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Meeting Abstracts

340-OR: Transcriptional Activation in Beta-Cells during ER Stress Linking iPLA₂beta with NFkB

XIAOYONG LEI, ANIL KUMAR CHALLA, YING TUSING, ERNESTO NAKAYASU, RAGHAVENDRA G. MIRMIRA, CHARLES E. CHALFANT, SASANKA RAMANADHAM

Diabetes 2024;73(Supplement_1):340-OR

https://doi.org/10.2337/db24-340-OR

Published: 14 June 2024

View articletitled, 340-OR: Transcriptional Activation in Beta-Cells during ER Stress Linking iPLA2beta with NFkB

Meeting Abstracts

288-OR: Inflammation-Induced Repression of Insulin Production by Targeting Its mRNA to Stress Granules via ADP-Ribosylation Machinery

SOUMYADEEP SARKAR, FANGJIA LI, EMILY ELLIOTT, MIREIA RAMOS-RODRÍGUEZ, YOUNGKI YOU, LORENZO PASQUALI, LORI SUSSEL, THOMAS METZ, RAGHAVENDRA G. MIRMIRA, ERNESTO NAKAYASU

Diabetes 2024;73(Supplement_1):288-OR

https://doi.org/10.2337/db24-288-OR

Published: 14 June 2024

View articletitled, 288-OR: Inflammation-Induced Repression of Insulin Production by Targeting Its mRNA to Stress Granules via ADP-Ribosylation Machinery

Meeting Abstracts

1162-P: Promoting Career Development of Physicians Engaged in Type 1 Diabetes (T1D) Research—The New DiabDocs Multicenter National K12 Program

KOMAL D. DASANI, FRANZISKA K. BISHOP, SHERITA GOLDEN, LORI M. LAFFEL, RAGHAVENDRA G. MIRMIRA, ANDREA STECK, WILLIAM V. TAMBORLANE, STEVEN M. WILLI, DAVID M. MAAHS, LINDA DIMEGLIO

Diabetes 2023;72(Supplement_1):1162-P

https://doi.org/10.2337/db23-1162-P

Published: 20 June 2023

View articletitled, 1162-P: Promoting Career Development of Physicians Engaged in Type 1 Diabetes (T1D) Research—The New DiabDocs Multicenter National K12 Program

Meeting Abstracts

217-LB: Heterogeneity of Single Cells Obtained from Peripheral Blood Mononuclear Cells Collected from Youth with Recent-Onset Type 1 Diabetes

WENTING WU, CORINNE PARKS-SCHENCK, TINGBO GUO, CHI ZHANG, RAGHAVENDRA G. MIRMIRA, CARMELLA EVANS-MOLINA

Diabetes 2023;72(Supplement_1):217-LB

https://doi.org/10.2337/db23-217-LB

Published: 20 June 2023

View articletitled, 217-LB: Heterogeneity of Single Cells Obtained from Peripheral Blood Mononuclear Cells Collected from Youth with Recent-Onset Type 1 Diabetes

Meeting Abstracts

1469-P: Inhibition of the Integrated Stress Response Increases PD-L1 in Islet ß-Cells and Protects against Autoimmune Diabetes

FEI HUANG, ABHISHEK KULKARNI, FAROOQ SYED, DAVID J. MALONEY, SARAH A. TERSEY, RAGHAVENDRA G. MIRMIRA

Diabetes 2022;71(Supplement_1):1469-P

https://doi.org/10.2337/db22-1469-P

Published: 01 June 2022

View articletitled, 1469-P: Inhibition of the Integrated Stress Response Increases PD-L1 in Islet ß-Cells and Protects against Autoimmune Diabetes

Meeting Abstracts

259-LB: Inhibition of the Polyamine-Hypusine Circuit Delimits Islet ß-Cell Stress in the Context of T1D via Suppression of IRE-1a Signaling

ANDY ANDERSON, ABHISHEK KULKARNI, RAGHAVENDRA G. MIRMIRA

Diabetes 2022;71(Supplement_1):259-LB

https://doi.org/10.2337/db22-259-LB

Published: 01 June 2022

View articletitled, 259-LB: Inhibition of the Polyamine-Hypusine Circuit Delimits Islet ß-Cell Stress in the Context of T1D via Suppression of IRE-1a Signaling

Journal Articles

Impact of Proinflammatory Cytokines on Alternative Splicing Patterns in Human Islets

Wenting Wu, Farooq Syed, Edward Simpson, Chih-Chun Lee, Jing Liu, Garrick Chang, Chuanpeng Dong, Clayton Seitz, Decio L. Eizirik, Raghavendra G. Mirmira, Yunlong Liu, Carmella Evans-Molina

Diabetes 2022;71(1):116–127

https://doi.org/10.2337/db20-0847

Published: 25 October 2021

View articletitled, Impact of Proinflammatory Cytokines on Alternative Splicing Patterns in Human Islets

Meeting Abstracts

291-OR: GPR31 Appears to Mediate the Downstream Actions of 12-Lipoxygenase in the Setting of Diabetic Inflammation

SARAH A. TERSEY, MELISSA WALSH, MARIMAR HERNANDEZ-PEREZ, JONATHAN DOWGIELEWICZ, ABHISHEK KULKARNI, RYAN ANDERSON, RAGHAVENDRA G. MIRMIRA

Diabetes 2021;70(Supplement_1):291-OR

https://doi.org/10.2337/db21-291-OR

Published: 01 June 2021

View articletitled, 291-OR: GPR31 Appears to Mediate the Downstream Actions of 12-Lipoxygenase in the Setting of Diabetic Inflammation

Meeting Abstracts

1164-P: A Zebrafish Nonalcoholic Fatty Liver Disease Model Links Liver Inflammation with Pancreatic Inflammation and Hyperglycemia

SARA IBRAHIM, ISRA HAIDER, ABHISHEK KULKARNI, ILIANA DOYCHEVA, RAGHAVENDRA G. MIRMIRA, EMILY K. SIMS, RYAN ANDERSON

Diabetes 2021;70(Supplement_1):1164-P

https://doi.org/10.2337/db21-1164-P

Published: 01 June 2021

View articletitled, 1164-P: A Zebrafish Nonalcoholic Fatty Liver Disease Model Links Liver Inflammation with Pancreatic Inflammation and Hyperglycemia

Meeting Abstracts

1240-P: Changes in Protein Expression during Islet Regeneration in a Cystic Fibrosis-Related Diabetes (CFRD) Ferret Model

HEBA M. ISMAIL, RAGHAVENDRA G. MIRMIRA, CARMELLA EVANS-MOLINA, ROBERT N. BONE

Diabetes 2021;70(Supplement_1):1240-P

https://doi.org/10.2337/db21-1240-P

Published: 01 June 2021

View articletitled, 1240-P: Changes in Protein Expression during Islet Regeneration in a Cystic Fibrosis-Related Diabetes (CFRD) Ferret Model

Journal Articles

Interleukin-6 Reduces β-Cell Oxidative Stress by Linking Autophagy With the Antioxidant Response

Michelle R. Marasco, Abass M. Conteh, Christopher A. Reissaus, John E. Cupit, V, Evan M. Appleman, Raghavendra G. Mirmira, Amelia K. Linnemann

Diabetes 2018;67(8):1576–1588

https://doi.org/10.2337/db17-1280

Published: 21 May 2018

View articletitled, Interleukin-6 Reduces β-Cell Oxidative Stress by Linking Autophagy With the Antioxidant Response

Includes: Supplementary data

Journal Articles

Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice

Diabetes 2018;67(9):1867–1879

https://doi.org/10.2337/db18-0158

Published: 30 April 2018

View articletitled, Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice

Includes: Supplementary data

Journal Articles

Inhibition of 12/15-Lipoxygenase Protects Against β-Cell Oxidative Stress and Glycemic Deterioration in Mouse Models of Type 1 Diabetes

Marimar Hernandez-Perez, Gaurav Chopra, Jonathan Fine, Abass M. Conteh, Ryan M. Anderson, Amelia K. Linnemann, Chanelle Benjamin, Jennifer B. Nelson, Kara S. Benninger, Jerry L. Nadler, David J. Maloney, Sarah A. Tersey, Raghavendra G. Mirmira

Diabetes 2017;66(11):2875–2887

https://doi.org/10.2337/db17-0215

Published: 25 August 2017

View articletitled, Inhibition of 12/15-Lipoxygenase Protects Against β-Cell Oxidative Stress and Glycemic Deterioration in Mouse Models of Type 1 Diabetes

Includes: Supplementary data

Journal Articles

Elevations in Circulating Methylated and Unmethylated Preproinsulin DNA in New-Onset Type 1 Diabetes

Marisa M. Fisher, Renecia A. Watkins, Janice Blum, Carmella Evans-Molina, Naga Chalasani, Linda A. DiMeglio, Kieren J. Mather, Sarah A. Tersey, Raghavendra G. Mirmira

Diabetes 2015;64(11):3867–3872

https://doi.org/10.2337/db15-0430

Published: 27 July 2015

View articletitled, Elevations in Circulating Methylated and Unmethylated Preproinsulin DNA in New-Onset Type 1 Diabetes

Includes: Supplementary data

Journal Articles

Palmitate Induces mRNA Translation and Increases ER Protein Load in Islet β-Cells via Activation of the Mammalian Target of Rapamycin Pathway

Masayuki Hatanaka, Bernhard Maier, Emily K. Sims, Andrew T. Templin, Rohit N. Kulkarni, Carmella Evans-Molina, Raghavendra G. Mirmira

Diabetes 2014;63(10):3404–3415

https://doi.org/10.2337/db14-0105

Published: 15 September 2014

View articletitled, Palmitate Induces mRNA Translation and Increases ER Protein Load in Islet β-Cells via Activation of the Mammalian Target of Rapamycin Pathway

Includes: Supplementary data

Journal Articles

Achieving “PeaK-A” Insulin Secretion

Carmella Evans-Molina, Raghavendra G. Mirmira

Diabetes 2013;62(5):1389–1390

https://doi.org/10.2337/db13-0196

Published: 16 April 2013

View articletitled, Achieving “PeaK-A” Insulin Secretion

Journal Articles

Islet β-Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model

Sarah A. Tersey, Yurika Nishiki, Andrew T. Templin, Susanne M. Cabrera, Natalie D. Stull, Stephanie C. Colvin, Carmella Evans-Molina, Jenna L. Rickus, Bernhard Maier, Raghavendra G. Mirmira

Diabetes 2012;61(4):818–827

https://doi.org/10.2337/db11-1293

Published: 14 March 2012

View articletitled, Islet β-Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model

Includes: Supplementary data

Journal Articles

Δ40 Isoform of p53 Controls β-Cell Proliferation and Glucose Homeostasis in Mice

Charlotte Hinault, Dan Kawamori, Chong Wee Liew, Bernhard Maier, Jiang Hu, Susanna R. Keller, Raghavendra G. Mirmira, Heidi Scrable, Rohit N. Kulkarni

Diabetes 2011;60(4):1210–1222

https://doi.org/10.2337/db09-1379

Published: 22 March 2011

View articletitled, Δ40 Isoform of p53 Controls β-Cell Proliferation and Glucose Homeostasis in Mice

Includes: Supplementary data

Journal Articles

Methyltransferase Set7/9 Maintains Transcription and Euchromatin Structure at Islet-Enriched Genes

Tye G. Deering, Takeshi Ogihara, Anthony P. Trace, Bernhard Maier, Raghavendra G. Mirmira

Diabetes 2009;58(1):185–193

https://doi.org/10.2337/db08-1150

Published: 01 January 2009

View articletitled, Methyltransferase Set7/9 Maintains Transcription and Euchromatin Structure at Islet-Enriched Genes

Includes: Supplementary data

Journal Articles

Cyclical and Alternating Infusions of Glucose and Intralipid in Rats Inhibit Insulin Gene Expression and Pdx-1 Binding in Islets

Derek K. Hagman, Martin G. Latour, Swarup K. Chakrabarti, Ghislaine Fontes, Julie Amyot, Caroline Tremblay, Meriem Semache, James A. Lausier, Violet Roskens, Raghavendra G. Mirmira, Thomas L. Jetton, Vincent Poitout

Diabetes 2008;57(2):424–431

https://doi.org/10.2337/db07-1285

Published: 01 February 2008

View articletitled, Cyclical and Alternating Infusions of Glucose and Intralipid in Rats Inhibit Insulin Gene Expression and Pdx-1 Binding in Islets

Includes: Supplementary data

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340-OR: Transcriptional Activation in Beta-Cells during ER Stress Linking iPLA₂beta with NFkB

288-OR: Inflammation-Induced Repression of Insulin Production by Targeting Its mRNA to Stress Granules via ADP-Ribosylation Machinery

1162-P: Promoting Career Development of Physicians Engaged in Type 1 Diabetes (T1D) Research—The New DiabDocs Multicenter National K12 Program

217-LB: Heterogeneity of Single Cells Obtained from Peripheral Blood Mononuclear Cells Collected from Youth with Recent-Onset Type 1 Diabetes

1469-P: Inhibition of the Integrated Stress Response Increases PD-L1 in Islet ß-Cells and Protects against Autoimmune Diabetes

259-LB: Inhibition of the Polyamine-Hypusine Circuit Delimits Islet ß-Cell Stress in the Context of T1D via Suppression of IRE-1a Signaling

Impact of Proinflammatory Cytokines on Alternative Splicing Patterns in Human Islets

291-OR: GPR31 Appears to Mediate the Downstream Actions of 12-Lipoxygenase in the Setting of Diabetic Inflammation

1164-P: A Zebrafish Nonalcoholic Fatty Liver Disease Model Links Liver Inflammation with Pancreatic Inflammation and Hyperglycemia

1240-P: Changes in Protein Expression during Islet Regeneration in a Cystic Fibrosis-Related Diabetes (CFRD) Ferret Model

Interleukin-6 Reduces β-Cell Oxidative Stress by Linking Autophagy With the Antioxidant Response

Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice

Inhibition of 12/15-Lipoxygenase Protects Against β-Cell Oxidative Stress and Glycemic Deterioration in Mouse Models of Type 1 Diabetes

Elevations in Circulating Methylated and Unmethylated Preproinsulin DNA in New-Onset Type 1 Diabetes

Palmitate Induces mRNA Translation and Increases ER Protein Load in Islet β-Cells via Activation of the Mammalian Target of Rapamycin Pathway

Achieving “PeaK-A” Insulin Secretion

Islet β-Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model

Δ40 Isoform of p53 Controls β-Cell Proliferation and Glucose Homeostasis in Mice

Methyltransferase Set7/9 Maintains Transcription and Euchromatin Structure at Islet-Enriched Genes

Cyclical and Alternating Infusions of Glucose and Intralipid in Rats Inhibit Insulin Gene Expression and Pdx-1 Binding in Islets

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