Resistance in Mice
Meeting Abstracts

315-OR: Two Brown Adipocyte Subpopulations with Distinct Thermogenic Activity Coexist and Undergo Dynamic Interconversions upon Changes in Environmental Temperature

ANYING SONG, MIN JEE JANG, XIWEI WU, LEI JIANG, PHILIPP E. SCHERER, QIONG WANG
Journal: Diabetes
Diabetes 2019;68(Supplement_1):315-OR
https://doi.org/10.2337/db19-315-OR
Published: 01 June 2019
View article titled, 315-OR: Two Brown Adipocyte Subpopulations with Distinct Thermogenic Activity Coexist and Undergo Dynamic Interconversions upon Changes in Environmental Temperature
Meeting Abstracts

TLR4-Induced Local Adipose Inflammation Critically Regulates Glucose Homeostasis

SHANGANG ZHAO, PHILIPP E. SCHERER
Journal: Diabetes
Diabetes 2018;67(Supplement_1):2032-P
https://doi.org/10.2337/db18-2032-P
Published: 01 July 2018
View article titled, TLR4-Induced Local Adipose Inflammation Critically Regulates Glucose Homeostasis
Meeting Abstracts

Thiazolidinediones’ Insulin-Sensitizing Properties Depend on Adiponectin-Mediated Reductions in Certain Ceramide Species

RUTH GORDILLO, KEHAO ZHANG, PHILIPP E. SCHERER, MEREDITH HAWKINS
Journal: Diabetes
Diabetes 2018;67(Supplement_1):277-LB
https://doi.org/10.2337/db18-277-LB
Published: 01 July 2018
View article titled, Thiazolidinediones’ Insulin-Sensitizing Properties Depend on Adiponectin-Mediated Reductions in Certain Ceramide Species
Meeting Abstracts

Targeting the Amyloid Precursor Protein (APP) to Mitochondria of White Adipose Tissues Triggers Mitochondrial Dysfunction and Obesity

YU A. AN, PHILIPP E. SCHERER
Journal: Diabetes
Diabetes 2018;67(Supplement_1):276-OR
https://doi.org/10.2337/db18-276-OR
Published: 01 July 2018
View article titled, Targeting the Amyloid Precursor Protein (APP) to Mitochondria of White Adipose Tissues Triggers Mitochondrial Dysfunction and Obesity
Meeting Abstracts

Fasting-Induced Changes in Glucagon Secretion Are Dysregulated in Obesity

JENNIFER H. STERN, GORDON I. SMITH, ROGER H. UNGER, SAMUEL KLEIN, PHILIPP E. SCHERER
Journal: Diabetes
Diabetes 2018;67(Supplement_1):271-LB
https://doi.org/10.2337/db18-271-LB
Published: 01 July 2018
View article titled, Fasting-Induced Changes in Glucagon Secretion Are Dysregulated in Obesity
Meeting Abstracts

VEGF-A-Expressing Adipose Tissue Shows Rapid Beiging, Enhanced Survival after Transplantation

MIN KIM, YU A. AN, HYUN SEOK BANG, PHILIPP E. SCHERER, JIYOUNG PARK
Journal: Diabetes
Diabetes 2018;67(Supplement_1):279-LB
https://doi.org/10.2337/db18-279-LB
Published: 01 July 2018
View article titled, VEGF-A-Expressing Adipose Tissue Shows Rapid Beiging, Enhanced Survival after Transplantation
Journal Articles

Hepatic GALE Regulates Whole-Body Glucose Homeostasis by Modulating Tff3 Expression

Yi Zhu, Shangang Zhao, Yingfeng Deng, Ruth Gordillo, Alexandra L. Ghaben, Mengle Shao, Fang Zhang, Ping Xu, Yang Li, Huachuan Cao, Olga Zagnitko, David A. Scott, Rana K. Gupta, Chao Xing, Bei B. Zhang, Hua V. Lin, Philipp E. Scherer
Journal: Diabetes
Diabetes 2017;66(11):2789–2799
https://doi.org/10.2337/db17-0323
Published: 06 September 2017
View article titled, Hepatic GALE Regulates Whole-Body Glucose Homeostasis by Modulating <em>Tff3</em> Expression
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Includes: Supplementary data
Journal Articles

VEGF-A–Expressing Adipose Tissue Shows Rapid Beiging and Enhanced Survival After Transplantation and Confers IL-4–Independent Metabolic Improvements

Jiyoung Park, Min Kim, Kai Sun, Yu Aaron An, Xue Gu, Philipp E. Scherer
Journal: Diabetes
Diabetes 2017;66(6):1479–1490
https://doi.org/10.2337/db16-1081
Published: 02 March 2017
View article titled, VEGF-A–Expressing Adipose Tissue Shows Rapid Beiging and Enhanced Survival After Transplantation and Confers IL-4–Independent Metabolic Improvements
Open the PDF for VEGF-A–Expressing Adipose Tissue Shows Rapid Beiging and Enhanced Survival After Transplantation and Confers IL-4–Independent Metabolic Improvements in another window
Includes: Supplementary data
Journal Articles

Adipocyte-Specific Deletion of Manganese Superoxide Dismutase Protects From Diet-Induced Obesity Through Increased Mitochondrial Uncoupling and Biogenesis

Yong Hwan Han, Márcio Buffolo, Karla Maria Pires, Shaobo Pei, Philipp E. Scherer, Sihem Boudina
Journal: Diabetes
Diabetes 2016;65(9):2639–2651
https://doi.org/10.2337/db16-0283
Published: 09 June 2016
View article titled, Adipocyte-Specific Deletion of Manganese Superoxide Dismutase Protects From Diet-Induced Obesity Through Increased Mitochondrial Uncoupling and Biogenesis
Open the PDF for Adipocyte-Specific Deletion of Manganese Superoxide Dismutase Protects From Diet-Induced Obesity Through Increased Mitochondrial Uncoupling and Biogenesis in another window
Includes: Supplementary data
Journal Articles

The Multifaceted Roles of Adipose Tissue—Therapeutic Targets for Diabetes and Beyond: The 2015 Banting Lecture

Philipp E. Scherer
Journal: Diabetes
Diabetes 2016;65(6):1452–1461
https://doi.org/10.2337/db16-0339
Published: 18 May 2016
View article titled, The Multifaceted Roles of Adipose Tissue—Therapeutic Targets for Diabetes and Beyond: The 2015 Banting Lecture
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