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Piero Marchetti
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Journal Articles

PNLIPRP1 Hypermethylation in Exocrine Pancreas Links Type 2 Diabetes and Cholesterol Metabolism

Lucas Maurin, Lorella Marselli, Mathilde Boissel, Lijiao Ning, Raphael Boutry, Justine Fernandes, Mara Suleiman, Carmela De Luca, Audrey Leloire, Vincent Pascat, Bénédicte Toussaint, Souhila Amanzougarene, Mehdi Derhourhi, Anne Jörns, Sigurd Lenzen, François Pattou, Julie Kerr-Conte, Mickaël Canouil, Piero Marchetti, Amélie Bonnefond, Philippe Froguel, Amna Khamis
Journal: Diabetes
Diabetes 2024;73(11):1908–1918
https://doi.org/10.2337/db24-0215
Published: 13 August 2024
View article titled, <em>PNLIPRP1</em> Hypermethylation in Exocrine Pancreas Links Type 2 Diabetes and Cholesterol Metabolism
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Meeting Abstracts

1750-P: Rescuing Human Beta-Cell Dysfunction Induced by Proinflammatory Cytokines and Glucotoxicity

MARTA TESI, MARA SULEIMAN, ROBERTO SEMERARO, CARMELA DE LUCA, EMANUELE BOSI, SILVIA DEL GUERRA, ALBERTO MAGI, MIRIAM CNOP, DECIO L. EIZIRIK, LORELLA MARSELLI, PIERO MARCHETTI
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1750-P
https://doi.org/10.2337/db24-1750-P
Published: 14 June 2024
View article titled, 1750-P: Rescuing Human Beta-Cell Dysfunction Induced by Proinflammatory Cytokines and Glucotoxicity
Meeting Abstracts

415-P: Different Diabetic Kidney Disease (DKD) Phenotypes and Urinary Fetuin-A Levels in Subjects with Type 2 Diabetes

MONIA GAROFOLO, DANIELA LUCCHESI, MASSIMO GIAMBALVO, MARTINA CAPOBIANCO, GABRIELE MANCINI, STEFANO DEL PRATO, PIERO MARCHETTI, GIUSEPPE PENNO
Journal: Diabetes
Diabetes 2024;73(Supplement_1):415-P
https://doi.org/10.2337/db24-415-P
Published: 14 June 2024
View article titled, 415-P: Different Diabetic Kidney Disease (DKD) Phenotypes and Urinary Fetuin-A Levels in Subjects with Type 2 Diabetes
Meeting Abstracts

1315-P: Pre– and Post–Liver Transplant Diabetes (DM) and Prediabetes (PD), and the Impact on Transplant Outcomes—Results of a Large Single-Center Study

MILENA SCOPELLITI, CATO VAN STRIJDONCK, GIZEM GEZICI, PAOLA CARRAI, STEFANIA PETRUCCELLI, GABRIELE CATALANO, CATERINA MARTINELLI, JESSICA BRONZONI, DANIELE PEZZATI, GIOVANNI TINCANI, EMANUELE BALZANO, FRANCESCA R. FEMIA, ROBERTA DEL TESTA, ROBERTO PELLUNGRINI, DINO PEDRESCHI, FOSCA GIANNOTTI, PIERO MARCHETTI, DAVIDE GHINOLFI, PAOLO DE SIMONE, LORELLA MARSELLI
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1315-P
https://doi.org/10.2337/db24-1315-P
Published: 14 June 2024
View article titled, 1315-P: Pre– and Post–Liver Transplant Diabetes (DM) and Prediabetes (PD), and the Impact on Transplant Outcomes—Results of a Large Single-Center Study
Meeting Abstracts

1465-P: The C1858T Polymorphism in PTPN22 Modulates the Human Pancreatic Islet Transcriptome

MARA SULEIMAN, CARMELA DE LUCA, ROBERTO SEMERARO, EMANUELE BOSI, ALBERTO MAGI, MARTA TESI, SILVIA DEL GUERRA, OLIVIA PAGLIAROSI, ANNAMARIA CUDINI, LEONARDO ROSSI, DECIO L. EIZIRIK, MIRIAM CNOP, PIERO MARCHETTI, LORELLA MARSELLI, ALESSANDRA FIERABRACCI
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1465-P
https://doi.org/10.2337/db24-1465-P
Published: 14 June 2024
View article titled, 1465-P: The C1858T Polymorphism in PTPN22 Modulates the Human Pancreatic Islet Transcriptome
Meeting Abstracts

1251-P: CGM-Derived Metrics and Neonatal Outcomes in Pregnant Women with Insulin-Treated Diabetes—Time for Refinement?

FABRIZIA CITRO, CRISTINA BIANCHI, MICHELE ARAGONA, PIERO MARCHETTI, ALESSANDRA BERTOLOTTO
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1251-P
https://doi.org/10.2337/db24-1251-P
Published: 14 June 2024
View article titled, 1251-P: CGM-Derived Metrics and Neonatal Outcomes in Pregnant Women with Insulin-Treated Diabetes—Time for Refinement?
Meeting Abstracts

1471-P: Impaired Delta Opioid Receptor Function Protects against Type 2 Diabetes and Results in Enhanced Insulin Secretion—A Functional Genetic Study

AMELIE BONNEFOND, RADIO GROUP, RAPHAEL SCHARFMANN, PIERO MARCHETTI, MIRIAM CNOP, PHILIPPE FROGUEL
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1471-P
https://doi.org/10.2337/db24-1471-P
Published: 14 June 2024
View article titled, 1471-P: Impaired Delta Opioid Receptor Function Protects against Type 2 Diabetes and Results in Enhanced Insulin Secretion—A Functional Genetic Study
Journal Articles

CD4+ T Cells From Individuals With Type 1 Diabetes Respond to a Novel Class of Deamidated Peptides Formed in Pancreatic Islets

Aïsha Callebaut, Perrin Guyer, Rita Derua, Mijke Buitinga, Anthony Manganaro, Xiaoyan Yi, Fernanda Marques Câmara Sodré, Saurabh Vig, Mara Suleiman, Piero Marchetti, Decio L. Eizirik, Sally C. Kent, Chantal Mathieu, Eddie A. James, Lut Overbergh
Journal: Diabetes
Diabetes 2024;73(5):728–742
https://doi.org/10.2337/db23-0588
Published: 22 February 2024
View article titled, CD4<sup>+</sup> T Cells From Individuals With Type 1 Diabetes Respond to a Novel Class of Deamidated Peptides Formed in Pancreatic Islets
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Meeting Abstracts

227-LB: Kynurenine Pathway Is Associated with Preservation of Beta-Cell Function in Autoimmune Diabetes

ERNESTO MADDALONI, AMALIA GASTALDELLI, LUCA NAVARINI, ROCCO AMENDOLARA, SIMONA FENIZIA, SAMANTHA PEZZICA, MARTA TESI, LUCA D'ONOFRIO, EMANUELE BOSI, FRANCESCO DOTTA, PIERO MARCHETTI, RAFFAELLA BUZZETTI
Journal: Diabetes
Diabetes 2023;72(Supplement_1):227-LB
https://doi.org/10.2337/db23-227-LB
Published: 20 June 2023
View article titled, 227-LB: Kynurenine Pathway Is Associated with Preservation of Beta-Cell Function in Autoimmune Diabetes
Journal Articles

The p66Shc Protein Mediates Insulin Resistance and Secretory Dysfunction in Pancreatic β-Cells Under Lipotoxic Conditions

Giuseppina Biondi, Nicola Marrano, Lucia Dipaola, Anna Borrelli, Martina Rella, Rossella D’Oria, Valentina A. Genchi, Cristina Caccioppoli, Immacolata Porreca, Angelo Cignarelli, Sebastio Perrini, Piero Marchetti, Leonardo Vincenti, Luigi Laviola, Francesco Giorgino, Annalisa Natalicchio
Journal: Diabetes
Diabetes 2022;71(8):1763–1771
https://doi.org/10.2337/db21-1066
Published: 21 August 2022
View article titled, The p66<sup>Shc</sup> Protein Mediates Insulin Resistance and Secretory Dysfunction in Pancreatic β-Cells Under Lipotoxic Conditions
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Journal Articles

Glucose-Dependent miR-125b Is a Negative Regulator of β-Cell Function

Rebecca Cheung, Grazia Pizza, Pauline Chabosseau, Delphine Rolando, Alejandra Tomas, Thomas Burgoyne, Zhiyi Wu, Anna Salowka, Anusha Thapa, Annabel Macklin, Yufei Cao, Marie-Sophie Nguyen-Tu, Matthew T. Dickerson, David A. Jacobson, Piero Marchetti, James Shapiro, Lorenzo Piemonti, Eelco de Koning, Isabelle Leclerc, Karim Bouzakri, Kei Sakamoto, David M. Smith, Guy A. Rutter, Aida Martinez-Sanchez
Journal: Diabetes
Diabetes 2022;71(7):1525–1545
https://doi.org/10.2337/db21-0803
Published: 27 April 2022
View article titled, Glucose-Dependent miR-125b Is a Negative Regulator of β-Cell Function
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Meeting Abstracts

87-LB: Binding Kinetics, Bias, Receptor Internalization, and Effects on Insulin Secretion for a Novel GLP1R-GIPR Dual Agonist, HISHS-2001

YUSMAN MANCHANDA, BEN JONES, GAELLE CARRAT, ZENOUSKA RAMCHUNDER, PIERO MARCHETTI, ISABELLE LECLERC, RAJAMANNAR THENNATI, VINOD S. BURADE, ALEJANDRA TOMAS, GUY A. RUTTER
Journal: Diabetes
Diabetes 2021;70(Supplement_1):87-LB
https://doi.org/10.2337/db21-87-LB
Published: 01 June 2021
View article titled, 87-LB: Binding Kinetics, Bias, Receptor Internalization, and Effects on Insulin Secretion for a Novel GLP1R-GIPR Dual Agonist, HISHS-2001
Meeting Abstracts

2087-P: Functional Genomics of Human Islet Gluco/Lipotoxicity and Type 2 Diabetes

XIAOYAN YI, LORELLA MARSELLI, ANTHONY PIRON, MARA SULEIMAN, FLORIAN SZYMCZAK, DECIO L. EIZIRIK, PIERO MARCHETTI, MIRIAM CNOP
Journal: Diabetes
Diabetes 2020;69(Supplement_1):2087-P
https://doi.org/10.2337/db20-2087-P
Published: 01 June 2020
View article titled, 2087-P: Functional Genomics of Human Islet Gluco/Lipotoxicity and Type 2 Diabetes
Meeting Abstracts

273-OR: Intrapancreatic Adipose Tissue of Nondiabetic and Type 2 Diabetic Subjects and Relationships with Islet Morphometry

MARA SULEIMAN, CARMELA DE LUCA, PAOLO DE SIMONE, UGO BOGGI, FRANCESCA GRANO, MARCO BUGLIANI, PIERO MARCHETTI, LORELLA MARSELLI
Journal: Diabetes
Diabetes 2019;68(Supplement_1):273-OR
https://doi.org/10.2337/db19-273-OR
Published: 01 June 2019
View article titled, 273-OR: Intrapancreatic Adipose Tissue of Nondiabetic and Type 2 Diabetic Subjects and Relationships with Islet Morphometry
Meeting Abstracts

195-OR: The P66Shc Protein Mediates Insulin Resistance in Pancreatic ß Cells Under Lipotoxic Conditions

LUCIA DIPAOLA, ANNALISA NATALICCHIO, GIUSEPPINA BIONDI, NICOLA MARRANO, MARCO BUGLIANI, ANGELO CIGNARELLI, SEBASTIO PERRINI, PIERO MARCHETTI, LUIGI LAVIOLA, FRANCESCO GIORGINO
Journal: Diabetes
Diabetes 2019;68(Supplement_1):195-OR
https://doi.org/10.2337/db19-195-OR
Published: 01 June 2019
View article titled, 195-OR: The P66<sup>Shc</sup> Protein Mediates Insulin Resistance in Pancreatic ß Cells Under Lipotoxic Conditions
Meeting Abstracts

2136-P: Effects of Cytokine Exposure on the Proteome of Human Islets as Evaluated by Shotgun and 2DE Analysis

FRANCESCA GRANO, FEDERICA CIREGIA, MAURIZIO RONCI, MARIA ROSA MAZZONI, LUTGART OVERBERGH, CARMELA DE LUCA, MARA SULEIMAN, LORELLA MARSELLI, PAOLO DE SIMONE, UGO BOGGI, CHANTAL MATHIEU, DECIO L. EIZIRIK, SR., ANTONIO LUCACCHINI, LAURA GIUSTI, PIERO MARCHETTI, MARCO BUGLIANI
Journal: Diabetes
Diabetes 2019;68(Supplement_1):2136-P
https://doi.org/10.2337/db19-2136-P
Published: 01 June 2019
View article titled, 2136-P: Effects of Cytokine Exposure on the Proteome of Human Islets as Evaluated by Shotgun and 2DE Analysis
Journal Articles

A Call for Improved Reporting of Human Islet Characteristics in Research Articles

Vincent Poitout, Leslie S. Satin, Steven E. Kahn, Doris A. Stoffers, Piero Marchetti, Maureen Gannon, C. Bruce Verchere, Kevan C. Herold, Martin G. Myers, Jr., Sally M. Marshall
Journal: Diabetes
Diabetes 2019;68(2):239–240
https://doi.org/10.2337/dbi18-0055
Published: 14 December 2018
View article titled, A Call for Improved Reporting of Human Islet Characteristics in Research Articles
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Journal Articles

Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes

Mijke Buitinga, Aïsha Callebaut, Fernanda Marques Câmara Sodré, Inne Crèvecoeur, Gabriele Blahnik-Fagan, Mei-Ling Yang, Marco Bugliani, David Arribas-Layton, Meghan Marré, Dana P. Cook, Etienne Waelkens, Roberto Mallone, Jon D. Piganelli, Piero Marchetti, Mark J. Mamula, Rita Derua, Eddie A. James, Chantal Mathieu, Lut Overbergh
Journal: Diabetes
Diabetes 2018;67(11):2337–2348
https://doi.org/10.2337/db18-0295
Published: 11 October 2018
View article titled, Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes
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Includes: Supplementary data
Meeting Abstracts

The Increment of Noradrenergic Fibers Correlates with the Density of Dedifferentiated ß Cells in Humans

FRANCESCA CINTI, ILENIA SEVERI, MARA SULEIMAN, LORELLA MARSELLI, PIERO MARCHETTI, SAVERIO CINTI, DOMENICO ACCILI
Journal: Diabetes
Diabetes 2018;67(Supplement_1):2142-P
https://doi.org/10.2337/db18-2142-P
Published: 01 July 2018
View article titled, The Increment of Noradrenergic Fibers Correlates with the Density of Dedifferentiated ß Cells in Humans
Journal Articles

A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic β-Cells

Teresa Buenaventura, Nisha Kanda, Phoebe C. Douzenis, Ben Jones, Stephen R. Bloom, Pauline Chabosseau, Ivan R. Corrêa, Jr., Domenico Bosco, Lorenzo Piemonti, Piero Marchetti, Paul R. Johnson, A.M. James Shapiro, Guy A. Rutter, Alejandra Tomas
Journal: Diabetes
Diabetes 2018;67(3):385–399
https://doi.org/10.2337/db17-0639
Published: 28 December 2017
View article titled, A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic β-Cells
Open the PDF for A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic β-Cells in another window
Includes: Supplementary data