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Ralph A. DeFronzo
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Journal Articles

Effect of Hyperketonemia on Myocardial Function in Patients With Heart Failure and Type 2 Diabetes

Carolina Solis-Herrera, Yuejuan Qin, Henri Honka, Eugenio Cersosimo, Curtis Triplitt, Sivaram Neppala, Jemena Rajan, Francisca M. Acosta, Alexander J. Moody, Patricio Iozzo, Peter Fox, Geoffrey Clarke, Ralph A. DeFronzo
Journal: Diabetes
Diabetes 2024;74(1):43–52
https://doi.org/10.2337/db24-0406
Published: 24 October 2024
View article titled, Effect of Hyperketonemia on Myocardial Function in Patients With Heart Failure and Type 2 Diabetes
Open the PDF for Effect of Hyperketonemia on Myocardial Function in Patients With Heart Failure and Type 2 Diabetes in another window
Meeting Abstracts

1667-P: Mesenteric Visceral Lipectomy (MVL) Improves Glucose Tolerance in Patients with Type 2 Diabetes (T2D)

GOZDE BASKOY, RICHARD M. PETERSON, JASON W. KEMPENICH, CURTIS L. TRIPLITT, GEOFFREY D. CLARKE, EUGENIO CERSOSIMO, MARK S. ANDREW, AURORA MEROVCI, OLGA LAVRYNENKO, ANDREA A. HANSIS-DIARTE, CAROLINA SOLIS-HERRERA, ALBERTO CHAVEZ, MARZIEH SALEHI, RALPH A. DEFRONZO
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1667-P
https://doi.org/10.2337/db24-1667-P
Published: 14 June 2024
View article titled, 1667-P: Mesenteric Visceral Lipectomy (MVL) Improves Glucose Tolerance in Patients with Type 2 Diabetes (T2D)
Meeting Abstracts

138-OR: Pioglitazone Amplifies the Decrease in HbA1c and Prevents the Increase in Plasma Ketone Caused by Dapagliflozin in Type 1 Diabetes Mellitus Patients

MUHAMMAD ABDUL-GHANI, GOZDE BASKOY, AFIF NAKHLEH, SIHAM ABDELGANI, FAHD AL-MULLA, MOHAMED ABU-FARHA, FAHAD ALAJMI, THAMER ALESSA, RALPH A. DEFRONZO, NAIM SHEHADEH
Journal: Diabetes
Diabetes 2024;73(Supplement_1):138-OR
https://doi.org/10.2337/db24-138-OR
Published: 14 June 2024
View article titled, 138-OR: Pioglitazone Amplifies the Decrease in HbA1c and Prevents the Increase in Plasma Ketone Caused by Dapagliflozin in Type 1 Diabetes Mellitus Patients
Meeting Abstracts

910-P: Novel Mechanism of Action Associated with SGLT2 Inhibition, Peripheral Energy Utilization, and CV Benefits in Subjects with Type 2 Diabetes Mellitus and HFrEF

YUEJUAN QIN, NOAH D. SANCHEZ, FRANCISCA M. ACOSTA, ALEXANDER MOODY, SIVARAM NEPPALA, CURTIS L. TRIPLITT, GEOFFREY D. CLARKE, EUGENIO CERSOSIMO, RALPH A. DEFRONZO, CAROLINA SOLIS-HERRERA
Journal: Diabetes
Diabetes 2024;73(Supplement_1):910-P
https://doi.org/10.2337/db24-910-P
Published: 14 June 2024
View article titled, 910-P: Novel Mechanism of Action Associated with SGLT2 Inhibition, Peripheral Energy Utilization, and CV Benefits in Subjects with Type 2 Diabetes Mellitus and HFrEF
Meeting Abstracts

139-OR: Empagliflozin Enhances Hepatic Glucose Production and Reduces Total-Body Norepinephrine Turnover Rate—A Randomized Trial

SIHAM ABDELGANI, GOZDE BASKOY, JOHN M. ADAMS, II, AHMED KHATTAB, RALPH A. DEFRONZO, MUHAMMAD ABDUL-GHANI
Journal: Diabetes
Diabetes 2024;73(Supplement_1):139-OR
https://doi.org/10.2337/db24-139-OR
Published: 14 June 2024
View article titled, 139-OR: Empagliflozin Enhances Hepatic Glucose Production and Reduces Total-Body Norepinephrine Turnover Rate—A Randomized Trial
Meeting Abstracts

278-OR: Single-Nucleus Multiomics Profiling across 49 Individuals of Hispanic Ancestry Reveals Cell-Specific Skeletal Muscle Insulin-Responsive Gene Regulatory Signatures

BENJAMIN LI, ARUSHI VARSHNEY, ADELAIDE TOVAR, NANDINI MANICKAM, PETER ORCHARD, RALPH A. DEFRONZO, LUKE NORTON, STEPHEN PARKER
Journal: Diabetes
Diabetes 2024;73(Supplement_1):278-OR
https://doi.org/10.2337/db24-278-OR
Published: 14 June 2024
View article titled, 278-OR: Single-Nucleus Multiomics Profiling across 49 Individuals of Hispanic Ancestry Reveals Cell-Specific Skeletal Muscle Insulin-Responsive Gene Regulatory Signatures
Meeting Abstracts

1550-P: Changes in Beta-Cell Function during Dapagliflozin Therapy in Combination with Exenatide in Type 2 Diabetes Patients (T2D)

RALPH A. DEFRONZO, GOZDE BASKOY, CURTIS L. TRIPLITT, EUGENIO CERSOSIMO, CAROLINA SOLIS-HERRERA, JOHN M. ADAMS, II, ANDREA A. HANSIS-DIARTE, AMALIA GASTALDELLI, ALBERTO CHAVEZ
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1550-P
https://doi.org/10.2337/db24-1550-P
Published: 14 June 2024
View article titled, 1550-P: Changes in Beta-Cell Function during Dapagliflozin Therapy in Combination with Exenatide in Type 2 Diabetes Patients (T2D)
Journal Articles

Effect of Dapagliflozin on Renal and Hepatic Glucose Kinetics in T2D and NGT Subjects

Xi Chen, Devjit Tripathy, Robert Chilton, Andrea Hansis-Diarte, Marzieh Salehi, Carolina Solis-Herrera, Eugenio Cersosimo, Ralph A. DeFronzo
Journal: Diabetes
Diabetes 2024;73(6):896–902
https://doi.org/10.2337/db23-0457
Published: 21 March 2024
View article titled, Effect of Dapagliflozin on Renal and Hepatic Glucose Kinetics in T2D and NGT Subjects
Open the PDF for Effect of Dapagliflozin on Renal and Hepatic Glucose Kinetics in T2D and NGT Subjects in another window
Meeting Abstracts

869-P: Effect of Dapagliflozin on Renal Oxygen Delivery and Consumption in T2DM and NGT Subjects

DEVJIT TRIPATHY, XI CHEN, ROBERT CHILTON, ANDREA A. HANSIS-DIARTE, MARZIEH SALEHI, CAROLINA SOLIS-HERRERA, EUGENIO CERSOSIMO, RALPH A. DEFRONZO
Journal: Diabetes
Diabetes 2023;72(Supplement_1):869-P
https://doi.org/10.2337/db23-869-P
Published: 20 June 2023
View article titled, 869-P: Effect of Dapagliflozin on Renal Oxygen Delivery and Consumption in T2DM and NGT Subjects
Meeting Abstracts

68-LB: Early Pharmacological Intervention (EPIC) to Preserve Beta-Cell Function in Prediabetes (PreDM)

ALBERTO CHAVEZ, AURORA MEROVCI, SIVARAM NEPPALA, LUIS A. CRUZ MORENO, GOZDE BASKOY, FRANCISCA M. ACOSTA, ANDREA A. HANSIS-DIARTE, CURTISS L. PUCKETT, JR., JOHN M. ADAMS, III, MUHAMMAD ABDUL-GHANI, CURTIS L. TRIPLITT, EUGENIO CERSOSIMO, RALPH A. DEFRONZO
Journal: Diabetes
Diabetes 2023;72(Supplement_1):68-LB
https://doi.org/10.2337/db23-68-LB
Published: 20 June 2023
View article titled, 68-LB: Early Pharmacological Intervention (EPIC) to Preserve Beta-Cell Function in Prediabetes (PreDM)
Meeting Abstracts

124-OR: Effects of Dapagliflozin Therapy on Renal Hemodynamics in Type 2 Diabetes Patients

YUEJUAN QIN, GOZDE BASKOY, CURTIS L. TRIPLITT, CAROLINA SOLIS-HERRERA, JOHN M. ADAMS__III, RALPH A. DEFRONZO, EUGENIO CERSOSIMO
Journal: Diabetes
Diabetes 2023;72(Supplement_1):124-OR
https://doi.org/10.2337/db23-124-OR
Published: 20 June 2023
View article titled, 124-OR: Effects of Dapagliflozin Therapy on Renal Hemodynamics in Type 2 Diabetes Patients
Meeting Abstracts

99-LB: Myocardial Blood Flow in Association with Baseline Ejection Fraction after Elevation in Plasma Ketones in Patients with T2DM and Heart Failure

CAROLINA SOLIS-HERRERA, YUEJUAN QIN, HENRI HONKA, FRANCISCA M. ACOSTA, ALEXANDER MOODY, ALBERTO CHAVEZ, CURTIS L. TRIPLITT, GEOFFREY D. CLARKE, EUGENIO CERSOSIMO, RALPH A. DEFRONZO
Journal: Diabetes
Diabetes 2023;72(Supplement_1):99-LB
https://doi.org/10.2337/db23-99-LB
Published: 20 June 2023
View article titled, 99-LB: Myocardial Blood Flow in Association with Baseline Ejection Fraction after Elevation in Plasma Ketones in Patients with T2DM and Heart Failure
Meeting Abstracts

853-P: Effect of Ketogenic Diet with Weight Maintenance in Type 2 Diabetes (T2D)

AURORA MEROVCI, BRITTANY FINLEY, ALBERTO CHAVEZ, ANDREA A. HANSIS-DIARTE, SIVARAM NEPPALA, DEVJIT TRIPATHY, RALPH A. DEFRONZO
Journal: Diabetes
Diabetes 2023;72(Supplement_1):853-P
https://doi.org/10.2337/db23-853-P
Published: 20 June 2023
View article titled, 853-P: Effect of Ketogenic Diet with Weight Maintenance in Type 2 Diabetes (T2D)
Meeting Abstracts

887-P: Renal Benefit of Dapagliflozin Therapy in Hyperfiltering Type 2 Diabetes Patients

GOZDE BASKOY, YUEJUAN QIN, EUGENIO CERSOSIMO, CAROLINA SOLIS-HERRERA, JOHN M. ADAMS, III, RALPH A. DEFRONZO, CURTIS L. TRIPLITT
Journal: Diabetes
Diabetes 2023;72(Supplement_1):887-P
https://doi.org/10.2337/db23-887-P
Published: 20 June 2023
View article titled, 887-P: Renal Benefit of Dapagliflozin Therapy in Hyperfiltering Type 2 Diabetes Patients
Meeting Abstracts

98-LB: Effects of SGLT2 Inhibition on Skeletal Muscle Bioenergetics and Myocellular Lipids in Patients with T2D and HFrEF

YUEJUAN QIN, NOAH D. SANCHEZ, ALEXANDER MOODY, FRANCISCA M. ACOSTA, SIVARAM NEPPALA, MARISSA BROWN, HENRI HONKA, LUIS A. CRUZ MORENO, CURTIS L. TRIPLITT, GEOFFREY D. CLARKE, EUGENIO CERSOSIMO, RALPH A. DEFRONZO, CAROLINA SOLIS-HERRERA
Journal: Diabetes
Diabetes 2023;72(Supplement_1):98-LB
https://doi.org/10.2337/db23-98-LB
Published: 20 June 2023
View article titled, 98-LB: Effects of SGLT2 Inhibition on Skeletal Muscle Bioenergetics and Myocellular Lipids in Patients with T2D and HFrEF
Meeting Abstracts

97-LB: Empagliflozin Improves Cardiopulmonary Function and VE/VCO2 in Patients with T2D and HFrEF

YUEJUAN QIN, FRANCISCA M. ACOSTA, SIVARAM NEPPALA, TIFFANY M. CORTES, ALLISON STEPANENKO, ALEXANDER MOODY, NOAH D. SANCHEZ, MARISSA BROWN, LUIS A. CRUZ MORENO, CURTIS L. TRIPLITT, GEOFFREY D. CLARKE, EUGENIO CERSOSIMO, SARA E. ESPINOZA, RALPH A. DEFRONZO, CAROLINA SOLIS-HERRERA
Journal: Diabetes
Diabetes 2023;72(Supplement_1):97-LB
https://doi.org/10.2337/db23-97-LB
Published: 20 June 2023
View article titled, 97-LB: Empagliflozin Improves Cardiopulmonary Function and VE/VCO2 in Patients with T2D and HFrEF
Meeting Abstracts

54-LB: Distinct Mechanisms Are Responsible for the Increase in Endogenous Glucose Production and Ketone Formation following Empagliflozin in T2DM Patients

SIHAM ABDELGANI, JOHN M. ADAMS, III, GIUSEPPE DANIELE, FAHD ALMULLA, RALPH A. DEFRONZO, MUHAMMAD ABDUL-GHANI, MOHAMED ABU-FARHA, STEFANO DEL PRATO
Journal: Diabetes
Diabetes 2022;71(Supplement_1):54-LB
https://doi.org/10.2337/db22-54-LB
Published: 01 June 2022
View article titled, 54-LB: Distinct Mechanisms Are Responsible for the Increase in Endogenous Glucose Production and Ketone Formation following Empagliflozin in T2DM Patients
Meeting Abstracts

644-P: Effect of PharmacologIC (EPIC) Therapy on Insulin Sensitivity and Beta-Cell Function in Prediabetes (PreDM)

ALBERTO O. CHAVEZ VELAZQUEZ, EMAD ALI, AURORA MEROVCI, CHRISTINA AGYIN, IV, TOMOKO TERASAWA, MUHAMMAD ABDUL-GHANI, CURTIS L. TRIPLITT, EUGENIO CERSOSIMO, RALPH A. DEFRONZO
Journal: Diabetes
Diabetes 2022;71(Supplement_1):644-P
https://doi.org/10.2337/db22-644-P
Published: 01 June 2022
View article titled, 644-P: Effect of PharmacologIC (EPIC) Therapy on Insulin Sensitivity and Beta-Cell Function in Prediabetes (PreDM)
Meeting Abstracts

1298-P: Metabolic Clearance of Insulin Is Altered after Gastric Bypass and Sleeve Gastrectomy

MARIA S. RAYAS, RALPH A. DEFRONZO, AMALIA GASTALDELLI, MARZIEH SALEHI
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1298-P
https://doi.org/10.2337/db22-1298-P
Published: 01 June 2022
View article titled, 1298-P: Metabolic Clearance of Insulin Is Altered after Gastric Bypass and Sleeve Gastrectomy
Meeting Abstracts

1324-P: Short-Term Effects of Glycemia-Lowering Medications on ß-Cell Function in the GRADE Study

NEDA RASOULI, JEANINE ALBU, ROBERT M. COHEN, RALPH A. DEFRONZO, ELSA DIAZ, ALOKANANDA GHOSH, JOSE A. LUCHSINGER, JANET B. MCGILL, LAURE SAYYED KASSEM, WILLIAM SIVITZ, WILLIAM V. TAMBORLANE, KRISTINA UTZSCHNEIDER, NAJI YOUNES, STEVEN E. KAHN, GRADE RESEARCH GROUP
Journal: Diabetes
Diabetes 2022;71(Supplement_1):1324-P
https://doi.org/10.2337/db22-1324-P
Published: 01 June 2022
View article titled, 1324-P: Short-Term Effects of Glycemia-Lowering Medications on ß-Cell Function in the GRADE Study