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Raphael Scharfmann
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Journal Articles

Imaging Human Pancreatic Endocrinogenesis During Early Prenatal Life

Adrian Villalba, Yorick Gitton, Virginie Aiello, Maryne Toupin, Séverine Mazaud-Guittot, Alain Chédotal, Raphaël Scharfmann
Journal: Diabetes
Diabetes 2025;74(3):368–375
https://doi.org/10.2337/db24-0641
Published: 27 November 2024
View article titled, Imaging Human Pancreatic Endocrinogenesis During Early Prenatal Life
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Meeting Abstracts

1471-P: Impaired Delta Opioid Receptor Function Protects against Type 2 Diabetes and Results in Enhanced Insulin Secretion—A Functional Genetic Study

AMELIE BONNEFOND, RADIO GROUP, RAPHAEL SCHARFMANN, PIERO MARCHETTI, MIRIAM CNOP, PHILIPPE FROGUEL
Journal: Diabetes
Diabetes 2024;73(Supplement_1):1471-P
https://doi.org/10.2337/db24-1471-P
Published: 14 June 2024
View article titled, 1471-P: Impaired Delta Opioid Receptor Function Protects against Type 2 Diabetes and Results in Enhanced Insulin Secretion—A Functional Genetic Study
Journal Articles

Peptidylarginine Deiminase Inhibition Prevents Diabetes Development in NOD Mice

Fernanda M.C. Sodré, Samal Bissenova, Ylke Bruggeman, Ronak Tilvawala, Dana P. Cook, Claire Berthault, Santanu Mondal, Aïsha Callebaut, Sylvaine You, Raphael Scharfmann, Roberto Mallone, Paul R. Thompson, Chantal Mathieu, Mijke Buitinga, Lut Overbergh
Journal: Diabetes
Diabetes 2021;70(2):516–528
https://doi.org/10.2337/db20-0421
Published: 17 November 2020
View article titled, Peptidylarginine Deiminase Inhibition Prevents Diabetes Development in NOD Mice
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Journal Articles

Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling

Geoffrey P. Roberts, Pierre Larraufie, Paul Richards, Richard G. Kay, Sam G. Galvin, Emily L. Miedzybrodzka, Andrew Leiter, H. Joyce Li, Leslie L. Glass, Marcella K.L. Ma, Brian Lam, Giles S.H. Yeo, Raphaël Scharfmann, Davide Chiarugi, Richard H. Hardwick, Frank Reimann, Fiona M. Gribble
Journal: Diabetes
Diabetes 2019;68(5):1062–1072
https://doi.org/10.2337/db18-0883
Published: 07 February 2019
View article titled, Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling
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Includes: Supplementary data
Journal Articles

Bromodomain and Extra Terminal Protein Inhibitors Promote Pancreatic Endocrine Cell Fate

Lukas Huijbregts, Maja Borup Kjær Petersen, Claire Berthault, Mattias Hansson, Virginie Aiello, Latif Rachdi, Anne Grapin-Botton, Christian Honore, Raphael Scharfmann
Journal: Diabetes
Diabetes 2019;68(4):761–773
https://doi.org/10.2337/db18-0224
Published: 17 January 2019
View article titled, Bromodomain and Extra Terminal Protein Inhibitors Promote Pancreatic Endocrine Cell Fate
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Includes: Supplementary data
Journal Articles

MondoA Is an Essential Glucose-Responsive Transcription Factor in Human Pancreatic β-Cells

Paul Richards, Latif Rachdi, Masaya Oshima, Piero Marchetti, Marco Bugliani, Mathieu Armanet, Catherine Postic, Sandra Guilmeau, Raphael Scharfmann
Journal: Diabetes
Diabetes 2018;67(3):461–472
https://doi.org/10.2337/db17-0595
Published: 27 December 2017
View article titled, MondoA Is an Essential Glucose-Responsive Transcription Factor in Human Pancreatic β-Cells
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Includes: Supplementary data
Journal Articles

Mitochondrial Protein UCP2 Controls Pancreas Development

Benjamin Broche, Selma Ben Fradj, Esther Aguilar, Tiphaine Sancerni, Matthieu Bénard, Fatna Makaci, Claire Berthault, Raphaël Scharfmann, Marie-Clotilde Alves-Guerra, Bertrand Duvillié
Journal: Diabetes
Diabetes 2018;67(1):78–84
https://doi.org/10.2337/db17-0118
Published: 27 October 2017
View article titled, Mitochondrial Protein UCP2 Controls Pancreas Development
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Includes: Supplementary data
Journal Articles

Systematic Functional Characterization of Candidate Causal Genes for Type 2 Diabetes Risk Variants

Soren K. Thomsen, Alessandro Ceroni, Martijn van de Bunt, Carla Burrows, Amy Barrett, Raphael Scharfmann, Daniel Ebner, Mark I. McCarthy, Anna L. Gloyn
Journal: Diabetes
Diabetes 2016;65(12):3805–3811
https://doi.org/10.2337/db16-0361
Published: 23 August 2016
View article titled, Systematic Functional Characterization of Candidate Causal Genes for Type 2 Diabetes Risk Variants
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Includes: Supplementary data
Journal Articles

Loss-of-Function Mutations in the Cell-Cycle Control Gene CDKN2A Impact on Glucose Homeostasis in Humans

Aparna Pal, Thomas P. Potjer, Soren K. Thomsen, Hui Jin Ng, Amy Barrett, Raphael Scharfmann, Tim J. James, D. Timothy Bishop, Fredrik Karpe, Ian F. Godsland, Hans F.A. Vasen, Julia Newton-Bishop, Hanno Pijl, Mark I. McCarthy, Anna L. Gloyn
Journal: Diabetes
Diabetes 2016;65(2):527–533
https://doi.org/10.2337/db15-0602
Published: 05 November 2015
View article titled, Loss-of-Function Mutations in the Cell-Cycle Control Gene <em>CDKN2A</em> Impact on Glucose Homeostasis in Humans
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Includes: Supplementary data
Journal Articles

Mouse Muscle As an Ectopic Permissive Site for Human Pancreatic Development

Carmen Capito, Marie-Thérèse Simon, Virginie Aiello, Anne Clark, Yves Aigrain, Philippe Ravassard, Raphael Scharfmann
Journal: Diabetes
Diabetes 2013;62(10):3479–3487
https://doi.org/10.2337/db13-0554
Published: 17 September 2013
View article titled, Mouse Muscle As an Ectopic Permissive Site for Human Pancreatic Development
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Includes: Supplementary data
Journal Articles

Fetal Pancreas Transplants Are Dependent on Prolactin for Their Development and Prevent Type 1 Diabetes in Syngeneic but Not Allogeneic Mice

Gwladys Fourcade, Bruno M. Colombo, Sylvie Grégoire, Audrey Baeyens, Latif Rachdi, Fanny Guez, Vincent Goffin, Raphael Scharfmann, Benoît L. Salomon
Journal: Diabetes
Diabetes 2013;62(5):1646–1655
https://doi.org/10.2337/db12-0448
Published: 16 April 2013
View article titled, Fetal Pancreas Transplants Are Dependent on Prolactin for Their Development and Prevent Type 1 Diabetes in Syngeneic but Not Allogeneic Mice
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Includes: Supplementary data
Journal Articles

l-Leucine Alters Pancreatic β-Cell Differentiation and Function via the mTor Signaling Pathway

Latif Rachdi, Virginie Aïello, Bertrand Duvillié, Raphaël Scharfmann
Journal: Diabetes
Diabetes 2012;61(2):409–417
https://doi.org/10.2337/db11-0765
Published: 17 January 2012
View article titled, <sc>l</sc>-Leucine Alters Pancreatic β-Cell Differentiation and Function via the mTor Signaling Pathway
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Includes: Supplementary data
Journal Articles

Specific Control of Pancreatic Endocrine β- and δ-Cell Mass by Class IIa Histone Deacetylases HDAC4, HDAC5, and HDAC9

Olivia Lenoir, Kathleen Flosseau, Feng Xia Ma, Bertrand Blondeau, Antonello Mai, Rhonda Bassel-Duby, Philippe Ravassard, Eric N. Olson, Cécile Haumaitre, Raphaël Scharfmann
Journal: Diabetes
Diabetes 2011;60(11):2861–2871
https://doi.org/10.2337/db11-0440
Published: 17 October 2011
View article titled, Specific Control of Pancreatic Endocrine β- and δ-Cell Mass by Class IIa Histone Deacetylases HDAC4, HDAC5, and HDAC9
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Includes: Supplementary data
Journal Articles

Mesenchymal Bone Morphogenetic Protein Signaling Is Required for Normal Pancreas Development

Jonas Ahnfelt-Rønne, Philippe Ravassard, Corinne Pardanaud-Glavieux, Raphaél Scharfmann, Palle Serup
Journal: Diabetes
Diabetes 2010;59(8):1948–1956
https://doi.org/10.2337/db09-1010
Published: 03 June 2010
View article titled, Mesenchymal Bone Morphogenetic Protein Signaling Is Required for Normal Pancreas Development
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Includes: Supplementary data
Journal Articles

Oxygen Tension Regulates Pancreatic β-Cell Differentiation Through Hypoxia-Inducible Factor 1α

Mylène Heinis, Marie-Thérèse Simon, Karine Ilc, Nathalie M. Mazure, Jacques Pouysségur, Raphael Scharfmann, Bertrand Duvillié
Journal: Diabetes
Diabetes 2010;59(3):662–669
https://doi.org/10.2337/db09-0891
Published: 15 December 2009
View article titled, Oxygen Tension Regulates Pancreatic β-Cell Differentiation Through Hypoxia-Inducible Factor 1α
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Includes: Supplementary data
Journal Articles

Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes–Associated Variants

Tamara J. Nicolson, Elisa A. Bellomo, Nadeeja Wijesekara, Merewyn K. Loder, Jocelyn M. Baldwin, Armen V. Gyulkhandanyan, Vasilij Koshkin, Andrei I. Tarasov, Raffaella Carzaniga, Katrin Kronenberger, Tarvinder K. Taneja, Gabriela da Silva Xavier, Sarah Libert, Philippe Froguel, Raphael Scharfmann, Volodymir Stetsyuk, Philippe Ravassard, Helen Parker, Fiona M. Gribble, Frank Reimann, Robert Sladek, Stephen J. Hughes, Paul R.V. Johnson, Myriam Masseboeuf, Remy Burcelin, Stephen A. Baldwin, Ming Liu, Roberto Lara-Lemus, Peter Arvan, Frans C. Schuit, Michael B. Wheeler, Fabrice Chimienti, Guy A. Rutter
Journal: Diabetes
Diabetes 2009;58(9):2070–2083
https://doi.org/10.2337/db09-0551
Published: 19 June 2009
View article titled, Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes–Associated Variants
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Includes: Supplementary data
Journal Articles

Heterozygous Missense Mutations in the Insulin Gene Are Linked to Permanent Diabetes Appearing in the Neonatal Period or in Early Infancy: A Report From the French ND (Neonatal Diabetes) Study Group

Michel Polak, Aurélie Dechaume, Hélène Cavé, Revital Nimri, Hélène Crosnier, Véronique Sulmont, Marc de Kerdanet, Raphael Scharfmann, Yael Lebenthal, Philippe Froguel, Martine Vaxillaire
Journal: Diabetes
Diabetes 2008;57(4):1115–1119
https://doi.org/10.2337/db07-1358
Published: 01 April 2008
View article titled, Heterozygous Missense Mutations in the Insulin Gene Are Linked to Permanent Diabetes Appearing in the Neonatal Period or in Early Infancy: <subtitle>A Report From the French ND (Neonatal Diabetes) Study Group</subtitle>
Open the PDF for Heterozygous Missense Mutations in the Insulin Gene Are Linked to Permanent Diabetes Appearing in the Neonatal Period or in Early Infancy: <subtitle>A Report From the French ND (Neonatal Diabetes) Study Group</subtitle> in another window
Journal Articles

New ABCC8 Mutations in Relapsing Neonatal Diabetes and Clinical Features

Martine Vaxillaire, Aurélie Dechaume, Kanetee Busiah, Hélène Cavé, Sabrina Pereira, Raphael Scharfmann, Guiomar Perez de Nanclares, Luis Castano, Philippe Froguel, Michel Polak, and the SUR1–Neonatal Diabetes Study Group
Journal: Diabetes
Diabetes 2007;56(6):1737–1741
https://doi.org/10.2337/db06-1540
Published: 01 June 2007
View article titled, New <em>ABCC8</em> Mutations in Relapsing Neonatal Diabetes and Clinical Features
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Includes: Supplementary data
Journal Articles

Control of β-Cell Differentiation by the Pancreatic Mesenchyme

Myriam Attali, Volodymyr Stetsyuk, Annie Basmaciogullari, Virginie Aiello, Maria A. Zanta-Boussif, Bertrand Duvillie, Raphael Scharfmann
Journal: Diabetes
Diabetes 2007;56(5):1248–1258
https://doi.org/10.2337/db06-1307
Published: 01 May 2007
View article titled, Control of β-Cell Differentiation by the Pancreatic Mesenchyme
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Journal Articles

The Mesenchyme Controls the Timing of Pancreatic β-Cell Differentiation

Bertrand Duvillié, Myriam Attali, Ali Bounacer, Philippe Ravassard, Annie Basmaciogullari, Raphael Scharfmann
Journal: Diabetes
Diabetes 2006;55(3):582–589
https://doi.org/10.2337/diabetes.55.03.06.db05-0839
Published: 01 March 2006
View article titled, The Mesenchyme Controls the Timing of Pancreatic β-Cell Differentiation
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