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Rachel M. Freathy
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Journal Articles

Babies of South Asian and European Ancestry Show Similar Associations With Genetic Risk Score for Birth Weight Despite the Smaller Size of South Asian Newborns

Suraj S. Nongmaithem, Robin N. Beaumont, Akshay Dedaniya, Andrew R. Wood, Babatunji-William Ogunkolade, Zahid Hassan, Ghattu V. Krishnaveni, Kalyanaraman Kumaran, Ramesh D. Potdar, Sirazul A. Sahariah, Murali Krishna, Chiara Di Gravio, Inder D. Mali, Alagu Sankareswaran, Akhtar Hussain, Biswajit W. Bhowmik, Abdul Kalam A. Khan, Bridget A. Knight, Timothy M. Frayling, Sarah Finer, Caroline H.D. Fall, Chittaranjan S. Yajnik, Rachel M. Freathy, Graham A. Hitman, Giriraj R. Chandak
Journal: Diabetes
Diabetes 2022;71(4):821–836
https://doi.org/10.2337/db21-0479
Published: 21 January 2022
View articletitled, Babies of South Asian and European Ancestry Show Similar Associations With Genetic Risk Score for Birth Weight Despite the Smaller Size of South Asian Newborns
Open the PDF for Babies of South Asian and European Ancestry Show Similar Associations With Genetic Risk Score for Birth Weight Despite the Smaller Size of South Asian Newborns in another window
Journal Articles

Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype Is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension

Yingjie Ji, Andrianos M. Yiorkas, Francesca Frau, Dennis Mook-Kanamori, Harald Staiger, E. Louise Thomas, Naeimeh Atabaki-Pasdar, Archie Campbell, Jessica Tyrrell, Samuel E. Jones, Robin N. Beaumont, Andrew R. Wood, Marcus A. Tuke, Katherine S. Ruth, Anubha Mahajan, Anna Murray, Rachel M. Freathy, Michael N. Weedon, Andrew T. Hattersley, Caroline Hayward, Jürgen Machann, Hans-Ulrich Häring, Paul Franks, Renée de Mutsert, Ewan Pearson, Norbert Stefan, Timothy M. Frayling, Karla V. Allebrandt, Jimmy D. Bell, Alexandra I. Blakemore, Hanieh Yaghootkar
Journal: Diabetes
Diabetes 2019;68(1):207–219
https://doi.org/10.2337/db18-0708
Published: 23 October 2018
View articletitled, Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype Is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension
Open the PDF for Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype Is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension in another window
Includes: Supplementary data
Meeting Abstracts

Physical Inactivity and Sleep Inefficiency Accentuate the Genetic Risk of Obesity

ANDREW R. WOOD, SAMUEL E. JONES, REBECCA RICHMOND, SHAFQAT AHMAD, HANIEH YAGHOOTKAR, ROBERT BEAUMONT, KATHERINE S. RUTH, MARCUS TUKE, ANNA MURRAY, RACHEL M. FREATHY, GEORGE DAVEY SMITH, I-MIN LEE, NIC TIMPSON, DANIEL CHASMAN, ZOLTAN KUTALIK, MICHAEL N. WEEDON, JESSICA TYRRELL, TIMOTHY M. FRAYLING
Journal: Diabetes
Diabetes 2018;67(Supplement_1):23-OR
https://doi.org/10.2337/db18-23-OR
Published: 01 July 2018
View articletitled, Physical Inactivity and Sleep Inefficiency Accentuate the Genetic Risk of Obesity
Journal Articles

Fetal Genotype and Maternal Glucose Have Independent and Additive Effects on Birth Weight

Alice E. Hughes, Michael Nodzenski, Robin N. Beaumont, Octavious Talbot, Beverley M. Shields, Denise M. Scholtens, Bridget A. Knight, William L. Lowe, Jr., Andrew T. Hattersley, Rachel M. Freathy
Journal: Diabetes
Diabetes 2018;67(5):1024–1029
https://doi.org/10.2337/db17-1188
Published: 20 February 2018
View articletitled, Fetal Genotype and Maternal Glucose Have Independent and Additive Effects on Birth Weight
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Includes: Supplementary data
Journal Articles

Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease

Hanieh Yaghootkar, Luca A. Lotta, Jessica Tyrrell, Roelof A.J. Smit, Sam E. Jones, Louise Donnelly, Robin Beaumont, Archie Campbell, Marcus A. Tuke, Caroline Hayward, Katherine S. Ruth, Sandosh Padmanabhan, J. Wouter Jukema, Colin C. Palmer, Andrew Hattersley, Rachel M. Freathy, Claudia Langenberg, Nicholas J. Wareham, Andrew R. Wood, Anna Murray, Michael N. Weedon, Naveed Sattar, Ewan Pearson, Robert A. Scott, Timothy M. Frayling
Journal: Diabetes
Diabetes 2016;65(8):2448–2460
https://doi.org/10.2337/db15-1671
Published: 26 April 2016
View articletitled, Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease
Open the PDF for Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease in another window
Includes: Supplementary data
Journal Articles

Association Analysis of 29,956 Individuals Confirms That a Low-Frequency Variant at CCND2 Halves the Risk of Type 2 Diabetes by Enhancing Insulin Secretion

Hanieh Yaghootkar, Alena Stancáková, Rachel M. Freathy, Jagadish Vangipurapu, Michael N. Weedon, Weijia Xie, Andrew R. Wood, Ele Ferrannini, Andrea Mari, Susan M. Ring, Debbie A. Lawlor, George Davey Smith, Torben Jørgensen, Torben Hansen, Oluf Pedersen, Valgerdur Steinthorsdottir, Daniel F. Guðbjartsson, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Kari Stefansson, Andrew T. Hattersley, Mark Walker, Andrew D. Morris, Mark I. McCarthy, Colin N.A. Palmer, Markku Laakso, Timothy M. Frayling
Journal: Diabetes
Diabetes 2015;64(6):2279–2285
https://doi.org/10.2337/db14-1456
Published: 20 January 2015
View articletitled, Association Analysis of 29,956 Individuals Confirms That a Low-Frequency Variant at CCND2 Halves the Risk of Type 2 Diabetes by Enhancing Insulin Secretion
Open the PDF for Association Analysis of 29,956 Individuals Confirms That a Low-Frequency Variant at CCND2 Halves the Risk of Type 2 Diabetes by Enhancing Insulin Secretion in another window
Includes: Supplementary data
Journal Articles

Mendelian Randomization Studies Do Not Support a Role for Raised Circulating Triglyceride Levels Influencing Type 2 Diabetes, Glucose Levels, or Insulin Resistance

N. Maneka G. De Silva, Rachel M. Freathy, Tom M. Palmer, Louise A. Donnelly, Jian'an Luan, Tom Gaunt, Claudia Langenberg, Michael N. Weedon, Beverley Shields, Beatrice A. Knight, Kirsten J. Ward, Manjinder S. Sandhu, Roger M. Harbord, Mark I. McCarthy, George Davey Smith, Shah Ebrahim, Andrew T. Hattersley, Nicholas Wareham, Debbie A. Lawlor, Andrew D. Morris, Colin N.A. Palmer, Timothy M. Frayling
Journal: Diabetes
Diabetes 2011;60(3):1008–1018
https://doi.org/10.2337/db10-1317
Published: 21 February 2011
View articletitled, Mendelian Randomization Studies Do Not Support a Role for Raised Circulating Triglyceride Levels Influencing Type 2 Diabetes, Glucose Levels, or Insulin Resistance
Open the PDF for Mendelian Randomization Studies Do Not Support a Role for Raised Circulating Triglyceride Levels Influencing Type 2 Diabetes, Glucose Levels, or Insulin Resistance in another window
Includes: Supplementary data
Journal Articles

Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: Common Genetic Variants in GCK and TCF7L2 Are Associated With Fasting and Postchallenge Glucose Levels in Pregnancy and With the New Consensus Definition of Gestational Diabetes Mellitus From the International Association of Diabetes and Pregnancy Study Groups

Rachel M. Freathy, M. Geoffrey Hayes, Margrit Urbanek, Lynn P. Lowe, Hoon Lee, Christine Ackerman, Timothy M. Frayling, Nancy J. Cox, David B. Dunger, Alan R. Dyer, Andrew T. Hattersley, Boyd E. Metzger, William L. Lowe, Jr, for the HAPO Study Cooperative Research Group
Journal: Diabetes
Diabetes 2010;59(10):2682–2689
https://doi.org/10.2337/db10-0177
Published: 03 August 2010
View articletitled, Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: Common Genetic Variants in GCK and TCF7L2 Are Associated With Fasting and Postchallenge Glucose Levels in Pregnancy and With the New Consensus Definition of Gestational Diabetes Mellitus From the International Association of Diabetes and Pregnancy Study Groups
Open the PDF for Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: Common Genetic Variants in GCK and TCF7L2 Are Associated With Fasting and Postchallenge Glucose Levels in Pregnancy and With the New Consensus Definition of Gestational Diabetes Mellitus From the International Association of Diabetes and Pregnancy Study Groups in another window
Includes: Supplementary data
Journal Articles

Type 2 Diabetes Risk Alleles Are Associated With Reduced Size at Birth

Rachel M. Freathy, Amanda J. Bennett, Susan M. Ring, Beverley Shields, Christopher J. Groves, Nicholas J. Timpson, Michael N. Weedon, Eleftheria Zeggini, Cecilia M. Lindgren, Hana Lango, John R.B. Perry, Anneli Pouta, Aimo Ruokonen, Elina Hyppönen, Chris Power, Paul Elliott, David P. Strachan, Marjo-Riitta Järvelin, George Davey Smith, Mark I. McCarthy, Timothy M. Frayling, Andrew T. Hattersley
Journal: Diabetes
Diabetes 2009;58(6):1428–1433
https://doi.org/10.2337/db08-1739
Published: 19 February 2009
View articletitled, Type 2 Diabetes Risk Alleles Are Associated With Reduced Size at Birth
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Includes: Supplementary data
Journal Articles

Common Variation in the FTO Gene Alters Diabetes-Related Metabolic Traits to the Extent Expected Given Its Effect on BMI

Rachel M. Freathy, Nicholas J. Timpson, Debbie A. Lawlor, Anneli Pouta, Yoav Ben-Shlomo, Aimo Ruokonen, Shah Ebrahim, Beverley Shields, Eleftheria Zeggini, Michael N. Weedon, Cecilia M. Lindgren, Hana Lango, David Melzer, Luigi Ferrucci, Giuseppe Paolisso, Matthew J. Neville, Fredrik Karpe, Colin N.A. Palmer, Andrew D. Morris, Paul Elliott, Marjo-Riitta Jarvelin, George Davey Smith, Mark I. McCarthy, Andrew T. Hattersley, Timothy M. Frayling
Journal: Diabetes
Diabetes 2008;57(5):1419–1426
https://doi.org/10.2337/db07-1466
Published: 01 May 2008
View articletitled, Common Variation in the FTO Gene Alters Diabetes-Related Metabolic Traits to the Extent Expected Given Its Effect on BMI
Open the PDF for Common Variation in the FTO Gene Alters Diabetes-Related Metabolic Traits to the Extent Expected Given Its Effect on BMI in another window
Includes: Supplementary data